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Lead Isotope and Rock Geochemistry of Zaibian Mafic-Ultramafic Rock,Southeast Guizhou Province,China 被引量:1
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作者 LIU Yong-kun1,ZHOU Jia-xi2,HUANG Zhi-long2,WANG Jing-song1,YANG De-zhi1,3,DING wei2,CHEN Yuan-xing1,BAO Guang-ping2(1. The 102 Geological Team,Guizhou Bureau of Exploration and Development of Geology and Mineral Resources,Zunyi 563003,China 2. State key Laboratory of Ore Deposits Geochemistry,Institute of Geochemistry,Chinese Academy of Science,Guiyang 550002,China 3. China University of Geosciences(Wuhan) ,Wuhan 430074,China) 《矿物学报》 CAS CSCD 北大核心 2009年第S1期70-70,共1页
The Zaibian mafic-ultramafic rock is located in the transitional zone of the Yangtze craton and south China fold system,where is the southwest of Jiangnan orogenic belt(Zeng et al.,2003;Wang et al.,in press).
关键词 PB rock Lead Isotope and rock Geochemistry of Zaibian mafic-ultramafic rock Southeast Guizhou Province China
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Early Paleozoic Mafic-Ultramafic Rocks in the East Kunlun: Trace Subduction of Proto-Tethys
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作者 MENG Fancong CUI Meihui +1 位作者 REN Yufeng Paul T.ROBINSON 《Acta Geologica Sinica(English Edition)》 SCIE CAS CSCD 2016年第S1期231-233,共3页
The East Kunlun located in the northern margin of the Qinghai-Xizang(Tibet)Plateau,is a composite orogenic belt which has underwent multi-stages tectonic evolution(e.g.Wang and Chen,1987;Jiang et al.,1992;Yang et al.,... The East Kunlun located in the northern margin of the Qinghai-Xizang(Tibet)Plateau,is a composite orogenic belt which has underwent multi-stages tectonic evolution(e.g.Wang and Chen,1987;Jiang et al.,1992;Yang et al.,1996,2009).The East Kunlun orogenic belt(EKOB)is bounded by Altyn Tagh Fault in the west and Wenquan Fault in the east,bounded by the south margin of Qaidam 展开更多
关键词 Trace Subduction of Proto-Tethys Early Paleozoic mafic-ultramafic rocks in the East Kunlun PB PPM
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Geochemistry of Platinum Group Elements in Mafic-Ultramafic Rocks of Xinjie Intrusion
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作者 张成江 汪云亮 +2 位作者 李晓林 修淑芝 黄永建 《Chinese Journal Of Geochemistry》 EI CAS 1999年第3期242-249,共8页
The platinum group elements (PGE) in the mafic ultramafic suite in the Xinjie layered intrusion and associated basalts and syenites were analyzed using neutron activation techniques after fire assay preconcentration. ... The platinum group elements (PGE) in the mafic ultramafic suite in the Xinjie layered intrusion and associated basalts and syenites were analyzed using neutron activation techniques after fire assay preconcentration. On this basis, the geochemistry of the platinum group during the magmatic stage is discussed. With respect to PGE distribution, the Xinjie layered intrusion is similar to the Bushveld ferruginous ultramafic series and is distinct from komatiite and Alpine type peridotite. It is also similar to the Emeishan basalt in PGE characteristics, implying that the original magmas of them may be of the same type. 展开更多
关键词 地球化学 铂元素 地层 超基性铁镁质岩 四川
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U-Pb isotopic geochemistry of the post-collisional mafic-ultramafic rocks from the Dabie Mountains——Crust-mantle interaction and LOMU component 被引量:2
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作者 黄方 李曙光 +1 位作者 周红英 李惠民 《Science China Earth Sciences》 SCIE EI CAS 2003年第4期320-332,共13页
The U-Pb isotope geochemical study of the pyroxenite-gabbro intrusion in the Dabie Mountains shows that the post-collisional mafic-ultramafic rocks of the Dabie Mountains are char-acterized by relative high Pb content... The U-Pb isotope geochemical study of the pyroxenite-gabbro intrusion in the Dabie Mountains shows that the post-collisional mafic-ultramafic rocks of the Dabie Mountains are char-acterized by relative high Pb contents, low U contents and low U/Pb ratios. These characters may be results of interaction between lithosphere or depleted asthenospheric mantle (DMM) and lower crust, but have nothing to do with mantle plume and subducted continental crust. It was first ob-served that some samples with lower 206Pb/204Pb and higher 207Pb/204Pb ratios show typical char-acters of the LOMU component. The Pb, Sr, and Nd isotopic tracing shows that three components are needed in the source of the Zhujiapu pyroxenite-gabbro intrusion. They could be old enriched sub-continental lithospheric mantle (LOMU component), lower crust and depleted asthenospheric mantle. The crust-mantle interaction process producing primitive magma of post-collisional ma-fic-ultramafic rocks in the Dabie Mountains could be described by a lithospheric delamination and magma underplating model. After continent-continent collision, delamination of the thickened lithosphere induced the upwelling of depleted asthenospheric mantle, which caused partial melting of asthenospheric mantle and residual sub-continental lithospheric mantle. The basaltic magma produced in this process underplated in the boundary between the crust and mantle and interacted with lower crust resulting in the geochemical characters of both enriched lithospheric mantle and lower crust. 展开更多
关键词 mafic-ultramafic rocks CRUST-MANTLE interaction U-PB ISOTOPIC geochemistry DABIE Mountains LOMU component.
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Origin of the Fanjingshan Mafic-Ultramafic Rocks, Western Jiangnan Orogen, South China: Implications for PGE Fractionation and Mineralization 被引量:1
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作者 Sifang Huang Wei Wang 《Journal of Earth Science》 SCIE CAS CSCD 2019年第2期258-271,共14页
The Fanjingshan mafic-ultramafic rocks in the west Jiangnan Orogen of South China are considered to be a potential target for mineral exploration. However, the petrogenesis and magma evolution of these rocks are not y... The Fanjingshan mafic-ultramafic rocks in the west Jiangnan Orogen of South China are considered to be a potential target for mineral exploration. However, the petrogenesis and magma evolution of these rocks are not yet clearly constrained, let along their economic significance. The compositions of platinum group elements(PGE) in the Fanjingshan mafic-ultramafic rocks can provide particular insight into the generation and evolution of the mantle-derived magma and thus the potential of Cu-Ni-PGE sulphide mineralization. The Fanjingshan mafic-ultramafic rocks have relatively high Pd-subgroup PGE(PPGE) relative to Ir-subgroup PGE(IPGE) in the primitive mantle-normalized diagrams. Meanwhile, the Fanjingshan mafic-ultramafic rocks have low Pd/Ir(11–28) ratios, implying relatively low degree of partial melting in the mantle. Low Cu/Pd ratios(545–5 216) and high Cu/Zr ratios(0.4–5.8 with the majority greater than 1) of Fanjingshan ultramafic rocks indicate that the S-undersaturated parental magma with relatively high PGE was formed. Although the Fanjingshan mafic rocks have remarkably higher Cu/Pd ratios(8 913–107 016) likely resulting from sulphide segregation, the degree of sulphide removal is insignificant. Fractionation of olivine rather than chromite and platinum group minerals or alloys governed the fractionation of PGE and produced depletion of IPGE(Os, Ir and Ru) relative to PPGE(Rh, Pt and Pd), as supported by the positive correlation between Pd/Ir and V, Y and REE. Collectively, original S-undersaturated magma and insignificant crustal contamination during magma ascent and emplacement result in the separation of immiscible sulphide impossible and thus impede the formation of economic CuNi-PGE sulphide mineralization within the Fanjingshan mafic-ultramafic rocks. 展开更多
关键词 MAGMA differentiation platinum group elements mafic-ultramafic rocks Jiangnan OROGEN South China
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Correlation between the rock mass properties and maximum horizontal stress:A case study of overcoring stress measurements
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作者 Peng Li Meifeng Cai +2 位作者 Shengjun Miao Yuan Li Yu Wang 《International Journal of Minerals,Metallurgy and Materials》 SCIE EI CAS 2025年第1期39-48,共10页
Understanding the mechanical properties of the lithologies is crucial to accurately determine the horizontal stress magnitude.To investigate the correlation between the rock mass properties and maximum horizontal stre... Understanding the mechanical properties of the lithologies is crucial to accurately determine the horizontal stress magnitude.To investigate the correlation between the rock mass properties and maximum horizontal stress,the three-dimensional(3D)stress tensors at 89 measuring points determined using an improved overcoring technique in nine mines in China were adopted,a newly defined characteristic parameter C_(ERP)was proposed as an indicator for evaluating the structural properties of rock masses,and a fuzzy relation matrix was established using the information distribution method.The results indicate that both the vertical stress and horizontal stress exhibit a good linear growth relationship with depth.There is no remarkable correlation between the elastic modulus,Poisson's ratio and depth,and the distribution of data points is scattered and messy.Moreover,there is no obvious relationship between the rock quality designation(RQD)and depth.The maximum horizontal stress σ_(H) is a function of rock properties,showing a certain linear relationship with the C_(ERP)at the same depth.In addition,the overall change trend of σ_(H) determined by the established fuzzy identification method is to increase with the increase of C_(ERP).The fuzzy identification method also demonstrates a relatively detailed local relationship betweenσ_H and C_(ERP),and the predicted curve rises in a fluctuating way,which is in accord well with the measured stress data. 展开更多
关键词 overcoring stress measurements elastic modulus Poisson's ratio rock quality designation maximum horizontal stress fuzzy identification
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SLC9A3-AS1调控miR-148a-3p/ROCK1信号轴影响肾癌细胞生物学功能 被引量:1
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作者 向威 吕磊 +2 位作者 郑福鑫 章传华 袁敬东 《华中科技大学学报(医学版)》 CAS CSCD 北大核心 2024年第2期161-167,共7页
目的检测lncRNA SLC9A3-AS1在肾透明细胞癌(clear cell renal cell carcinoma,ccRCC)组织与肾癌细胞中的表达水平,探讨其促进肾癌细胞恶性生物学行为的机制。方法应用GEPIA2在线软件(http://gepia2.cancer-pku.cn/)分析TCGA数据库中SLC9... 目的检测lncRNA SLC9A3-AS1在肾透明细胞癌(clear cell renal cell carcinoma,ccRCC)组织与肾癌细胞中的表达水平,探讨其促进肾癌细胞恶性生物学行为的机制。方法应用GEPIA2在线软件(http://gepia2.cancer-pku.cn/)分析TCGA数据库中SLC9A3-AS1在ccRCC组织中的表达水平;采用实时荧光定量聚合酶链反应(qRT-PCR)检测SLC9A3-AS1在不同肾癌细胞系、24例ccRCC组织与癌旁正常肾脏组织中的表达水平;应用细胞增殖/毒性检测试剂盒(cell counting kit-8,CCK-8)和Transwell小室迁移实验检测敲低SLC9A3-AS1表达对肾癌细胞增殖与迁移的影响;应用蛋白质免疫印迹法检测增殖与迁移相关信号通路蛋白的表达水平;采用双荧光素酶报告基因实验验证SLC9A3-AS1与miR-148a-3p/ROCK1轴的靶向调控关系。结果GEPIA2软件分析结果显示,相较正常肾脏组织,SLC9A3-AS1在肾透明细胞癌组织中表达显著上调(P<0.01)。qRT-PCR结果显示,相较癌旁正常肾脏组织,SLC9A3-AS1在24例ccRCC组织中表达显著上调(P<0.01);相较永生化肾小管上皮细胞,SLC9A3-AS1在4种肾癌细胞系中表达均显著上调,以786-O细胞最为显著(P<0.01)。干扰SLC9A3-AS1表达,可显著抑制786-O细胞的增殖与迁移能力,上调E-cadherin的蛋白表达水平,而下调N-cadherin、MMP2的蛋白表达水平(均P<0.05);过表达miR-148a-3p可显著抑制786-O细胞的增殖与迁移能力(P<0.01)。双荧光素酶报告基因检测结果表明,SLC9A3-AS1可特异性结合miR-148a-3p,后者进一步靶向结合ROCK1 mRNA的3′UTR区域;过表达miR-148a-3p可明显下调ROCK1 mRNA的表达水平,敲低miR-148a-3p表达则产生相反的效应;敲低SLC9A3-AS1表达可显著下调786-O细胞中ROCK1 mRNA与蛋白的表达水平(P<0.01);下调miR-148a-3p表达可部分逆转SLC9A3-AS1沉默对786-O细胞增殖与迁移的抑制作用(P<0.05)。结论SLC9A3-AS1在ccRCC中通过调控miR-148a-3p/ROCK1轴发挥促癌作用,有望成为ccRCC的一个新的分子标志物。 展开更多
关键词 肾透明细胞癌 SLC9A3-AS1 miR-148a-3p rock1
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贝母素乙调节RhoA/ROCK信号通路对膝骨关节炎大鼠软骨损伤的影响
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作者 彭博文 冯立 覃剑 《中国骨质疏松杂志》 CAS CSCD 北大核心 2024年第7期980-984,共5页
目的 探讨贝母素乙调节Ras同源基因家族成员A(RhoA)/Rho相关的卷曲螺旋激酶(ROCK)信号通路对膝骨关节炎(knee osteoarthritis, KOA)大鼠软骨损伤的影响。方法 以碘乙酸钠(MIA)法制备KOA大鼠模型,随机分为模型组、贝母素乙(3.5 mg/kg)组... 目的 探讨贝母素乙调节Ras同源基因家族成员A(RhoA)/Rho相关的卷曲螺旋激酶(ROCK)信号通路对膝骨关节炎(knee osteoarthritis, KOA)大鼠软骨损伤的影响。方法 以碘乙酸钠(MIA)法制备KOA大鼠模型,随机分为模型组、贝母素乙(3.5 mg/kg)组、贝母素乙(3.5 mg/kg)+LPA(RhoA激活剂,1 mg/kg)组,每组10只,另选10只大鼠为对照组。机械刺激法和热辐射法检测大鼠膝关节疼痛症状;检测大鼠关节肿胀度、膝关节宽度并以步态评分评测其关节功能;透射电镜检测大鼠膝关节软骨细胞超微结构;TUNEL染色检测大鼠关节软骨细胞凋亡比;酶联免疫吸附(ELISA)法检测大鼠血清和关节液促炎因子白细胞介素(IL)-18、单核细胞趋化蛋白1(MCP-1)水平;免疫印迹检测各组大鼠关节软骨组织凋亡(Cleaved caspase-3、Bax)和RhoA/ROCK通路相关蛋白表达。结果 贝母素乙可降低KOA大鼠关节肿胀度、膝关节宽度、步态评分、软骨细胞凋亡比、血清及关节液IL-18、MCP-1水平、软骨组织Cleaved caspase-3、Bax、RhoA、ROCK1、ROCK1蛋白表达,升高机械痛阈值、热痛阈值(P<0.05);LPA可减弱贝母素乙对KOA大鼠关节软骨损伤的改善作用。结论 贝母素乙可通过抑制RhoA/ROCK信号激活而抑制KOA大鼠关节炎症反应和关节软骨细胞凋亡,减轻软骨损伤。 展开更多
关键词 贝母素乙 RhoA/rock 膝骨关节炎 软骨损伤 信号通路
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桃叶珊瑚苷调节RhoA/ROCK信号通路对胶质母细胞瘤细胞活力和上皮间质转化的影响
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作者 李娟 石海平 李维民 《天津中医药》 CAS 2024年第3期386-392,共7页
[目的]研究桃叶珊瑚苷(AU)对胶质母细胞瘤(GBM)细胞活力和上皮间质转化(EMT)的影响,并对其作用机制进行探讨。[方法]将U87细胞随机分为对照组、AU低浓度组、AU中浓度组、AU高浓度组、Y-27632组、AU高浓度+Y-27632组。细胞计数器试剂盒(C... [目的]研究桃叶珊瑚苷(AU)对胶质母细胞瘤(GBM)细胞活力和上皮间质转化(EMT)的影响,并对其作用机制进行探讨。[方法]将U87细胞随机分为对照组、AU低浓度组、AU中浓度组、AU高浓度组、Y-27632组、AU高浓度+Y-27632组。细胞计数器试剂盒(CCK-8)法检测细胞活力,流式细胞术检测细胞凋亡,Transwell小室实验检测细胞迁移和侵袭,蛋白免疫印迹法(Western Blot)检测基质金属蛋白酶(MMP)2、MMP9、波形蛋白(Vimentin)、上皮钙黏蛋白(E-cadherin)、神经钙黏蛋白(N-cadherin)、Ras同源基因家族成员A(RhoA)、Rho相关卷曲螺旋蛋白激酶(ROCK)1、ROCK2表达。构建GBM裸鼠模型,随机分为裸鼠对照组、AU组、Y-27632组、AU+Y-27632组,测量肿瘤质量与体积,免疫组化法检测移植瘤组织RhoA、ROCK1、ROCK2蛋白表达。[结果]GBM细胞活力随着AU浓度的升高而逐渐降低(P<0.05),选择U87作为后续实验细胞,选择10、25、50μmol/L浓度作为AU后续实验浓度。与对照组比较,AU低、中、高浓度组和Y-27632组细胞活力、迁移和侵袭细胞数、MMP2、MMP9、N-cadherin、Vimentin、RhoA、ROCK1、ROCK2表达显著下降,凋亡率、E-cadherin表达显著升高(P<0.05),其中高浓度AU和Y-27632组共同处理的细胞变化更显著(P<0.05)。AU和Y-27632均能抑制移植瘤质量和体积,降低RhoA/ROCK信号通路蛋白表达(P<0.05)。[结论]AU能抑制GBM细胞活力、迁移侵袭和EMT,促进细胞凋亡,其作用机制可能与抑制RhoA/ROCK信号通路有关。 展开更多
关键词 胶质母细胞瘤 细胞活力 上皮间质转化 桃叶珊瑚苷 RhoA/rock信号通路
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芍药苷调节RhoA/ROCK信号通路对实验性自身免疫性葡萄膜炎小鼠Th17/Treg免疫平衡的影响 被引量:2
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作者 庞彬彬 陈震 邢怡桥 《中药新药与临床药理》 CAS CSCD 北大核心 2024年第4期506-512,共7页
目的探讨芍药苷调节Ras同源基因家族蛋白A(RhoA)/Rho相关卷曲螺旋形成蛋白激酶(ROCK)信号通路对实验性自身免疫性葡萄膜炎(experimental autoimmune uveitis,EAU)小鼠辅助性T淋巴细胞17(Th17)/调节性T细胞(Treg)免疫平衡的影响。方法随... 目的探讨芍药苷调节Ras同源基因家族蛋白A(RhoA)/Rho相关卷曲螺旋形成蛋白激酶(ROCK)信号通路对实验性自身免疫性葡萄膜炎(experimental autoimmune uveitis,EAU)小鼠辅助性T淋巴细胞17(Th17)/调节性T细胞(Treg)免疫平衡的影响。方法随机选出10只小鼠作为正常对照组,其余小鼠构建EAU模型,将造模成功小鼠随机平分为模型组、芍药苷组(10 mg·kg^(-1)芍药苷)、RhoA/ROCK信号通路激活剂溶血磷脂酸(LPA)组(25μmol·L^(-1)LPA)、芍药苷+LPA组(10 mg·kg^(-1)芍药苷+25μmol·L^(-1)LPA),每组10只。模型组和正常对照组给予等量生理盐水,给药每天1次,持续14 d。眼前节临床表现评分评估炎症严重程度;HE染色观察眼球组织病理形态;ELISA法检测血清中炎性因子转化生长因子-β(trarsforming growth factor beta,TGF-β)、白细胞介素10(IL-10)、白细胞介素17(IL-17)、白细胞介素23(IL-23)水平;流式细胞术检测脾脏Th17/Treg细胞水平;Western Blot法检测维甲酸相关核孤儿受体γt(RORγt)、叉头状转录因子3(Foxp3)以及RhoA/ROCK信号通路蛋白表达。结果正常对照组小鼠无虹膜、结膜血管舒张充血,与正常对照组比,模型组小鼠出现虹膜血管舒张充血,前房、虹膜、睫状体和视网膜内均有大量炎性细胞膨胀,眼前节临床表现评分、IL-17和IL-23含量、Th17细胞水平、Th17/Treg、RORγt、RhoA、ROCK1蛋白水平明显升高(P<0.05),IL-10和TGF-β含量、Treg细胞水平、Foxp3水平明显下降(P<0.05)。与模型组比,芍药苷组小鼠虹膜血管充血症状明显缓解,眼前节临床表现评分、IL-17和IL-23含量、Th17细胞水平、Th17/Treg、RORγt、RhoA、ROCK1蛋白水平明显降低(P<0.05),IL-10和TGF-β含量、Treg细胞水平、Foxp3水平明显升高(P<0.05);而LPA加重了眼部损伤(P<0.05),逆转了芍药苷对EAU小鼠的改善效果(P<0.05)。结论芍药苷可通过下调RhoA/ROCK信号通路调节EAU小鼠Th17/Treg免疫平衡减轻EAU小鼠葡萄膜炎。 展开更多
关键词 芍药苷 RhoA/rock信号通路 自身免疫性葡萄膜炎 TH17/TREG 小鼠
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The Gaojiacun Mafic-Ultramafic Complex(Sichuan,SW China):Neoproterozoic Magmatic Activity at the Western Margin of the Yangtze Craton 被引量:3
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作者 Marian MUNTEANU YAO Yong +3 位作者 Allan H. WILSON Gordon CHUNNETT LUO Yaonan ZHAO Qixue 《Acta Geologica Sinica(English Edition)》 SCIE CAS CSCD 2006年第5期705-723,共19页
The Neoproterozoic Gaojiacun intrusive complex (GIC) is composed of one big intrusion (ca. 9 × 7.5 km) and numerous satellite intrusions, emplaced in the low-grade schists of the Neoproterozoic Yanbian Group.... The Neoproterozoic Gaojiacun intrusive complex (GIC) is composed of one big intrusion (ca. 9 × 7.5 km) and numerous satellite intrusions, emplaced in the low-grade schists of the Neoproterozoic Yanbian Group. The main intrusion is concentrically zoned, with peridotite bodies + leucogabbroids in its core (inner zone) and the sequence: olivine hornblende gabbronorite - porphyric pyroxene hornblende gabbronorite (transitional zone) - pyroxene hornblende gabbronorite + hornblende gabbro + diorite (outer zone), towards the margins. The satellite intrusions are composed either of a single rock type (peridotite, gabbro, diorite or granite) or of different rock types (peridotite + diorite + granite). Upper crustal contamination is evidenced by the occurrence of numerous metamorphic enclaves, migmatites and mixed rocks in the outer zone of the main intrusion and in the satellite intrusions. Hornblende (often oikocrystic) is present in all mafic and ultramafic rocks. Cu-Ni (-PGE) deposits occur in several satellite intrusions, hosted in peridotite. The geochemical and mineralogical features of GIC support the presence of a subduction zone at the western edge of the Yangtze Craton. A feederrelated genesis of the satellite intrusions is inferred. 展开更多
关键词 China NEOPROTEROZOIC ultramafic-mafic rocks CUMULATE Cu-Ni deposits
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Geochemical Characteristics and Metallogenesis of the Qingkuangshan Ni-Cu-PGE Mineralized Mafic-Ultramafic Intrusion in Huili County, Sichuan Province, SW China 被引量:5
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作者 ZHU Feilin TAO Yan +1 位作者 HU Ruizhong MA Yansheng 《Acta Geologica Sinica(English Edition)》 SCIE CAS CSCD 2012年第3期590-607,共18页
The Qingkuangshan Ni-Cu-PGE deposit, located in the Xiaoguanhe region of Huili County, Sichuan Province, is one of several Ni-Cu-PGE deposits in the Emeishan Large Igneous Province (ELIP). The ore-bearing intrusion ... The Qingkuangshan Ni-Cu-PGE deposit, located in the Xiaoguanhe region of Huili County, Sichuan Province, is one of several Ni-Cu-PGE deposits in the Emeishan Large Igneous Province (ELIP). The ore-bearing intrusion is a mafic-ultramafic body. This paper reports major elements, trace elements and platinum-group elements in different types of rocks and sulfide-mineralized samples in the intrusion. These data are used to evaluate the source mantle characteristics, the degree of mantle partial melting, the composition of parental magma and the ore-forming processes. The results show that Qingkuangshan intrusion is part of the ELIP. The rocks have trace element ratios similar to the coeval Emeishan basalts. The primitive mantle-normalized patterns of Ni-Cu-PGE have positive slopes, and the ratios of Pd/Ir are lower than 22. The PGE compositions of sulfide ores and associated rocks are characterized by Ru depletion. The PGE contents in bulk sulfides are slightly depleted relative to Ni and Cu, which is similar to the Yangliuping Ni-Cu-PGE deposit. The composition of the parental magma for the intrusion is estimated to contain about 14.65 wt% MgO, 48.66 wt% SiO2 and 15.48 wt% FeOt, and the degree of mantle partial melting is estimated to be about 20%. In comparison with other typical Ni-Cu-PGE deposits in the ELIP, the Qingkuangshan Ni-Cu-PGE deposit has lower PGE contents than the Jinbaoshan PGE deposit, but has higher PGE contents than the Limahe and Baimazhai Ni-Cu deposit, and has similar PGE contents to the Yangliuping Ni-Cu-PGE deposit. The moderate PGE depletions in the bulk sulfide of the Qingkuanghan deposit suggest that the parental magma of the host intrusion may have undergone minor sulfide segregation at depth. The mixing calculations suggests that an average of 10% crustal contamination in the magma, which may have been the main cause of sulfide saturation in the magma. We propose that sulfide segregation from a moderately PGE depleted magma took place prior to magma emplacement at Qingkuangshan, that small amounts of immiscible sulfide droplets and olivine and chromite crystals were suspended in the ascending magma, and that the suspended materials settled down when the magma passed trough the Qingkuangshan conduit. The Qingkuangshan sulfide-bearing intrusion is interpreted to a feeder of Emeishan flood basalts in the region. 展开更多
关键词 Magmatic sulfide deposit mafic-ultramafic intrusion PGE Qingkuangshan Emeishan Large Igneous Province
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苍术素调节RhoA/ROCK信号通路对弥漫大B细胞淋巴瘤细胞恶性生物学行为的影响 被引量:1
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作者 张薇 陈姣敏 +2 位作者 许卫星 尹凤雷 王娟 《陕西医学杂志》 CAS 2024年第5期593-597,共5页
目的:探讨苍术素(ATR)调节Ras同源基因家族成员A(RhoA)/Rho相关卷曲螺旋形成蛋白激酶(ROCK)信号通路对弥漫大B细胞淋巴瘤(DLBCL)细胞恶性生物学行为的影响。方法:常规培养DLBCL细胞SUDHL-4,将其随机分为对照组、低浓度ATR组(ATR-L组,5μ... 目的:探讨苍术素(ATR)调节Ras同源基因家族成员A(RhoA)/Rho相关卷曲螺旋形成蛋白激酶(ROCK)信号通路对弥漫大B细胞淋巴瘤(DLBCL)细胞恶性生物学行为的影响。方法:常规培养DLBCL细胞SUDHL-4,将其随机分为对照组、低浓度ATR组(ATR-L组,5μmol/L ATR)、中浓度ATR组(ATR-M组,10μmol/L ATR)、高浓度ATR组(ATR-H组,20μmol/L ATR)和高浓度ATR+RhoA激活剂U46619组(ATR+U46619组,20μmol/L ATR+10 nmol/L U46619)。CCK-8法测定细胞增殖活性。划痕实验检测细胞迁移能力。Transwell实验测定细胞侵袭能力。流式细胞术检测细胞凋亡率。实时荧光定量PCR(RT-qPCR)法测定细胞中RhoA、ROCK1 mRNA表达。免疫印迹法(Western blot)测定各组细胞B细胞淋巴瘤-2(Bcl-2)、Bcl-2相关X蛋白(Bax)、RhoA、ROCK1蛋白表达。结果:与对照组比较,ATR-M组、ATR-H组SUDHL-4细胞OD450值(48、72 h)、细胞迁移率、细胞侵袭数目、RhoA、ROCK1 mRNA和蛋白表达、Bcl-2蛋白表达降低,细胞凋亡率、Bax蛋白表达升高(均P<0.05)。RhoA激活剂U46619减弱了ATR对DLBCL细胞恶性生物学行为的抑制作用。结论:ATR可能通过下调RhoA/ROCK信号通路抑制DLBCL细胞恶性生物学行为。 展开更多
关键词 弥漫大B细胞淋巴瘤 苍术素 RhoA/rock通路 细胞凋亡 细胞增殖 细胞侵袭 细胞迁移
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Geochemical and Petrological Studies on the Early Carboniferous Sidingheishan Mafic-Ultramafic Iintrusion in the Southern Margin of the Central Asian Orogenic Belt,NW China 被引量:3
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作者 SUN Tao QIAN Zhuangzhi +5 位作者 THAKURTA Joyashish YANG Shenghong XU Gang DUAN Jun GAO Bo WANG Jing 《Acta Geologica Sinica(English Edition)》 CAS CSCD 2018年第3期952-971,共20页
The Sidingheishan mafic-ultramafic intrusion is located in the eastern part of the Northern Tianshan Mountain, along the southern margin of the Central Asian Orogenic Belt in northern Xinjiang autonomous region of Chi... The Sidingheishan mafic-ultramafic intrusion is located in the eastern part of the Northern Tianshan Mountain, along the southern margin of the Central Asian Orogenic Belt in northern Xinjiang autonomous region of China. The Sidingheishan intrusion is mainly composed of wehrlite, olivine websterite, olivine gabbro, gabbro and hornblende gabbro. At least two pulses of magma were involved in the formation of the intrusion. The first pulse of magma produced an olivine-free unit and the second pulse produced an olivine-bearing unit. The magmas intruded the Devonian granites and granodiorites.An age of 351.4±5.8 Ma(Early Carboniferous) for the Sidingheishan intrusion has been determined by U-Pb SHRIMP analysis of zircon grains separated from the olivine gabbro unit. A U-Pb age of 359.2±6.4 Ma from the gabbro unit has been obtained by LA-ICP-MS. Olivine of the Sidingheishan intrusion reaches 82.52 mole% Fo and 1414 ppm Ni. On the basis of olivine-liquid equilibria, it has been calculated that the MgO and FeO included in the parental magma of a wehrlite sample were approximately10.43 wt% and 13.14 wt%, respectively. The Sidingheishan intrusive rocks are characterized by moderate enrichments in Th and Sm, slight enrichments in light REE, and depletions in Nb, Ta, Zr and Hf. The εNd(t) values in the rock units vary from +6.70 to +9.64, and initial87Sr/86Sr ratios range between 0.7035 and0.7042. Initial206Pb/204Pb,207Pb/204Pb and208Pb/204Pb values fall in the ranges of 17.23-17.91,15.45-15.54 and 37.54-38.09 respectively. These characteristics are collectively similar to the Heishan intrusion and the Early Carboniferous subduction related volcanic rocks in the Santanghu Basin, North Tianshan and Beishan area. The low(La/Gd)PMvalues between 0.26 and 1.77 indicate that the magma of the Sidingheishan intrusion was most likely derived from a depleted spinel-peridotite mantle.(Th/Nb)PMratios from 0.59 to 20.25 indicate contamination of the parental magma in the upper crust.Crystallization modeling methods suggest that the parental magma of the Sidingheishan intrusion was generated by flush melting of the asthenosphere and subsequently there was about 10 vol%contamination from a granitic melt. This was followed by about 5 vol% assimilation of upper crustal rocks. Thus, the high-Mg basaltic parental magma of Sidingheishan intrusion is interpreted to have formed from partial melting of the asthenosphere during the break-off of a subducted slab. 展开更多
关键词 break-off of subducted slab zircon U-Pb dating whole-rock Sr-Nd-Pb isotopes mafic-ultramafic intrusion southern margin of Central Asian Orogenic Belt China
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Late Carboniferous-Early Permian Mafic-Ultramafic Complexes in Beishan,Southwestern Central Asian Orogenic Belt and Their Significance 被引量:2
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作者 KANG Lei JI Wenhua +3 位作者 WANG Tao LI Wenming SUN Jiming 《Acta Geologica Sinica(English Edition)》 SCIE CAS CSCD 2019年第S01期113-115,共3页
Numeral Permian mafic-ultramafic complexes occur in the Beishan terrane atthe northeastern margin of the Tarim craton,southwestern Central Asian Orogenic Belt,including the Pobei,Cantoushan,Bijiashan,Hongshishan,Xuanw... Numeral Permian mafic-ultramafic complexes occur in the Beishan terrane atthe northeastern margin of the Tarim craton,southwestern Central Asian Orogenic Belt,including the Pobei,Cantoushan,Bijiashan,Hongshishan,Xuanwoling,Zhongposhan and Luodong etc.,intrusions(Qin et al.,2011;Zhang et al.,2017;Xue et al.,2018).These Beishan mafic-ultramafic complexes are composed of peridotite,pyroxenite. 展开更多
关键词 LATE Carboniferous-Early PERMIAN mafic-ultramafic Complexes Beishan TARIM Large IGNEOUS Province
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艾灸联合保真汤加减治疗糖尿病肾病的疗效观察及对CT灌注参数、Rho/ROCK信号通路蛋白的影响 被引量:1
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作者 赵小艳 王俊杰 《上海针灸杂志》 CSCD 2024年第1期17-23,共7页
目的 观察艾灸联合保真汤加减治疗糖尿病肾病气阴两虚证的临床疗效及对CT灌注参数、Rho/ROCK信号通路蛋白的影响。方法 将146例糖尿病肾病气阴两虚证患者随机分为观察组(74例)和对照组(72例)。在对症治疗的基础上,对照组给予厄贝沙坦片... 目的 观察艾灸联合保真汤加减治疗糖尿病肾病气阴两虚证的临床疗效及对CT灌注参数、Rho/ROCK信号通路蛋白的影响。方法 将146例糖尿病肾病气阴两虚证患者随机分为观察组(74例)和对照组(72例)。在对症治疗的基础上,对照组给予厄贝沙坦片,观察组给予艾灸联合保真汤加减。观察两组中医主症积分、CT灌注参数[血尿素氮(blood urea nitrogen, BUN)、血肌酐(serum creatinine, SCr)、尿白蛋白排泄率(urinary albumin excretion rate, UAER)和24 h尿蛋白定量(24-hour urinary protein quantification, 24 h Upro)]、肾血流指标[舒张末期血流速度(end-diastolic velocity, EDV)、肾段动脉的收缩期峰值流速(peak-systolic velocity, PSV)、搏动指数(pulsatility index, PI)和阻力指数(resistive index, RI)]、血清炎性因子[肿瘤坏死因子-α(tumor necrosis factor-α, TNF-α)、白细胞介素-1β(interleukin-1β, IL-1β)、白细胞介素-6(interleukin-6, IL-6)和C反应蛋白(C-reactive protein, CRP)]水平及Rho/ROCK信号通路[Ras同源基因家族成员A(Ras homolog gene family member A, RhoA)、Rho关联含卷曲螺旋蛋白激酶Ⅰ(Rho-associated coiled-coil containing protein kinaseⅠ, ROCKI)、α-平滑肌肌动蛋白(α-smooth muscle actin, α-SMA)和钙黏附蛋白-E(E-cadherin, E-Cad)]蛋白水平,并比较两组临床疗效及不良反应。结果 观察组总有效率为97.3%(72/74),明显高于对照组的81.9%(59/72)(P<0.05)。观察组治疗后中医主症积分低于治疗前和对照组(P<0.05)。两组治疗后CT灌注参数降低(P<0.05),且观察组低于对照组(P<0.05)。观察组治疗后PSV、EDV较治疗前和对照组加快(P<0.05),RI、PI较治疗前和对照组降低(P<0.05)。观察组治疗后血清炎性因子水平较治疗前和对照组降低(P<0.05)。观察组治疗后Rho A、ROCKI、α-SMA蛋白水平较治疗前和对照组降低(P<0.05),E-Cad蛋白水平较治疗前和对照组升高(P<0.05)。观察组不良反应发生率为1.4%(1/74),低于对照组的19.4%(14/72)(P<0.05)。结论 在对症治疗的基础上,艾灸联合保真汤加减可明显提高糖尿病肾病气阴两虚证患者的治疗效果,其机制可能与改善CT灌注参数,调节血清Rho/ROCK信号通路蛋白相关。 展开更多
关键词 灸法 糖尿病并发症 糖尿病肾病 气阴两虚 Rho/rock信号通路蛋白
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黄芩苷通过ROS依赖性调节RhoA/ROCK通路保护氯化钴诱导心肌细胞损伤的实验研究 被引量:2
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作者 沈艳玲 刘承红 +3 位作者 王世魁 徐尧 张云波 顾申红 《海南医学院学报》 CAS 北大核心 2024年第7期481-488,共8页
目的:本研究旨在探讨黄芩苷(Baicalin)对氯化钴(CoCl_(2))诱导H9c2心肌细胞缺氧损伤的作用机制。方法:采用CoCl_(2)建立心肌细胞缺氧损伤模型,并分别加入不同浓度的黄芩苷培养。将正常氧培养设置为对照组,CoCl_(2)培养H9c2心肌细胞设置... 目的:本研究旨在探讨黄芩苷(Baicalin)对氯化钴(CoCl_(2))诱导H9c2心肌细胞缺氧损伤的作用机制。方法:采用CoCl_(2)建立心肌细胞缺氧损伤模型,并分别加入不同浓度的黄芩苷培养。将正常氧培养设置为对照组,CoCl_(2)培养H9c2心肌细胞设置为CoCl_(2)组;Baicalin、Y27632(Rho激酶抑制剂)预处理的H9c2缺氧心肌细胞设置为CoCl_(2)+Baicalin组、CoCl_(2)+Y27632组、CoCl_(2)+Baicalin+Y27632组。通过细胞毒性检测试剂盒(CCK8)检测细胞活性;荧光探针测定细胞中活性氧(ROS)的表达;WST-8检测心肌细胞超氧化歧化酶(SOD)活力;TBA法测定丙二醇(MDA)浓度;同时采用WesternBlot方法分析RhoA、ROCK1、ROCK2、TNF-α、IL-1β蛋白表达情况。结果:处理H9c2细胞24 h后,1 000μmol/L的CoCl_(2)和75μmol/L黄芩苷对治疗心肌细胞缺氧损伤具有较好的细胞活力。CoCl_(2)组细胞活性明显低于对照组,加入黄芩苷后可显著提高细胞活性(P<0.05);与对照组相比,CoCl_(2)组心肌细胞可上调ROS、MDA表达,下调SOD活力,升高RhoA、ROCK1、ROCK2、TNF-α、IL-1β蛋白表达水平,加入Baicalin后可逆转上诉蛋白的表达水平;与CoCl_(2)组相比,CoCl_(2)+Baicalin可抑制ROS、MDA的表达,上调SOD含量,下调RhoA、ROCK1、ROCK2、TNF-α、IL-1β蛋白表达水平,而加入Y27632(Rho激酶抑制剂)后则可显著增强Baicalin带来的保护作用。结论:Baicalin可减轻CoCl_(2)诱导H9c2心肌细胞缺氧损伤的炎症、氧化应激反应,其机制与抑制ROS依赖性RhoA/ROCK通路有关。 展开更多
关键词 黄芩苷 RhoA/Rho相关激酶(rock)信号通路 缺氧损伤模型
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Mafic-ultramafic magma activity and copper-nickel sulfide metallogeny during Paleozoic in the Eastern Kunlun Orogenic Belt,Qinghai Province,China 被引量:14
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作者 Zhao-wei Zhang Ya-lei Wang +4 位作者 Chi-yuan Wang Bing Qian Wen-yuan Li Jiang-wei Zhang Min-xin You 《China Geology》 2019年第4期467-477,共11页
The Eastern Kunlun Orogenic Belt(EKOB)has a complex geological structure and diverse magmatic activities,which are closely related to the Qaidam Basin and the Tethys tectonic evolution.There are at least 3 stages mafi... The Eastern Kunlun Orogenic Belt(EKOB)has a complex geological structure and diverse magmatic activities,which are closely related to the Qaidam Basin and the Tethys tectonic evolution.There are at least 3 stages mafic-ultramafic rocks occurred in the Early Paleozoic in EKOB.The first stage is the Later-Silurian to Early Devonian,represented by the giant Xiarihamu super large magmatic Cu-Ni deposit,containing about 1.18 million metric tons(Mt)of nickel with average grades of 0.65%Ni,and its age of ore-forming pyroxene peridotite is 411 Ma;The second stage is the Early Carboniferous,represented by the large Shitoukengde magmatic Cu-Ni sulfide deposit,and its ore-forming age of the olivine websterite is 334 Ma;The third stage of mafic-ultramafic rocks occurred mainly during the Middle-Late Triassic,represented by Xiaojianshan,Lalinggaoli,and Kaimuqi complexes,and no economical ore bodies have been found in this period.The authors summarized the difference between the ore-bearing and the nonmineralized mafic-ultramafic rocks in the EKOB.The olivine of the ore-bearing complexes contains higher MgO and SiO2 content but lower FeO and CaO contents,and the clinopyroxene of ore-bearing complexes contains lower FeO and CaO contents.Crustal sulfur contamination is key to the formation of the giant Xiarihamu Ni deposit,and crustal sulfur contamination degree of the giant magmatic Ni deposit is higher than that of large Ni deposit.The above indicators could guide the exploration and evaluation of similar deposits in the EKOB. 展开更多
关键词 EARLY DEVONIAN EARLY Carboniferous mafic-ultramafic complexes Cu-Ni deposit Mineral exploration engineering Eastern KUNLUN OROGENIC belt Qinghai China
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川芎嗪抑制ROCK的表达降低模拟失重大鼠血管Ca^(2+)敏感性
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作者 王慧平 白晓镯 +4 位作者 赵晶 赵省心 刘朕印 党凯 高云芳 《西北大学学报(自然科学版)》 CAS CSCD 北大核心 2024年第5期919-928,共10页
研究失重条件下血管平滑肌收缩性、Ca^(2+)敏感性及其调控通路RhoA-ROCK蛋白表达的变化,以及川芎嗪干预对其的影响。大鼠尾部悬吊模拟失重,在机体前、后部分别选取颈总动脉和肠系膜上动脉。在模拟失重大鼠颈总动脉中,由苯肾上腺素(PHE)... 研究失重条件下血管平滑肌收缩性、Ca^(2+)敏感性及其调控通路RhoA-ROCK蛋白表达的变化,以及川芎嗪干预对其的影响。大鼠尾部悬吊模拟失重,在机体前、后部分别选取颈总动脉和肠系膜上动脉。在模拟失重大鼠颈总动脉中,由苯肾上腺素(PHE)或KCl诱发的血管收缩性和Ca^(2+)敏感性增强,RhoA激酶2(ROCK II)的表达、肌球蛋白磷酸酶靶亚基1(MYPT1)和肌球蛋白调节轻链(MLC)的磷酸化水平均上升,血管孵育Y-27632(ROCK特异性抑制剂)后可降低以上变化。模拟失重大鼠灌饲川芎嗪亦可降低以上变化。模拟失重后,大鼠肠系膜上动脉的收缩性和Ca^(2+)敏感性、ROCK II的表达、MYPT1和MLC的磷酸化水平降低,血管孵育Y-27632对以上变化无明显作用。模拟失重大鼠灌饲川芎嗪亦对以上变化无明显作用。结果表明,由RhoA-ROCK调控的血管平滑肌Ca^(2+)敏感性的变化可能是失重条件下机体前后部血管收缩性发生区域性重塑的关键因素。川芎嗪可抑制ROCK蛋白的表达,降低血管平滑肌升高的Ca^(2+)敏感性,从而纠正失重条件下机体前部血管收缩性的增强,但对失重条件下机体后部血管收缩性的减弱无恢复作用。 展开更多
关键词 Ca^(2+)敏感性 RhoA-rock 血管收缩性 模拟失重 川芎嗪
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Geochronology,Petrology and Geochemistry of Xingdi No.3 Mafic-Ultramafic Intrusions in the Northeastern Tarim Craton,NW China 被引量:2
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作者 XIA Zhaode XIA Mingzhe JIANG Changyi 《Acta Geologica Sinica(English Edition)》 SCIE CAS CSCD 2017年第2期500-514,共15页
The Xingdi mafic-ultramafic intrusions occur in the northeastern margin of the Tarim craton. The Xingdi No. 3 intrusion is the smallest of four intrusions, with an exposed area of 1.7 km2, and the zircon U-Pb age of t... The Xingdi mafic-ultramafic intrusions occur in the northeastern margin of the Tarim craton. The Xingdi No. 3 intrusion is the smallest of four intrusions, with an exposed area of 1.7 km2, and the zircon U-Pb age of the intrusion is 752±4 Ma. The intrusion consists of gabbros, pyroxenites and peridotites, and exhibits a crystallization sequence of the main rock-forming minerals as olivine, orthopyroxene, clinopyroxene and plagioclase. Mineralization occurred at or near the boundaries of the intrusion between pyroxenites and peridotites, and appears as a layered or lenticular shape about 500 m long and 4–15 m wide. The primary sulfides have a relatively simple mineralogy dominated by pyrrhotite-pentlandite-chalcopyrite assemblages, which occur as droplet, star-like and graphic texture and locally sideronitic structures. Geochronological and geochemistry investigations suggest that the Xingdi mafic-ultramafic intrusions and coeval volcanic rock in the Kuluktag area of the Tarim craton formed in an intracontinental breakup environment. Based on the composition of the dominant rockforming minerals and covariant relationships of other oxides versus Mg O, the parental magma of the Xingdi No.3 intrusion belongs to high-Mg tholeiitic basaltic magmas with Mg O of 10.78 wt%. The Xingdi No.3 intrusive rocks are characterized by light REE enrichment relative to heavy REE, negative Nb-Ta anomalies, low 143Nd/144Nd ratios(from 0.511183 to 0.511793) and high initial 87Sr/86Sr ratios(from 0.7051 to 0.7113). The magma was derived from the enriched-lithospheric mantle and was contaminated during emplacement. According to rock assemblages, mineralization, olivine characteristics, geochemical characteristics and mass balance, there are better copper-nickel ore prospects in the Xingdi No.3 intrusion than in the other three intrusions in the area. 展开更多
关键词 mafic-ultramafic GEOCHRONOLOGY GEOCHEMISTRY copper-nickel ore prospects Xingdi No.3 intrusion Tarim craton Xinjiang the Northern margin of Tibetean Proto-Tethys
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