Parkinson＇s disease （PD） is the most common motor neurode- generative disorder affecting approximately 4 million people worldwide. Although PD presents primarily with motor dysfunction, non-motor symptoms including...Parkinson＇s disease （PD） is the most common motor neurode- generative disorder affecting approximately 4 million people worldwide. Although PD presents primarily with motor dysfunction, non-motor symptoms including cognitive decline, mood disorders, reduced olfaction and constipation are also of- ten present, with some of these non-motor symptoms even pre- senting prior to the onset of motor symptoms. It is well known that PD is largely caused by the gradual degeneration of dopa- minergic neurons within the substantia nigra pars compacta （SNc）, along with the presence of protein aggregates called Lewy bodies, which consist primarily of ct-synuclein and are found in the cytoplasm of surviving neurons. This ongoing cell loss and Lewy body pathology is not confined to the SNc, but is also seen in other brain regions implicated in PD pathogenesis such as the locus ceruleus.展开更多
Neurodegeneration is one of the biggest public health problems in modern society. Age-associated neurodegeneration, which is accelerated several-fold in Alzheimer＇s disease （AD） alone, is not only an enormous socia...Neurodegeneration is one of the biggest public health problems in modern society. Age-associated neurodegeneration, which is accelerated several-fold in Alzheimer＇s disease （AD） alone, is not only an enormous social and economic burden to the affected in- dividuals and their families, but is also a great scientific challenge. Currently 25-35 million people worldwide suffer from AD, the single largest cause of dementia in middle- to old-aged individuals. These numbers are projected to triple by 2050 if no treatment to prevent or reverse AD is developed.展开更多
The twentieth century the seventies and eighties of the modern influx of Chinese mainland pop music-music school in Taiwan,with its pristine purity of musical styles,catchy melodies fresh,really meaningful lyrics,the ...The twentieth century the seventies and eighties of the modern influx of Chinese mainland pop music-music school in Taiwan,with its pristine purity of musical styles,catchy melodies fresh,really meaningful lyrics,the arrangement is simple and unique form of singing affect generation after gen-eration of young people. It is both spirited and close to the voice of young people (especially close to the university campus life),among young people a strong resonance. At the same time,it is the emergence of China's Mainland the concept of pop mu-sic’s aesthetic,value orientation,creative tactics,techniques and style of singing had a dramatic impact,as well as future changes in the mainland pop and development has injected new impetus.展开更多
Huntington＇s disease （HD） is the most common dominantly inherited neurodegenerative disorder, mainly characterized by the progressive striatal and cortical neurodegeneration and as- sociated motor, cognitive and be...Huntington＇s disease （HD） is the most common dominantly inherited neurodegenerative disorder, mainly characterized by the progressive striatal and cortical neurodegeneration and as- sociated motor, cognitive and behavioural disturbances （Zuccato et al., 2010）. The disease-causing mutation is an expansion of a GAG trinucleotide repeat （〉 36 repeats） encoding a polygluta- mine stretch in the N-terminal region ofhuntingtin （Htt） （Zuc- cato et al., 2010）, a ubiquitous protein whose function is still unclear （Zuccato et al., 2010）. Expansion of the polyQ stretch endows mutant Htt （mHtt） with toxic properties, and results in the development of a broad array of undesirable effects in both neuronal and non-neuronal cells （Zuccato et al., 2010）. Among all cellular dysfunctions and biochemical imbalances classically associated with HD, perturbed metabolism of （glyco） sphingolipids appears to play a crucial role in the pathogenesis of the disease. Over the last years, we and other have extensively contributed to these findings （Desplats et al., 2007;展开更多
As the literary pride from the black land of northeast China,Xiao hong’s works show the unique regional culture of northeast China.With her meticulous brush strokes,she showed us the distinct geographical environment...As the literary pride from the black land of northeast China,Xiao hong’s works show the unique regional culture of northeast China.With her meticulous brush strokes,she showed us the distinct geographical environment of the four seasons in north China,the strong local flavor and people’s sentiment,as well as the servility and ferocity of the people in the northeast.Xiao hong’s criticism of callous and ignorant servile characters and his praise of the consciousness of resistance and the indomitable life form,prompts us to think about the“national character”of northeast China and makes us feel the tragedy of society,the philosophy of life and the spirit of poets.展开更多
In Auster’s novels,the racial prejudice occupies a vital part;the whites presently take a majority privileged position in the mainstream culture;both the blacks and Jews become the target of racial prejudice which is...In Auster’s novels,the racial prejudice occupies a vital part;the whites presently take a majority privileged position in the mainstream culture;both the blacks and Jews become the target of racial prejudice which is vividly embodied in City of Glass:The Graphic Novel,Ghosts,Man in the Dark,In the Country of Last Things.展开更多
Reaction of dimers of (R) thionophosphine sulfide (R = P - C6H4OMe,SMe ) with Co, (CO), yields the novel hexacobalt cluster [Co'(μ3, -S)2, (CO) 14 (μ4 -μ4- and the trinuclear clusterPSCH,)J 2' In 1, tw0 Co3...Reaction of dimers of (R) thionophosphine sulfide (R = P - C6H4OMe,SMe ) with Co, (CO), yields the novel hexacobalt cluster [Co'(μ3, -S)2, (CO) 14 (μ4 -μ4- and the trinuclear clusterPSCH,)J 2' In 1, tw0 Co3S(C0)7 units linked by a novel phosphido-thio1ato bifunc-tiona1 bridging p'-SPR ligand as backbone.展开更多
The Yangzi Petrochemical Company is the first one among domestic aromatics manufacturers to adopt the UOP’s latest novel adsorbent during quality upgrading of its No.2 xylene unit.On October 23,2013 this unit has bee...The Yangzi Petrochemical Company is the first one among domestic aromatics manufacturers to adopt the UOP’s latest novel adsorbent during quality upgrading of its No.2 xylene unit.On October 23,2013 this unit has been continuously delivering xylene product with a purity展开更多
At present, gravity field and steady-state ocean circulation explorer（GOCE） gravity data are always used to compute regional gravity anomaly and geoid height. In this study, the latest GOCE gravity field model data...At present, gravity field and steady-state ocean circulation explorer（GOCE） gravity data are always used to compute regional gravity anomaly and geoid height. In this study, the latest GOCE gravity field model data（from Oct. 2009 to Jul. 2010） are used to compute the gravity gradient of China's Mainland according to a rigorous recursion formula（in all the six directions）. The results show that the numerical values of the gravity gradients are larger in the T rr direction than those in the other directions. They reflect the terrain characteristics in detail and correlate with the regional tectonics; however, in the T ql and T r l directions,the numerical values are relatively smaller and the gravity gradients in the T r l direction do not reflect the terrain characteristics in detail.展开更多
Living a dynamic life physically,intellectually and politically, Jack London had a career that was representative of the vigor of his time with working-class origins, he was, in some of his literary and political writ...Living a dynamic life physically,intellectually and politically, Jack London had a career that was representative of the vigor of his time with working-class origins, he was, in some of his literary and political writing,one of the most articulate and militant spokesmen of his class. His work is absent from many American authologies,but included in some. "Martin Eden", London’s most autobiographical novel,is considered by many critics to be his most mature work which is read all over the world.展开更多
基金in part has been supported by the Neurosurgical Research Foundation, South Australia, Australia
文摘Parkinson＇s disease （PD） is the most common motor neurode- generative disorder affecting approximately 4 million people worldwide. Although PD presents primarily with motor dysfunction, non-motor symptoms including cognitive decline, mood disorders, reduced olfaction and constipation are also of- ten present, with some of these non-motor symptoms even pre- senting prior to the onset of motor symptoms. It is well known that PD is largely caused by the gradual degeneration of dopa- minergic neurons within the substantia nigra pars compacta （SNc）, along with the presence of protein aggregates called Lewy bodies, which consist primarily of ct-synuclein and are found in the cytoplasm of surviving neurons. This ongoing cell loss and Lewy body pathology is not confined to the SNc, but is also seen in other brain regions implicated in PD pathogenesis such as the locus ceruleus.
基金supported in part by the New York State Office of People with Developmental Disabilities(OPWDD)Zenith Award ZEN-12-241233 from Alzheimer’s Associationa research grant#20121203 from Alzheimer’s Drug Discovery Foundation,New York
文摘Neurodegeneration is one of the biggest public health problems in modern society. Age-associated neurodegeneration, which is accelerated several-fold in Alzheimer＇s disease （AD） alone, is not only an enormous social and economic burden to the affected in- dividuals and their families, but is also a great scientific challenge. Currently 25-35 million people worldwide suffer from AD, the single largest cause of dementia in middle- to old-aged individuals. These numbers are projected to triple by 2050 if no treatment to prevent or reverse AD is developed.
文摘The twentieth century the seventies and eighties of the modern influx of Chinese mainland pop music-music school in Taiwan,with its pristine purity of musical styles,catchy melodies fresh,really meaningful lyrics,the arrangement is simple and unique form of singing affect generation after gen-eration of young people. It is both spirited and close to the voice of young people (especially close to the university campus life),among young people a strong resonance. At the same time,it is the emergence of China's Mainland the concept of pop mu-sic’s aesthetic,value orientation,creative tactics,techniques and style of singing had a dramatic impact,as well as future changes in the mainland pop and development has injected new impetus.
基金supported by"Fondazione Neuromed"funded by Italian Ministry of Health"Ricerca Corrente"funding program
文摘Huntington＇s disease （HD） is the most common dominantly inherited neurodegenerative disorder, mainly characterized by the progressive striatal and cortical neurodegeneration and as- sociated motor, cognitive and behavioural disturbances （Zuccato et al., 2010）. The disease-causing mutation is an expansion of a GAG trinucleotide repeat （〉 36 repeats） encoding a polygluta- mine stretch in the N-terminal region ofhuntingtin （Htt） （Zuc- cato et al., 2010）, a ubiquitous protein whose function is still unclear （Zuccato et al., 2010）. Expansion of the polyQ stretch endows mutant Htt （mHtt） with toxic properties, and results in the development of a broad array of undesirable effects in both neuronal and non-neuronal cells （Zuccato et al., 2010）. Among all cellular dysfunctions and biochemical imbalances classically associated with HD, perturbed metabolism of （glyco） sphingolipids appears to play a crucial role in the pathogenesis of the disease. Over the last years, we and other have extensively contributed to these findings （Desplats et al., 2007;
文摘As the literary pride from the black land of northeast China,Xiao hong’s works show the unique regional culture of northeast China.With her meticulous brush strokes,she showed us the distinct geographical environment of the four seasons in north China,the strong local flavor and people’s sentiment,as well as the servility and ferocity of the people in the northeast.Xiao hong’s criticism of callous and ignorant servile characters and his praise of the consciousness of resistance and the indomitable life form,prompts us to think about the“national character”of northeast China and makes us feel the tragedy of society,the philosophy of life and the spirit of poets.
基金This paper is a part of project PXY-BSQD-2018019,and sponsored by Pingdingshan University.
文摘In Auster’s novels,the racial prejudice occupies a vital part;the whites presently take a majority privileged position in the mainstream culture;both the blacks and Jews become the target of racial prejudice which is vividly embodied in City of Glass:The Graphic Novel,Ghosts,Man in the Dark,In the Country of Last Things.
文摘Reaction of dimers of (R) thionophosphine sulfide (R = P - C6H4OMe,SMe ) with Co, (CO), yields the novel hexacobalt cluster [Co'(μ3, -S)2, (CO) 14 (μ4 -μ4- and the trinuclear clusterPSCH,)J 2' In 1, tw0 Co3S(C0)7 units linked by a novel phosphido-thio1ato bifunc-tiona1 bridging p'-SPR ligand as backbone.
文摘The Yangzi Petrochemical Company is the first one among domestic aromatics manufacturers to adopt the UOP’s latest novel adsorbent during quality upgrading of its No.2 xylene unit.On October 23,2013 this unit has been continuously delivering xylene product with a purity
基金supported by Key Projects of Henan Province Department of Education Science and Technology(14B420001)
文摘At present, gravity field and steady-state ocean circulation explorer（GOCE） gravity data are always used to compute regional gravity anomaly and geoid height. In this study, the latest GOCE gravity field model data（from Oct. 2009 to Jul. 2010） are used to compute the gravity gradient of China's Mainland according to a rigorous recursion formula（in all the six directions）. The results show that the numerical values of the gravity gradients are larger in the T rr direction than those in the other directions. They reflect the terrain characteristics in detail and correlate with the regional tectonics; however, in the T ql and T r l directions,the numerical values are relatively smaller and the gravity gradients in the T r l direction do not reflect the terrain characteristics in detail.
文摘Living a dynamic life physically,intellectually and politically, Jack London had a career that was representative of the vigor of his time with working-class origins, he was, in some of his literary and political writing,one of the most articulate and militant spokesmen of his class. His work is absent from many American authologies,but included in some. "Martin Eden", London’s most autobiographical novel,is considered by many critics to be his most mature work which is read all over the world.
