Molecular mechanism of noradrenaline during the stress-induced major depressive disorder

Chronic stress-induced depression is a common hallmark of many psychiatric disorders with high morbidity rate.Stress-induced dysregulation of noradrenergic system has been implicated in the pathogenesis of depression.Lack of monoamine in the brain has been believed to be the main causative factor behind pathophysiology of major depressive disorder（MDD） and several antidepressants functions by increasing the monoamine level at the synapses in the brain.However,it is undetermined whether the noradrenergic receptor stimulation is critical for the therapeutic effect of antidepressant.Contrary to noradrenergic receptor stimulation,it has been suggested that the desensitization of β-adrenoceptor is involved in the therapeutic effect of antidepressant.In addition,enhanced noradrenaline（NA） release is central response to stress and thought to be a risk factor for the development of MDD.Moreover,fast acting antidepressant suppresses the hyperactivation of noradrenergic neurons in locus coeruleus（LC）.However,it is unclear how they alter the firing activity of LC neurons.These inconsistent reports about antidepressant effect of NA-reuptake inhibitors（NRIs） and enhanced release of NA as a stress response complicate our understanding about the pathophysiology of MDD.In this review,we will discuss the role of NA in pathophysiology of stress and the mechanism of therapeutic effect of NA in MDD.We will also discuss the possible contributions of each subtype of noradrenergic receptors on LC neurons,hypothalamic-pituitary-adrenal axis（HPA-axis） and brain derived neurotrophic factor-induced hippocampal neurogenesis during stress and therapeutic effect of NRIs in MDD.

应激性高血糖比值对急性心肌梗死患者院内不良预后的影响

目的探讨应激性高血糖比值(stress hyperglycemia ratio,SHR)对急性心肌梗死(acute myocardial infarction,AMI)患者院内主要不良心血管事件(major adverse cardiovascular events,MACEs)的预测价值。方法回顾性分析2022年1月至2022年12月在首都医科大学附属北京同仁医院心血管中心住院,资料完整的AMI患者共442例。根据入院测得的第一个静脉随机血糖(admission blood glucose,ABG)和糖化血红蛋白(glycosylated hemoglobin,HbA1c)值计算得出SHR。根据是否发生院内MACEs分为MACEs组(n=79)和非MACEs组(n=363)。采用多因素Logistic回归分析探讨AMI患者院内MACEs发生的危险因素。应用受试者工作特征(receiver operating characteristic,ROC)曲线评估SHR对院内MACEs发生的预测价值。结果院内MACEs组的SHR显著高于非MACEs组(1.30±0.44 vs 1.15±0.17,P<0.001)。多因素Logistic回归分析中,SHR是AMI患者院内MACEs发生的危险因素(OR=2.69,95%CI:1.26~5.73,P=0.011)。ROC曲线分析结果显示,SHR对AMI患者院内MACEs有预测价值(AUC=0.63,95%CI:0.57~0.70,P<0.001),最佳截断值为1.29,预测价值高于HbA1c(P=0.011)。结论SHR是AMI患者院内MACEs发生的危险因素,对院内MACEs有预测价值,最佳截断值为1.29,优于HbA1c。

黑龙江省高校网球专业学生心理压力来源和应对策略研究

目的:探究网球运动员主要压力来源并探寻解决之道。方法:通过对网球运动员应用自制量表进行问卷调查,并利用t检验和方差分析进行统计。结果:高校网球学生心理压力来源由大到小依次是实习压力,训练压力,学业压力和就业压力。女生在训练和实习压力两个方面显著高于男生,且具有统计学差异(P<0.01)。不同年级的学生在实习压力、训练压力、就业压力和学业压力四个维度有统计学差异(P<0.01)。面临压力时,网球专业的学生更愿意通过自己的努力实现目标。应对策略:对不同性别学生进行针对性心理教育,对不同年级的学生设置不同的培养重点。

抗逆力、压力知觉在轨道交通行业驾驶类专业大学生情绪稳定性中的效应研究——以天津铁道职业技术学院为例

本研究通过对轨道交通行业驾驶类专业大学生量表测量,结果显示,抗逆力、压力知觉和情绪稳定性之间两两相关,压力知觉、抗逆力能够预测情绪稳定性,抗逆力在压力知觉与情绪稳定性之间起到了部分中介作用。为此,提出一系列教育启示,通过提高轨道交通行业驾驶类专业学生抗逆力和减小压力知觉的方式提升情绪稳定性。

盐胁迫对福建主栽水稻品种芽期生长的影响

[目的]确定适合筛选芽期耐盐水稻的盐浓度,并筛选耐盐品种,为盐碱地种植优质高产水稻品种提供依据。[方法]分别以50、100和150 mmol·L^(-1) NaCl溶液胁迫种子,测定福建省12个主栽水稻品种的形态和生理指标,并采用相关性分析、隶属函数法和聚类分析综合评价各品种的耐盐水平。[结果](1)随着盐浓度的升高,参试水稻品种的相对发芽势、相对根长、相对芽长和相对淀粉酶活性均不断下降,而相对电导率则不断提高,表明盐处理对芽期生长有抑制作用,且明显损害细胞膜透性。(2)10项指标中,相对发芽势、相对根长、相对芽长、相对蛋白含量、相对淀粉酶活性、相对电导率和相对CAT活性的变异性均于150 mmol·L^(-1)盐浓度下达到最大,表明该盐浓度适合芽期的品种筛选。(3)获得的强耐盐品种有荃优212、荃优822和两优H108,中度耐盐品种有昌两优8号、中浙优8号、甬优1540、野香优676、晶两优1212和野香优744,敏盐品种有谷优676、甬优15号和甬优2640。[结论]筛选芽期耐盐品种的适宜盐浓度为150 mmol·L^(-1);荃优212、荃优822和两优H108的芽期耐盐性强。该结果可为后续强耐盐品种的耐盐机制研究和盐碱地推广种植提供参考。

重型β地中海贫血眼部变化的研究现状

重型β地中海贫血(β-TM)是一种由珠蛋白合成缺陷引起的遗传性疾病。该病需要长期输血和服用祛铁剂药物治疗,可引起眼部组织的各种继发性变化。与正常同龄人相比,β-TM患者的眼部表现为角膜曲率更为陡峭、前房更浅、晶状体厚度增加、眼轴更短和泪液分泌减少等改变;同时,营养缺乏和使用铁螯合剂药物治疗会增加罹患并发性白内障及视网膜变性的风险,从而影响β-TM患者的生存质量。本文结合国内外相关文献,对β-TM患者眼部相关变化进行探讨和综述,旨在为临床实践提供有价值的见解。

Unified semi-analytical solution for elastic-plastic stress of deep circular hydraulic tunnel with support yielding

A unified semi-analytical solution is presented for elastic-plastic stress of a deep circular hydraulic tunnel with support yielding under plane strain conditions.The rock mass is assumed to be elastic-perfectly plastic and governed by the unified strength theory (UST).Different major principal stresses in different engineering situations and different support yielding conditions are both considered.The unified solution obtained in this work is a series of results,rather than one specific solution,hence it is suitable for a wide range of rock masses.In addition,parametric study is conducted to investigate the effect of intermediate principal stress.The result shows the major principal stress should be rationally chosen according to different engineering conditions.Finally,the applicability of the unified solution is discussed according to the critical pressures.

新型冠状病毒感染疫情阶段和地区对孤独症儿童父母压力状态及压力源的影响

目的:评估新型冠状病毒感染疫情的不同阶段和不同地区孤独症儿童父母的压力状态与压力来源。方法:选取173名孤独症儿童父母为研究对象。运用压力评估公式计算疫情各阶段父母的压力值,并使用社区发现算法探究其不同阶段的压力源变化。结果:疫情阶段主效应显著[F((2,340))=8.883,P<0.001,η_(p)^(2)=0.050]。疫情爆发阶段压力值显著高于常态化阶段以及潜伏阶段(P<0.01),常态化阶段压力值显著高于潜伏阶段(P<0.01)。地区主效应显著[F_((2,170))=57.556,P<0.001,η_(p)^(2)=0.404],东部地区孤独症儿童父母压力值显著高于中部地区与西部地区(P<0.01)。疫情阶段与疫情地区的交互作用显著[F_((4,340))=2.490,P<0.043,η_(p)^(2)=0.028]。进一步简单效应分析表明,东部地区孤独症儿童父母在疫情爆发阶段的压力值显著高于潜伏阶段(P<0.001)以及常态化阶段(P<0.001)。对新冠疫情各阶段语义网络中的社区主题进行强度计算,结果发现疫情潜伏阶段压力源分别是陪护压力(0.351)、康复资源短缺压力(0.222)、核心障碍改善的教育压力(0.169);疫情爆发阶段分别是在线干预压力(0.316)、全天候教养压力(0.213)、社交隔离压力(0.119);疫情常态化阶段分别是陪护压力(0.411)、教育康复压力(0.204)。结论:新冠疫情的阶段和地区显著影响了孤独症儿童父母的压力值。此外,随着疫情阶段的变化,孤独症儿童父母的压力来源也发生了一定程度的变化。未来需要考虑重大突发公共事件的不同阶段以及地区差异有针对性地缓解孤独症儿童父母的压力。

The Effect of Aerobic Indoor Exercise Compared with Green Exercise on Different Symptoms of Depression: An Investigation of Psychological Mediators of Stress and Coping

Objectives: Considering the growing need for using a variety of new nonpharmacological methods in treating depression, this quasi experimental study was conducted to investigate the effect of aerobic indoor exercise in a gym compared with green exercise in an outdoor green environment of an urban park on triple categories of affective, cognitive and somatic symptoms of depression and to examine its psychological mediators of perceived stress and coping strategies. Methods: Forty six female outpatients with major depressive disorder were divided into 3 conditions of indoor exercise + routine pharmacotherapy (n = 15), green exercise + routine pharmacotherapy (n = 15), and a routine pharmacotherapy alone as the control group (n = 16). The exercise used for both indoor and green exercise conditions consisted of 36 one hour sessions (three times per week) with an intensity of 50% - 70% of the maximum heart rate. The participants completed the pre- and post-intervention depression, stress and coping questionnaires including Beck Depression Inventory-II, Perceived Stress Scale and Coping Inventory for Stressful Situations. Results: The findings indicated a significant decrease in the post-intervention scores of all three categories of affective, cognitive and somatic symptoms of depression and perceived stress in both exercise groups compared with the control group, but there was no significant difference between two exercise groups. With respect to the use of problem-focused, emotion-focused and avoidant-focused coping methods, there was no significant difference between post-intervention scores of all groups. Conclusion: In the clinical settings, both of the indoor exercise and green exercise programs can help to further improvement in all three categories of affective, cognitive and somatic symptoms of depression as an adjunct (or independent) treatment to the same degree, especially mediated by reducing the amount of perceived stress, but not through any significant changes in cognitive-behavioral coping strategies.

Plantago major treatment enhanced innate antioxidant activity in experimental acetaminophen toxicity

Objective: To determine the ef ect of Plantago major(P. major) extract on the liver injury following acetaminophen(APAP) toxicity. Methods: The male Sprague Dawley rats(n = 38) were randomly divided into normal control(n = 6) and experiment(n = 32) groups. The latter was subdivided into four groups and induced with APAP(1 000 mg/kg) per oral, followed by P. major extract and N-acetylcysteine orally to the respective groups for six days. Results: On the seventh day, the serum bilirubin, liver enzymes and tissue malondialdehyde were increased in APAP groups whereas the total protein in serum, tissue superoxide dismutase and glutathione levels were reduced. The plant extract treatment reduced the histological deteriorations such as aggregation of hepatocellular cords, formation of binucleated cells and vacuolisation of the cells with scanty cytoplasm. It also revealed signii cant reduction of malondialdehyde and increased level of superoxide dismutase and glutathione. The i ndings in the extract treated groups were comparable to the group treated with N-acetylcysteine. Conclusions: In conclusion, P. major can enhance innate antioxidant activity and ameliorate the APAP-induced liver injury.

Finite element modelling for formation of major regions of great earthquakes in the Chinese mainland and its vicinity

Great earthquakes of Chinese mainland and its vicinity usually cluster in certain regions during certain periods. We call it major regions of great earthquakes, or major regions briefly in this paper.The major regions of different periods can migrate through long distance in space. We have studied mechanism of formation of major regions. It is proposed that the ductile layer of the lithosphere is the place where the major regions form, and deformation of the ductile layer controls the locations and shape of major regions. and the actions of the plate boundaries around the continent are the main driving forces. A two-dimensional viscoelastic finite element model is established to model the deformation field and Stress field of the Chinese mainland and its vicinity The boundary of the model is divided into 12 segments to represent non-uniform of boundary conditions. The stress concentration areas in the continental ductile Iayer are simulated under various compoundings of different boundary scgments. Six models are worked out in which the stress con centration regions are consistent with the realistic major regions. It is proved that stress concentfation regions can be produced in the ductile layer which are roughly in agreement with the realistic major regions under various actions of different boundary segments.

The Effect of Aerobic Exercise on Different Symptoms of Depression: An Investigation of Psychological Mechanisms of Stress and Coping

Objectives: Considering the growing need for encouraging greater use of a variety of non-pharmacological methods in treating depression, the aim of this quasi experimental study was to examine the effect of aerobic exercise on triple categories of affective, cognitive and somatic symptoms of depression and to investigate its psychological mediators of perceived stress and coping strategies. Methods: Forty five female outpatients with major depressive disorder were divided into three groups including exercise + usual pharmacotherapy (n = 15), psychotherapy + usual pharmacotherapy (n = 14) and a control group receiving only usual pharmacotherapy (n = 16). The exercise used was included 36 one hour session (three sessions per week) with a low to medium intensity of 50% to 70% of the maximal heart rate. The psychotherapy used in this study was the behavioral activation treatment for depression revised. The Persian version of Beck Depression Inventory-II, Perceived Stress Scale and Coping Inventory for Stressful Situations were applied to assess the pre- and post-intervention depression, perceived stress, and coping strategies. Results: The findings indicated a significant decrease in the post-intervention scores of all three categories of affective, cognitive and somatic symptoms of depression and the perceived stress level in the adjunctive exercise and psychotherapy conditions compared with the control condition (p = 0.001), but there was no significant difference between the exercise and psychotherapy groups. In addition, no significant improvement was observed regarding the problem-centered, emotion-centered and avoidant-centered stress coping methods in the post-intervention scores of the exercise group compared with the control group. Conclusion: An adjunctive aerobic exercise program can be as effective as adding the psychotherapy to usual pharmacotherapy in further improvement in all three categories of depression symptoms especially mediated by reducing the amount of perceived stress, but not through any significant change in cognitive-behavioral coping strategies.

Ischemia Modified Albumin and C-Reactive Protein in Children with β-Thalassemia Major

Background: Beta-thalassemia is a hereditary haemoglobinopathy caused by defective hemoglobin (Hb) β-globin synthesis, leading to excess α-globin chains that cause hemolysis and impair erythropoiesis. Ischemia modified albumin (IMA) is not a signal protein and not generated in pro-inflammatory state alone but rather an end product of oxidative stress. Objectives: The aim of the study was to evaluate ischemia modified albumin (IMA) and C-reactive protein (CRP) in children with β-thalassemia major and its relation to different iron chelators. Patients and Methods: The study was carried on 40 children diagnosed as beta-thalassemia major recruited from the outpatient clinic and the pediatric department, at Al-Zahraa University Hospital, Faculty of medicine for Girls, Al-Azhar University and EL Minia Insurance Hospital. They were 20 male and 20 female, aged from 4 - 11 years. Another 40 apparently healthy children age and sex matched as control group. CRP and IMA were determined for all participants. Results: There were significant increases in serum CRP, IMA and ferritin levels in patients group compared to control group. There were significant decreases of IMA and CRP levels of thalassemic patients on chelation deferiprone (DFP) compared to deferasirox (DFX) P-value (<0.01) for each. There was a significant positive correlation between serum ferritin and both CRP and IMA levels in thalassemic children (r = 0.40, p < 0.01), (r = 0.44, p < 0.01) respectively. There was a significant positive correlation between IMA and CRP in beta-thalassemic patients (r = 0.31, p = 0.02). Conclusion: IMA, CRP and Serum ferritin were higher in children with β-thalassemia major than controls. Moreover, IMA and CRP levels in thalassemic children on deferiprone (DFP) were significantly lower compared with children on deferasirox (DFX). So it could be considered as useful markers in the follow up assessment of thalassemic patients for early detection of complications.

安徽省三甲医院影像专业规培生压力源与心理健康状况分析

目的了解影像专业规培生的压力源和心理健康状况,探讨影响心理健康状况的影响因素,为改善规培生压力源与心理健康状况提供参考依据。方法采用分层随机抽样的方法选取安徽省三所三甲医院影像专业规培生,应用自编一般人口学调查表调查基本情况;采用压力源量表调查规培生压力源状况;应用症状自评量表(SCL-90)调查规培生的心理健康状况。结果影像专业规培生的压力源主要是知识与能力、工作认知和教学安排,各压力源维度与心理健康状况得分呈正相关(P<0.01),多重逐步线性回归显示心理健康状况的影响因素包括知识与能力(β=0.204,P=0.008)、工作认知(β=0.161,P=0.041)、教学安排(β=0.171,P=0.039)、接受心理卫生教育情况(β=0.370,P<0.001)。结论影像规培生的心理健康状况影响因素来自多方面,应加强对影像规培生的心理健康教育,正确面对压力源因素,促进心理健康。

基于冠状动脉CT造影的生物机械应力在斑块评估及不良心血管事件预测中的应用

冠状动脉长期暴露于危险因素会引起粥样硬化,进而导致斑块形成与进展。通过早期识别高危斑块特征将有助于预防斑块破裂或糜烂,从而避免急性心血管事件的发生。而生物机械应力(biomechanical stress)在动脉粥样硬化斑块进展及破裂中发挥重要的作用。近些年,已经可以通过无创冠脉CT血管造影(coronary computed tomography angiography,CCTA)利用计算流体力学(computational fluid dynamic,CFD)进行建模,从而得到相应的生物机械应力参数,尤其是壁面剪切应力(wall shear stress,WSS)将有助于更好地构建临床模型从而预测斑块进展及主要不良心血管事件(major adverse cardiac events,MACE)。本文重点介绍生物机械应力以及CCTA所计算得出的WSS在动脉粥样硬化中的作用,并讨论有关CCTA生物机械应力与冠心病相关的研究。

SHR与GRACE评分对急性心肌梗死患者院内不良事件发生的预测价值

目的评估应激性高血糖比值(SHR)与全球急性冠状动脉事件注册(GRACE)评分对急性心肌梗死患者院内不良事件发生率的预测价值。方法选取2020年6月—2023年3月就诊于盐城市第三人民医院确诊为ST段抬高型心肌梗死的患者共计207例。结局指标为主要不良心脏事件(MACE),包括全因死亡率、再次血运重建、心肌梗死和脑卒中。依照是否发生MACE进行分组,对比组间各临床指标是否存在差异。使用logistic回归分析评估SHR与GRACE评分对急性心肌梗死患者院内MACE发生率的预测价值,SHR计算公式为ABG/(1.59×HbA1c(%)-2.59)。依据受试者工作特征(ROC)曲线计算SHR与GRACE评分预测急性心肌梗死患者院内MACE发生率的最大约登指数所对应的灵敏度及特异度。结果所观察207例患者中,33例患者出现MACE,MACE发生率为15.9%。依照是否发生MACE进行分组,结果显示GRACE评分变量中,MACE组患者年龄、心率(HR)、收缩压(SBP)、血肌酐水平以及Killip分级的比较差异有统计学意义(P<0.05)。在实验室检查方面,MACE组患者入院血糖(ABG)、脑钠肽(BNP)、血红蛋白(Hb)比较差异有统计学意义(P<0.05)。MACE组患者SHR、GRACE评分明显高于非MACE组患者,差异有统计学意义(P<0.05)。Logistic回归分析结果显示,BNP水平升高与MACE发生风险增加存在明显相关性(OR=1.021,95%CI:1.012~1.030;P<0.001);SHR升高与MACE发生风险增加存在明显相关性(OR=1.670,95%CI:1.205~2.313;P=0.002);GRACE评分升高与MACE发生风险增加存在明显相关性(OR=1.051,95%CI:1.032~1.069;P<0.001);Hb水平与MACE发生风险不存在明显相关性(OR=1.006,95%CI:0.909~1.113;P=0.910)。ROC曲线分析结果显示,SHR预测MACE的曲线下面积(AUC)为0.620,最大约登指数为0.140,对应敏感度为48.5%,特异度为65.5%。GRACE评分预测MACE的AUC为0.826,最大约登指数为0.554,对应敏感度为81.8%,特异度为73.6%。SHR联合GRACE评分预测MACE的AUC为0.838,最大约登指数为0.609,对应敏感度为87.9%,特异度为73.0%。结论SHR和GRACE评分升高均与急性心肌梗死患者院内MACE发生风险增加存在明显相关性。SHR和GRACE评分联合检测对急性心肌梗死患者院内MACE具有较高的预测价值,但SHR单独预测价值较低。

早年应激与重性抑郁障碍机制研究进展(综述)

重性抑郁障碍(major depression disorder,MDD)因其高复发率、高致残率、低治愈率,严重影响着人类的生活。早年应激(early life stress,ELS)被认为是成年后MDD发生的重要环境因素。ELS会导致相关脑区的结构和功能发生改变、脑源性神经营养因子(brain-derived neurotrophic factor,BDNF)表达下降、影响下丘脑-垂体-肾上腺(hypothalamic-pituitary-adrenal,HPA)轴功能、增加相关炎症因子表达等导致抑郁症的发生。同时早年应激可能通过特定的表观遗传作用,与环境因素共同影响精神疾病的发生。本文将综述早年应激与重性抑郁障碍机制研究方面的新进展。

捕食胁迫对“四大家鱼”幼鱼生理反应的影响

本研究选取乌鳢(Channa argus)和南方大口鲶(Silurus soldatovi meridionalis)为捕食者,青鱼(Mylopharyngodon piceus)、草鱼(Ctenopharyngodon idellus)、鲢(Hypophthalmichthys molitrix)、鳙(Aristichthys nobilis)幼鱼为猎物鱼,比较了在无捕食(空白对照)、低捕食(隔网胁迫)和高捕食(直接胁迫)压力下,胁迫0、7、14d后,“四大家鱼”幼鱼血清皮质醇(COR)水平和血液生化指标的变化。结果显示,不同捕食胁迫水平下,“四大家鱼”幼鱼的血液生化指标和COR水平变化程度不同,但变化趋势一致。“四大家鱼”幼鱼的COR水平随着捕食胁迫程度和胁迫时长的增加显著升高,表现为无捕食组<低捕食组<高捕食组,0 d<7 d<14 d。在血液生化指标中,血清蛋白浓度和总胆固醇(CHO)浓度较为稳定,各组相比无显著变化;血糖(GLU)浓度和碱性磷酸酶(ALK)在捕食胁迫下升高,甘油三酯(TG)则相反,呈下降趋势。研究表明,“四大家鱼”幼鱼会根据捕食风险来增强自身生存能力的方式及调整生理反应。捕食胁迫处理后,“四大家鱼”幼鱼均产生了应激反应,与隔网捕食相比,直接捕食对鱼体生理反应影响更为显著,且随着胁迫时长的增加应激程度也随之增加。各检测指标中,血清蛋白和CHO可能不是捕食胁迫下鱼类应激的敏感指标;COR和GLU的变化最为显著,这可能是为了弥补应激期间机体对能量需求的增大。

大补元煎加味对早中期糖尿病肾病气阴两虚夹瘀证患者微炎症状态及肾纤维化相关生长因子的影响

目的:观察大补元煎加味对早中期糖尿病肾病气阴两虚夹瘀证患者微炎症状态及肾纤维化相关生长因子的影响。方法:选取2020年7月至2021年6月北京市西城区广外医院治疗的糖尿病肾病患者80例,按照随机数字表法分为治疗组和常规组,每组40例。常规组给予常规西医治疗,治疗组在常规组治疗的基础上给予大补元煎加味治疗。观察两组患者治疗前后可溶性糖基化终末产物受体(soluble receptor for advanced glycation end products,sRAGE)、甘肽过氧化物酶(glutathione peroxidase,GSH-Px)、核苷酸结合寡聚化结构域样受体3(nucleotide-binding oligomerization domain-like receptor protein 3,NLRP3)、晚期糖基化终末产物(Advanced glycosylation endproducts,AGEs)、NADPH氧化酶4(nadph oxidase4,NOX4)、转化生长因子-β(transforming growth factor-β,TGF-β)、核因子-κB(nuclear factor kappa-B,NF-κB)、单核细胞趋化蛋白-1(monocyte chemotactic protein 1,MCP-1)、结缔组织生长因子(connective tissue growth factor,CTGF)、中性粒细胞明胶酶相关脂质运载蛋白(neutrophil gelatinase-associated lipocalin,NGAL)、Dickkopf相关蛋白1(dickkopf related protein 1,DKK1)、糖化血红蛋白(hemoglobinA1c,HbA1c)、可溶性肿瘤坏死因子受体1(soluble tnf receptor 1,sTNFR-1)、空腹血糖(fasting plasma glucose,FPG)、尿白蛋白排泄率(urinary albumin excretion rates,UAER)、肾阻力指数(resistive Index,RI)、肾动脉收缩期最大流速(maximum systolic velocity,Vsmax)、肾全血流量(renal blood flow,RBF)变化情况及临床疗效。结果:治疗组治疗后HbA1c、UAER、FPG水平低于常规组(P<0.05);治疗阻治疗后MCP-1、NLRP3、NGAL、NF-κB低于常规组(P<0.05);治疗组治疗后sRAGE、GSH-Px水平高于常规组,AGEs、NOX4水平低于常规组(P<0.05);治疗组治疗后CTGF、DKK1、TGF-β、sTNFR-1水平低于常规组(P<0.05);治疗组治疗后Vsmax、RBF高于常规组,RI低于常规组(P<0.05);治疗阻有效率为97.50%,常规组有效率为85.00%,治疗组有效率高于常规组(P<0.05)。结论:大补元煎加味治疗早中期糖尿病肾病气阴两虚夹瘀证,可调节患者HbA1c、UAER、FPG水平,抑制机体微炎症状态,减少氧化应激损伤,改善肾纤维化相关生长因子水平,改善肾血流动力学,提升临床疗效。

常规测井三向应力计算方法研究

大庆油田注水开发油藏套管损坏的主要原因是长期高压注水造成的区域或局域孔隙压力不平衡,导致地层滑动或地层应力集中释放的结果,套损预测的关键是有效地求取地层应力参数。首先以地层测试资料为标准,利用常规测井建立了水淹油藏孔隙压力计算方法,进而以交叉偶极子声波测井解释结果为相对标准,给出了水平主应力与孔隙压力关系,实现了常规测井计算水平主应力方法,为油水井地层应力求取提供技术保证。通过5口井交叉偶极子声波测井资料检验,平均相对误差5%,最大绝对误差1.1 MPa,基本满足工程要求。