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Circular RNAs in breast cancer diagnosis,treatment and prognosis 被引量:1
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作者 XIAOJIA HUANG CAILU SONG +2 位作者 JINHUI ZHANG LEWEI ZHU HAILIN TANG 《Oncology Research》 SCIE 2024年第2期241-249,共9页
Breast cancer has surpassed lung cancer to become the most common malignancy worldwide.The incidence rate and mortality rate of breast cancer continue to rise,which leads to a great burden on public health.Circular RN... Breast cancer has surpassed lung cancer to become the most common malignancy worldwide.The incidence rate and mortality rate of breast cancer continue to rise,which leads to a great burden on public health.Circular RNAs(circRNAs),a new class of noncoding RNAs(ncRNAs),have been recognized as important oncogenes or suppressors in regulating cancer initiation and progression.In breast cancer,circRNAs have significant roles in tumorigenesis,recurrence and multidrug resistance that are mediated by various mechanisms.Therefore,circRNAs may serve as promising targets of therapeutic strategies for breast cancer management.This study reviews the most recent studies about the biosynthesis and characteristics of circRNAs in diagnosis,treatment and prognosis evaluation,as well as the value of circRNAs in clinical applications as biomarkers or therapeutic targets in breast cancer.Understanding the mechanisms by which circRNAs function could help transform basic research into clinical applications and facilitate the development of novel circRNA-based therapeutic strategies for breast cancer treatment. 展开更多
关键词 CircRNa Breast cancer diagnosis treatment BIOMaRKER
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Pathogenesis, diagnosis, and treatment of epilepsy: electromagnetic stimulation-mediated neuromodulation therapy and new technologies
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作者 Dian Jiao Lai Xu +3 位作者 Zhen Gu Hua Yan Dingding Shen Xiaosong Gu 《Neural Regeneration Research》 SCIE CAS 2025年第4期917-935,共19页
Epilepsy is a severe,relapsing,and multifactorial neurological disorder.Studies regarding the accurate diagnosis,prognosis,and in-depth pathogenesis are crucial for the precise and effective treatment of epilepsy.The ... Epilepsy is a severe,relapsing,and multifactorial neurological disorder.Studies regarding the accurate diagnosis,prognosis,and in-depth pathogenesis are crucial for the precise and effective treatment of epilepsy.The pathogenesis of epilepsy is complex and involves alterations in variables such as gene expression,protein expression,ion channel activity,energy metabolites,and gut microbiota composition.Satisfactory results are lacking for conventional treatments for epilepsy.Surgical resection of lesions,drug therapy,and non-drug interventions are mainly used in clinical practice to treat pain associated with epilepsy.Non-pharmacological treatments,such as a ketogenic diet,gene therapy for nerve regeneration,and neural regulation,are currently areas of research focus.This review provides a comprehensive overview of the pathogenesis,diagnostic methods,and treatments of epilepsy.It also elaborates on the theoretical basis,treatment modes,and effects of invasive nerve stimulation in neurotherapy,including percutaneous vagus nerve stimulation,deep brain electrical stimulation,repetitive nerve electrical stimulation,in addition to non-invasive transcranial magnetic stimulation and transcranial direct current stimulation.Numerous studies have shown that electromagnetic stimulation-mediated neuromodulation therapy can markedly improve neurological function and reduce the frequency of epileptic seizures.Additionally,many new technologies for the diagnosis and treatment of epilepsy are being explored.However,current research is mainly focused on analyzing patients’clinical manifestations and exploring relevant diagnostic and treatment methods to study the pathogenesis at a molecular level,which has led to a lack of consensus regarding the mechanisms related to the disease. 展开更多
关键词 diagnosis drug treatment ELECTROENCEPHaLOGRaPHY epilepsy monitoring EPILEPSY nerve regeneration NEUROSTIMULaTION non-drug interventions PaTHOGENESIS prediction
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Expediting carbon dots synthesis by the active adaptive method with machine learning and applications in dental diagnosis and treatment
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作者 Yaoyao Tang Quan Xu +3 位作者 Xinyao Zhang Rongye Zhu Nuo Zhao Juncheng Wang 《Nano Research》 SCIE EI CSCD 2024年第11期10109-10118,共10页
Synthesis of functional nanostructures with the least number of tests is paramount towards the propelling materials development. However, the synthesis method containing multivariable leads to high uncertainty, exhaus... Synthesis of functional nanostructures with the least number of tests is paramount towards the propelling materials development. However, the synthesis method containing multivariable leads to high uncertainty, exhaustive attempts, and exorbitant manpower costs. Machine learning (ML) burgeons and provokes an interest in rationally designing and synthesizing materials. Here, we collect the dataset of nano-functional materials carbon dots (CDs) on synthetic parameters and optical properties. ML is applied to assist the synthesis process to enhance photoluminescence quantum yield (QY) by building the methodology named active adaptive method (AAM), including the model selection, max points screen, and experimental verification. An interactive iteration strategy is the first time considered in AAM with the constant acquisition of the furnished data by itself to perfect the model. CDs exhibit a strong red emission with QY up to 23.3% and enhancement of around 200% compared with the pristine value obtained through the AAM guidance. Furthermore, the guided CDs are applied as metal ions probes for Co^(2+) and Fe^(3+), with a concentration range of 0–120 and 0–150 µM, and their detection limits are 1.17 and 0.06 µM. Moreover, we also apply CDs for dental diagnosis and treatment using excellent optical ability. It can effectively detect early caries and treat mineralization combined with gel. The study shows that the error of experiment verification gradually decreases and QY improves double with the effective feedback loops by AAM, suggesting the great potential of utilizing ML to guide the synthesis of novel materials. Finally, the code is open-source and provided to be referenced for further investigation on the novel inorganic material prediction. 展开更多
关键词 machine learning simulated annealing active adaptive method carbon dots Ions detection dental diagnosis and treatment
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Intestinal Behçet's disease: A review of clinical diagnosis and treatment
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作者 Ying Liu Feng Gao +1 位作者 Ding-Quan Yang Yan Jiao 《World Journal of Gastrointestinal Surgery》 SCIE 2024年第6期1493-1500,共8页
Behçet's disease(BD)is a chronic inflammatory disorder prone to frequent re-currences,with a high predilection for intestinal involvement.However,the ef-ficacy and long-term effects of surgical treatment for ... Behçet's disease(BD)is a chronic inflammatory disorder prone to frequent re-currences,with a high predilection for intestinal involvement.However,the ef-ficacy and long-term effects of surgical treatment for intestinal BD are unknown.In the current issue of World J Gastrointest Surg,Park et al conducted a retrospec-tive analysis of 31 patients with intestinal BD who received surgical treatment.They found that elevated C-reactive protein levels and emergency surgery were poor prognostic factors for postoperative recurrence,emphasizing the adverse impact of severe inflammation on the prognosis of patients with intestinal BD.This work has clinical significance for evaluating the postoperative condition of intestinal BD.The editorial attempts to summarize the clinical diagnosis and treatment of intestinal BD,focusing on the impact of adverse factors on surgical outcomes.We hope this review will facilitate more precise postoperative management of patients with intestinal BD by clinicians. 展开更多
关键词 Intestinal Behçet's disease diagnosis treatment SURGERY RECURRENCE
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Automation in road distress detection,diagnosis and treatment
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作者 Xu Yang Jianqi Zhang +3 位作者 Wenbo Liu Jiayu Jing Hao Zheng Wei Xu 《Journal of Road Engineering》 2024年第1期1-26,共26页
Road transportation plays a crucial role in society and daily life,as the functioning and durability of roads can significantly impact a nation's economic development.In the whole life cycle of the road,the emerge... Road transportation plays a crucial role in society and daily life,as the functioning and durability of roads can significantly impact a nation's economic development.In the whole life cycle of the road,the emergence of disease is unavoidable,so it is necessary to adopt relevant technical means to deal with the disease.This study comprehensively reviews the advancements in computer vision,artificial intelligence,and mobile robotics in the road domain and examines their progress and applications in road detection,diagnosis,and treatment,especially asphalt roads.Specifically,it analyzes the research progress in detecting and diagnosing surface and internal road distress and related techniques and algorithms are compared.In addition,also introduces various road gover-nance technologies,including automated repairs,intelligent construction,and path planning for crack sealing.Despite their proven effectiveness in detecting road distress,analyzing diagnoses,and planning maintenance,these technologies still confront challenges in data collection,parameter optimization,model portability,system accuracy,robustness,and real-time performance.Consequently,the integration of multidisciplinary technologies is imperative to enable the development of an integrated approach that includes road detection,diagnosis,and treatment.This paper addresses the challenges of precise defect detection,condition assessment,and unmanned construction.At the same time,the efficiency of labor liberation and road maintenance is achieved,and the automation level of the road engineering industry is improved. 展开更多
关键词 Road detection Road diagnosis Road treatment Deep learning Intelligent maintenance
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Research Progress of Ultrasound Radiomics in The Diagnosis and Treatment of Breast Cancer
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作者 Hanjiao Zhou Huhu Chen 《Journal of Clinical and Nursing Research》 2024年第4期334-339,共6页
With the advancement of medical research in recent years and the frequent occurrence of different types of cancer, breast cancer has gradually attracted the public’s attention. The incidence of breast cancer is risin... With the advancement of medical research in recent years and the frequent occurrence of different types of cancer, breast cancer has gradually attracted the public’s attention. The incidence of breast cancer is rising, mainly affecting women with a high mortality rate. According to the clinical treatment effect, early diagnosis and early treatment can effectively control the mortality of breast cancer and improve patient’s quality of life. Ultrasound radiomics is an emerging field that can extract quantitative high-dimensional data from ultrasound images. Recently, ultrasound radiomics has been widely used in the clinical treatment of breast cancer. This paper analyzed the research progress of ultrasound radiomics in the diagnosis and treatment of breast cancer. 展开更多
关键词 Ultrasound radiomics Breast cancer diagnosis and treatment Research progress
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Endoscopic diagnosis and management of gallbladder carcinoma in minimally invasive era:New needs,new models
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作者 La-Cuo Deqing Jun-Wen Zhang Jian Yang 《World Journal of Gastrointestinal Oncology》 SCIE 2024年第11期4333-4337,共5页
Gallbladder cancer(GBC)is a rare and lethal malignancy;however,it represents the most common type of biliary tract cancer.Patients with GBC are often diagnosed at an advanced stage,thus,unfortunately,losing the opport... Gallbladder cancer(GBC)is a rare and lethal malignancy;however,it represents the most common type of biliary tract cancer.Patients with GBC are often diagnosed at an advanced stage,thus,unfortunately,losing the opportunity for curative surgical intervention.This situation leads to lower quality of life and higher mortality rates.In recent years,the rapid development of endoscopic equipment and techniques has provided new avenues and possibilities for the early and minimally invasive diagnosis and treatment of GBC.This editorial comments on the article by Pavlidis et al.Building upon their work,we explore the new needs and corresponding models for managing GBC from the endoscopic diagnosis and treatment perspective. 展开更多
关键词 ENDOSCOPY diagnosis and treatment Gallbladder carcinoma Minimal invasive New need New model
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Challenges and prospects in bridging precision medicine and artificial intelligence in genomic psychiatric treatment
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作者 Uchenna Esther Okpete Haewon Byeon 《World Journal of Psychiatry》 SCIE 2024年第8期1148-1164,共17页
Precision medicine is transforming psychiatric treatment by tailoring personalized healthcare interventions based on clinical,genetic,environmental,and lifestyle factors to optimize medication management.This study in... Precision medicine is transforming psychiatric treatment by tailoring personalized healthcare interventions based on clinical,genetic,environmental,and lifestyle factors to optimize medication management.This study investigates how artificial intelligence(AI)and machine learning(ML)can address key challenges in integrating pharmacogenomics(PGx)into psychiatric care.In this integration,AI analyzes vast genomic datasets to identify genetic markers linked to psychiatric conditions.AI-driven models integrating genomic,clinical,and demographic data demonstrated high accuracy in predicting treatment outcomes for major depressive disorder and bipolar disorder.This study also examines the pressing challenges and provides strategic directions for integrating AI and ML in genomic psychiatry,highlighting the importance of ethical considerations and the need for personalized treatment.Effective implementation of AI-driven clinical decision support systems within electronic health records is crucial for translating PGx into routine psychiatric care.Future research should focus on developing enhanced AI-driven predictive models,privacy-preserving data exchange,and robust informatics systems to optimize patient outcomes and advance precision medicine in psychiatry. 展开更多
关键词 Precision medicine Psychiatric treatment Genomic data Machine learning Deep learning Clinical decision making Data privacy Review
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Cervical Myelopathy: Diagnostic Aspects, Surgical Treatment and Evolution of Patients Operated upon in Yaounde
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作者 Bello Figuim Djoubairou Ben Ousmanou +3 位作者 Oumarou Haman Nassourou Ndome Toto Orlande Amadou Tidjani Djientcheu Vincent de Paul 《Open Journal of Modern Neurosurgery》 2024年第1期72-82,共11页
Introduction: Although cervical myelopathy is the most common degenerative cervical spine pathology in adults, the indications and approaches of surgical treatment have not yet been clearly defined in the literature. ... Introduction: Although cervical myelopathy is the most common degenerative cervical spine pathology in adults, the indications and approaches of surgical treatment have not yet been clearly defined in the literature. Very few studies exist regarding these aspects in our setting, and they are mostly outdated. This study aimed to describe the diagnostic aspects, current surgical treatment with technical improvements, and progression in patients. Patients and Methods: We conducted a multicentre retrospective descriptive study over a 10-year period between January 2011 and January 2020 in three referral centres in Yaoundé. All patients who underwent surgery for cervical myelopathy were included. Results: Fifty-two patients were recruited. The rate of operated cervical myelopathies among all degenerative spinal pathologies was 14.05%. The M/F sex ratio was 3/1, and the average age was 52 ± 10 years. All included patients had gait problems, 90.38% demonstrated motor deficiency, and 67.30% experienced at least three levels of compression. Surgery was decided based on the Nurick grade;a posterior approach was applied to 86.54% of patients. Postoperative progression showed a neurological improvement of 82% with an average follow-up of 4 years. Conclusion: In this study, the patients who underwent surgery were relatively young, their clinical presentations were mostly advanced, and surgical management showed good results in well-selected cases. 展开更多
关键词 Cervical Myelopathy diagnosis treatment EVOLUTION Cameroon
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Radiomics in the diagnosis and treatment of hepatocellular carcinoma 被引量:5
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作者 Chun Jiang Yi-Qi Cai +5 位作者 Jia-Jia Yang Can-Yu Ma Jia-Xi Chen Lan Huang Ze Xiang Jian Wu 《Hepatobiliary & Pancreatic Diseases International》 SCIE CAS CSCD 2023年第4期346-351,共6页
Hepatocellular carcinoma(HCC)is a common malignant tumor.At present,early diagnosis of HCC is dif-ficult and therapeutic methods are limited.Radiomics can achieve accurate quantitative evaluation of the lesions withou... Hepatocellular carcinoma(HCC)is a common malignant tumor.At present,early diagnosis of HCC is dif-ficult and therapeutic methods are limited.Radiomics can achieve accurate quantitative evaluation of the lesions without invasion,and has important value in the diagnosis and treatment of HCC.Radiomics fea-tures can predict the development of cancer in patients,serve as the basis for risk stratification of HCC patients,and help clinicians distinguish similar diseases,thus improving the diagnostic accuracy.Further-more,the prediction of the treatment outcomes helps determine the treatment plan.Radiomics is also helpful in predicting the HCC recurrence,disease-free survival and overall survival.This review summa-rized the role of radiomics in the diagnosis,treatment and prognosis of HCC. 展开更多
关键词 Hepatocellular carcinoma Radiomics diagnosis PROGNOSIS treatment
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Electroencephalography in the diagnosis and management of treatment-resistant depression with comorbid epilepsy:a novel strategy 被引量:2
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作者 Harinder Jaseja 《General Psychiatry》 CSCD 2023年第5期435-439,共5页
INTRODUCTION.Depression,a common mental disorder,is a leading cause of disability worldwide,with a global prevalence ranging from 20% to 25% in women and 7% to 12% in men,and it has exhibited an increasing trend in re... INTRODUCTION.Depression,a common mental disorder,is a leading cause of disability worldwide,with a global prevalence ranging from 20% to 25% in women and 7% to 12% in men,and it has exhibited an increasing trend in recent decades.Despite being known for decades,a consensus on the definition and diagnosis of treatment-resistant depression(TRD)is still lacking. 展开更多
关键词 diagnosis EPILEPSY treatment
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Expert Consensus on the Diagnosis and Treatment of Anticancer Drug-Induced Interstitial Lung Disease 被引量:2
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作者 Fei MA Hua-ping DAI 《Current Medical Science》 SCIE CAS 2023年第1期1-12,共12页
Drug-induced interstitial lung disease(DILD)is the most common pulmonary adverse event of anticancer drugs.In recent years,the incidence of anticancer DILD has gradually increased with the rapid development of novel a... Drug-induced interstitial lung disease(DILD)is the most common pulmonary adverse event of anticancer drugs.In recent years,the incidence of anticancer DILD has gradually increased with the rapid development of novel anticancer agents.Due to the diverse clinical manifestations and the lack of specific diagnostic criteria,DILD is difficult to diagnose and may even become fatal if not treated properly.Herein,a multidisciplinary group of experts from oncology,respiratory,imaging,pharmacology,pathology,and radiology departments in China has reached the“expert consensus on the diagnosis and treatment of anticancer DILD”after several rounds of a comprehensive investigation.This consensus aims to improve the awareness of clinicians and provide recommendations for the early screening,diagnosis,and treatment of anticancer DILD.This consensus also emphasizes the importance of multidisciplinary collaboration while managing DILD. 展开更多
关键词 drug-induced interstitial lung disease anticancer drug diagnosis treatment
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Progress in diagnosis and treatment of acute injury to the anterior talofibular ligament 被引量:2
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作者 Run-Peng Chen Qing-Hua Wang +4 位作者 Ming-Yue Li Xiao-Fang Su Dong-Yang Wang Xing-Hui Liu Zhi-Li Li 《World Journal of Clinical Cases》 SCIE 2023年第15期3395-3407,共13页
Injury to the anterior talofibular ligament(ATFL)is a common acute injury of the lateral foot ligament.Untimely and improper treatment significantly affects the quality of life and rehabilitation progress of patients.... Injury to the anterior talofibular ligament(ATFL)is a common acute injury of the lateral foot ligament.Untimely and improper treatment significantly affects the quality of life and rehabilitation progress of patients.The purpose of this paper is to review the anatomy and the current methods of diagnosis and treatment of acute injury to the ATFL.The clinical manifestations of acute injury to the ATFL include pain,swelling,and dysfunction.At present,non-surgical treatment is the first choice for acute injury of the ATFL.The standard treatment strategy involves the“peace and love”principle.After initial treatment in the acute phase,personalized rehabilitation training programs can be followed.These may involve proprioception training,muscle training,and functional exercise to restore limb coordination and muscle strength.Static stretching and other techniques to loosen joints,acupuncture,moxibustion massage,and other traditional medical treatments can relieve pain,restore range of motion,and prevent joint stiffness.If the non-surgical treatment is not ideal or fails,surgical treatment is feasible.Currently,arthroscopic anatomical repair or anatomical reconstruction surgery is commonly used in clinical practice.Although open Broström surgery provides good results,the modified arthroscopic Broström surgery has many advantages,such as less trauma,rapid pain relief,rapid postoperative recovery,and fewer complications,and is more popular with patients.In general,when treating acute injury to the ATFL,treatment management and methods should be timely and reasonably arranged according to the specific injury scenario and attention should be paid to the timely combination of multiple therapies to achieve the best treatment results. 展开更多
关键词 anterior talofibular ligament acute injury diagnosis aETIOLOGY treatment
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Glioblastoma multiforme:Diagnosis, treatment, and invasion 被引量:1
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作者 Jiawei Li Lili Feng Yingmei Lu 《The Journal of Biomedical Research》 CAS CSCD 2023年第1期47-58,共12页
Glioblastoma multiforme(GBM) is an essentially incurable brain tumor, which has been explored for approximately a century. Nowadays, surgical resection, chemotherapy, and radiation therapy are still the standardized t... Glioblastoma multiforme(GBM) is an essentially incurable brain tumor, which has been explored for approximately a century. Nowadays, surgical resection, chemotherapy, and radiation therapy are still the standardized therapeutic options. However, due to the intrinsic invasion and metastasis features and the resistance to chemotherapy, the survival rate of glioblastoma patients remains unsatisfactory. To improve the current situation, much more research is needed to provide comprehensive knowledge of GBM. In this review, we summarize the latest updates on GBM treatment and invasion. Firstly, we review the traditional and emerging therapies that have been used for GBM treatment. Given the limited efficiency of these therapies, we further discuss the role of invasion in GBM recurrence and progression, and present current research progress on the mode and mechanisms of GBM invasion. 展开更多
关键词 glioblastoma multiforme diagnosis treatment patterns of invasion invasion mechanism
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Multidisciplinary diagnosis and treatment nutritional support intervention for gastrointestinal tumor radiotherapy:Impact on nutrition and quality of life 被引量:1
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作者 Lin Hui Ying-Ying Zhang Xiao-Dan Hu 《World Journal of Gastrointestinal Surgery》 SCIE 2023年第12期2719-2726,共8页
BACKGROUND Gastrointestinal tumors are a major cause of cancer-related deaths and have become a major public health problem.This study aims to provide a scientific basis for improving clinical treatment effects,qualit... BACKGROUND Gastrointestinal tumors are a major cause of cancer-related deaths and have become a major public health problem.This study aims to provide a scientific basis for improving clinical treatment effects,quality of life,and prognosis of patients with gastrointestinal tumors.AIM To explore the clinical effect of the multidisciplinary diagnosis and treatment(MDT)nutrition intervention model on patients with gastrointestinal tumors.METHODS This was a case control study which included patients with gastrointestinal tumors who received radiotherapy at the Department of Oncology between January 2021 and January 2023.Using a random number table,120 patients were randomly divided into MDT and control groups with 60 patients in each group.To analyze the effect of MDT on the nutritional status and quality of life of the patients,the nutritional status and quality of life scores of the patients were measured before and after the treatment.RESULTS Albumin(ALB),transferrin(TRF),hemoglobin(Hb),and total protein(TP)levels significantly decreased after the treatment.The control group had significantly lower ALB,TRF,Hb,and TP levels than the MDT group,and the differences in these levels between the two groups were statistically significant(P<0.05).After the treatment,the MDT group had significantly more wellnourished patients than the control group(P<0.05).The quality of life total score,somatic functioning,role functioning,and emotional functioning were higher in the MDT group than in the control group.By contrast,pain,fatigue,nausea,and vomiting scores were lower in the MDT group than in the control group(P<0.05).CONCLUSION MDT nutritional intervention model effectively improves the nutritional status and quality of life of the patients.The study provides a rigorous theoretical basis for improving the prognosis of cancer patients.In the future,we intend to provide additional treatment methods for improving the quality of life of patients with cancer. 展开更多
关键词 Nutritional support Gastrointestinal tumor Radiotherapy NUTRITION Quality of life Multidisciplinary diagnosis and treatment intervention
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Pathogenesis,clinical manifestations,diagnosis,and treatment progress of achalasia of cardia
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作者 Ming-Yue Li Qing-Hua Wang +2 位作者 Run-Peng Chen Xiao-Fang Su Dong-Yang Wang 《World Journal of Clinical Cases》 SCIE 2023年第8期1741-1752,共12页
Achalasia cardia,type of esophageal dynamic disorder,is a relatively rare primary motor esophageal disease characterized by the functional loss of plexus ganglion cells in the distal esophagus and lower esophageal sph... Achalasia cardia,type of esophageal dynamic disorder,is a relatively rare primary motor esophageal disease characterized by the functional loss of plexus ganglion cells in the distal esophagus and lower esophageal sphincter.Loss of function of the distal and lower esophageal sphincter ganglion cells is the main cause of achalasia cardia,and is more likely to occur in the elderly.Histological changes in the esophageal mucosa are considered pathogenic;however,studies have found that inflammation and genetic changes at the molecular level may also cause achalasia cardia,resulting in dysphagia,reflux,aspiration,retrosternal pain,and weight loss.Currently,the treatment options for achalasia focus on reducing the resting pressure of the lower esophageal sphincter,helping to empty the esophagus and relieve symptoms.Treatment measures include botulinum toxin injection,inflatable dilation,stent insertion,and surgical myotomy(open or laparoscopic).Surgical procedures are often subject to controversy owing to concerns about safety and effectiveness,particularly in older patients.Herein,we review clinical epidemiological and experimental data to determine the prevalence,pathogenesis,clinical presentation,diagnostic criteria,and treatment options for achalasia to support its clinical management. 展开更多
关键词 achalasia cardia PaTHOGENESIS Clinical manifestations diagnosis treatment
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Advances and future directions in keloid research:Pathogenesis,diagnosis and personalized treatment strategies
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作者 Song-Yun Zhao Dan Wu +1 位作者 Chao Cheng Jia-Heng Xie 《World Journal of Clinical Cases》 SCIE 2023年第34期8094-8098,共5页
Keloids,which are abnormal manifestations of wound healing,can result in significant functional impairment and aesthetic deformities.The pathogenesis of keloids is multifaceted and complex and influenced by various fa... Keloids,which are abnormal manifestations of wound healing,can result in significant functional impairment and aesthetic deformities.The pathogenesis of keloids is multifaceted and complex and influenced by various factors,such as genetics,the environment,and immune responses.The evolution of keloid treatment has progressed from traditional surgical excision to a contemporary combination of therapies including injection and radiation treatments,among others.This article provides a comprehensive review of keloid pathogenesis and treatment,emphasizing the latest advances in the field.Ultimately,this review underscores the necessity for continued research to enhance our understanding of keloid pathogenesis and to devise more effective treatments for this challenging condition. 展开更多
关键词 KELOIDS PaTHOGENESIS diagnosis treatment Personalized therapy
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Optimizing nutrition in hepatic cirrhosis:A comprehensive assessment and care approach 被引量:1
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作者 Osvely Mendez-Guerrero Anaisa Carranza-Carrasco +2 位作者 Luis Alberto Chi-Cervera Aldo Torre Nalu Navarro-Alvarez 《World Journal of Gastroenterology》 SCIE CAS 2024年第10期1313-1328,共16页
Cirrhosis is considered a growing cause of morbidity and mortality,which represents a significant public health problem.Currently,there is no effective treatment to reverse cirrhosis.Treatment primarily centers on add... Cirrhosis is considered a growing cause of morbidity and mortality,which represents a significant public health problem.Currently,there is no effective treatment to reverse cirrhosis.Treatment primarily centers on addressing the underlying liver condition,monitoring,and managing portal hypertension-related complications,and evaluating the potential for liver transplantation in cases of decompensated cirrhosis,marked by rapid progression and the emer-gence of complications like variceal bleeding,hepatic encephalopathy,ascites,malnutrition,and more.Malnutrition,a prevalent complication across all disease stages,is often underdiagnosed in cirrhosis due to the complexities of nutritional assessment in patients with fluid retention and/or obesity,despite its crucial impact on prognosis.Increasing emphasis has been placed on the collaboration of nutritionists within hepatology and Liver transplant teams to deliver compre-hensive care,a practice that has shown to improve outcomes.This review covers appropriate screening and assessment methods for evaluating the nutritional status of this population,diagnostic approaches for malnutrition,and context-specific nutrition treatments.It also discusses evidence-based recommendations for supplementation and physical exercise,both essential elements of the standard care provided to cirrhotic patients. 展开更多
关键词 CIRRHOSIS Nutritional diagnosis treatment DIET GUIDELINES
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Heart failure in China:epidemiology and current management
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作者 Sheng-Shou HU the Writing Committee of the Report on Cardiovascular Health and Diseases in China 《Journal of Geriatric Cardiology》 SCIE CAS CSCD 2024年第6期631-641,共11页
The Annual Report on Cardiovascular Health and Diseases in China(2022)intricate landscape of cardiovascularhealth in China.In connection with the previous section,this sixth section of the report offers a comprehensiv... The Annual Report on Cardiovascular Health and Diseases in China(2022)intricate landscape of cardiovascularhealth in China.In connection with the previous section,this sixth section of the report offers a comprehensive analysis of heart failure(HF)in China.HF is one of the most important cardiovascular disease in the 21st century.Its mortality is equivalent to that of cancer.It is an important public health problem that seriously affects the health of Chinese residents.In recent years,with the deepeningof understanding,the change of treatment principles,the innovation of treatment methods and the update of treatment guidelines,the in-hospital mortality of HF patients has declined,and the long-term prognosis is also improving.However,there are stilldifferences in the management level of HF among different hospitals in China.How to improve the standardized diagnosis andtreatment level of HF in China remains an important challenge. 展开更多
关键词 EPIDEMIOLOGY diagnosis treatment
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Extrahepatic cholestasis associated with paracoccidioidomycosis:Challenges in the differential diagnosis of biliopancreatic neoplasia
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作者 Jose Sebastiao dos Santos Vitor de Moura Arrais +9 位作者 William Jose Rosseto Ferreira Ricardo Ribeiro Correa Filho Mariangela Ottoboni Brunaldi Rafael Kemp Ajith Kumar Sankanrakutty Jorge Elias Junior Fernando Bellissimo-Rodrigues Roberto Martinez Edson Zangiacomi Martinez Jose Celso Ardengh 《World Journal of Gastrointestinal Oncology》 SCIE 2024年第6期2531-2540,共10页
BACKGROUND Paracoccidioidomycosis(PCM)may involve the hepatic pedicle and peripan creatic lymph nodes,cause damage to the bile duct and manifest,exceptionally,in combination with extrahepatic cholestasis(EHC),making i... BACKGROUND Paracoccidioidomycosis(PCM)may involve the hepatic pedicle and peripan creatic lymph nodes,cause damage to the bile duct and manifest,exceptionally,in combination with extrahepatic cholestasis(EHC),making investigation and treatment challenging.AIM To investigate the management of patients with visceral PCM admitted with EHC.METHODS All patients diagnosed with PCM treated in a public,tertiary teaching hospital between 1982 and 2020 were retrospectively evaluated.Those also identified with EHC were allocated to two groups according to the treatment approach for the purpose of comparing clinical,laboratory,and imaging findings,resources used for etiological diagnosis,treatment results,and prognosis.Statistical analyses were performed using the linear mixed-effects model(random and fixed effects),which was adjusted using the PROC MIXED procedure of the SAS®9.0 software,and Fisher’s exact test.RESULTS Of 1645 patients diagnosed with PCM,40(2.4%)had EHC.Of these,20(50.0%)lived in the rural area and 29(72.5%)were men,with a mean age of 27.1 years(3-65 years).Jaundice as first symptom and weight loss of at least 10 kg were observed in 16 patients(40.0%),and a mass in the head of the pancreas was observed in 8(20.0%).The etiological diagnosis was made by tissue collection during surgery in 4 cases(10.0%)and by endoscopic methods in 3 cases(7.5%).Twenty-seven patients(67.5%)received drug treatment alone(Group 1),whereas 13(32.5%)underwent endoscopic and/or surgical procedures in combination with drug treatment(Group 2).EHC was significantly reduced in both groups(40.7% in Group 1,with a mean time of 3 months;and 38.4% in Group 2,with a mean time of 7.5 months),with no statistically significant difference between them.EHC recurrence rates,associated mainly with treatment nonadherence,were similar in both groups:37% in Group 1 and 15.4% in Group 2.The mortality rate was 18.5% in Group 1 and 23% in Group 2,with survival estimates of 71.3% and 72.5%,respectively,with no statistically significant difference.CONCLUSION Although PCM-related EHC is rare,it needs to be included in the differential diagnosis of malignancies,as timely treatment can prevent hepatic and extrahepatic sequelae. 展开更多
关键词 CHOLESTaSIS JaUNDICE Obstructive BLaSTOMYCOSIS Paracoccidioides diagnosis treatment
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