It has been reported that overweight Japanese males have poorly organised dermis and their skin may be fragile to external forces because of decreased dermal echogenicity. However, it is unknown whether the changes in...It has been reported that overweight Japanese males have poorly organised dermis and their skin may be fragile to external forces because of decreased dermal echogenicity. However, it is unknown whether the changes in the dermal structure actually affect the dermal function. The objective of this study was to clarify the relationship between dermal structural parameters and dermal functional parameters in overweight and obese Japanese males. A cross-sectional, observational study was conducted on Japanese male volunteers. Two ultrasound scanners, a 20-MHz Dermascan C<sup>®</sup> and an 18-MHz Mylab<sup>TM</sup> five<sup>®</sup> were used to evaluate dermal structure. Echogenicity of the lower dermis and dermal thickness of the participants’ abdomens and thighs were measured. A Cutometer<sup>®</sup> MPA580 was used to evaluate skin viscoelasticity, skin deformation (R0) and elasticity (R2, R7). The correlation between dermal structural parameters and skin viscoelasticity were validated using Pearson’s correlation coefficient or Spearman’s correlation coefficient by rank test. A total of 79 male volunteers were recruited of which 43 were control subjects with BMI <25 (age, 22 - 63 years), 25 were overweight subjects with BMI ≥ 25 to <30 (age, 23 - 64 years) and the 11 obese subjects had a BMI ≥ 30 (age, 26 - 47 years). There was no correlation between dermal structural parameters and skin viscoelasticity in the abdomens or thighs of all 79 participants. On the other hand, in the 36 overweight and obese participants, thigh dermal echogenicity was significantly and negatively correlated with R0 (r = -0.456, p < 0.01) and dermal thickness in the abdomen was significantly and positively correlated with R0 (r = 0.464, p < 0.01). The dermal functional parameter was significantly correlated with dermal structural parameters in overweight and obese males;in other words, a decrease in dermal function may be caused by structural changes in the dermis during obesity.展开更多
It is well-documented that male overweight and obesity causes endocrine disorders that might diminish the male reproductive capacity; however, reports have been conflicting regarding the influence of male body mass in...It is well-documented that male overweight and obesity causes endocrine disorders that might diminish the male reproductive capacity; however, reports have been conflicting regarding the influence of male body mass index （BMI） on semen quality and the outcome of assisted reproductive technology （ART）. The aim of this study was to investigate whether increased male BMI affects sperm quality and the outcome of assisted reproduction in couples with an overweight or obese man and a non-obese partner. Data was prospectively collected from 612 infertile couples undergoing ART at a Danish fertility center. Self-reported information on paternal height and weight were recorded and BMI was calculated. The men were divided into four BMI categories： underweight BMI 〈 20 kgm^-2, normal BMI 20-24.9 kg m^-2, overweight BMI 25-29.9 kgm^-2 and obese BMI 〉 30 kgm^-2. Conventional semen analysis was performed according to the World Health Organization guideline and sperm DNA integrity was analyzed by the Sperm Chromatin Structure Assay （SCSA）. No statistically significant effect of male BMI was seen on conventional semen parameters （sperm concentration, total sperm count, seminal volume and motility） or on SCSA-results. Furthermore, the outcome of ART regarding fertilization rate, number of good quality embryos （GQE）, implantation and pregnancy outcome was not influenced by the increasing male BMIo展开更多
文摘It has been reported that overweight Japanese males have poorly organised dermis and their skin may be fragile to external forces because of decreased dermal echogenicity. However, it is unknown whether the changes in the dermal structure actually affect the dermal function. The objective of this study was to clarify the relationship between dermal structural parameters and dermal functional parameters in overweight and obese Japanese males. A cross-sectional, observational study was conducted on Japanese male volunteers. Two ultrasound scanners, a 20-MHz Dermascan C<sup>®</sup> and an 18-MHz Mylab<sup>TM</sup> five<sup>®</sup> were used to evaluate dermal structure. Echogenicity of the lower dermis and dermal thickness of the participants’ abdomens and thighs were measured. A Cutometer<sup>®</sup> MPA580 was used to evaluate skin viscoelasticity, skin deformation (R0) and elasticity (R2, R7). The correlation between dermal structural parameters and skin viscoelasticity were validated using Pearson’s correlation coefficient or Spearman’s correlation coefficient by rank test. A total of 79 male volunteers were recruited of which 43 were control subjects with BMI <25 (age, 22 - 63 years), 25 were overweight subjects with BMI ≥ 25 to <30 (age, 23 - 64 years) and the 11 obese subjects had a BMI ≥ 30 (age, 26 - 47 years). There was no correlation between dermal structural parameters and skin viscoelasticity in the abdomens or thighs of all 79 participants. On the other hand, in the 36 overweight and obese participants, thigh dermal echogenicity was significantly and negatively correlated with R0 (r = -0.456, p < 0.01) and dermal thickness in the abdomen was significantly and positively correlated with R0 (r = 0.464, p < 0.01). The dermal functional parameter was significantly correlated with dermal structural parameters in overweight and obese males;in other words, a decrease in dermal function may be caused by structural changes in the dermis during obesity.
文摘It is well-documented that male overweight and obesity causes endocrine disorders that might diminish the male reproductive capacity; however, reports have been conflicting regarding the influence of male body mass index （BMI） on semen quality and the outcome of assisted reproductive technology （ART）. The aim of this study was to investigate whether increased male BMI affects sperm quality and the outcome of assisted reproduction in couples with an overweight or obese man and a non-obese partner. Data was prospectively collected from 612 infertile couples undergoing ART at a Danish fertility center. Self-reported information on paternal height and weight were recorded and BMI was calculated. The men were divided into four BMI categories： underweight BMI 〈 20 kgm^-2, normal BMI 20-24.9 kg m^-2, overweight BMI 25-29.9 kgm^-2 and obese BMI 〉 30 kgm^-2. Conventional semen analysis was performed according to the World Health Organization guideline and sperm DNA integrity was analyzed by the Sperm Chromatin Structure Assay （SCSA）. No statistically significant effect of male BMI was seen on conventional semen parameters （sperm concentration, total sperm count, seminal volume and motility） or on SCSA-results. Furthermore, the outcome of ART regarding fertilization rate, number of good quality embryos （GQE）, implantation and pregnancy outcome was not influenced by the increasing male BMIo
