Background: Infertility affects 8% - 12% of couples globally, with approximately half of the cases reported in males. Oxidative stress is a common factor increased in the varicocele condition and particularly affects ...Background: Infertility affects 8% - 12% of couples globally, with approximately half of the cases reported in males. Oxidative stress is a common factor increased in the varicocele condition and particularly affects spermatozoa, due to their sensitivity to oxidative signals and testicular hypotrophy. The objective of this clinical trial is to study the effectiveness of Spermotrend in the improvement of sperm parameters in male infertility. Methods: A total of 170 males aged > 18 years with a diagnosis of infertility and varicocele were consecutively enrolled in a Phase II, open-label clinical trial. Spermotrend was administered 1 capsule (450 mg) orally every 8 hours for 6 months and was evaluated through semen analysis at 4 and 6 months of follow-up. Results: The trial results show a significant improvement following the administration of Spermotrend over 6 months in sperm concentration (44.1% at baseline vs. 64.1% at 6 months), sperm survival (28.2% with sperm survival ≥ 2 hours vs.56.5%), normalization of sperm morphology (31.2% vs. 72.9%). Varicocele condition decreased in all patients and, by the end of the study, 55.3% of patients had normal venous flow and dilation. Only 5.9% of the patients showed grade 2 varicocele at the end of the study, while 38.8% showed grade 1 varicocele, with no patients showing grade 3 varicocele. Regarding testicular hypotrophy, 90.6% of the patients completed the study with normalized testicular volume by recovering normal venous flow. Conclusion: A short-term course of Spermotrend may significantly improve sperm parameters associated with male infertility. Clinical Trial Registration: The clinical trial protocol was registered in the international clinical trial registry, ClinicalTrials.gov, with the code: NCT05222841 on 15/06/2021.展开更多
<abstract>Profound and diffuse alterations in the production of gonadal and adrenal androgens as well as growth hormone are associated with aging. To convey this concept more appropriately, partial endocrine def...<abstract>Profound and diffuse alterations in the production of gonadal and adrenal androgens as well as growth hormone are associated with aging. To convey this concept more appropriately, partial endocrine deficiency in the aging male (PEDAM) was introduced as a term for the phenomenon of hormonal alterations in the aging male. Hormones responsible for some of the manifestations associated with male aging are testosterone, growth hormone, dehydroepiansdrosterone (DHEA), melatonin, thyroid hormones and leptin. Of these, testosterone has been widely investigated and its beneficial and adverse effects on male bodily systems are relatively well established. However, a serious body of confusion and misunderstandings surrounding the diagnosis, treatment and monitoring of men suspected of having androgen deficiency has been raised. Therefore, it is timely to provide practical criteria for diagnosis and treatment to avoid misconception about the use of testosterone in the aging male. To provide an understanding and information of the issues, the following headings are summarized: (1) Important clinical consideration on testosterone supplementation in the aging male; (2) Asian practical recommendations on testosterone supplementation in the aging male.展开更多
Plesiophrictus guangxiensis Yin et Tan,2000,and Selenocosmia hainan Liang et al. ,are reported in the present paper. The specimens are deposited in College of Life Sciences, Hunan Normal University. All the measuremen...Plesiophrictus guangxiensis Yin et Tan,2000,and Selenocosmia hainan Liang et al. ,are reported in the present paper. The specimens are deposited in College of Life Sciences, Hunan Normal University. All the measurements given are in?mm. Plesiophrictus guangxiensis Yin et Tan, 2000 (Figs 1 4) Male. Total length 29 1 43 0. A specimen measured total length 37 40, cephalothorax 19 6×17 8;abdomen 20 2×12 5. Carapace red brown, covered with light brown fine hairs. Head region slightly raised, red brown to black. Abdomen elongated oval, without any patterns. Palp organ simple, cymbium clothed with dense hairs. From prolateral view, genitalbulb subovoid, the opening of the central groove of embolus visible. Selenocosmia hainana Liang, Peng, Wang et Chen, 1999(Figs 5 10) Male.Total length 35 0 43 0. A specimen measured total length 38 60, cephalothorax 20 3×15 5;abdomen 18 3×13 0. The exosteleton of carapace and legs dark red brown, clothed with dense black hairs, sparsely and uniformly scattered with yellow brown long setae. Ocular area balck. Abdomen ellipsoid, with a longitudinal middle stria and several chevrons. Palpal organ simple, genital bulb elongated ovoid, red color, the embolus almost paralleled to the main axis of the bulb, its distal end never twisted, spoon like.展开更多
文摘Background: Infertility affects 8% - 12% of couples globally, with approximately half of the cases reported in males. Oxidative stress is a common factor increased in the varicocele condition and particularly affects spermatozoa, due to their sensitivity to oxidative signals and testicular hypotrophy. The objective of this clinical trial is to study the effectiveness of Spermotrend in the improvement of sperm parameters in male infertility. Methods: A total of 170 males aged > 18 years with a diagnosis of infertility and varicocele were consecutively enrolled in a Phase II, open-label clinical trial. Spermotrend was administered 1 capsule (450 mg) orally every 8 hours for 6 months and was evaluated through semen analysis at 4 and 6 months of follow-up. Results: The trial results show a significant improvement following the administration of Spermotrend over 6 months in sperm concentration (44.1% at baseline vs. 64.1% at 6 months), sperm survival (28.2% with sperm survival ≥ 2 hours vs.56.5%), normalization of sperm morphology (31.2% vs. 72.9%). Varicocele condition decreased in all patients and, by the end of the study, 55.3% of patients had normal venous flow and dilation. Only 5.9% of the patients showed grade 2 varicocele at the end of the study, while 38.8% showed grade 1 varicocele, with no patients showing grade 3 varicocele. Regarding testicular hypotrophy, 90.6% of the patients completed the study with normalized testicular volume by recovering normal venous flow. Conclusion: A short-term course of Spermotrend may significantly improve sperm parameters associated with male infertility. Clinical Trial Registration: The clinical trial protocol was registered in the international clinical trial registry, ClinicalTrials.gov, with the code: NCT05222841 on 15/06/2021.
文摘<abstract>Profound and diffuse alterations in the production of gonadal and adrenal androgens as well as growth hormone are associated with aging. To convey this concept more appropriately, partial endocrine deficiency in the aging male (PEDAM) was introduced as a term for the phenomenon of hormonal alterations in the aging male. Hormones responsible for some of the manifestations associated with male aging are testosterone, growth hormone, dehydroepiansdrosterone (DHEA), melatonin, thyroid hormones and leptin. Of these, testosterone has been widely investigated and its beneficial and adverse effects on male bodily systems are relatively well established. However, a serious body of confusion and misunderstandings surrounding the diagnosis, treatment and monitoring of men suspected of having androgen deficiency has been raised. Therefore, it is timely to provide practical criteria for diagnosis and treatment to avoid misconception about the use of testosterone in the aging male. To provide an understanding and information of the issues, the following headings are summarized: (1) Important clinical consideration on testosterone supplementation in the aging male; (2) Asian practical recommendations on testosterone supplementation in the aging male.
文摘Plesiophrictus guangxiensis Yin et Tan,2000,and Selenocosmia hainan Liang et al. ,are reported in the present paper. The specimens are deposited in College of Life Sciences, Hunan Normal University. All the measurements given are in?mm. Plesiophrictus guangxiensis Yin et Tan, 2000 (Figs 1 4) Male. Total length 29 1 43 0. A specimen measured total length 37 40, cephalothorax 19 6×17 8;abdomen 20 2×12 5. Carapace red brown, covered with light brown fine hairs. Head region slightly raised, red brown to black. Abdomen elongated oval, without any patterns. Palp organ simple, cymbium clothed with dense hairs. From prolateral view, genitalbulb subovoid, the opening of the central groove of embolus visible. Selenocosmia hainana Liang, Peng, Wang et Chen, 1999(Figs 5 10) Male.Total length 35 0 43 0. A specimen measured total length 38 60, cephalothorax 20 3×15 5;abdomen 18 3×13 0. The exosteleton of carapace and legs dark red brown, clothed with dense black hairs, sparsely and uniformly scattered with yellow brown long setae. Ocular area balck. Abdomen ellipsoid, with a longitudinal middle stria and several chevrons. Palpal organ simple, genital bulb elongated ovoid, red color, the embolus almost paralleled to the main axis of the bulb, its distal end never twisted, spoon like.
基金the Foundation of Science and Technology Department of Hunan Province the National Science Foundation of the USA through the ＂Biotic Survey of the Gaoligongshan, a Biodiversity Hotspot in Westem Yunnan, China＂ （Grant No. DEB-0103795）
文摘本文描述了园蛛科3种蜘蛛:多齿园蛛,新种Araneus polydentatus sp.nov.,舜皇园蛛Ara-neus shunhuangensis Yin et al.,1990和松阳芒果蛛Mangora songyangensis Yin et al.,1990。舜皇园蛛和松阳芒果蛛的雄性均系首次报道。本文同时提供了这3种蜘蛛的地理分布图。
