The best surgical technique for the treatment of mammary tumors in female dogs has been exhaustively debated among the scientific community. Despite biological knowledge of these tumors, some authors have suggested ag...The best surgical technique for the treatment of mammary tumors in female dogs has been exhaustively debated among the scientific community. Despite biological knowledge of these tumors, some authors have suggested aggressive procedures, without any clinical advantage. The aim of this study was to evaluate the influence of surgical procedure on the overall survival, disease-free interval and new lesion development interval in dogs with mammary tumors treated according to established prognostic factors. This prospective study included 143 intact female dogs that underwent surgery for mammary neoplasms and were followed up for about 738.5 days. Each animal represented a repetition. Each surgical technique represented a group: lumpectomy (P1), mammectomy (P2), regional mastectomy without cranial abdominal gland involvement (P3), regional mastectomy with cranial abdominal gland involvement (P4), and radical mastectomy (P5). Considering only the first surgical event, 84.6% of animals had more than one mammary tumor, and tumors were identified in two mammary chains in 52.5%. There was no difference in ipsilateral and contralateral tumor development when surgical techniques were compared. Only 33 dogs developed new lesions in remaining mammary tissue, without correlation with primary lesion. Surgical technique had no effect on the overall survival, disease-free interval and new lesion development interval in patients on this study, which respected oncological surgery principles and established prognostic factors for mammary gland tumors in dogs.展开更多
Colonic lymphangioma is an unusual benign malformation.We herein describe two cases.A 36-year-old woman was admitted with one year of intermittent abdominal pain;colonoscopy,abdominopelvic computed tomography and endo...Colonic lymphangioma is an unusual benign malformation.We herein describe two cases.A 36-year-old woman was admitted with one year of intermittent abdominal pain;colonoscopy,abdominopelvic computed tomography and endoscopic ultrasonography(EUS)revealed enlarged cystic masses at the ascending colon.In another 40-year-old man,colonoscopy and EUS revealed an asymptomatic lobulated cystic mass with four small sessile polyps at the sigmoid colon.Both patients underwent laparoscopic segmental colectomy.Both masses were histologically confirmed as cystic lymphangiomas,and the patients were discharged without complications.The management of colonic lymphangioma depends on the individual situation;close surveillance or endoscopic therapy may be appropriate for asymptomatic lesions smaller than 2.5 cm in diameter.Surgical intervention can be considered for larger lesions or in patients who develop complication risks.Laparoscopic segmental colon resection may be recommended to excise relatively large submucosal lesions because it is a definitive,minimally invasive intervention with a fast postoperative recovery.展开更多
Mammary neoplasms are the most common tumors in female dogs. They are usually treated using solely surgical mastectomy—which is recognized as unsatisfactory in many cases. Given this, the benefits of chemotherapy in ...Mammary neoplasms are the most common tumors in female dogs. They are usually treated using solely surgical mastectomy—which is recognized as unsatisfactory in many cases. Given this, the benefits of chemotherapy in dogs with mammary cancer need to be further explored. Some drugs that can be used for treating canines with mammary tumors may be substrates of uptake and/or efflux transporters such as the ATP-binding cassette (ABC) transporters. Unfortunately, very little is known regarding the pathobiology of such proteins in canine tumors, including mammary cancer. Accordingly, this study was designed to characterize the expression of ABC transporters P-glycoprotein, MRP1, and MRP2 and their relation with clinicopathologic factors in order to allow a better understanding of their influence in canine mammary cancer. P-glycoprotein was expressed in tumors from 55.8% of patients, while MRP1 and MRP2 were expressed in 37.2% and 39.5% of tumors, respectively. P-glycoprotein expression showed to be related with regional lymph node spread (P = 0.0038), as well as with tumor grade (P = 0.0353) and with a shorter survival (P = 0.0245). MRP1 revealed a strong association with a higher histological grade (P < 0.0001) and overall survival (P = 0.0002). Additionally, MRP1 was determined as prognostic indicator independent of lymph node status using Cox proportional-hazards regression multivariate analysis (P = 0.0216). No relations between MRP2 and clinicopathologic features were observed. We have found that P-glycoprotein and MRP1 are expressed in highly aggressive canine mammary tumors and are related with poor prognosis. Our results suggest that they may play a significant role in the course of canine mammary cancer progression and be promising candidate markers for a validation study on therapy outcome.展开更多
文摘The best surgical technique for the treatment of mammary tumors in female dogs has been exhaustively debated among the scientific community. Despite biological knowledge of these tumors, some authors have suggested aggressive procedures, without any clinical advantage. The aim of this study was to evaluate the influence of surgical procedure on the overall survival, disease-free interval and new lesion development interval in dogs with mammary tumors treated according to established prognostic factors. This prospective study included 143 intact female dogs that underwent surgery for mammary neoplasms and were followed up for about 738.5 days. Each animal represented a repetition. Each surgical technique represented a group: lumpectomy (P1), mammectomy (P2), regional mastectomy without cranial abdominal gland involvement (P3), regional mastectomy with cranial abdominal gland involvement (P4), and radical mastectomy (P5). Considering only the first surgical event, 84.6% of animals had more than one mammary tumor, and tumors were identified in two mammary chains in 52.5%. There was no difference in ipsilateral and contralateral tumor development when surgical techniques were compared. Only 33 dogs developed new lesions in remaining mammary tissue, without correlation with primary lesion. Surgical technique had no effect on the overall survival, disease-free interval and new lesion development interval in patients on this study, which respected oncological surgery principles and established prognostic factors for mammary gland tumors in dogs.
基金Supported by National Natural Science Foundation of China,No.51377024the Basic Research Project of Shanghai Science and Technology Commission,No.13JC1407202
文摘Colonic lymphangioma is an unusual benign malformation.We herein describe two cases.A 36-year-old woman was admitted with one year of intermittent abdominal pain;colonoscopy,abdominopelvic computed tomography and endoscopic ultrasonography(EUS)revealed enlarged cystic masses at the ascending colon.In another 40-year-old man,colonoscopy and EUS revealed an asymptomatic lobulated cystic mass with four small sessile polyps at the sigmoid colon.Both patients underwent laparoscopic segmental colectomy.Both masses were histologically confirmed as cystic lymphangiomas,and the patients were discharged without complications.The management of colonic lymphangioma depends on the individual situation;close surveillance or endoscopic therapy may be appropriate for asymptomatic lesions smaller than 2.5 cm in diameter.Surgical intervention can be considered for larger lesions or in patients who develop complication risks.Laparoscopic segmental colon resection may be recommended to excise relatively large submucosal lesions because it is a definitive,minimally invasive intervention with a fast postoperative recovery.
基金the Coordination for the Improvement of Higher Education Personnel(CAPES),Brazil,for financial support and Cleuso Cesario for his help with technical issues.
文摘Mammary neoplasms are the most common tumors in female dogs. They are usually treated using solely surgical mastectomy—which is recognized as unsatisfactory in many cases. Given this, the benefits of chemotherapy in dogs with mammary cancer need to be further explored. Some drugs that can be used for treating canines with mammary tumors may be substrates of uptake and/or efflux transporters such as the ATP-binding cassette (ABC) transporters. Unfortunately, very little is known regarding the pathobiology of such proteins in canine tumors, including mammary cancer. Accordingly, this study was designed to characterize the expression of ABC transporters P-glycoprotein, MRP1, and MRP2 and their relation with clinicopathologic factors in order to allow a better understanding of their influence in canine mammary cancer. P-glycoprotein was expressed in tumors from 55.8% of patients, while MRP1 and MRP2 were expressed in 37.2% and 39.5% of tumors, respectively. P-glycoprotein expression showed to be related with regional lymph node spread (P = 0.0038), as well as with tumor grade (P = 0.0353) and with a shorter survival (P = 0.0245). MRP1 revealed a strong association with a higher histological grade (P < 0.0001) and overall survival (P = 0.0002). Additionally, MRP1 was determined as prognostic indicator independent of lymph node status using Cox proportional-hazards regression multivariate analysis (P = 0.0216). No relations between MRP2 and clinicopathologic features were observed. We have found that P-glycoprotein and MRP1 are expressed in highly aggressive canine mammary tumors and are related with poor prognosis. Our results suggest that they may play a significant role in the course of canine mammary cancer progression and be promising candidate markers for a validation study on therapy outcome.
