Ibrutinib and atrial fibrillation:An in-depth review of clinical implications and management strategies

Ibrutinib,a targeted therapy for B-cell malignancies,has shown remarkable efficacy in treating various hematologic cancers.However,its clinical use has raised concerns regarding cardiovascular complications,notably atrial fibrillation(AF).This comprehensive review critically evaluates the association between ibrutinib and AF by examining incidence,risk factors,mechanistic links,and management strategies.Through an extensive analysis of original research articles,this review elucidates the complex interplay between ibrutinib’s therapeutic benefits and cardiovascular risks.Moreover,it highlights the need for personalized treatment approaches,vigilant monitoring,and interdisciplinary collaboration to optimize patient outcomes and safety in the context of ibrutinib therapy.The review provides a valuable resource for healthcare professionals aiming to navigate the intricacies of ibrutinib’s therapeutic landscape while prioritizing patient well-being.

Human Rights and Development:China's Contributions Based on a Larger Concept of Human Rights

The Western liberal view of global governance can no longer effectively address the challenges facing the world today or respond to the demands of developing countries in the fields of human rights and development.Meanwhile,the United Nations human rights and development agenda also has its limitations.Against such a backdrop,China's path of human rights development has avoided the trap of human rights confrontation and the clash of civilizations.It has set an example of complementarity and positive interaction between human rights and development by unifying collective human rights with individual human rights and integrating the universality and particularity of human rights.Xi Jinping,general secretary of the Communist Party of China(CPC)Central Committee,delivered a speech at the 37th group study session of the Political Bureau of the CPC Central Committee on China's Path of Human Rights Development.This elevated China's human rights development to a new historical height.Practice has proved that China's concept and path of human rights in the new era have not only effectively promoted the development of its human rights cause,but also contributed Chinese wisdom to the global cause of human rights and development with a larger concept of human rights.Under the framework of the concept of building a community with a shared future for mankind,the Belt and Road Initiative,and the Global Development Initiative,China has contributed to enhancing the discourse power of developing countries in human rights and building a fairer,more just,more reasonable and more inclusive system for global human rights governance.

An Overview of the Application of Big Data in Supply Chain Management and Adaptation in Nigeria

That the world is a global village is no longer news through the tremendous advancement in the Information Communication Technology (ICT). The metamorphosis of the human data storage and analysis from analogue through the jaguars-loom mainframe computer to the present modern high power processing computers with sextillion bytes storage capacity has prompted discussion of Big Data concept as a tool in managing hitherto all human challenges of complex human system multiplier effects. The supply chain management (SCM) that deals with spatial service delivery that must be safe, efficient, reliable, cheap, transparent, and foreseeable to meet customers’ needs cannot but employ bid data tools in its operation. This study employs secondary data online to review the importance of big data in supply chain management and the levels of adoption in Nigeria. The study revealed that the application of big data tools in SCM and other industrial sectors is synonymous to human and national development. It is therefore recommended that both private and governmental bodies should key into e-transactions for easy data assemblage and analysis for profitable forecasting and policy formation.

Pioneering a New Realm of Human Rights Civilization in the Chinese Path to Modernization——An Overview of the Symposium on“The Chinese Path to Modernization and the Promotion of Free and Comprehensive Human Development”

On October 14,2023,a symposium themed“The Chinese Path to Modernization and the Promotion of Free and Comprehensive Human Development”was held in Changchun,Jilin Province,China.More than fifty experts,scholars,and researchers from national institutions and universities engaged in discussions and exchanges on human rights on the Chinese path to modernization,including the path,practice,knowledge systems,and civilization forms of human rights.This symposium played a significant role in advancing the construction of the disciplinary system,academic system,and discourse system of human rights in China.

Ⅰ导联R/(R+S)对胸前V3导联移行流出道室性心律失常起源部位的鉴别价值

目的:探索鉴别胸前V3导联移行流出道室性心律失常(OT-VA)起源部位的体表心电图指标。方法:连续选择2017年1月至2022年8月行导管射频消融术的胸前V3导联移行OT-VA患者65例。比较左室流出道起源组(LVOT组)和右室流出道起源组(RVOT组)室性心律失常发作时体表心电图QRS波振幅及相关指标的差异,选择差异有统计学意义的指标,绘制ROC曲线评价所选取指标鉴别OT-VA起源部位的效能。结果:LVOT组11例,RVOT组54例,两组间差异有统计学意义且ROC曲线下面积(AUC)最大的指标为Ⅰ导联R波/(R+S)波振幅比[R/(R+S)],其鉴别OT-VA起源部位的AUC(95%CI)为0.949(0.894~1.000),截断值为0.50。Ⅰ导联R/(R+S)<0.50诊断胸前V3导联移行LVOT起源OT-VA的敏感度、特异度和准确度分别为0.909、0.944和0.938。结论:Ⅰ导联R/(R+S)<0.50可准确鉴别LVOT起源的胸前V3导联移行OT-VA。

基于C/S架构和物联网技术的可移动医疗设备共享调配系统的设计与应用

目的 设计一个可移动医疗设备高效管理与临床科室共享调配相结合的医疗设备共享管理平台,实现可移动医疗设备使用的全过程管理。方法 基于C/S架构,利用物联网技术优化整合现有医疗设备大数据资源,结合医院需求,构建可移动医疗设备共享调配系统,实现医疗设备共享管理、预约借用、统计分析等核心功能。通过比较系统上线前后呼吸机调配次数、平均调配时间、呼吸机使用率、单台呼吸机日均收入4个指标,分析系统应用效果。结果 系统上线后,呼吸机调配次数明显增加、平均调配时间明显降低,呼吸机使用率、单台呼吸机日均收入明显升高,且差异均有统计学意义(P﹤0.05),表明系统对提高呼吸机调配效率与使用效率有促进作用。结论 可移动医疗设备共享调配系统优化了医院设备管理流程,实现了医疗资源的统一调配,有效满足临床紧急抢救时医疗设备调配使用的相关需求,提高了医疗设备周转率以及设备管理人员的工作效率,有助于医院节约人员成本、降低采购费用,为医院管理者制定相关决策提供数据支撑。

基于S-CAD方法的宅基地“三权分置”改革试点政策评估——以新疆试点市县为例

采用S-CAD政策评估方法对新疆宅基地“三权分置”政策试点地区伊宁市和奇台县的政策执行效果进行评价,研究发现伊宁市和奇台县两试点政策整体逻辑一致性较好、政策要素之间具备充分性与必要性,利益相关者支持程度较高,有效实现了宅基地“三权分置”改革的政策目标,但仍存在政策手段与政策目标充要性不足,预期政策效果与实际政策效果有一定偏差等问题。针对此,提出宅基地“三权分置”改革政策应适应城乡融合发展趋势,加强农户利益保障机制建设;坚持因地制宜,创新农村宅基地“三权分置”改革思路;兼顾多方利益与公平,提升综合价值效应的建议。

Problems in Rural Land Management Right Confirmation Pilots and the Countermeasures

The affirmation registration and certification of land contracted management right are the essential conditions for the effective promotion of land management right circulation and the development of agricultural moderate scale management. However, the following problems are found in the process of the pilot work： insufficient propaganda work, inconsistent recognition of affirmation registration work, low enthusiasm of grass-roots work; lack of unified regulations, each company working on their own; requiring large amount of manpower and resources for rural land contracted management rights, and severe shortage of national and municipal inputs; incomplete land ownership information and lack of marks between land plots, leading to resolving difficulty of the disputes; urgent need of strengthening subsequent work, untimely adjustment of related policies. Therefore, it needs to intensify propaganda, so that farmers can know the land right confirmation registration and certifi- cation, and recognize its importance; unify the introduction of job specification and results storage standard, making it convenient for the unified use of the results unified; set up special funds, and make experiments first in the areas with better economic conditions; establish arbitral institutions for land ownership disputes; earnestly make great effort to the supporting and subsequent work for right confirmation registration, and give full play to the role of land registration results.

基于B/S的高校实验室预约管理系统设计与实现

为了实现实验室管理信息化,更好地为师生服务,文章设计并开发一套高校实验室预约管理系统。该系统是基于B/S结构,采用Vue视图框架、Nginx服务器及MySQL数据库构建而成的;支持专业实验室、教室和会议室的预约管理;入口对接华中科技大学统一身份认证系统,在校师生可直接使用已有的统一身份认证系统账号密码登录系统。用户可通过浏览器完成在线预约、预约查询、预约管理和数据统计等功能。该系统的应用提高了实验室管理的规范性和信息化程度。

基于三层B/S架构的企业信息化管理系统的设计

为解决企业管理系统中存在的数据冗余、不一致、数据同步效率低等问题,文章通过引入三层浏览器/服务器(B/S)架构模式,实现了对企业信息化管理系统的研究。该系统的设计主要包含数据库设计、系统管理、生产管理、统计报表等主要功能模块的设计。系统由浏览器向服务器发送请求,服务器接收请求并处理,然后将结果返回给浏览器。系统采用了MVC设计模式,将数据层、业务层和表示层分离开来,提高了可维护性、可扩展性和可重用性。该系统的应用不仅达到了数据远程共享的目的,还实现了对现骨干数据及报表的查询功能,可充分满足企业的信息化管理需求。

Digital Rights Management：Model,Technology and Application

with rapid achievement of current information technology and computing ability and applications,much more digital content such as films,cartoons,design drawings,office documents and software source codes are produced in daily work,however to protect the content being copying,shared or deliberately stolen by inside or outside,digital rights management(DRM) became more and more important for digital content protection.In this paper,we studied various DRM model,technology and application,and first proposed DRM Security Infrastructure(DSI),in which we defined encryption,hash,signature algorithm,watermarking algorithms,authentication,usage control,trusted counter,conditional trace,secure payment,and based on the DSI we then proposed a whole classification approach and architecture of all kinds of DRMs,in which we proposed 6 typical classes of copyrights and content protection DRMs architecture:(1) Software-oriented DRM,(2) e Book-oriented DRM,(3) Video-oriented DRM,(4) Image-Oriented DRM(5) Unstructured data oriented DRM,(6) Text-oriented DRM.Based on the above DSI,we then proposed a dynamic DRM model selection method for various DRM application,which can be adapted dynamically for different technology of different applications,which can provide awhole solution for variant DRM development in a rapid and customized mode.The proposed DRM method,technology and application in this paper provided a common,flexible and extendable solution for variant DRM scenes,and can support rapid and customized development.Moreover,we proposed an opinion that the future life will enter into a new era that the content usage and consumption will not again adopt DRM technology rather than with law,liberty and morality.

Research on the Circulation Problems of Contractual Management Right of Rural Land

Based on the judicial explanation of the contractual management right of land, the thesis elaborates the definition of main body of contractual management right of rural land; right of possession, use right, usufruct of contractual management right of land; autonomy of production and operation; disposition of the products; expropriation and occupation compensation authority of contractual land respectively, in order to demonstrate the connotation of land contractual management. The thesis also analyzes perspicaciously the phenomenon of non-agricultural-use land and proclaiming phenomenon of contractual management right of land. We should establish normalized rural land property rights register system to perfect contractual management right of land. Proclaiming of agriculture land right also should adopt registration effectiveness so as to guarantee the legality of transference of agricultural land to non-agricultural land in terms of system. We should perfect rural land circulation in terms of normalizing land circulation laws and normalizing contractual farmers fees: in terms of the movable agricultural land right, we should further perfect the types and content of circulation and lessen non-legal form restrictions of circulation; in terms of contractual fees, we should normalize contractual fees of land in order to preclude the contradiction between the contractees and contractors arising from blank space of laws.

Disputes over Circulation of Rural Land Contractual Management Right and Control Countermeasures

On the basis of current situations of disputes over rural land contractual management right,this paper analyzes causes of disputes from four aspects. It states that controlling disputes,regulating and strengthening land circulation in accordance with laws are core works of new socialist countryside construction and rural reform. Finally,it presents five control countermeasures,including improving laws and regulations on circulation of rural land contractual management right,strengthening popularization and guidance of relevant laws and regulations,government departments administering in accordance with laws,stressing management of land contractual management right circulation contract,and establishing and perfecting land circulation intermediaries to realize market-oriented circulation.

A Probe into the Mortgage Rates of Land Contract Management Rights Based on Unified Annual Output Value

The mortgage of land contract management rights has launched a pilot project in Ningxia,Hubei,Henan,Guizhou,Chongqing and other provinces,municipalities and autonomous regions,which provides a good solution to the problem of funds for rural development and plays a huge role in promoting local rural economic development.In the mortgage financing of land contract management rights implemented in various regions,how to determine a scientific,accurate and reasonable mortgage rate of land contract management rights becomes a difficulty troubling the mortgage financing of land.On the basis of unified annual output value of land,this article uses survey method,income capitalization method,and comparison method to analyze the value of land contract management rights,and finally determine the mortgage rates of land contract management rights.

Study on Transfer Problem of Contract and Management Right of Agricultural Land in Anhui Province

The status quo and significance of contract and management right transfer of rural land are analyzed,and major problems existed in contract and management right transfer of rural land in Anhui Province are studied,containing unsound transfer market,insufficient flow demand motion,single transfer form,non-standard register,right determination and certificate issuing. On this basis,several policies and suggestions are proposed,such as combining practical use with suitable use of land right determination and certificate issuing,establishing multilayer rural social security system and expanding land management range.

Home Network and Digital Rights Management Technology

The home network is a major concern for the growth of digital and information society. Yet, how to guarantee the security of its digital content and protect the legal benefits for each section of the value chain becomes a crucial "bottleneck" in the home network development. The Digital Rights Management (DRM) technology provides total solution for usage, storage, transfer, and tracing the digital contents and rights. Its basic features are systematic and controllability. Considering the growth of the new media and services and the requirements of the Intellectual Property Rights (IPR) protection in a home network, it's necessary to solve consistency problems in usage, storage, and transfer of contents and rights. In addition, it is inevitable to conduct researches of key techniques such as end-to-end secure transmission, conditional access and play, and right description.

Constructing China’s Human Rights Science:Cause,Cognition,and Paradigm

“China’s Human Rights Science”is undoubtedly a brand-new concept.Just as China has its own philosophy,literature,history,law,political science,and sociology,it should also have its own human rights science.China’s Human Rights Science refers to the cognitive science of human rights in China.Developing its disciplinary system,academic system,and discourse system,and constructing an independent Chinese human rights knowledge system,are essential requirements for promoting the great rejuvenation of the Chinese nation through Chinese modernization and creating a new form of human civilization.China’s Human Rights Science originated in China,grew in China,and deepened through China’s human rights practices.China’s Human Rights Science adhere to the universality of human rights principles and possess distinctive characteristics.It works as the knowledge-based organization,academic refinement,and theoretical expression of the path of human rights development that conforms to the trend of the times and suits China’s national conditions,as pursued by the Communist Party of China in leading the people.China’s Human Rights Science can enrich and develop the theory of human rights civilization,and should become a global public product of human rights.

Right Heart Failure Indicative of Ebstein’s Disease in Adulthood about a Case

Ebstein disease is a rare congenital malformation whose clinical presentation differs according to the anatomical form and age of the patient. In adults, it presents mainly in the form of right or global heart failure or rhythm disorders. Survival is exceptionally long in some forms. We report the case of a 70-year-old patient with Ebstein’s disease in right heart failure.

The Core of the Chinese Democracy Is to Respect and Protect Human Rights——A Summary of the Academic Seminar on Chinese Democracy and Human Rights Protection

On March 26,2023,a Seminar on Chinese Democracy and Human Rights Protection was held,jointly organized by the National Human Rights Education and Training Base and the Human Rights Research Center of Central South University under the guidance of the Chinese Society for Human Rights Studies.The event adopted a combination of online and offline channels.Over 30 experts and scholars from universities,research institutions,and practical departments across the country participated in extensive discussions on“Theoretical and Practical Aspects of Chinese Democracy and Protection of Human Rights.”The seminar aimed to focused on the essence,characteristics,advantages,and human rights implications of Chinese democracy and interpreted the concept of Chinese democracy and the protection of human rights through academic and theoretical methods.

农地经营权强度能缓解新型农业经营主体供给型信贷配给吗?——基于fsQCA方法的路径分析

新型农业经营主体虽然有着强烈的机构贷款需求,但因缺乏有效抵押品,正规金融机构普遍对其施加严格的供给型信贷配给。“三权分置”从法律层面激活农地经营权,是破解供给型信贷配给难题的重要契机。本文从法律维度、事实维度、感知维度对农地经营权强度展开维度化分析,厘清其影响新型农业经营主体供给型信贷配给的作用机理与具体路径,并使用组态视角的模糊集定性比较分析(fsQCA)方法进行实证检验。研究发现,新型农业经营主体的供给型信贷配给,既能由法律维度、事实维度和感知维度的农地经营权同时具有较高强度而得以缓解,也能仅凭法律维度或事实维度的农地经营权具有较高强度得以缓解,但感知维度的农地经营权具有较高强度尚不足以单独发挥缓解之效。为进一步释放农地经营权改革的信贷效应,既要完善农地经营权的法律赋权与保障转入农地的实际权利,也要强化主体对农地经营权的安全感知。本文既从理论上深化了对农地经营权强度的理解,揭示了法律赋权、事实拥有、先验认知等不同层面的产权排他性、稳定性和安全性的内涵,也在实践上拓宽了破解供给型信贷配给难题的现实途径。