Background: Data from a pilot study suggested that noetic therapies -healing practices that are not mediated by tangible elements -can reduce preprocedural distress and might affect outcomes in patients undergoing per...Background: Data from a pilot study suggested that noetic therapies -healing practices that are not mediated by tangible elements -can reduce preprocedural distress and might affect outcomes in patients undergoing percutaneous coronary intervention. We undertook a multicentre, prospective trial of two such practices: intercessory prayer and music, imagery, and touch(MIT) therapy. Methods: 748 patients undergoing percutaneous coronary intervention or elective catheterisation in nine USA centres were assigned in a 2×2 factorial randomisation either off-site prayer by established congregations of various religions or no off-site prayer(double-blinded) and MIT therapy or none(unmasked). The primary endpoint was combined in-hospital major adverse cardiovascular events and 6-month readmission or death. Prespecified secondary endpoints were 6-month major adverse cardiovascular events, 6 month death or readmission, and 6-month mortality. Findings: 371 patients were assigned prayer and 377 no prayer; 374 were assigned MIT therapy and 374 no MIT therapy. The factorial distribution was: standard care only, 192; prayer only, 182; MIT therapy only, 185; and both prayer and MIT therapy, 189. No significant difference was found for the primary composite endpoint in any treatment comparison. Mortality at 6 months was lower with MIT therapy than with no MIT therapy(hazard ratio 0.35,95%CI 0.15-0.82, p=0.016). Interpretation: Neither masked prayer nor MIT therapy significantly improved clinical outcome after elective catheterisation or percutaneous coronary intervention.展开更多
Predicting potential changes in groundwater salinity in low-lying coastal regions due to climate change is important, where coastal vegetation is abundant, succession competition between halophytes and glycophytes pla...Predicting potential changes in groundwater salinity in low-lying coastal regions due to climate change is important, where coastal vegetation is abundant, succession competition between halophytes and glycophytes plays a significant role in the salinity budget. Sea level rise enhances salinity intrusion, contributing an additional dimension to vegetation competition. A new simulation model known as mangrove-hardwood hammock model coupled with saturated-unsaturated transport （MANTRA） has recently been developed by the authors to simulate groundwater salinity regimes in the presence of vegetation competition, subject to climate change. MANTRA is based upon linking two existing Unites States geological survey （USGS） simulation models known as mangrove-hardwood hammock model （MANHAM） and saturated-unsaturated transport （SUTRA）. MANHAM simulates the evolution of vegetation succession subject to changing groundwater salinity. SUTRA simulates saturated and unsaturated transport of solutes and salinity in groundwater given sea salinity. MANTRA improves the simulation robustness to simultaneously simulate groundwater hydrology, salinity and coastal vegetation succession subject to sea level rise. Some simulation results will be presented to demonstrate the impact of sea level rise on coastal vegetation succession and groundwater salinity.展开更多
文摘Background: Data from a pilot study suggested that noetic therapies -healing practices that are not mediated by tangible elements -can reduce preprocedural distress and might affect outcomes in patients undergoing percutaneous coronary intervention. We undertook a multicentre, prospective trial of two such practices: intercessory prayer and music, imagery, and touch(MIT) therapy. Methods: 748 patients undergoing percutaneous coronary intervention or elective catheterisation in nine USA centres were assigned in a 2×2 factorial randomisation either off-site prayer by established congregations of various religions or no off-site prayer(double-blinded) and MIT therapy or none(unmasked). The primary endpoint was combined in-hospital major adverse cardiovascular events and 6-month readmission or death. Prespecified secondary endpoints were 6-month major adverse cardiovascular events, 6 month death or readmission, and 6-month mortality. Findings: 371 patients were assigned prayer and 377 no prayer; 374 were assigned MIT therapy and 374 no MIT therapy. The factorial distribution was: standard care only, 192; prayer only, 182; MIT therapy only, 185; and both prayer and MIT therapy, 189. No significant difference was found for the primary composite endpoint in any treatment comparison. Mortality at 6 months was lower with MIT therapy than with no MIT therapy(hazard ratio 0.35,95%CI 0.15-0.82, p=0.016). Interpretation: Neither masked prayer nor MIT therapy significantly improved clinical outcome after elective catheterisation or percutaneous coronary intervention.
基金supported by (1001/PMATHS/811093,1001/PMATHS/821045)
文摘Predicting potential changes in groundwater salinity in low-lying coastal regions due to climate change is important, where coastal vegetation is abundant, succession competition between halophytes and glycophytes plays a significant role in the salinity budget. Sea level rise enhances salinity intrusion, contributing an additional dimension to vegetation competition. A new simulation model known as mangrove-hardwood hammock model coupled with saturated-unsaturated transport （MANTRA） has recently been developed by the authors to simulate groundwater salinity regimes in the presence of vegetation competition, subject to climate change. MANTRA is based upon linking two existing Unites States geological survey （USGS） simulation models known as mangrove-hardwood hammock model （MANHAM） and saturated-unsaturated transport （SUTRA）. MANHAM simulates the evolution of vegetation succession subject to changing groundwater salinity. SUTRA simulates saturated and unsaturated transport of solutes and salinity in groundwater given sea salinity. MANTRA improves the simulation robustness to simultaneously simulate groundwater hydrology, salinity and coastal vegetation succession subject to sea level rise. Some simulation results will be presented to demonstrate the impact of sea level rise on coastal vegetation succession and groundwater salinity.
