Regulations for the Manufacture and Control of Live Poliovirus Vaccine: International Experience and China’s Path

The eradication of poliomyelitis is a landmark achievement in the history of public health, providing strong protection for children’s health. The introduction of the Chinese Regulations for the Manufacture and Control of Live Poliovirus Vaccine is a prerequisite and safeguard for the large-scale production and use of domestically produced live poliovirus vaccines, serving as an indispensable component of vaccine safety. This article, based on archival documents, letters, collections of essays, and oral interviews, examines the historical experience of the development of Chinese Regulations for the Manufacture and Control of Live Poliovirus Vaccine. It contends that the emphasis on localization and the active engagement in international cooperation are critical factors in the swift introduction of Chinese Regulations for the Manufacture and Control of Live Poliovirus Vaccine.

Management and Control of Outsourcing in Dispersed Network Manufacturing Systems

The trend of economic globalisation and advances in i nformation technology has led to the emergence of dispersed manufacturing system s as a form of the virtual organisation. New manufacturing strategy pays more at tention to the management of the total value chain and therefore puts emphasis o n outsourcing. In fact, outsourcing is an efficient way of utilizing available r esources and has become one key aspect of the manufacturing strategy. Improved d ecision and organization on outsourcing will result in cost production and short er lead-times. However, most concepts and practice of traditional outsourcing do not adapt to t he changing environment and meet increasing performance requirements. On the oth er hand, virtual organisations might display instability between pure outsourcin g and establishing alliance. Balance and trade-off between independent agents a nd creating alliance are thus required. Therefore, the purpose of this paper is to develop a model to support decision-making, management and control on outsou rcing in a dispersed network manufacturing system and to discuss several key iss ues that are relevant to the relationship between the agents of the network. Dev elopment of the model will deploy Applied System Theory and will be built on fou ndations of earlier research on industrial management such the theories of Outso urcing, Order Entry Points, Design of Organisations and Logistic Control. The is sues that will be addressed in this paper are: · The selection of suppliers and co-makers; · Communication between suppliers and clients; · The mechanisms for profit-sharing between agents; · The product data management to integrate the knowledge of the different agent s into product design. Industrial companies will benefit from this research by the practical methods an d implementation extending their business models beyond concepts for outsourcing and alliances. Additionally, the exploration will lead to proactive contributio n of manufacturing during engineering, which would improve management and contro l of dispersed manufacturing systems.

APPLICATION OF IMPROVED PRODUCTION ACTIVITY CONTROL ARCHITECTURE FOR SHOP FLOOR INFORMATION SYSTEM IN DIGITAL MANUFACTURING

Shop floor control （SFC） is responsible for the coordination and control of the manufacturing physical and information flow within the shop floor in the manufacturing system. Weaknesses of the production activity control （PAC） architecture of the shop floor are addressed by the Maglica＇s new system architecture. This architecture gives rise to unlimited number of movers and producers thus evolving more complex but decentralized architecture. Beijing Institute of Technology - production activity control （BIT-PAC） architecture introduces an idea of sub-producars and sub-movers thus reducing the complexity of the architecture. All the equipments including sub-producars and sub-movers are considered to be passive in the proposed shop floor information system. The dissemination of information from sub-producers and sub-movers is done manually through a PC. Proposed BIT-PAC SFC architecture facilitates the information flow from shop floor to the other area of the organization. Effective use of interact information services （IIS） and SQL2000 is done along with the ASP.NET technology to implement the application logic. Applicability of the software based on BIT-PAC architecture is checked by running application software on a network PC that supports the dynamic flow of information from sub-producers and sub-movers to the other parts of the organization. Use of software is also shown at the end for BIT training workshop thus supporting the use of SFC architecture for similar kind of environments.

Production Control of a Manufacturing System with Random Machine Breakdowns

We consider a serial production system with machine breakdowns, where the machine at each station alternates between up and down states with exponential up and down time distributions. To obtain insight about the optimal production strategy, we focus on one production station. Its production process (output) and that of the previous station (input) are modeled by point processes with stochastic intensities. Our objectives is to control both input and output intensities such that expected discounted profit is maximized. We show that the optimal control policy is of a threshold type which is characterized by two threshold values.When each station in the serial system has reliable machines, the well known Kanban production strategy, which was first developed in Toyota Motor Co. of Japan, is usually used to control the production process at each station. Our result in this paper implies that, among other things, the traditional Kanban control rule has to be modified if the production environment is random.

Emerging biotechnology applications in natural product and synthetic pharmaceutical analyses

Pharmaceutical analysis is a discipline based on chemical, physical, biological, and information technologies. At present, biotechnological analysis is a short branch in pharmaceutical analysis;however, bioanalysis is the basis and an important part of medicine. Biotechnological approaches can provide information on biological activity and even clinical efficacy and safety, which are important characteristics of drug quality. Because of their advantages in reflecting the overall biological effects or functions of drugs and providing visual and intuitive results, some biotechnological analysis methods have been gradually applied to pharmaceutical analysis from raw material to manufacturing and final product analysis,including DNA super-barcoding, DNA-based rapid detection, multiplex ligation-dependent probe amplification, hyperspectral imaging combined with artificial intelligence, 3D biologically printed organoids,omics-based artificial intelligence, microfluidic chips, organ-on-a-chip, signal transduction pathwayrelated reporter gene assays, and the zebrafish thrombosis model. The applications of these emerging biotechniques in pharmaceutical analysis have been discussed in this review.

A NEUROENDOCRINE-INSPIRED BIONIC MANUFACTURING SYSTEM

Due to rapid changes of markets and pressures of competitions, the manufacturing companies are forced to adapt their production ways to support diversity of customer＇s needs and increase of new product developments. As biological organisms are quite capable of adapting to environmental changes and stimulus, bio-inspired concepts have been recognized much suitable for adaptive manufacturing system control. This paper, therefore, proposes a novel concept of NeuroEndocrine-Inspired Manufacturing System （NEIMS）. The proposed NEIMS control architecture is based on analogies with neuro-control and hormone-regulation principles. It has the capability to explicitly specify production control schemes including control points, material, information flow paths and logical operations, and to agilely deal with the frequent occurrence of unexpected disturbances at the shop floor level. From the cybernetics point of view, the control model of NEIMS indicates adaptive behavior to the changes in products demands due to external environment and malfunction of manufacturing cells as an intemal environment. Finally, a prototype system has been set up to enable the NEIMS simulation.

Metallurgical concepts for optimized processing and properties of carburizing steel

Carburized steel grades are widely used in applications where high surface near hardness is required in combination with good core toughness as well as high strength and fatigue resistance. The process of carburizing lower to medium carbon containing steel can generally provide this combination of properties and has been prac- ticed for several decades. Such steel is essential in the vehicle power-train, machines and power generation equipment. However, the increasing performance demands by such applications as well as economical considerations forced steel producers to develop better alloys and fabri- cators to design more efficient manufacturing processes. The present paper describes recent concepts for alloy design optimization of carburizing steel and demonstrates the forthcoming beneficial consequences with regard to manufacturing processes and final properties.