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第十期领军家电班开展TechMark企业经营管理实战模拟培训
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作者 姜雪 《电器》 2024年第11期42-43,共2页
2024年10月12~14日,第十期领军家电班第二次课程在上海举办。本次课程聚焦企业运营管理主题,以TechMark教学加实战模拟方式,引导学员深入思考在复杂多变的市场环境下如何进行战略决策,以及提高企业运营效率的影响因素,使得投资收益最大化。
关键词 企业运营效率 企业运营管理 领军 收益最大化 mark 战略决策 家电 管理实战模拟
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沉默MARK4通过NF-κB信号通路抑制溃疡性结肠炎细胞焦亡和炎症因子表达 被引量:1
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作者 叶璐 廖盛涛 +5 位作者 李传飞 苏建淋 余兴涟 王彦辉 宋亚 吕琳 《免疫学杂志》 CAS CSCD 2024年第2期131-137,共7页
目的探讨MARK4(microtubule-affinity regulating kinase 4,MARK4)在脂多糖(lipopolysaccharide,LPS)诱导的FHC细胞溃疡性结肠炎(ulcerative colitis,UC)模型中对FHC细胞焦亡、炎症因子释放和肠道屏障相关蛋白表达的影响及其可能分子机... 目的探讨MARK4(microtubule-affinity regulating kinase 4,MARK4)在脂多糖(lipopolysaccharide,LPS)诱导的FHC细胞溃疡性结肠炎(ulcerative colitis,UC)模型中对FHC细胞焦亡、炎症因子释放和肠道屏障相关蛋白表达的影响及其可能分子机制。方法采用Western blot检测UC患者、健康人群结肠组织和LPS诱导的FHC细胞炎症模型中MARK4和细胞焦亡相关的因子Caspase-1、NLRP3和GSDMD的表达水平;通过质粒转染shRNA沉默FHC细胞中MARK4,在正常对照组、LPS组和沉默MARK4+LPS组中采用Western blot分别检测Caspase-1、NLRP3、GSDMD、肠道屏障相关蛋白和NF-κB信号通路相关蛋白的表达水平;ELISA和RT-qPCR检测炎症因子IL-1β、IL-6和TNF-α表达水平;流式细胞术检测细胞凋亡情况。结果在UC患者结肠组织和LPS诱导FHC细胞体外UC炎症模型中MARK4和焦亡相关蛋白包括NLRP3、Caspase-1和GSDMD的表达水平显著升高。沉默MARK4能够抑制LPS诱导FHC细胞中焦亡相关蛋白NLRP3、Caspase-1、GSDMD表达水平,下调炎症相关细胞因子IL-1β、IL-6和TNF-α的表达水平,抑制FHC细胞凋亡,上调肠道屏障相关蛋白ZO-1、Occludin表达和上调Claudin2的表达水平。GSEA富集分析显示,MARK4与NF-κB信号通路呈正相关。沉默MARK4能够抑制NF-κB信号通路中p-P65、p-IKKα的表达水平。结论MARK4在UC组织和细胞中显著高表达,沉默MARK4能够通过阻滞NF-κB信号通路激活,进而抑制UC细胞焦亡和炎症因子表达。MARK4可能成为UC患者治疗的一个潜在靶点。 展开更多
关键词 溃疡性结肠炎 mark4 焦亡 炎症 NF-ΚB信号通路
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Parametric Transformation of Timed Weighted Marked Graphs:Applications in Optimal Resource Allocation 被引量:1
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作者 Zhou He Ziyue Ma +1 位作者 Zhiwu Li Alessandro Giua 《IEEE/CAA Journal of Automatica Sinica》 SCIE EI CSCD 2021年第1期179-188,共10页
Timed weighted marked graphs are a subclass of timed Petri nets that have wide applications in the control and performance analysis of flexible manufacturing systems.Due to the existence of multiplicities(i.e.,weights... Timed weighted marked graphs are a subclass of timed Petri nets that have wide applications in the control and performance analysis of flexible manufacturing systems.Due to the existence of multiplicities(i.e.,weights)on edges,the performance analysis and resource optimization of such graphs represent a challenging problem.In this paper,we develop an approach to transform a timed weighted marked graph whose initial marking is not given,into an equivalent parametric timed marked graph where the edges have unitary weights.In order to explore an optimal resource allocation policy for a system,an analytical method is developed for the resource optimization of timed weighted marked graphs by studying an equivalent net.Finally,we apply the proposed method to a flexible manufacturing system and compare the results with a previous heuristic approach.Simulation analysis shows that the developed approach is superior to the heuristic approach. 展开更多
关键词 Discrete event system resource allocation timed Petri net weighted marked graph
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基于三圆轨迹规划的MARKⅢ型LNG薄膜舱波纹板机器人焊接
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作者 商泽坤 何建萍 +1 位作者 华学明 李芳 《材料科学与工艺》 CAS CSCD 北大核心 2024年第5期34-41,共8页
MARKⅢ型LNG薄膜舱波纹板的焊接质量是LNG船建造成功与否的关键之一。为了实现MARKⅢ型LNG薄膜舱1.2mm厚304L不锈钢波纹板的机器人焊接,研究了基于“三圆”连接构思的波纹板机器人焊接的轨迹规划模型,通过模型计算了沿波纹板轨迹焊接过... MARKⅢ型LNG薄膜舱波纹板的焊接质量是LNG船建造成功与否的关键之一。为了实现MARKⅢ型LNG薄膜舱1.2mm厚304L不锈钢波纹板的机器人焊接,研究了基于“三圆”连接构思的波纹板机器人焊接的轨迹规划模型,通过模型计算了沿波纹板轨迹焊接过程中的焊枪位置和焊枪姿态坐标,并对模型和计算的结果进行了仿真验证;在此基础上,进行了不锈钢波纹板机器人搭接焊的脉冲等离子弧焊的工艺优化研究。结果表明:本文建立的波纹板机器人焊接的“三圆”轨迹规划模型以及基于该模型计算的焊枪位姿坐标准确;基于模型和计算,结合优化后的脉冲等离子弧焊工艺参数,实现了焊缝成形良好的MARKⅢ型LNG薄膜舱1.2mm厚304L不锈钢波纹板搭接的机器人焊接,焊缝成形达到了法国GTT公司标准文件中提供的成形尺寸标准。 展开更多
关键词 轨迹规划 markⅢ型LNG薄膜舱 304L不锈钢 波纹板 焊接
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A Comparison between Chinese Topics and English Marked Theme
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作者 王小曼 石维钊 《科技信息》 2007年第13期158-158,164,共2页
This article focuses on the discussion of Chinese topics and English marked theme. It will be divided into four parts. Part I is introduction part. It introduces the concepts of Chinese topic and English marked theme.... This article focuses on the discussion of Chinese topics and English marked theme. It will be divided into four parts. Part I is introduction part. It introduces the concepts of Chinese topic and English marked theme. Part II tells different types of Chinese topics and English marked themes. Part III discusses the functions of Chinese topics and English themes. Part IV is the conclusion part. 展开更多
关键词 英语 汉语 主题 标记性主位 功能
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Comparison of the Effectiveness of Marked Suction Tubes vs. Plain Suction Tubes in Pediatric Mechanically Ventilated Patients
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作者 Kexin Yang Yang Zhang +5 位作者 Menghui Duan Qiuju Liang Jianfei Zhang Ping Kong Mengqi Duan Xiangwei Chen 《Open Journal of Pediatrics》 2023年第6期774-784,共11页
Introduction: Endotracheal suction plays a crucial role in the management of mechanically ventilated patients. This study aims to evaluate the clinical effectiveness and safety of suction tubes with markings in mechan... Introduction: Endotracheal suction plays a crucial role in the management of mechanically ventilated patients. This study aims to evaluate the clinical effectiveness and safety of suction tubes with markings in mechanically ventilated pediatric patients. Materials and Methods: A randomized assignment was carried out on a cohort of 52 pediatric patients who underwent mechanical ventilation in the Pediatric Intensive Care Unit at the Third Affiliated Hospital of Sun Yat-sen University, covering the period from January 2022 to December 2022. These patients were divided into two groups: an improved group (n = 26) utilizing marked suction tubes, and a regular group (n = 26) employing conventional suction tubes. The objective of our study was to evaluate the clinical effectiveness of marked suction tubes. Results: The effects of the improved group on the vital signs of children undergoing mechanical ventilation were small and statistically significant compared with the regular group (p < 0.05). Additionally, the improved group exhibited a reduced frequency of sputum suction, shorter mechanical ventilation duration, and fewer days of hospitalization in the PICU compared to the regular group during the ventilation period. Notably, the difference in the duration of PICU hospitalization was statistically significant (p < 0.05). Moreover, the incidence of adverse reactions in the improved group was notably lower, with statistically significant differences observed in airway mucous membrane damage and irritating cough when compared to the regular group (p < 0.05). Conclusion: The utilization of marked suction tubes provides clinical nurses with clear guidance for performing suctioning with ease, efficiency and safety. Consequently, advocating for the widespread implementation of marked suction tubes in clinical practice is a commendable pursuit. 展开更多
关键词 marked Suction Tubes Endotracheal Suction Mechanical Ventilation Different Depth of Aspiration
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Design and Construction of an Equipment for the Radiochemistry Process of Molecules Marked for the Sector Health
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作者 Jose Alanis Hector Flores +1 位作者 Simon de la Cruz Jose Carlos Vazquez 《Journal of Environmental Science and Engineering(A)》 2015年第4期196-202,共7页
At the Plant of Production of Radioisotopes part of Nuclear Center of Mexico (ININ), weekly radiofarmaceutics of sodium iodohippurate and meta-iodobenzyl-guanidine are prepared, these compounds are known as marked m... At the Plant of Production of Radioisotopes part of Nuclear Center of Mexico (ININ), weekly radiofarmaceutics of sodium iodohippurate and meta-iodobenzyl-guanidine are prepared, these compounds are known as marked molecules with iodine-131. Currently the processes for the preparation of these compounds are carried out individually and in manual form, in box of gloves, presenting radiological risks. To avoid these risks, this work, shows equipment that is inside a warm cell with the finality of minimizing the radiological risks. Also, this semi-automated equipment has the purpose of to reduce the radiation exposure of personnel involved in the process of marking molecules. The routine industrial production with this equipment starts with the preparation of 9 marked doses of sodium iodohippurate of 2.73 mCi of iodine-131, each of the vials with saline solution of 4.5 mL and the product that containing the marked molecules of 0.5 mL with a percentage of marked of 95.6%. The innovation of this work consists in presenting a new design of equipment, for marked molecules, formed by electrical, mechanical, vacuum systems, and air extraction system. 展开更多
关键词 Construction EQUIPMENT molecules marked sector health
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CARBOXYMETHYLPACHYMAN(Ⅰ),A NEW WATER SOLUBLE POLYSACCHARIDE WITH MARKED ANTITUMOUR ACTIVITY
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作者 Zhong Yuan YU Hui Jie WAN Li Ya WANG Lian Xi CHEN Hong Ming ZHANG Hubei Research Institute of Chemistry,Wuhan 430074 《Chinese Chemical Letters》 SCIE CAS CSCD 1992年第1期1-2,共2页
Carboxymethylpachyman(Ⅰ)was formed by carboxymethylation of β-pachyman.The antitumour activity of carboxymethylpachyman(Ⅰ)against S_(180)、EAC、 MA、U_(14)was measured.The structure of carboxymethylpachyman(Ⅰ)was ... Carboxymethylpachyman(Ⅰ)was formed by carboxymethylation of β-pachyman.The antitumour activity of carboxymethylpachyman(Ⅰ)against S_(180)、EAC、 MA、U_(14)was measured.The structure of carboxymethylpachyman(Ⅰ)was proved by IR ^(13)CNMR spectroscopy. 展开更多
关键词 CARBOXYMETHYLPACHYMAN A NEW WATER SOLUBLE POLYSACCHARIDE WITH marked ANTITUMOUR ACTIVITY CMP
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运动对孤独症谱系障碍大鼠内侧前额叶皮层树突棘重塑的影响及MARK1/MAP1A/PSD-95通路的作用
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作者 凃耿红 封纪伟 廖八根 《中国病理生理杂志》 CAS CSCD 北大核心 2024年第6期1008-1016,共9页
目的:探讨游泳结合转轮跑步运动干预对丙戊酸(valproic acid,VPA)诱导的孤独症谱系障碍(autism spectrum disorder,ASD)大鼠内侧前额叶皮层树突棘结构重塑的影响,以及微管亲和力调节激酶1(microtubule affinity regulating kinase 1,MAR... 目的:探讨游泳结合转轮跑步运动干预对丙戊酸(valproic acid,VPA)诱导的孤独症谱系障碍(autism spectrum disorder,ASD)大鼠内侧前额叶皮层树突棘结构重塑的影响,以及微管亲和力调节激酶1(microtubule affinity regulating kinase 1,MARK1)、微管相关蛋白1A(microtubule-associated protein 1A,MAP1A)和突触后致密蛋白95(postsynaptic density protein-95,PSD-95)的作用。方法:通过妊娠期VPA或生理盐水暴露的方法收集雄性子代制备ASD模型大鼠及对照大鼠,随机分为运动组和静置组,每组9~11只。采用三箱社交实验评价运动对ASD大鼠社交行为的影响,荧光示踪病毒局部感染观察内侧前额叶皮层亚区边缘前皮层(prelimbic cortex,PrL)和边缘下皮层(infralimbic cortex,IL)树突棘密度和形态,Western blot检测PSD-95和突触小泡蛋白(synaptophysin,Syn)蛋白表达,RNA原位杂交检测MARK1、MAP1A和PSD-95阳性颗粒数及共定位情况。结果:与对照组相比,ASD模型组大鼠社交行为存在缺陷,表现为在陌生大鼠箱体的活动时间、嗅探陌生大鼠的时间和频率均显著减少(P<0.05);经过运动干预后ASD大鼠的社交行为显著改善。树突棘形态观察发现ASD大鼠PrL区而不是IL区总树突棘密度显著增加,主要表现为蘑菇型和短粗型树突棘密度增加(P<0.05);运动干预能有效改善树突棘异常重塑。Western blot发现运动干预能有效逆转ASD大鼠PrL区的PSD-95蛋白表达上升的趋势;而PrL区的Syn及IL区的PSD-95和Syn蛋白表达在各组均无统计学差异。RNA原位杂交发现运动干预能有效降低ASD大鼠PrL区异常增多的MARK1、MAP1A和PSD-95的RNA阳性颗粒数,降低MARK1+MAP1A、MARK1+PSD-95和MAP1A+PSD-95的共定位。结论:运动干预可能通过PrL区MARK1/MAP1A/PSD-95分子通路改善ASD大鼠树突棘结构重塑,从而改善社交相关行为障碍。 展开更多
关键词 孤独症谱系障碍 树突棘 结构重塑 mark1/MAP1A/PSD-95信号通路
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The Nominative Case and Topic-marked NPs in Modern Chinese
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作者 柯欢欢 《中国校外教育》 2010年第4期33-34,共2页
The essay first reviews the grammatical cases in English and Chinese,and focus on the nominative case in Chinese.Then it studies Chinese language as Topic-construction.On the basis of the above research,the essay stud... The essay first reviews the grammatical cases in English and Chinese,and focus on the nominative case in Chinese.Then it studies Chinese language as Topic-construction.On the basis of the above research,the essay studies the nominative case assigned to Topic-marked NPs in Modern Chinese according to Jie Xu's theory. 展开更多
关键词 英语 语法 语言学 高校
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Marked Improvement in China's Maternal and Child Health
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《China Population Today》 1996年第4期10-10,共1页
MarkedImprovementinChina′sMaternalandChildHealthMaternalandchildhealthcare(MCH)inChinahasimprovedconsiderabl... MarkedImprovementinChina′sMaternalandChildHealthMaternalandchildhealthcare(MCH)inChinahasimprovedconsiderablycomparedwithteny... 展开更多
关键词 marked Improvement in China’s Maternal and Child Health
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Methods to prevent side marks from rusting on heavy steel plates
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作者 HAN Jianhong LI Wenjie 《Baosteel Technical Research》 CAS 2024年第1期22-26,共5页
When a steel plate produced by a steel plant leaves the factory,its upper surface should be marked with the specification,variety,batch number,and other identifying information,and its side should be marked with a sid... When a steel plate produced by a steel plant leaves the factory,its upper surface should be marked with the specification,variety,batch number,and other identifying information,and its side should be marked with a side marking.The side marking contains the plate number,specification,batch number,and other information,which are convenient for customers to accurately identify relevant information after stacking.However,because of the influence of weather,environment,and other factors,the side marking becomes unidentifiable when the steel plate is corroded,affecting the customer’s loading,unloading,and other operations.The development and application of side anticorrosion devices and cleaning of finished heavy steel plates with antirust agents will solve the problem of unrecognizable side marking due to corrosion. 展开更多
关键词 identification side marking RUST ANTIRUST
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基于机器视觉的工件Mark点快速提取方法研究
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作者 鄢然 赵青 +1 位作者 夏磊 殷勤 《机电工程技术》 2024年第9期158-162,168,共6页
在现代化工业生产流程中,工件Mark点类型繁多且提取过程既复杂又低效。为解决这一问题,提出了一种基于机器视觉的工件Mark点快速提取的方法。首先,使用工业相机采集原始图像,然后对图像进行预处理以减少噪声和锯齿的影响。随后,针对目... 在现代化工业生产流程中,工件Mark点类型繁多且提取过程既复杂又低效。为解决这一问题,提出了一种基于机器视觉的工件Mark点快速提取的方法。首先,使用工业相机采集原始图像,然后对图像进行预处理以减少噪声和锯齿的影响。随后,针对目标边缘提取繁琐且不准确的问题,提出一种基于OpenCV的卡尺工具算法,该算法通过在检测边缘周围产生等大等距的测量矩形,利用亚像素图像及改进的Canny边缘检测算子获得测量矩形内的最佳边缘点,再利用基于梯度下降法的最小二乘法来进行直线或圆的拟合,通过该算法可以快速高效地获得工件的直线或圆边缘。最后,通过组合这些直线或圆边缘来获得所需的Mark点。实验证明,该方法可以快速而准确地拟合工件的直线边缘或圆边缘,并最终成功获取到相应的Mark点,定位精度可达到亚像素级,且具有较高的稳定性。 展开更多
关键词 机器视觉 mark点提取 OPENCV 卡尺算法 直线拟合 圆拟合
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Marked Effect in Handling Patent Disputes by China's Patent Administrative Organs
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作者 He Li 《China's Foreign Trade》 1997年第9期13-13,共1页
In handling patent disputes, China observes an operational method of mutual cooperation and coordination through two channels: judicial adjudication and administrative settlement. Over the past decade, practice has pr... In handling patent disputes, China observes an operational method of mutual cooperation and coordination through two channels: judicial adjudication and administrative settlement. Over the past decade, practice has proved that the specific way of handling patent disputes by patent administrative organs has played an important role in the prompt resolu tion of patent disputes, protecting the legitimate rights and interests of patent- 展开更多
关键词 marked Effect in Handling Patent Disputes by China’s Patent Administrative Organs
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Spatio-Temporal Video Motion Detection Using Marked-Watershed and Morphological Operations
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作者 Qingqing Fu Mehmet Celenk 《通讯和计算机(中英文版)》 2013年第9期1181-1189,共9页
关键词 多尺度形态学 分水岭算法 运动检测 视频序列 时空信息 标记 CANNY算子 运动物体
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Mark VIe控制系统在燃驱压缩机组控制系统升级改造中的应用
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作者 白敬 《燃气轮机技术》 2024年第2期69-72,共4页
针对当前集成了不同厂家几套子系统的一些燃驱压缩机组控制系统结构复杂、维护成本高等问题,应用基于Mark VIe控制平台来升级改造该系统。以某改造项目为例,应用双冗余Mark VIe控制系统架构,Mark VIe SIL3模件作为紧急停机和火气保护系... 针对当前集成了不同厂家几套子系统的一些燃驱压缩机组控制系统结构复杂、维护成本高等问题,应用基于Mark VIe控制平台来升级改造该系统。以某改造项目为例,应用双冗余Mark VIe控制系统架构,Mark VIe SIL3模件作为紧急停机和火气保护系统的硬件,同时采用Mark VIe ControlST统一软件平台。结果表明:新控制系统采用了一体化硬件、软件设计,提高了机组控制系统的安全可靠性,有利于日常运行维护,而且新系统具有在线监测功能,有助于系统故障排查。 展开更多
关键词 mark VIe控制系统 mark VIeS 双冗余系统架构 SIL3 Shared I/O技术
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立足创新发展,加速发力亚太市场——昂高集团首席执行官MarkGarrett先生和纺织染化事业部北亚区副总裁蔡晓松女士访谈
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作者 宋富佳 刘凯琳 《纺织导报》 CAS 2024年第3期19-20,共2页
作为全球性多元化的化学品供应商,Archroma(昂高)为品牌和高性能纺织品、包装和纸张、涂料、黏合剂和密封剂市场提供领先的创新性解决方案。4月17日,在第23届中国国际染料工业及有机颜料、纺织化学品展览会现场,昂高集团首席执行官Mark ... 作为全球性多元化的化学品供应商,Archroma(昂高)为品牌和高性能纺织品、包装和纸张、涂料、黏合剂和密封剂市场提供领先的创新性解决方案。4月17日,在第23届中国国际染料工业及有机颜料、纺织化学品展览会现场,昂高集团首席执行官Mark Garrett先生和纺织染化事业部北亚区副总裁蔡晓松女士接受了本刊采访,介绍了昂高的发展情况以及未来的战略布局。 展开更多
关键词 北亚区 副总裁 染料工业 首席执行官 纺织化学品 有机颜料 密封剂 mark
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Anniversary of the Tibet Development Fund Marked in Beijing
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《China's Tibet》 1997年第4期14-16,共3页
关键词 Anniversary of the Tibet Development Fund marked in Beijing
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61st Anniversary of Adoption of Universal Declaration of Human Rights Marked in Beijing
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作者 LI ZHOUFEI 《The Journal of Human Rights》 2010年第1期39-40,共2页
On Dec. 10, 2009, the International Human Rights Day, Scholars and students inBeijing gathered to commemorate the 61st anniversary of the adoption of the Universal Declaration of Human Rights in China University of Po... On Dec. 10, 2009, the International Human Rights Day, Scholars and students inBeijing gathered to commemorate the 61st anniversary of the adoption of the Universal Declaration of Human Rights in China University of Political Science and Law. The Human Rights and Humanitarian Law Institute of China University of Political Science and Law, the Law School of Renmin University of China, and the LawSchool of Tsinghua University jointly sponsored the commemorations. The commemoration consisted of four parts including "the 61 st Anniversary of the Adoption of the Universal Declaration of Human Rights Photo Exhibition", "Remembrance of the Universal Declaration of Human Rights", and relative academic seminars. 展开更多
关键词 Anniversary of Adoption of Universal Declaration of Human Rights marked in Beijing
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基于Zernike矩的PCB上氧化圆形Mark点定位算法研究
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作者 方宇轩 曾寿金 +1 位作者 戚云涛 蔡晓洁 《机电技术》 2024年第3期32-37,90,共7页
文章针对在PCB的整个生产过程中,Mark点因环境和人为等因素被氧化,导致Mark点的定位精度降低的问题,采用灰度变换法对PCB的灰度图进行处理,选用迭代选择阈值法进行图像分割,然后运用圆的特性对Mark点边缘进行筛选,用Zernike矩对其进行... 文章针对在PCB的整个生产过程中,Mark点因环境和人为等因素被氧化,导致Mark点的定位精度降低的问题,采用灰度变换法对PCB的灰度图进行处理,选用迭代选择阈值法进行图像分割,然后运用圆的特性对Mark点边缘进行筛选,用Zernike矩对其进行亚像素边缘提取,最后用最小二乘法拟合出圆并求出圆心。实验表明:该定位算法的平均误差小于0.05像素,标准误差小于等于0.025像素。 展开更多
关键词 PCB mark ZERNIKE矩 定位算法
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