Clinical outcome analysis of 98 elderly women with early-stage breast cancer undergoing modified radical mastectomy or simple mastectomy

Objective: The aim of our study was to analyze the clinical results and prognosis for early elderly patients after surgery and to explore the rational treatment. Methods: Between January 1992 and December 2008, 98 early elderly breast cancer patients aged ≥ 65 years were treated with surgery, of which 52 patients received modified radical mastectomy and 46 patients received simple mastectomy. Results: Sixty-four (65.3%) patients had comorbidities including coronary heart disease, hypertension, diabetes, etc. After a median follow up of 56 months (21 to 280 months), the 5-year cumulative survival rate of breast modified radical mastectomy group and mastectomy group were 84.0% and 82.7%, separately (P = 0.653). The 5-year recurrence rate were 3.8% and 8.1%, separately (P = 0.504). Conclusion: The simple mastectomy is suitable for the treatment of early elderly breast cancer patients for its lower complication and recurrence rate. Early old women with breast cancer may be safely treated by simple mastectomy. Our findings suggest that modified radical mastectomy does not significantly increase the overall survival.

Life′s Simple 7干预减轻Her⁃2阳性乳腺癌患者化疗相关心血管系统损害的研究

目的探讨Life′s Simple 7(LS7)干预减轻Her⁃2阳性乳腺癌患者根治术后化疗相关心血管系统损害的作用。方法将120例Her⁃2阳性并接受标准化乳腺癌化疗的患者随机等量分为对照组及LS7组,对照组为标准化疗方案,LS7组为对照组基础上给予LS7干预12个月,后续通过比较两组治疗前后心血管系统损伤程度、焦虑、抑郁及生活质量等指标评价其对心血管系统损害的改善作用。结果相较于对照组,LS7组LS7总评分及7项心血管健康指标均优于对照组(P<0.05),LS7组LVEF较高(P<0.05)、NT⁃proBNP较低(P<0.05),焦虑和抑郁评分较低(P<0.05)、生活质量评分较高(P<0.05)。结论LS7干预可显著减轻Her⁃2阳性乳腺癌化疗相关心血管系统损害并改善乳腺癌患者的心理状况和生活质量,值得在临床推广。

An Affordable and Easily Accessible Approach for Acrylonitrile Monomer Purification through a Simple Column Technique

This manuscript presents a dataset detailing a method for purifying monomers. Purification plays a crucial role in every chemical process, as it leads to an improvement in product quality through the removal of impurities. The primary method for monomer purification, like acrylonitrile (AN), is the distillation technique. However, this technique is unsafe and hard to set up or handle. A straightforward, risk-free, low-cost method like the column technique resolves these issues. A simple column technique demonstrated the successful execution of purifying AN. Fourier transform infrared (FTIR) and nuclear magnetic resonance (NMR) analyses confirmed that AN was successfully purified, with purity reaching 99.8%. FTIR spectra revealed changes in the position and intensity of the stretching vibration peaks after purification. Also, the functional groups of the inhibitor monomethyl ether of hydroquinone (MeHQ) were undetected after purification. Furthermore, after purification, NMR spectra revealed the absence of aromatic protons and carbons associated with MeHQ. In conclusion, the column technique is a successful and inexpensive way to purify AN monomers. This makes it useful for a wide range of applications, especially in polymerization reactions where MeHQ needs to be removed to prevent self-polymerization during the initiation process.

Heat Kernel Estimates on Simple Random Walks and On-Diagonal Upper Bounds

We primarily provide several estimates for the heat kernel defined on the 2-dimensional simple random walk. Additionally, we offer an estimate for the heat kernel on high-dimensional random walks, demonstrating that the heat kernel in higher dimensions converges rapidly. We also compute the constants involved in the estimate for the 1-dimensional heat kernel. Furthermore, we discuss the general case of on-diagonal estimates for the heat kernel.

CATGUT EMBEDDING FOR TREATMENT OF SIMPLE OBESITY COMPLICATED WITH ABNORMAL BLOOD FAT

Objective To compare the therapeutic effect of catgut embedding combined with diet plus exercise with that of diet plus exercise in treating simple obesity complicated with abnormal blood fat. Methods A prescription of diet plus exercise was given to the patients in a control group, and catgut embedding was added to the prescription in a treatment group. It was given once every 15 days for the 1st three treatments, and once every month for the 2^nd three treatments. Six treatments constituted a therapeutic course. Body weight and blood fat were measured before and half a year since treatment. Results After treatment, BMI, TO, TG and LDL were very significantly improved in the treatment group （P〈0.01）, and BMI and TG were very significantly （P〈0.01） and TO and LDL were significantly （P〈0.05） improved in the control group. HDL was not obviously improved in both groups （P〉0.05）. The improvement of TO, TG and LDL in the treatment group was significantly more than that in the control group （P〈0.01）, but no difference in improvement of BMI and HDL was found between the two groups （P〉0.05）. Conclusion The therapy of diet plus exercise was effective in body weight reduction and lowering blood fat in patients with simple obesity complicated with abnormal blood fat, and catgut embedding used in combination was even better in lowering blood fat.

Immediate nipple-areola-sparing mastectomy reconstruction: An update on oncological and reconstruction techniques

Nipple-sparing mastectomy(NSM) is a safe technique in patients who are candidates for conservation breast surgery. However, there is worry concerning its oncological safety and surgical outcome in terms of postoperative complications. The authors reviewed the literature to evaluate the oncological safety, patient selection, surgical techniques, and also to identify the factors influencing postoperative outcome and complication rates. Patient selection and safety related to NSM are based on oncological and anatomical parameters. Among the main criteria, the oncological aspects include the clinical stage of breast cancer, tumor characteristics and location including small, peripherally located tumors, without multicentricity, or for prophylactic mastectomy. Surgical success depends on coordinated planning with the oncological surgeon andcareful preoperative and intraoperative management. In general, the NSM reconstruction is related to autologous and alloplastic techniques and sometimes include contra-lateral breast surgery. Choice of reconstructive technique following NSM requires accurate consideration of various patient related factors, including: breast volume, degree of ptosis, areola size, clinical factors, and surgeon's experience. In addition, tumor related factors include dimension, location and proximity to the nipple-areola complex. Regardless of the fact that there is no unanimity concerning the appropriate technique, the criteria are determined by the surgeon's experience and the anatomical aspects of the breast. The positive aspects of the technique utilized should include low interference with the oncological treatment, reproducibility, and long-term results. Selected patients can have safe outcomes and therefore this may be a feasible option for early breast cancer management. However, available data demonstrates that NSM can be safely performed for breast cancer treatment in selected cases. Additional studies and longer follow-up are necessary to define consistent selection criteria for NSM.

Present status of endoscopic mastectomy for breast cancer

Endoscopy is now being used for breast cancer surgery. Though it is used for mastectomy, lymph node dissection, and breast reconstruction, its prime use is for mastectomy. Because an incision can be placed inconspicuously in the axillary site, a relatively largeincision can be created. A retractor with an endoscope, CO2, and an abrasion device with the endoscope are used for operation space security. It is extremely rare that an endoscope is used for lymph node dissection. For breast reconstruction, it may be used for latissimus muscle flap making, but an endoscope is rarely used for other reconstructions. Endoscopic mastectomy is limited to certain institutions and practiced hands, and it has not been significantly developed in breast cancer surgery. On the other hand, endoscopic surgery may be used widely in breast reconstruction. With respect to the spread of robotic surgery, many factors remain uncertain.

A Simple and Quick Method of Extracting Genomic DNA from Wheat Leaves

[ Objective] The aim was to seek a simple and quick method of extracting genomic DNA from wheat leaves. [ Method] Taking tender leaves of wheat as test materials, total DNA of transgenic wheat was extracted by using modified CTAB method. The extracted DNA was detected by 0.8% agarose gel electrophoresis. [ Result] DNA purity of extracted genome DNA from wheat was high and no degradation phenomenon using modified CTAB method, and was suitable for carrying out normal PCR amplification. [ Conclusion] This study provides a simple and quick method for extracting DNA from wheat with a spot of material.

Modeling of surface flux in Tongyu using the Simple Biosphere Model 2 (SiB2)

The modeling ability of a stand-alone version of the Simple Biosphere Model 2（SiB2） was tested mainly through diagnosing the simulated latent heat（LE）,sensible heat（H）,CO2 flux,and air temperature at the Tongyu field observation station（44°25＇N,122°52＇E,184 m elevation） of Coordinated Enhanced Observing Period（CEOP）,where the land cover is cropland and grassland.In the whole year of 2003,the canopy height and the leaf area index was variable.During non-growth period,the surface would become bare,while during the growth period,the canopy height could reach 2.0 m high over cropland and 0.8 m high over grassland,respectively,and max leaf area index could reach 4.2 and 2.4,respectively.The model was initialized with measurement and driven by half-hourly atmospheric observations.The simulation values for 2003 were compared against measurements.Results show that the model is of a good ability of simulating the hourly latent heat（LE）,sensible heat（H）,CO2 flux and temperature during the growth period.Moreover,the daily LE,H and CO2 flux simulated by SiB2 could reflect their yearly change reasonably.However,the model may overestimate the H generally.

TA载体pEASY-T1 Simple在基因克隆中的新应用

在基因克隆操作中,由于常用克隆载体多克隆位点的酶切位点数目有限,造成一些DNA片段的克隆、连接受限。为解决这一问题,本文利用pEASY-T1 S imp le载体无酶切位点的特点,通过TA克隆的方法引入多个单一酶切位点,并对所构建的克隆载体进行了验证。最后证明,这种方法可高效构建含有不同多克隆位点的载体,克服了对常用克隆载体的依赖,大大提高了基因操作的灵活性和有效性。

Breast-conserving therapy and modified radical mastectomy for primary breast carcinoma:a matched comparative study

Background- To compare two types of therapy for primary breast carcinoma, breast-conserving therapy （BCT） and modified radical mastectomy （MRM）, in a matched cohort study. Methods： A series of 1,746 patients with primary breast cancer treated with BCT or MRM in a single Chinese institute between January 2000 and February 2009 were analyzed retrospectively to compare their outcomes with respect to the incidence of local recurrence （LR）, distant metastasis, and survival. The patients were matched with regard to age at diagnosis, spreading to axillary lymph nodes, hormone receptor status, the use of neoadjuvant chemotherapy and maximal tumor diameter. The match ratio was 1：1, and each arm included 873 patients. Results： The median follow-up period was 71 months. The 6-year disease-free survival （DFS） and 6-year distant disease-free survival （DDFS） rates differed significantly between two groups. The 6-year local recurrence-free survival （LRFS） rates were 98.2% [95% confidence interval （CI）： 0.973-0.989] in the BCT group and 98.7% （95% CI： 0.980-0.994） in the MRM group （P=0.182）, respectively. DFS rates in BCT and MRM groups were 91.3% （95% CI： 0.894-0.932） and 86.3% （95% CI： 0.840-0.886） （P〈0.001）, respectively, whereas the DDFS rates in BCT and MRM groups were 93.6% （95% CI： 0.922-0.950） and 87.7% （95% CI： 0.854-0.900） （P〈0.001）, respectively. Conclusions： BCT in eligible patients is as effective as MRM with respect to local tumor control, DFS and DDFS, and may result in a better outcome than MRM in Chinese primary breast cancer patients.

Zone inhomogeneity with the random asymmetric simple exclusion process in a one-lane system

In this paper we use theoretical analysis and extensive simulations to study zone inhomogeneity with the random asymmetric simple exclusion process （ASEP）. In the inhomogeneous zone, the hopping probability is less than 1. Two typical lattice geometries are investigated here. In case A, the lattice includes two equal segments. The hopping probability in the left segment is equal to 1, and in the right segment it is equal to p, which is less than 1. In case B, there are three equal segments in the system; the hopping probabilities in the left and right segments are equal to 1, and in the middle segment it is equal to p, which is less than 1. Through theoretical analysis, we can discover the effect on these systems when p is changed.

The characterization of the time-dependent nonlinear viscoelastic of an LDPE melt using a simple thixotropy model

A new simple thixotropy model was proposed in the present paper to characterize the thixotropy-loop experiments and the start-up experiment of an LDPE （PE-FSB23D0221Q200） melt. The thixotropy model is a combination of a viscoelastic-component and a postulated kinetics process of structure change, which is constituted in terms of the indirect microstructural approach usually adopted in the characterization of thixotropy. The descriptions of the thixotropy model on both the thixotropy-loop tests and the startup test show good agreement with the experimental values, indicating the good capability of the model in characterizing the time-dependent nonlinear viscoelastic. The stress overshoot phenomenon and the stress relaxation after cessation of the thixotropy loop test can be described well by the model, whereas both of the typical viscoelastic phenomena could not be described in our previous work with a variant Huang model.

Multi-center investigation of breast reconstruction after mastectomy from Chinese Society of Breast Surgery:A survey based on 31 tertiary hospitals(CSBrS-004)

Objective:Multi-center data on the current status and trends of breast reconstruction after mastectomy in China are lacking.Herein,we conducted a cross-sectional survey to investigate the current clinical practice pattern of postmastectomy breast reconstruction among Chinese female patients with breast cancer.Methods:A standardized questionnaire used to collect information on breast reconstruction among females diagnosed with breast cancer was distributed by 31 members of the Chinese Society of Breast Surgery between January 1,2018 and December 31,2018.Information was collected on tumor characteristics,treatment,mesh application,nipple-areola complex(NAC)preservation,postoperative complications,bilateral reconstruction,patient satisfaction and local recurrence.The overall rate of breast reconstruction was assessed,and the characteristics were compared across patient groups with different reconstruction approaches.Results:A total of 1,554 patients underwent breast reconstruction after total mastectomy,with a reconstruction rate of 9.6%.Among them,1,190 were implant-based,and 262 underwent autologous reconstructions,while 102 cases underwent a combination of both.Patients who underwent implant-based reconstruction were younger than those who received autologous reconstruction(40.1±4.6 vs.45.0±5.9,P=0.004).Compared to patients with autologous reconstruction,mesh application(25.5%vs.6.5%),NAC preservation(51.8%vs.40.5%)and reconstruction failure(1.8%vs.0)were more frequently reported among those with implant-based reconstruction.There was no significant difference in general satisfaction across three reconstruction approaches,though patients with autologous reconstruction reported the highest aesthetic satisfaction among the three groups(P=0.044).Conclusions:Implant-based breast reconstruction remains the dominant choice among patients,while autologous reconstruction was associated with higher aesthetic satisfaction.Our multi-center investigation based on the findings of the tertiary hospitals of Chinese Society of Breast Surgery may guide a future series of clinical studies on breast reconstruction in China.

OD-CHARACTERIZATION OF ALMOST SIMPLE GROUPS RELATED TO U_6(2)

Let G be a finite group and π（G） = {pl,p2,…… ,pk} be the set of the primes dividing the order of G. We define its prime graph F（G） as follows. The vertex set of this graph is 7r（G）, and two distinct vertices p, q are joined by an edge if and only if pq ∈ πe（G）. In this case, we write p - q. For p ∈π（G）, put deg（p） ：= ｜{q ∈ π（G）｜p - q}｜, which is called the degree of p. We also define D（G） ：= （deg（p1）, deg（p2）,..., deg（pk））, where pl 〈 p2 〈 -……〈 pk, which is called the degree pattern of G. We say a group G is k-fold OD-characterizable if there exist exactly k non-isomorphic finite groups with the same order and degree pattern as G. Specially, a l-fold OD-characterizable group is simply called an OD-characterizable group. Let L ：= U6（2）. In this article, we classify all finite groups with the same order and degree pattern as an almost simple groups related to L. In fact, we prove that L and L.2 are OD-characterizable, L.3 is 3-fold OD-characterizable, and L.S3 is 5-fold OD-characterizable.

Axillary “Exclusion”—A Successful Technique for Reducing Seroma Formation after Mastectomy and Axillary Dissection

Introduction: A seroma is the commonest complication of breast cancer surgery, and although its consequences most often cause no more than discomfort and anxiety, more important sequelae include flap necrosis and wound breakdown. Infection developing within seroma increases morbidity and often results in the need for re-admission, re-imaging, drainage and antibiotic usage. Numerous methods to reduce post-mastectomy seroma formation have been tried with no consistent success. Methods: 24 consecutive patients undergoing mastectomy and axillary clearance were recruited before and after a departmental change in practice. At the point of skin closure, patients either underwent “axillary exclusion” or not. Total drain outputs were recorded by community district nursing staff for all patients. At the first post-operative visit, the presence and severity of seroma was recorded. Results: 24 patients were included (study group 14, control group 10). Age, size of tumour, and number of positive lymph nodes and laterality were comparable between groups. Mean drain output for the entire group was 471 ml (3 - 1030 ml) over 5.21 days. The control group had a drain output of 763.5 ml (95%CI 674.2 - 852.8) while the study group had a mean drainage of 262.2 ml (95%CI 161.9 - 362.5), a reduction of over 65%, p < 0.001. 15 (62.5%) out of 24 patients developed seroma. 42.9% of the study group and 90% of the control group developed seroma, p < 0.01. Conclusion: Seromas are a common complication following mastectomy and axillary clearance. Our technique of axillary exclusion has resulted in significantly reduced drainage volumes and fewer seromas.

LOCAL INFLUENCE ASSESSMENT IN A MULTIVARIATE t-MODEL WITH RAO'S SIMPLE STRUCTURE

The local influence analysis is an important problem in statistical inference and some models have been discussed in many literatures This paper deals with the problem of assessing local influences in a multivariate t-model with Rao's simple struc-ture(RSS). Based on Cook's likelihood displacement, the effects of some minor perturbation on the statistical inference is assessed. As an application, a common covariance-weighted perturbation is thoroughly discussed.

ASSESSMENT OF LOCAL INFLUENCE IN A GROWTH CURVE MODEL WITH RAO'S SIMPLE COVARIANCE STRUCTURE

The present paper deals with the problem of assessing the local influence in a growth curve model with Rao's simple covariance structure. Based on the likelihood displacement,the curvature measure is employed to evaluate the effects of some minor perturbations on the statistical inference, thus leading to the large curvature direction, which is the most critical diagnostic statistic in the context of the local influence analysis. As an application, the common covariance-weighted perturbation scheme is thoroughly considered.

Hypereosinophilia, mastectomy, and nephrotic syndrome in a male patient: A case report

BACKGROUND Hypereosinophilia(HE)is a heterogeneous disease of unknown etiology in which tissue and organ injury is inflicted by excess numbers of circulating or infiltrating eosinophils.Herein,we describe a patient with rare organ damage due to HE and review the pertinent literature.CASE SUMMARY A 43 year-old Chinese man with a 13-year history of eosinophilia and shortness of breath for 7 d presented to our hospital.During the course of his illness,the patient variably presented with gastrointestinal symptoms,eczema,vitiligo,mastitis,joint symptoms,nephrotic syndrome,and interstitial pneumonia.The chronic mastitis proved burdensome,necessitating bilateral mastectomy.HE was diagnosed by repeat bone marrow biopsy,and a kidney biopsy showed focal segmental glomerulosclerosis.Intermittent steroidal therapy is typically initiated to relieve such symptoms,although relapse and organ involvement often ensue once treatment is withdrawn.We administered methylprednisolone sodium succinate(40 mg/d)intravenously for 3 d,followed by oral tablets at the same dose.Subsequent computed tomography(CT)of the chest CT showed relative improvement of the interstitial pneumonia.The patient is currently on a continuous regimen of oral steroid,and his condition is stable.CONCLUSION HE is heterogeneous condition.This is the first reported case of bilateral mastectomy in a male patient with longstanding HE.

Light-Weight Simple Network Management Protocol in Wireless Sensor Networks

A Light-Weight Simple Network Management Protocol (LW-SNMP) for the wireless sensor network is proposed, which is a kind of hierarchical network management system including a sink manager, cluster proxies, and node agents. Considering the resource limitations on the sensor nodes, we design new management messages, new data types and new management information base completely. The management messages between the cluster proxy and node agents are delivered as normal data packets. The experiment results show that LW-SNMP can meet the management demands in the resource-limited wireless sensor networks and has a good performance in stability, effectiveness of memory, extensibility than the traditional Simple Network Management Protocol (SNMP).