Traditional Chinese medicine Master XIONG Jibo’s medication experience in treating arthralgia syndrome through data mining

Objective This study aimed to examine and propagate the medication experience and group formula of traditional Chinese medicine(TCM)Master XIONG Jibo in diagnosing and treat-ing arthralgia syndrome(AS)through data mining.Methods Data of outpatient cases of Professor XIONG Jibo were collected from January 1,2014 to December 31,2018,along with cases recorded in A Real Famous Traditional Chinese Medicine Doctor:XIONG Jibo's Clinical Medical Record 1,which was published in December 2019.The five variables collected from the patients’data were TCM diagnostic information,TCM and western medicine diagnoses,syndrome,treatment,and prescription.A database was established for the collected data with Excel.Using the Python environment,a custom-ized modified natural language processing(NLP)model for the diagnosis and treatment of AS by Professor XIONG Jibo was established to preprocess the data and to analyze the word cloud.Frequency analysis,association rule analysis,cluster analysis,and visual analysis of AS cases were performed based on the Traditional Chinese Medicine Inheritance Computing Platform(V3.0)and RStudio(V4.0.3).Results A total of 610 medical records of Professor XIONG Jibo were collected from the case database.A total of 103 medical records were included after data screening criteria,which comprised 187 times(45 kinds)of prescriptions and 1506 times(125 kinds)of Chinese herbs.The main related meridians were the liver,spleen,and kidney meridians.The properties of Chinese herbs used most were mainly warm,flat,and cold,while the flavors of herbs were mainly bitter,pungent,and sweet.The main patterns of AS included the damp heat,phlegm stasis,and neck arthralgia.The most commonly used herbs for AS were Chuanniuxi(Cyathu-lae Radix),Huangbo(Phellodendri Chinensis Cortex),Cangzhu(Atractylodis Rhizoma),Qinjiao(Gentianae Macrophyllae Radix),Gancao(Glycyrrhizae Radix et Rhizoma),Huangqi(Astragali Radix),and Chuanxiong(Chuanxiong Rhizoma).The most common effect of the herbs was“promoting blood circulation and removing blood stasis”,followed by“supple-menting deficiency(Qi supplementing,blood supplementing,and Yang supplementing)”,and“dispelling wind and dampness”.The data were analyzed with the support≥15%and con-fidence=100%,and after de-duplication,five second-order association rules,39 third-order association rules,39 fourth-order association rules,and two fifth-order association rules were identified.The top-ranking association rules of each were“Cangzhu(Atractylodis Rhizoma)→Huangbo(Phellodendri Chinensis Cortex)”“Cangzhu(Atractylodis Rhizoma)+Chuanniuxi(Cyathulae Radix)→Huangbo(Phellodendri Chinensis Cortex)”“Chuanniuxi(Cyathulae Radix)+Danggui(Angelicae Sinensis Radix)+Gancao(Glycyrrhizae Radix et Rhizoma)→Qinjiao(Gentianae Macrophyllae Radix)”and“Chuanniuxi(Cyathulae Radix)+Danggui(Angelicae Sinensis Radix)+Gancao(Glycyrrhizae Radix et Rhizoma)+Huangbo(Phello-dendri Chinensis Cortex)→Qinjiao(Gentianae Macrophyllae Radix)”,respectively.Five clusters were obtained using cluster analysis of the top 30 herbs.The herbs were mainly dry-ing dampness,supplementing Qi,and promoting blood circulation.The main prescriptions of AS were Ermiao San(二妙散),Gegen Jianghuang San(葛根姜黄散),and Huangqi Chongteng Yin(黄芪虫藤饮).The herbs of core prescription included Cangzhu(Atractylodis Rhizoma),Chuanniuxi(Cyathulae Radix),Gancao(Glycyrrhizae Radix et Rhizoma),Huangbo(Phellodendri Chinensis Cortex),Mugua(Chaenomelis Fructus),Qinjiao(Gentianae Macro-phyllae Radix),Danggui(Angelicae Sinensis Radix),and Yiyiren(Coicis Semen).Conclusion Clearing heat and dampness,relieving collaterals and pain,and invigorating Qi and blood are the most commonly used therapies for the treatment of AS by Professor XIONG Jibo.Additionally,customized NLP model could improve the efficiency of data mining in TCM.

Intra-set correlation analysis of medical records of thyroid cancer treated by traditional Chinese medicine Master ZHOU Zhongying

Objective Based on intra-set correlation analysis, this paper deconstructs the clinical medical records of traditional Chinese medicine(TCM) Master ZHOU Zhongying in treating thyroid cancer, and analyzes the experience in “mechanism-syndrome-medicine-prescription” for thyroid cancer.Methods Through Medcase data processing platform, based on Frequent Pattern(FP)-Growth enhanced correlation analysis algorithm, the medical records of Professor ZHOU Zhongying for the treatment of thyroid cancer from June 1, 2001 to February 28, 2015 were analyzed within the set.Results This study involved 43 medical records, 43 patients, and 167 visits. After processing intra-set correlations, 28 groups of highly correlated symptoms, 21 groups of highly correlated tongue images, 10 groups of highly correlated pulse conditions, 28 groups of highly correlated pathogenesis, 34 groups of highly correlated herbs, and 26 groups of highly correlated western medicine diagnosis were selected. Professor ZHOU Zhongying treats thyroid cancer according to syndrome differentiation. Symptoms with more association rules included neck swelling, neck pain, cough, and dry mouth;tongue images with more association rules included dark purple tongue, dark red tongue, and fissured tongue;pulse conditions with more association rules were wiry pulse, thready pulse, small pulse, and slippery pulse;the pathogenesis with more association rules was phlegm and blood stasis, damp-heat accumulation,and impairment of both Qi and Yin;herbs with more association rules were Chaihu(Bupleuri Radix), Zeqi(Sun Euphoribiae Herb), and Tiandong(Asparagi Radix);western medicine diagnosis with more association rules included thyroid cancer, insomnia, and chronic gastritis.Conclusion Thyroid cancer mostly presents as deficiency in origin and excess in manifestations. The basic pathogenesis is phlegm and blood stasis, damp-heat accumulation, and impairment of both Qi and Yin, which are closely related to liver, kidney, and spleen. Professor ZHOU Zhongying adopts both attack and supplement approaches as the general treatment principle, with a strong emphasis on regulating Qi and relieving depression, eliminating phlegm and resolving stagnation, eliminating dampness and turbidity, clearing fire and destroying poison, moistening dryness and softening hard mass, invigorating Qi and nourishing Yin, and paying attention to nourishing liver and kidney, invigorating spleen and stomach,while protecting the heart and lungs.

Analysis on the Culture behind Worship to Traditional Chinese Medicine Master Sun Simiao

Worship to traditional Chinese medicine mater Sun Simiao is rooted in the traditional Chinese culture of Confucianism and Taoism,which attaches great importance to life and life in this world.The development and spread of Taoism is a platform for the promotion of traditional Chinese medicine master Sun Simiao.People's demand for medicine and health care is the basis of the folk culture behind worship to Sun Simiao.Medicine master culture of and worship to Sun Simiaors promoted people's healthy life and national prosperity,so it was widely recognized and spread.

World Integrated Medicine Master TANG You-zhi——Doctor of Ophthalmological Surgery for Chairman Mao

INTRODUCTION OF TANG YOUZHI TANG You-zhi, alias Kunwu, born in July 1926 in Hangzhou, Zhejiang province, is an Ophthalmological scientist on Chinese medicine.From 1942 to1947, he learned from Lu Nanshan, a famous doctor of Traditional Chinese Medicine Ophthalmology in Shanghai.After returning to Hangzhou, he opened up the TANG Kunwu Eye Clinic.In 1952, the Ministry of Health enrolled students to train Chinese medicine researchers.

World Integrated Medicine Master Shen Ziyin

Academician Shen Ziyin(1928-),ethnic Han,born in Zhenhai,Zhejiang Province,graduated from Shanghai Medical Schoolas a medical undergraduate in 1952 and startedle a rning traditional Chinese medicine with Prof.Jiang Chunhua since 1955.He was rewarded the gold medal of"Carry forward Chinese Medical Heritage"with his tutor in 1959 and became academician of Chinese Academy of Sciences in 1997.Academician Shen was rated as Shanghai famous doctors in 1995 and won the honorary title of"National Famous Doctor of Traditional Chinese Medicine"in 2017.Academician Shen served as professor and doctoral supervisor of Shanghai Medical School,the director of traditional Chinese medicine department,the head of the Institutes of Integrative Chinese and Western Medicine,the head of the department of Integrative Chinese and Western Medicine of Huashan Hospital affiliated to Fudan University,the member of degree and academic committee in the university and the hospital,the member of medical evaluation by the academic degree committee of state council,the chairman of Chinese medicine evaluation committee of ministry of health,the vice president of Chinese Association of Integrative Medicine,president of Shanghai Association of Integrated Chinese and Western Medicine.At present,he is the honorary dean of the Institutes of Integrative Chinese and Western Medicine of Fudan University and lifetime professor of Huashan Hospital Affiliated to Fudan University.Academician Shen's study is mainly based on the exploration of integrated Chinese and Western Medicine,the nature of kidney and traditional geriatric medicine.

Data mining analysis of Professor Liu Shangyi＇s prescription characteristics in clinical medicine for the treatment of cancer patients with stomachache

Objective： To analyze National Chinese Medicine Master Liu Shangyi’s prescription characteristics of clinical medicinefor the treatment of cancer patients with stomachache. Methods： Data on prescriptions for cancer patients withstomachache between January 2014 and July 2016 were collected. The composing principles were analyzed byunsupervised data mining methods including Apriori algorithm in association rules and complex system entropy cluster.Results： Based on the analysis of 120 prescriptions, the frequency of each herb and association rules among the herbswere computed. Four core combinations and two new prescriptions were mined from the database. Compared to thebefore treatment, the clinical symptomatic grading of stomachache after treatment was lower （P 〈 0.001）. Conclusion：Professor Liu has been successful in the treatment of cancer patients with stomachache by prescribing medication thataids in activating blood circulation, removing dampness, and alleviating pain.

Interpretation of the prevention and treatment of COVID-19 in Jiangxi based on"unified coldness and warmness"

`Since the outbreak of COVID-19,various regions have introduced their own TCM prevention and treatment methods.However,there are two opposing views on the nature of cold and temperature.Since modern times,the thought of the unification of cold and temperature has developed rapidly,and many doctors gradually realized the importance and practicability of the unification of cold and temperature,and began to advocate the unification of cold and temperature syndrome.The prevention and treatment of COVID-19 in Jiangxi was developed by Professor Wu Bingcai,a master of Chinese medicine,based on the unified idea of cold and temperature,according to the characteristics of humid climate in Jiangxi,and in combination with the characteristics of COVID-19,the anti-toxin prescription for dispelling cold and desiccating dampness and the anti-toxin prescription for clearing heat and dehumidifying,which achieved exact and satisfactory results in clinical application.