We present the rationale and design of a master protocol study that clarifies the effectiveness and safety of Chinese herbal formulas on Qi-stagnation and blood-stasis pattern(QBP).Three randomized controlled trials(R...We present the rationale and design of a master protocol study that clarifies the effectiveness and safety of Chinese herbal formulas on Qi-stagnation and blood-stasis pattern(QBP).Three randomized controlled trials(RCTs)and real-world observational studies.Based on three registry cohorts of stable angina,tension-type headache and primary dysmenorrhea,patients with QBP will be enrolled in RCTs to receive either Xuefu Zhuyu(血府逐瘀,XFZY)oral liquid or a placebo,while patients with non-QBP will be enrolled in the observational studies and experience follow-up.1414 patients(RCTs:574;observational studies:840)will be recruited at seven centers in China over a 3-year period.The primary outcome is the visual analog scale of pain intensity.Adverse events will also be reported.The analysis will be undertaken separately in each sub-study,and then an overall analysis combining multiple subgroups will be performed to comprehensively investigate the effect of XFZY oral liquid.This study will provide high-quality evidence of XFZY oral liquid for QBP patients and show a paradigm of post-marketing evaluation of the effectiveness and safety for Chinese medicine following the notion of the pattern dominating different disease research models.展开更多
Aiming at the weaknesses of LON bus, combining the coexistence of fieldbus and DCS (Distribu ted Control Systems) in control networks, the authors introduce a hierarchical hybrid control network design based on LON an...Aiming at the weaknesses of LON bus, combining the coexistence of fieldbus and DCS (Distribu ted Control Systems) in control networks, the authors introduce a hierarchical hybrid control network design based on LON and master slave RS 422/485 protocol. This design adopts LON as the trunk, master slave RS 422/485 control networks are connected to LON as special subnets by dedicated gateways. It is an implementation method for isomerous control network integration. Data management is ranked according to real time requirements for different network data. The core components, such as control network nodes, router and gateway, are detailed in the paper. The design utilizes both communication advantage of LonWorks technology and the more powerful control ability of universal MCUs or PLCs, thus it greatly increases system response speed and performance cost ratio.展开更多
目的全面检索国内外母方案设计的相关研究,了解其临床应用所覆盖的研究领域,为国内护理人员开展母方案设计相关研究的实施和推广提供参考。方法采用Arksey和O’Malley提出的范围综述方法,系统检索中国知网、万方数据库、中国生物医学文...目的全面检索国内外母方案设计的相关研究,了解其临床应用所覆盖的研究领域,为国内护理人员开展母方案设计相关研究的实施和推广提供参考。方法采用Arksey和O’Malley提出的范围综述方法,系统检索中国知网、万方数据库、中国生物医学文献数据库、维普、PubMed、Cochrane Library、Embase、Web of Science,检索时限为从建库至2023年4月。根据纳入、排除标准筛选文献,2名研究者独立提取母方案设计核心要素及其应用领域相关资料,采用描述性分析及主题分析法对提取结果进行整理。结果共纳入104篇文献,研究领域涉及肿瘤、临床心理学、新型冠状病毒肺炎等的药物开发评估及个性化健康计划的制定。母方案在国内外应用存在着明显差异,主要体现在3个方面:(1)应用范围不同,国外主要用于评估新药、疗法或医学器材的有效性和安全性,而在我国广泛应用于中医药领域;(2)研究类型有别,国外主要应用多中心随机对照试验、队列研究,而我国此类型研究相对较少;(3)经验和技术支持方面,由于历史和文化背景等原因,国外研究者在母方案的设计和实施方面拥有更丰富的经验和技术支持。因此,在推广和应用母方案时,需充分考虑国内外的差异,并结合本土实际情况探索出适合自身条件下的研究模式和方法,以推进其更广泛和深入的应用。结论母方案的实施是临床研究模式的一次突破性创新,当前母方案设计的应用多集中在肿瘤学、新型冠状病毒肺炎领域,但伞式试验和篮式试验可用于健康领域,平台试验的范围可应用于临床心理学和数字心理健康干预,国内护理研究者应重视对母方案设计的应用,在其指导下开展相关研究,提升护士创新行为,积极寻找新方法和技术,循证优化试验设计,解决临床护理问题,快速适应精准医学的发展。展开更多
为满足管道空间位置与焊接参数相匹配的智能全位置焊接系统的工艺要求,构建了以焊接电源通信模块为从站节点的主从式CAN(Controller Area Network)总线网络控制焊接系统.提出基于PC控制的服务数据对象(ADS)通信方式访问焊接电源对象词典...为满足管道空间位置与焊接参数相匹配的智能全位置焊接系统的工艺要求,构建了以焊接电源通信模块为从站节点的主从式CAN(Controller Area Network)总线网络控制焊接系统.提出基于PC控制的服务数据对象(ADS)通信方式访问焊接电源对象词典,采用过程同步数据对象传输保证了数据传输实时性,同时使用基于视窗技术的组态软件可实现焊接过程的监视和数据的传输,实现了焊接电源CAN-open总线控制在管道全位置焊接系统的计算机集成.实验表明,该系统数据传输快速、稳定,可满足管道全位置焊接工艺要求.展开更多
基金the National Key Research and Development Program of China:Research on“the Pattern Dominating Disease”of Postmarket Evaluation on Two Classic Chinese Herbal Formulas based on Basket Design(No.2018YFC1707407)。
文摘We present the rationale and design of a master protocol study that clarifies the effectiveness and safety of Chinese herbal formulas on Qi-stagnation and blood-stasis pattern(QBP).Three randomized controlled trials(RCTs)and real-world observational studies.Based on three registry cohorts of stable angina,tension-type headache and primary dysmenorrhea,patients with QBP will be enrolled in RCTs to receive either Xuefu Zhuyu(血府逐瘀,XFZY)oral liquid or a placebo,while patients with non-QBP will be enrolled in the observational studies and experience follow-up.1414 patients(RCTs:574;observational studies:840)will be recruited at seven centers in China over a 3-year period.The primary outcome is the visual analog scale of pain intensity.Adverse events will also be reported.The analysis will be undertaken separately in each sub-study,and then an overall analysis combining multiple subgroups will be performed to comprehensively investigate the effect of XFZY oral liquid.This study will provide high-quality evidence of XFZY oral liquid for QBP patients and show a paradigm of post-marketing evaluation of the effectiveness and safety for Chinese medicine following the notion of the pattern dominating different disease research models.
文摘Aiming at the weaknesses of LON bus, combining the coexistence of fieldbus and DCS (Distribu ted Control Systems) in control networks, the authors introduce a hierarchical hybrid control network design based on LON and master slave RS 422/485 protocol. This design adopts LON as the trunk, master slave RS 422/485 control networks are connected to LON as special subnets by dedicated gateways. It is an implementation method for isomerous control network integration. Data management is ranked according to real time requirements for different network data. The core components, such as control network nodes, router and gateway, are detailed in the paper. The design utilizes both communication advantage of LonWorks technology and the more powerful control ability of universal MCUs or PLCs, thus it greatly increases system response speed and performance cost ratio.
文摘目的全面检索国内外母方案设计的相关研究,了解其临床应用所覆盖的研究领域,为国内护理人员开展母方案设计相关研究的实施和推广提供参考。方法采用Arksey和O’Malley提出的范围综述方法,系统检索中国知网、万方数据库、中国生物医学文献数据库、维普、PubMed、Cochrane Library、Embase、Web of Science,检索时限为从建库至2023年4月。根据纳入、排除标准筛选文献,2名研究者独立提取母方案设计核心要素及其应用领域相关资料,采用描述性分析及主题分析法对提取结果进行整理。结果共纳入104篇文献,研究领域涉及肿瘤、临床心理学、新型冠状病毒肺炎等的药物开发评估及个性化健康计划的制定。母方案在国内外应用存在着明显差异,主要体现在3个方面:(1)应用范围不同,国外主要用于评估新药、疗法或医学器材的有效性和安全性,而在我国广泛应用于中医药领域;(2)研究类型有别,国外主要应用多中心随机对照试验、队列研究,而我国此类型研究相对较少;(3)经验和技术支持方面,由于历史和文化背景等原因,国外研究者在母方案的设计和实施方面拥有更丰富的经验和技术支持。因此,在推广和应用母方案时,需充分考虑国内外的差异,并结合本土实际情况探索出适合自身条件下的研究模式和方法,以推进其更广泛和深入的应用。结论母方案的实施是临床研究模式的一次突破性创新,当前母方案设计的应用多集中在肿瘤学、新型冠状病毒肺炎领域,但伞式试验和篮式试验可用于健康领域,平台试验的范围可应用于临床心理学和数字心理健康干预,国内护理研究者应重视对母方案设计的应用,在其指导下开展相关研究,提升护士创新行为,积极寻找新方法和技术,循证优化试验设计,解决临床护理问题,快速适应精准医学的发展。
文摘为满足管道空间位置与焊接参数相匹配的智能全位置焊接系统的工艺要求,构建了以焊接电源通信模块为从站节点的主从式CAN(Controller Area Network)总线网络控制焊接系统.提出基于PC控制的服务数据对象(ADS)通信方式访问焊接电源对象词典,采用过程同步数据对象传输保证了数据传输实时性,同时使用基于视窗技术的组态软件可实现焊接过程的监视和数据的传输,实现了焊接电源CAN-open总线控制在管道全位置焊接系统的计算机集成.实验表明,该系统数据传输快速、稳定,可满足管道全位置焊接工艺要求.
