Mathematical analysis and its experimental comparisons for the accumulative roll bonding(ARB)process with different superimposed layers

Based on the traditional two-layer accumulative roll bonding(TARB),the geometrical variations and mathematical relationship during the four-layer accumulative roll bonding(FARB)were derived and summarized.Furthermore,the multi-layer accumulative roll bonding(MARB)technology was proposed and the geometrical variations and mathematical relationship of MARB were simultaneously derived and summarized.Experimentally,Mg-14Li-3Al-2Gd(LAGd1432)sheets were fabricated by TARB and FARB,respectively.Compared with the TARB,the FARB has a higher accumulative efficiency in terms of accumulative layers,total number of interfaces,interface spacing,total deformation and equivalent strain.Therefore,the FARB-processed sheets in lower cycles have the similar microstructure and mechanical properties of the TARB-processed sheets in higher cycles.In addition,FARB process can further break through the deformation limit of TARB process in a single cycle through adopting two-step rolling in one cycle with 50%deformation in one pass and 75%accumulative deformation in one cycle,which can effectively solve the problem of poor interface bonding of the latest interface brought by the last cycle,and thus significantly improve the phenomenon of unstable performance of the ARB-processed sheets.

A Study on Table Olive Fermentations of Gemlik Olive cv. Through Physico-Chemical, Sensory Analyses and Mathematical Model Fitting

Gemlik olive was studied by a combined strategy consisting of physic-chemical, sensorial analyses and mathematical relationship among these parameters. Moisture contents of olive fruits decreased from 36.64% to 23.86%, both salt concentration and firmness increased to 9.35 g NaCI/100 g and 51.6% respectively. Total phenols of olive fruits changed from 1714.5 mg GAE/kg to 451.4 mg GAE/kg and radical scavenging activity （DPPH %） decreased from 91.48% to 32.14% respectively. L＊, a＊ and b＊ values of Gemlik olives were decreased during fermentation. There was a close relationship among physicochemical parameters of Gemlik olives in mathematically. In order to model this mathematical relation, Vandermonde matrix based 3th degree polynomial equations was used because it gave best model fits for the data of physical and chemical parameters of olive fruits. On the other hand, according to the results of sensory evaluation, the attributes of saltness and crispiness were highly scored （7.21-7.34） but the sensory scores of astringency and bitterness were evaluated from 4.56 to 5.61 by participants. The physico-chemical characteristic changes during the fermentation of Gemlik olives subjected to dry salting method for producing table olives were modeled and suggested with the determined physico-chemical evaluation scores to future studies.

Proposal and evaluation of a new norm index-based QSAR model to predict pEC50 and pCC50 activities of HEPT derivatives

The search and development of anti-HIV drugs is currently one of the most urgent tasks of pharmacological studies. In this work, a quantitative structure-activity relationship （QSAR） model based on some new norm indexes, was obtained to a series of more than 150 HEPT derivatives （1-[（2-hydroxyethoxy）methyl]-6-（phenylthio）thymine） to find their pEC50 （the required effective concentration to achieve 50% protection of MT-4 cells against the cytopathic effect of virus） and pCC50 （the required cytotoxic concentration to reduce visibility of 50% mock infected cell） activities. The model efficiencies were then validated using the leave-one-out cross validation （LOO-CV） and y- randomization test. Results indicated that this new model was efficient and could provide satisfactory results for prediction of pECso and pCC50 with the higher R2 train and the higher Rt2est. By using the leverage approach, the applicability domain of this model was further investigated and no response outlier was detected for HEFT derivatives involved in this work. Comparison results with reference methods demonstrated that this new method could result in significant improvements for predicting pEC50 and pCC50 of anti-HIV HEPT derivatives. Moreover, results shown in this present study suggested that these two absolutely different activities pECso and pCC50 of anti-HIV HEPT derivatives could be predicted well with a totally similar QSAR model, which indicated that this model mizht have the potential to be further utilized for other biological activities of HEFT derivatives.