Cortical hem signaling center: functions, development, and potential implications for evolution and brain disorders

Development of the telencephalon relies upon several signaling centers-localized cellular populations that supply secreted factors to pattern the cortical neuroepithelium.One such signaling center is the cortical hem,which arises during embryonic development at the telencephalic dorsal midline,adjacent to the choroid plexus and hippocampal primordium(Figure 1A).While the cortical hem has also been described in reptiles and birds,most of our knowledge about the developmental roles of the cortical hem is derived from the analysis in mice.The cortical hem produces several types of secreted molecules,including wingless-related integration site(Wnt)and bone morphogenetic(Bmp)proteins.The cortical hem is particularly important for the development of the hippocampus,which is involved in learning and memory,and the neocortex,which is the most complex brain region that mediates multiple types of behavior and higher cognitive functions(Mangale et al.,2008;Dal-Valle-Anton and Borrell,2022).

构建适用于高职教育的“Learner-centered”教学模式研究

当前,高职计算机学科的课堂存在着师生互动性欠缺,学生自主学习意识薄弱等明显的问题。在教育教学改革新动向、在线教育蓬勃发展新趋势的背景下,为了解决高职教育教学中存在的显著问题,我们提倡并研究"Learner Centered"教学模式.通过在相关计算机课程中的具体实施和问卷分析,总结"Learner-centered"教学模式对于高职教育的优势和可行性。

Chemical Bonds between Charged Atoms in the Even-Odd Rule and a Limitation to Eight Covalent Bonds per Atom in Centered-Cubic and Single Face-Centered-Cubic Crystals

A crystal is a highly organized arrangement of atoms in a solid, wherein a unit cell is periodically repeated to form the crystal pattern. A unit cell is composed of atoms that are connected to some of their first neighbors by chemical bonds. A recent rule, entitled the even-odd rule, introduced a new way to calculate the number of covalent bonds around an atom. It states that around an uncharged atom, the number of bonds and the number of electrons have the same parity. In the case of a charged atom on the contrary, both numbers have different parity. The aim of the present paper is to challenge the even-odd rule on chemical bonds in well-known crystal structures. According to the rule, atoms are supposed to be bonded exclusively through single-covalent bonds. A distinctive criterion, only applicable to crystals, states that atoms cannot build more than 8 chemical bonds, as opposed to the classical model, where each atom in a crystal is connected to every first neighbor without limitation. Electrical charges can be assigned to specific atoms in order to compensate for extra or missing bonds. More specifically the article considers di-atomic body-centered-cubic, tetra-atomic and dodeca-atomic single-face-centered-cubic crystals. In body-centered crystals, atoms are interconnected by 8 covalent bonds. In face-centered crystal, the unit cell contains 4 or 12 atoms. For di-element crystals, the total number of bonds for both elements is found to be identical. The neutrality of the unit cell is obtained with an opposite charge on the nearest or second-nearest neighbor. To conclude, the even-odd rule is applicable to a wide number of compounds in known cubic structures and the number of chemical bonds per atom is not related to the valence of the elements in the periodic table.

Family Centered Care versus Child Centered Care: The Malawi Context

Family Centered care is a model that is practiced and encouraged in child health care. It considers family as partners and collaborators in care of children. It aims at involving family in all aspects of child care. Family centered care also mentions involvement of child. However, emphasis is given more on family than child and does not take into account the older child’s capacity for independent decision making and right to privacy. As such, child’s needs are missed out. With child centered care, children are involved and supported at all levels of care based on their age and developmental stage. This paper aims to stress the importance of involving children within family centered care. Involving children in their care, makes them feel less threatened by the health care professional and their self esteem is promoted. Currently, no studies have been identified in Malawi that demonstrates full partnership between the family, child and the nurse. Furthermore, Family Centered Care and Child Centered Care as models are not fully practiced. It is therefore important to practice both family and child centered care in child health care if the needs of both family and children are to be addressed concurrently.

Comparison of visual effects of FS-LASIK for myopia centered on the coaxially sighted corneal light reflex or the line of sight

AIM：To compare visual quality after femtosecond laser in situ keratomileusis（FS-LASIK）,between the coaxially sighted corneal light reflex（CSCLR） group and conventional ablation line of sight（LOS） group.METHODS：In total,243 eyes（122 patients） were treated with centration on the CSCLR（visual axis） and 238 eyes（119 patients） treated with centration on the pupil center（LOS）.Postoperative outcomes [uncorrected visual acuity（UCVA）,best spectacle-corrected visual acuity（BSCVA）],safety index,efficacy index,refractive outcome,ablation center distance from the visual axis,corneal high-order aberrations,subjective discomfort glare and shadowing incidence rate,and contrast sensitivity at 1,3,and 6mo were measured and compared.RESULTS：The mean age was 27.77±7.1y in the CSCLR group and 26.03±7.70 y in the LOS group.Preoperatively,the manifest refraction spherical equivalent（MRSE） was-6.68±2.60 D in the CSCLR group and-6.65±2.68 D in the LOS group.The postoperative UCVA,BSCVA,MRSE（-0.03±0.263 D in the CSCLR group,-0.05±0.265 D in the LOS group）,efficacy index（1.04,1.03）,and safety index（1.09,1.08） were not significantly different between the groups（all P〉0.05）.In total,3% lost one line and more of BSCVA in the CSCLR group,as 9% in the LOS group postoperatively（P〈0.05）.The ablation center deviation was 0.20±0.15 mm from the visual axis（Pentacam system default setting;range,0-0.75 mm） in the CSCLR group,and 0.43±0.22 mm（range,0-1.32 mm） in the LOS group（P〈0.0001）.Statistically significant greater augmentationof total corneal higher-order aberrations（0.15±0.10 μm and 0.20±0.12 μm respectively,P=0.03） and vertical and horizontal coma（P〈0.0001） were noted in the LOS group.Subjective discomfort glare and shadowing incidence rates were 8.59% and 17.5% in the CSCLR and LOS groups,respectively（P〈0.05）.The 1-month postoperative contrast sensitivity visual acuity in the CSCLR group was significantly higher than that in the LOS group on contrast（100%,25%,10%） with a dark background,but there was no significant difference between the groups at 3 or 6m.CONCLUSION：Myopic LASIK centered on the CSCLR achieves significantly lower induction of loss of BSCVA,corneal high-order aberrations,and lower risk of subjective discomfort glare and shadowing,and lower decline in early contrast sensitivity by comparison with centration on the LOS,giving advantages in visual quality postoperatively.

Application of Student-centered Learning Approach to English Listening and Speaking Class in Vocational Schools

Student-centered learning approach is focused on the students' demands and interests.Applying student-centered approach puts forward higher requirement to English teachers.This article first analyzes the theory of student-centered learning approach and compares teacher-centered approach with it.Based on the research information and teaching experience,the author summarizes four strategies about how to apply student-centered learning approach to English listening and speaking class in vocational schools.

Fractional Optical Solitons and Fractional Noether’s Theorem with Ortigueira’s Centered Derivatives

This paper shows that the centered fractional derivatives introduced by Manuel Duarte Ortigueira in 2006 are useful in the description of optical solitons. It is shown that we can construct a fractional extension of the nonlinear Schrödinger (NLS) equation which incorporates Ortigueira’s derivatives and has soliton solutions. It is also shown that this fractional NLS equation has a Lagrangian density and can be derived from a variational principle. Finally, a fractional extension of Noether’s theorem is formulated to determine the conserved quantities associated to the invariances of the action integral under infinitesimal transformations.

Exploration on the Construction of "Student-centered" Professional Three-Dimensional Practical Teaching System

Talent cultivation is the primary task of universities.Local general undergraduate colleges and universities should adhere to the basic guidelines of systematization,practicality and integration,continuously explore the concept of"studentcentered"talent cultivation,and build a threedimensional practical teaching system from three aspects:strengthening the planning and design of the three-dimensional practical teaching system;building an internal and external practical teaching platform;and improving the evaluation and guarantee system of practical teaching quality.The system of practical teaching quality evaluation and guarantee is improved.In order to improve the cultivation ability of applied talents in all aspects.

Centered simple waves for the two-dimensional pseudo-steady isothermal ?ow around a convex corner

The two-dimensional(2D) pseudo-steady isothermal flow, which is isentropic and irrotational, around a convex corner is studied. The self-similar solutions for the supersonic flow around the convex corner are constructed, where the properties of the centered simple wave are used for the 2D isentropic irrotational pseudo-steady Euler equations. The geometric procedures of the center simple waves are given. It is proven that the supersonic flow turns the convex corner by an incomplete centered expansion wave or an incomplete centered compression wave, depending on the conditions of the downstream state.

CYCLIC DEFORMATION OF FACE CENTERED CUBIC CRYSTALS AND ITS DISLOCATION INTERACTION MODEL——Ⅱ.DISLOCATION INTERACTION MODEL OF CYCLIC DEFORMATION

A dislocation interaction model has been proposed for cyclic deformation of fcc crystals.Ac- cording to this model,cyclic stress-strain responses and saturation dislocation structures of a crystal are associated with the modes and intensities of dislocation interactions between slip systems active in the crystal; and,hence,may be predicted by the location of its tensile axis in the crystallographic triangle.This model has successfully explained the different behaviours of double-slip crystals and multi-slip behaviours of some crystals with orientations usually con- sidered as single-slip ones.

A Local Property of Hausdorff Centered Measure of Self-Similar Sets

We analyze the local behavior of the Hausdorff centered measure for self- similar sets. If E is a self-similar set satisfying the open set condition, thenC^s（E∩B（x,r））≤（2r）^sfor all x ∈ E and r〉 0, where Cs denotes the s-dimensional Hausdorff centered measure. The above inequality is used to obtain the upper bound of the Hausdorff centered measure. As the applications of above inequality, We obtained the upper bound of the Hausdorff centered measure for some self-similar sets with Hausdorff dimension equal to 1, and prove that the upper bound reach the exact Hausdorff centered measure.

A Monte Carlo Simulation of a Monomer Dimer CO-O2 Catalytic Reaction on the Surface and Subsurface of a Face-centered Cubic Lattice

The presence of oxygen in the subsurface in monomer-dimer reactions(CO-O_(2)and NO-CO)is observed experimentally.The effect of subsurface oxygen on a CO-O_(2)catalytic reaction on a face-centered cubic(FCC)lattice is studied using Monte Carlo simulation.The effect of adding subsurface neighbours on the phase diagram is also extensively explored.It is observed that the subsurface oxygen totally eliminates the typical second order phase transition.It is also shown that the introduction of the diffusion of O atoms and the subsurface of the FCC lattice shifts the single transition point towards the stoichiometric ratio.

Design of space-centered interaction using invisible and intangible spatial inputs

In this paper,we investigate methodologies to improve direct-touch interaction on invisible and intangible spatial input.We firstly discuss about the motive of looking for a new input method for whole body interaction and how it can be meaningful.We also describe the role that can play spatial interaction to improve the freedom of interaction for a user.We propose a method of spatial centered interaction using invisible and intangible spatial inputs.However,given their lack of tactile feedback and visual representation,direct touch interaction on such input can be confused.In order to make a step toward understanding causes and solutions for such phenomena,we made 2 user experiments.In the first one,we test 5 setups of helper that provide information of the location of the input by constraining the dimension it is located at.The results show that using marker on the ground and a relationship with the height of the user’s body improve significantly the locative task.In the second experiment,we create a dancing game using invisible and intangible spatial inputs and we stress the results obtained in the first experiment within this cognitively demanding context.Results show that the same setup of helper is still providing very good results in that context.

对流扩散方程的迎风Cell-centered混合元方法

讨论对流扩散方程的一种迎风Cell-centered混合元方法,在不同的矩形网格剖分下,分别用常量浓度元与常量通量元逼近原问题的解,得到了浓度与通量的一阶L2模误差估计,并通过数值算例验证了理论分析结果的正确性。

Differentiation between two healthcare concepts:Person-centered and patient-centered care

1.Background Engel's biopsychosocial model,which was constructed in 1977,was considered a momentous breakthrough from the traditional biomedical model of medicine that regards the person as a disease-carrier requiring diagnosis and treatment[1]towards recognition of the whole person and furnish customized care.This model argues that health should not be considered solely on biological factors but on a combination of biological,psychological,and social factors[2].This idea of considering individuals as a whole and respecting their rights to self-determination has led to a shift in the care model from disease-centered care to patient-centered or person-centered care.The latter two care models are both abbreviated as PCC.Ensuring that people are involved in and central to the healthcare process is now recognized as a key component in developing high-quality care.Studies have revealed that both concepts of care can help improve people's health condition and lower health service burdens.Thus,countries and healthcare organizations have been paying close attention to the patients'concerns.The National Health Service in England has made person-centered care as one of its seven core principles[3].

The Empathic Patient Centered Approach in the Anesthetic Preoperative Interview

Background: Multiple studies in the primary care field have indicated the benefits of using a patient centered approach in communication with the patient;such interviewing methods have been shown to improve patient satisfaction and adherence. There is a scarcity of anesthetic literature regarding communication skills in the perioperative period. The goal is to analyze to what extent empathic patient-centered communication methods are being used by anesthesia providers. Communication scores will be compared among providers, as well as to providers across several different subspecialties. Methods: This study is an observational descriptive study at a large tertiary care center, University Hospital in Newark, NJ. The observer observes and grades patient interviews, scoring against established criteria using an adapted version of the Kalamazoo grading tool. The researcher observes and grades the preoperative interview using the adapted Kalamazoo scale. At the end of the observed encounter, the anesthesia providers are asked to fill out a brief form detailing their demographic history, details regarding the providers’ length and type of clinical education and training, undergraduate education, previous communication training, number of years of practice, primary language, gender, and age will be obtained. Results: Anesthesia providers included in the study were physician anesthesiologists, residents, and nurse anesthetists. The average Kalamazoo score was 28.7 amongst all providers. There was no significant effect of provider level on the score at the p Conclusions: The data revealed anesthesia providers provide patient-centered encounters with a mean score of 28.7, which is higher than the average for providers from multiple different specialties observed in Joyce, et al. study (mean score of 25.25). The subcategories “Understanding patient’s perspective” and “reaches agreement” scored 3.86, and 3.83, respectively. This may indicate that anesthesia providers can improve on allowing the patient to communicate their understanding of anesthesia, as well as collecting information from the patient that can affect their anesthesia (i.e., severe nausea following previous anesthesia).

User Centered Design for Battlefield Screen

This thesis paper is a brief summary of user centered design, (particularly in the situation of under the battlefield), which incorporates the related information after reviewing many other papers. A display screen user requires an ability to provide proper information while considering a variety of information in a short period. While operating the display screen, the user is heavily pressed for time as the missions are allocated through many different steps of orders. In addition, since a failure would cause fatal damage or cause further defeat, this increases the pressure of time. The right environment for operating a display screen is most useful when the user is in the most vulnerable time period or long-term continuous operation of the display screen. In that kind of sterile environment, the operating display screen is there to help the user’s decisions for the matter at hand, in this it should follow the user centered design and improve the user’s handiness and use. Furthermore, the information should be provided in accordance with the user's informational and perceptional process, and the capacity of the information process should be improved with the movement through each process and step. This thesis paper can be used as a reference material when designing the display screen in order to apply a user’s experiences.

On the Learner-Centered Teaching Approach——The Reflection Getting from New College English By ZheJiang University

This paper first focuses on a brief evaluation of the teacher-centered and the learner-centered methodologies and the relevant result and the necessity for changing. Secondly ,it represents the practical ways of teaching based on the learner-centered approach in classrooms to show how students' initiative is given .Thirdly , it presents the guidance for fellow teachers and students in group activities .The author of the paper believes that getting students started is the initial step towards active learning and fruitful teaching. It is proposed that efforts made to get students involved should focus not only on forms of activities but also on their contents , skill integration and establishing cooperative relationships between teachers and students or among students.

A Survey of Human-centered Intelligent Robots:Issues and Challenges

Intelligent techniques foster the dissemination of new discoveries and novel technologies that advance the ability of robots to assist and support humans. The human-centered intelligent robot has become an important research field that spans all of the robot capabilities including navigation, intelligent control, pattern recognition and human-robot interaction. This paper focuses on the recent achievements and presents a survey of existing works on human-centered robots. Furthermore, we provide a comprehensive survey of the recent development of the human-centered intelligent robot and discuss the issues and challenges in the field.

The Lead-in in Learner-centered English Classroom Teaching

For many years,people have been exploring different kinds of teaching pattern of triggering the students' interests in English and enhancing the efficiency of teaching and have been seeking different kinds of approaches of optimizing the process of class teaching.So many English class teaching methods such as five-step teaching method and task-based teaching method are put forward,but these methods pay more attention to imparting new knowledge to students and to training their ability of using English than to triggering their interests in English.This article try to solve this problem by exploring different ways of lead-in in English classroom teaching to arouse students'interests in English learning.