Numerical simulation of solid tumor angiogenesis with Endostatin treatment:a combined analysis of inhibiting effect of anti-angiogenic factor and micro mechanical environment of extracellular matrix

To investigate the influence of anti-angiogenesis drug Endostatin on solid tumor angiogenesis, a mathematical model of tumor angiogenesis was developed with combined influences of local extra-cellular matrix mechanical environment, and the inhibiting effects of Angiostatin and Endostatin. Simulation results show that Angiostatin and Endostatin can effectively inhibit the process of tumor angiogenesis, and decrease the number of blood vessels in the tumor. The present model could be used as a valid theoretical method in the investigation of anti-angiogenic therapy of tumors.

Numerical simulation of tumor-induced angiogenesis influenced by the extra-cellular matrix mechanical environment

To investigate tumor-induced angiogenesis under the influence of the mechanical environments inside and outside the tumor, mathematical model of tumor angiogenesis was developed. In the model, extra-cellular matrix （ECM） was treated as a thin plane. The displacement of ECM is obtained from the force balance equation consisted of the ECs traction, the ECM visco-elastic forces and the exter- nal forces. Simulation results show that a layered capillary network is obtained with a well vascularized region at the periphery of the tumor. The present model can be used as a valid theoretical method in the basic researches in tumorinduced angiogenesis.

Seismogenic environment and mechanism of the Yangbi M_(S)6.4 earthquake in Yunnan,China

The Yangbi M_(S)6.4 earthquake occurred on May 21,2021 in western Yunnan,China,where moderate earthquakes strike frequently.It exhibited a typical“foreshock-mainshock-aftershock”sequence and did not occur on a pre-existing active fault.The seismogenic environment and mechanism of this earthquake have aroused considerable research attention.In this study,we obtain the three-dimensional v_(P),v_(S)and v_(P)/v_(S)images using the v_(P)/v_(S)consistency-constrained double-difference tomography method,which improves the accuracy of v_(P)/v_(S)models.We focus on characteristics of v_(P)/v_(S)images in areas with a lateral resolution of 0.1°,and reveal the seismogenic environment of the Yangbi M_(S)6.4 earthquake.The conclusions are as follows:(1)Low velocity and high-v_(P)/v_(S)anomalies are revealed at different depths around the northern segment of the Red River fault.v_(S)and v_(P)/v_(S)images along the Weixi-Qiaohou-Weishan fault and the buried faults on its west show obviously segmented feature.(2)The source region of the Yangbi M_(S)6.4 earthquake is located in a low-v_(P)/v_(S)zone implying high medium strength.High-v_(P)/v_(S)anomalies in its NW direction indicate cracks development and the existence of fluids or partial melts,which are unfavorable for stress accumulation and triggering large earthquakes.Such conditions have also prevented the earthquake sequence from extending northwestward.(3)With the southeastward extrusion of materials from the Tibetan Plateau,fluid migration was blocked by the low-v_(P)/v_(S)body in the source region.The high-v_(P)/v_(S)anomaly beneath the source region may implies that the fluids or partial melts in the middle and lower crust gradually weakened medium strength at the bottom of the seismogenic layer,and preparing the largest foreshock in the transition zone of high to low v_(P)/v_(S).Meanwhile,tectonic stress incessantly accumulated in the brittle upper crust,eventually led to the M_(S)6.4 earthquake occurrence.

Research on the Environmental Protection Mechanism under the Framework of WTO

WTO, as the most influencing international economic organization, has given rise to some problems worthy of thinking deeply when creating a great trade platform for all countries. For example, the original ecological environment has been destroyed by the development of trade and economy, so that the countries from all over the world are encountering serious environmental crisis. In this paper, the current situation under the new economic environment is introduced first, the environmental protection mechanism in the report of the WTO panel, and also comprehensive countermeasures performed in the new environmental protection mechanism are proposed. Hopefully, this paper can play a help in the further researches.

Endovascular stent-induced alterations in host artery mechanical environments and their roles in stent restenosis and late thrombosis

Cardiovascular stent restenosis remains a major challenge in interventional treatment of cardiovascular occlusive disease.Although the changes in arterial mechanical environment due to stent implantation are the main causes of the initiation of restenosis and thrombosis,the mechanisms that cause this initiation are still not fully understood.In this article,we reviewed the studies on the issue of stent-induced alterations in arterial mechanical environment and discussed their roles in stent restenosis and late thrombosis from three aspects:(i)the interaction of the stent with host blood vessel,involve the response of vascular wall,the mechanism of mechanical signal transmission,the process of re-endothelialization and late thrombosis;(ii)the changes of hemodynamics in the lumen of the vascular segment and(iii)the changes of mechanical microenvironment within the vascular segment wall due to stent implantation.This review has summarized and analyzed current work in order to better solve the two main problems after stent implantation,namely in stent restenosis and late thrombosis,meanwhile propose the deficiencies of current work for future reference.

The Structure of A Turbulent Jet in A Crossflow-Effect of Jet-Crossflow Velocity

A comprehensive numerical study on the three-dimensional structure of a turbulent jet in crossflow is performed. The jet-to-crossflow velocity ratio (R) varies in the range of 2 - 16; both vertical jets and inclined jets without excess streamwise momentum are considered. The numerical results of the Standard two-equation k-ε model show that the turbulent structure can be broadly categorised according to the jet-to-crossflow velocity ratio. For strong to moderate jet discharges, i.e. R> 4, the jet is characterized by a longitudinal transition through a bent-over phase during which the jet becomes almost parallel with the main freestream, to a sectional vortex-pair flow with double concentration maxima; the computed flow details and scalar mixing characteristics can be described by self-similar relations beyond a dimensionless distance of around 20-60. The similarity coefficients are only weakly dependent on R. The cross-section scalar field is kidney-shaped and bifurcated, vvith distinct double concentration maxima; the aspect ratio is found to be around 1.2. A loss in vertical momentum is ob-served and the added mass coefficient of the jet motion is found to be approximately 1. On the other hand, for weak jets in strong crossflow, i. e. R ≥ 2, the lee of the jet is characterized by a negative pressure region. Although the double vortex flow can stili be noted, the scalar field becomes more symmetrical and no longer bifurcated. The similarity coeffcients are al-so noticeably different. The predicted jet flovv characteristics and mixing rates are well supported by experimental and field dala

Treatment of condylar osteophyte in temporomandibular joint osteoarthritis with muscle balance occlusal splint and long-term follow-up:A case report

BACKGROUND Condylar osteophytes,a remodeling form of temporomandibular joint osteoarthritis(TMJ OA),mainly manifest as marginal angular outgrowths of the condyle.Previous researchers have advocated surgical removal of condylar osteophytes.Reports on the effect of occlusal splint on TMJ OA patients’joints have mostly focused on treatment with this splint,which can reduce the absorption of the affected condyle and promote repair and regeneration.However,the effect of the splint on the dissolution of condylar osteophytes has not yet been reported.CASE SUMMARY A 68-year-old female patient suffered from occlusal discomfort with left facial pain for 2 years.Cone beam computed tomography showed a rare osteophyte on top of her left condyle.She was finally diagnosed with TMJ OA.The patient refused surgical treatment and received conservative treatment with a muscle balance occlusal splint.The pain experienced by the patient on the left side of her face was relieved,and her chewing ability recovered after treatment.The osteophyte dissolved,and the condylar cortex remained stable during long-term follow-up observations.CONCLUSION The muscle balance occlusal splint could be a noninvasive means of treating condylar osteophytes in TMJ OA patients.

Numerical Solution of Lock-Release Gravity Current with Viscous Self-Similar Regime

Lock-release gravity currents with a viscous self-similar regime are simulated by use of the renormalization group (RNG) k-ε model for Reynolds-stress closure. Besides the turbulent regime with initially a slumping phase of a constant current front speed and later an inviscid self-similar phase of front speed decreasing as t -1/3 (where t is the time measured from release), the viscous self-similar regime is satisfactorily reproduced with front speed decreasing as t -4/5, consistent with well known experimental observations.

Numerical Experiment on Two-Dimensional Line Thermal

The time evolution of a two-dimensional line thermal-a turbulent flow produced by an initial element with significant buoyancy released in a large water body, is numerically studied with the two-equation k - epsilon model for turbulence closure. The numerical results show that the thermal is characterized by a vortex pair flow and a kidney shaped concentration structure with double peak maxima; the computed flow details and scalar mixing characteristics can be described by self-similar relations beyond a dimensionless time around 10. There are two regions in the flow field of a line thermal: a mixing region where the concentration of tracer fluid is high and the flow is turbulent and rotational with a pair of vortex eyes, and an ambient region where the concentration is zero and the flow is potential and well-described by a model of doublet with strength very close to those given by early experimental and analytical studies. The added virtual mass coefficient of the thermal motion is found to be approximately 1. The aspect ratio for the kidney-shaped sectional thermal is found to be around 1.45 for the self-similar phase. The predicted thermal spreading and mixing rate compares well with experimental data.

Review of the progress in preparing nano TiO_2: An important environmental engineering material

TiO2 nanomaterial is promising with its high potential and outstanding performance in photocatalytic environmental applications, such as CO2 conversion, water treatment, and air quality control. For many of these applications, the particle size, crystal structure and phase, porosity, and surface area influence the activity of TiO2 dramatically. TiO2 nanomaterials with special structures and morphologies, such as nanospheres, nanowires, nanotubes, nanorods, and nanoflowers are thus synthesized due to their desired characteristics. With an emphasis on the different morphologies of TiO2 and the influence factors in the synthesis, this review summarizes fourteen TiO2 preparation methods, such as the sol-gel method, solvothermal method, and reverse micelle method. The TiO2 formation mechanisms, the advantages and disadvantages of the preparation methods, and the photocatalytic environmental application examples are proposed as well.

Interactions between engineered nanoparticles and dissolved organic matter: A review on mechanisms and environmental effects

Dissolved organic matter（DOM） is ubiquitous in the environment and has high reactivity.Once engineered nanoparticles（ENPs） are released into natural systems, interactions of DOM with ENPs may significantly affect the fate and transport of ENPs, as well as the bioavailability and toxicity of ENPs to organisms. However, because of the complexity of DOM and the shortage of useful characterization methods, large knowledge gaps exist in our understanding of the interactions between DOM and ENPs. In this article, we systematically reviewed the interactions between DOM and ENPs, discussed the effects of DOM on the environmental behavior of ENPs, and described the changes in bioavailability and toxicity of ENPs caused by DOM. Critical evaluations of published references suggest further need for assessing and predicting the influences of DOM on the transport,transformation, bioavailability, and toxicity of ENPs in the environment.

The mechanism of environmental D-xylose perception by the bacterial membrane two-component complex XylFII-LytS

D-xylose,the main building block of plant biomass,is a pentose sugar that can be used by bacteria as a carbon source for bio-based fuel and chemical production through fermentation.In bacteria,the first step for D-xylose metabolism is signal perception at the membrane.Scientists previously identified a threecomponent system in Firmicutes bacteria comprising a membrane-associated sensor protein(XylFII)。

A new approach for one-pot,green synthesis of new polycyclic indoles in aqueous solution

Electro-oxidation of phenylamine derivatives（1a and 1b） have been studied in the presence of pyrazolidine-3,5-dione（3） as a nucleophile in phosphate buffer solution mixed with ethanol,using voltammetric and spectroscopic techniques.The obtained results indicated that the oxidized form of phenylamines（2a and 2b） participate in Michael addition type reactions with pyrazolidine-3,5-dione（3） and via ECECCCCC mechanisms convert to the corresponding new polycyclic indoles（12a and 12b）.In the present study,new polycyclic indole derivatives were synthesized with good yields and high purity using a facile,one-pot and environmentally friendly electrochemical method,without any chemical catalysts,toxic solvents and hard conditions.