Driving pressure in mechanical ventilation:A review

Driving pressure(ΔP)is a core therapeutic component of mechanical ventilation(MV).Varying levels ofΔP have been employed during MV depending on the type of underlying pathology and severity of injury.However,ΔP levels have also been shown to closely impact hard endpoints such as mortality.Considering this,conducting an in-depth review ofΔP as a unique,outcome-impacting therapeutic modality is extremely important.There is a need to understand the subtleties involved in making sureΔP levels are optimized to enhance outcomes and minimize harm.We performed this narrative review to further explore the various uses ofΔP,the different parameters that can affect its use,and how outcomes vary in different patient populations at different pressure levels.To better utilizeΔP in MV-requiring patients,additional large-scale clinical studies are needed.

Mechanical properties and damage characteristics of solidified body-coal combination in continuous driving and gangue backfilling

Recovery of the coal buried under buildings,railways and water bodies and the residual coal in irregularly arranged fully mechanized mining faces is a common engineering problem facing underground coal mining.In this study,a mining technology of continuous driving and gangue backfilling(CDGB)was proposed.The technology,which can not only alleviate ground subsidence and gangue discharge,but also release the above-mentioned coals,contributes to green and efficient sustainable development of mining.The stability of the system of the solidified body-reserved coal pillar combination(S-C combination)is crucial to the CDGB technology.Therefore,it is of great significance to explore the mechanical and damage characteristics of S-C combination in the synergistic bearing process.First,four sets of differentshaped S-C combination specimens were fabricated and a S-C combination bearing structure in CDGB was constructed to explore the differences in mechanical characteristics and damage modes of different-shaped S-C combination specimens during CDGB.Subsequently,their surface strain field evolutions and acoustic emission(AE)response characteristics in the load-bearing process were obtained with the aid of the digital image correlation technique and the AE signal monitoring system.Furthermore,a damage evolution model based on AE parameters and mechanical parameters was established to clarify the damage evolution law.The following results were obtained:(1)The free area of S-C combination can serve as a quantitative index to evaluate the stability of the overburden control system;(2)The concept of critical value k of the free area was first proposed.When the free area exceeds the critical value k(free area ratio greater than 1.13),the deformation resistance and the free area changes becomes negatively correlated;(3)As the free area expands,the failure of the S-C combination specimen evolves from tensile failure to shear failure.The distribution characteristics of the axial strain field also verified such a change in the failure mode;(4)When the free area expands,the peak AE count gradually changes from“double peaks”to“a single peak”.In this process,the expansion of free area shortens the time for accumulating and releasing energy during loading.Micro cracks generated in the specimen change from a phased steep growth to a continuous increase,and the process in which micro cracks develop,converge,intersect and connect to form macro cracks accelerates.The damage evolution law concluded based on AE parameters and mechanical parameters can well characterize the damage evolution process of S-C combination,providing certain reference for the study on the synergistic bearing of S-C combination during CDGB.

Influence and Suggestions on Trial Implementation Measures for Early Settlement Mechanism of Drug Patent Disputes

Objective To study the core contents of the“Implementation Measures for Early Settlement Mechanism of Drug Patent Disputes(Trial)”in China,and to clarify the concerns for enterprises in future work.Methods A comprehensive review of the literature was used to find out the key regulations for detailed decomposition and analysis.Results and Conclusion By analyzing the key clauses of China’s“Implementation Measures for Early Settlement Mechanism of Drug Patent Disputes(Trial)”,some practical countermeasures and suggestions are put forward for related research and development(R&D)innovation and drug declaration of enterprises.

Inhibition of hepatitis B virus via selective apoptosis modulation by Chinese patent medicine Liuweiwuling Tablet

BACKGROUND Liuweiwuling Tablet(LWWL)is a Chinese patent medicine approved for the treatment of chronic inflammation caused by hepatitis B virus(HBV)infection.Previous studies have indicated an anti-HBV effect of LWWL,specifically in terms of antigen inhibition,but the underlying mechanism remains unclear.AIM To investigate the potential mechanism of action of LWWL against HBV.METHODS In vitro experiments utilized three HBV-replicating and three non-HBV-replicating cell lines.The in vivo experiment involved a hydrodynamic injectionmediated mouse model with HBV replication.Transcriptomics and metabolomics were used to investigate the underlying mechanisms of action of LWWL.RESULTS In HepG2.1403F cells,LWWL(0.8 mg/mL)exhibited inhibitory effects on HBV DNA,hepatitis B surface antigen and pregenomic RNA(pgRNA)at rates of 51.36%,24.74%and 50.74%,respectively.The inhibition rates of LWWL(0.8mg/mL)on pgRNA/covalently closed circular DNA in HepG2.1403F,HepG2.2.15 and HepG2.A64 cells were 47.78%,39.51%and 46.74%,respectively.Integration of transcriptomics and metabolomics showed that the anti-HBV effect of LWWL was primarily linked to pathways related to apoptosis(PI3K-AKT,CASP8-CASP3 and P53 pathways).Apoptosis flow analysis revealed that the apoptosis rate in the LWWL-treated group was significantly higher than in the control group(CG)among HBV-replicating cell lines,including HepG2.2.15(2.92%±1.01%vs 6.68%±2.04%,P<0.05),HepG2.A64(4.89%±1.28%vs 8.52%±0.50%,P<0.05)and HepG2.1403F(3.76%±1.40%vs 7.57%±1.35%,P<0.05)(CG vs LWWL-treated group).However,there were no significant differences in apoptosis rates between the non-HBV-replicating HepG2 cells(5.04%±0.74%vs 5.51%±1.57%,P>0.05),L02 cells(5.49%±0.80%vs 5.48%±1.01%,P>0.05)and LX2 cells(6.29%±1.54%vs 6.29%±0.88%,P>0.05).TUNEL staining revealed a significantly higher apoptosis rate in the LWWL-treated group than in the CG in the HBVreplicating mouse model,while no noticeable difference in apoptosis rates between the two groups was observed in the non-HBV-replicating mouse model.CONCLUSION Preliminary results suggest that LWWL exerts a potent inhibitory effect on wild-type and drug-resistant HBV,potentially involving selective regulation of apoptosis.These findings offer novel insights into the anti-HBV activities of LWWL and present a novel mechanism for the development of anti-HBV medications.

Spatiotemporal characteristics and driving mechanisms of land use/land cover(LULC)changes in the Jinghe River Basin,China

Understanding the trajectories and driving mechanisms behind land use/land cover(LULC)changes is essential for effective watershed planning and management.This study quantified the net change,exchange,total change,and transfer rate of LULC in the Jinghe River Basin(JRB),China using LULC data from 2000 to 2020.Through trajectory analysis,knowledge maps,chord diagrams,and standard deviation ellipse method,we examined the spatiotemporal characteristics of LULC changes.We further established an index system encompassing natural factors(digital elevation model(DEM),slope,aspect,and curvature),socio-economic factors(gross domestic product(GDP)and population),and accessibility factors(distance from railways,distance from highways,distance from water,and distance from residents)to investigate the driving mechanisms of LULC changes using factor detector and interaction detector in the geographical detector(Geodetector).The key findings indicate that from 2000 to 2020,the JRB experienced significant LULC changes,particularly for farmland,forest,and grassland.During the study period,LULC change trajectories were categorized into stable,early-stage,late-stage,repeated,and continuous change types.Besides the stable change type,the late-stage change type predominated the LULC change trajectories,comprising 83.31% of the total change area.The period 2010-2020 witnessed more active LULC changes compared to the period 2000-2010.The LULC changes exhibited a discrete spatial expansion trend during 2000-2020,predominantly extending from southeast to northwest of the JRB.Influential driving factors on LULC changes included slope,GDP,and distance from highways.The interaction detection results imply either bilinear or nonlinear enhancement for any two driving factors impacting the LULC changes from 2000 to 2020.This comprehensive understanding of the spatiotemporal characteristics and driving mechanisms of LULC changes offers valuable insights for the planning and sustainable management of LULC in the JRB.

FORCE ANALYSIS CONSIDERING MANUFACTURE ERROR OF PIN-HOLE-OUTPUT MECHANISM IN CYCLOID DRIVE

Based on the analysis of the pin-hole-output mechanism in the cycloid drive,a more accurate force analysis method is provided, in which the manufacture error is considered, bywhich the contact force between pin and pin-hole can be calculated more accurately in the wholedriving process.

Strategy to control crawling vehicles with automated mechanical transmission

In order to move vehicles with automated mechanical transmission （AMT） a little bit of distance, such as reversing into or moving in a garage, a control strategy for crawling vehicles was proposed. Based on the dynamic analysis of vehicle starting process and requirements of crawl driv- ing for the vehicle, a control strategy of the clutch was designed. The strategy increased the.slipping friction torque first and then decreased it, in order to realize the crawl driving. The speed increased by the engagement of the clutch, and then the clutch turned to disengage to the half disengage point, when the speed met the requirements. Based on the control strategy, a control software was de- signed. In the end, the software was tested on a vehicle with AMT. The lowest steady vehicle speed was reduced to 40% of the original value, which was set in the control strategy.

OPTIMAL TORQUE CONTROL STRATEGY FOR PARALLEL HYBRID ELECTRIC VEHICLE WITH AUTOMATIC MECHANICAL TRANSMISSION

In parallel hybrid electrical vehicle （PHEV） equipped with automatic mechanical transmission （AMT）, the driving smoothness and the clutch abrasion are the primary considerations for powertrain control during gearshift and clutch operation. To improve these performance indexes of PHEV, a coordinated control system is proposed through the analyzing of HEV powertrain dynamic characteristics. Using the method of minimum principle, the input torque of transmission is optimized to improve the driving smoothness of vehicle. Using the methods of fuzzy logic and fuzzy-PID, the engaging speed of clutch and the throttle opening of engine are manipulated to ensure the smoothness of clutch engagement and reduce the abrasion of clutch friction plates. The motor provides the difference between the required input torque of transmission and the torque transmitted through clutch plates. Results of simulation and experiments show that the proposed control strategy performs better than the contrastive control system, the smoothness of driving and the abrasion of clutch can be improved simultaneously.

Study on destressing technology for a roadway driven along goaf in a fully mechanized top-coal caving face

Based on the deformation characteristics of the roadways driven along goaf in fully mechanized top coal caving faces, the author considers that it is the key to ensure the stability of surrounding rocks of roadway driven along goaf to control the deformation during the period affected by mining. Considering the characteristics of the roadway layout in fully mechanized top coal caving faces, a technical scheme of destressing is put forward and the destressing effect is analyzed by using the software of Universal Distinct Element Code 3 0(UDEC 3 0).

Study of mechanical principle of floor heave of roadway driving along next goaf in fully mechanized sub-level caving face

Abstract On the basis of analyzing floor strata mechanical circumstance of the roadway, the mechanical model was established. The relative displacement of roadway floor, narrow pillar floor coal mass and floor strata was calculated, the results showed that the high abutment pressure on coal mass beside the roadway was the main reason to lead to relative displacement of floor strata. And the roadway floor heave come mainly from three aspects. Firstly, the roadway floor strata is easily fractured by the stretch stress. Secondly, because the high abutment pressure is greater than the uniaxial compressive strength of floor strata, when the roadway floor strata are fractured, the coal mass floor strata at the same depth will be fractured, and broken rock will fluid into the open roadway. Thirdly, comparing with the coal mass floor, the roadway floor is relative ascending.

Phase-dependent double optomechanically induced transparency in a hybrid optomechanical cavity system with coherently mechanical driving

We propose a scheme that can generate tunable double optomechanically induced transparency in a hybrid optomechanical cavity system.In this system, the mechanical resonator of the optomechanical cavity is coupled with an additional mechanical resonator and the additional mechanical resonator can be driven by a weak external coherently mechanical driving field.We show that both the intensity and the phase of the external mechanical driving field can control the propagation of the probe field, including changing the transmission spectrum from double windows to a single-window.Our study also provides an effective way to generate intensity-controllable, narrow-bandwidth transmission spectra, with the probe field modulated from excessive opacity to remarkable amplification.

A NEW STATIC MECHANICS MODEL TO SOLVE CONTACT PROBLEMS IN MECHANICAL SYSTEMS

The coupling of the local contact problems between the components and the deformation of the components in the mechanical system were discovered.A series of coordinate systems have been founded to describe the mechanical system with the contact problems.The method of isolating the boundary of contact body from others has been used to describe the constraint between the contacting points.A more generalized static mechanics model of the mechanical system with the contact problems has been founded through the principle of virtual work.As an application,the model was used to study the multi_teeth engagement problems in the inner meshed planet gear systems.The stress distribution of contact gears was got.A test has verified that the static contact model and the computational method are right.

DYNAMICS OF THE LOOPER DRIVE MECHANISM ON A BLIND STITCHING MACHINE

The looper drive mechanism is a main moving part in the blind stitching machine, which is aspatial 5 bar RRRSR linkage. In this paper, a dynamic analysis of the looper drive mechanism is made by means of the ma-trix method. Two methods are adopted in the calculation of the shaking force and shaking moment, one isdone by the constraint reaction of the flame-connected kinematic parts; the other is the inertialforces of all moving links.

Deformation mechanism of surrounding rocks and key control technology for a roadway driven along goaf in fully mechanized top-coal caving face

The variation of the stress in the bolted surrounding rocks structure of the roadway driven along goaf in a fully mechanized top coal caving face with moderate stable conditions are studied by using numerical calculation. The essential deformation characteristics of the surrounding rocks in this kind of roadway are obtained and the key technology of bolting support used under these conditions is put forward.

Reasonable Drive Selecting of Parallel Mechanisms Based on Screw Theory

By rigidizing the input joints, all possible combinations of drive selecting for the 4-PPPS parallel mechanism are analyzed based on the screw theory in this paper, and the five of them are proved to be reasonable. Then choosing the one as mechanical actuators, the workspace of the 4-PPPS parallel mechanism is deduced according to the rational input scheme. Finally the rationality of input scheme for this mechanism is identified on the basis of the continuity of the workspace.

Slow driving control of tracked vehicles with automated mechanical transmission based on fuzzy logic

In order to move tracked vehicles at an extremely slowspeed with automated mechanical transmission（ AMT）,slowdriving function was added in the original system. The principle and requirement of slowdriving function were analyzed. Based on analysis of slow driving characteristic,identification of slowdriving condition and fuzzy control algorithm,a control strategy of the clutch was designed. In order to realize slowdriving,the clutch was controlled in a slipping mode as manual driving. The vehicle speed was increased to a required speed and kept in a small range by engaging or disengaging the clutch to the approximate half engagement point. Based on the control strategy,a control software was designed and tested on a tracked vehicle with AMT. The test results showthat the control of the clutch with the slowdriving function was smoother than that with original systemand the vehicle speed was slower and steadier.

Design, Manufacture and Measurements of Beta-Type Stirling Engine with Rhombic Drive Mechanism

The purpose of carrying out present work is to design, build and test a rhombic drive Stirling engine with a β-type configuration consisting of two dynamic pistons (displacer and power) reciprocates in the in-line concentric cylinder arrangement. The displacement rod is assembled concentrically inside the power piston rod. The rhombic drive mechanism is proposed in such a way that, by using a pair of gear wheels the sliding motion of both piston rods is controlled and thus, an engine is balanced. The developed prototype has a swept volume of 75 cm3 with the displacer piston and power piston cylinder hot ends heated by liquefied petroleum gas (LPG) burner and cooled water, respectively. It uses air as the working gas at atmospheric pressure for initial charging of the engine. Several designs were studied before settling on a β-type configuration. The LPG gas burner was considered as a potential heat source. The various elements of an engine (heater, cooler, re-generator, flywheel and piping systems) were designed, constructed and analyzed. The testing results revealed that the engine at initial atmospheric air filling started working in only about 120 seconds at an LPG heater temperature of 400℃ (824°F) with 280 rpm. At a heater temperature of 550℃ (1022°F), the engine speed was 630 rpm. At the engine speed of 245 rpm, the maximum torque was 0.215 Nm, while the maximum power was 8 Watts at 355 rpm. Engine speed increased with the increase of flame temperature. Several tests were performed on the engine to improve its running efficiency and critical problem areas were isolated and addressed. Moreover, results revealed that Stirling engines working with relatively low-temperature air are potentially attractive engines of the future, especially LPG powered low temperature differential Stirling engines. The Stirling engine was capable of generating between 50 to 100 Watts of electricity.

Research on Influence Mechanism of Transmission Accuracy for Harmonic Drive Mechanism Considering Multi-factor Coupling

The influence mechanism of transmission accuracy for harmonic drive mechanism considering multi-factor coupling was studied. According to analysis of influence factors of transmission accuracy for harmonic drive mechanism, it was obtained that the transmission errors of harmonic drive mechanism include processing errors and installation errors. The transmission error is produced by eccentric vector, it directly affects the rotation angle of output shaft and it makes harmonic drive mechanism produce backlash. Then analyze the movement error caused by the rigid wheel machining error, the flexible wheel machining error, the assembly error of the rigid wheel and the flexible wheel, the wave generator component, and the comprehensive expression method of motion error generated by each error source was obtained. The performance test device of space drive mechanism was used to test, and the law of the transmission accuracy of harmonic drive mechanism with temperature, speed and assembly clearance was obtained. The test results show that the transmission accuracy of harmonic drive mechanism decreases with increasing temperature, and the speed has little effect on the transmission accuracy of harmonic drive mechanism;the assembly quality has a significant impact on harmonic drive accuracy.

卵圆孔未闭相关疾病研究2023 年度进展

卵圆孔未闭(PFO)是一种在人群中患病率较高的先天性心脏病,既往研究已明确其与脑卒中之间的关联,并认可封堵治疗对于PFO相关脑卒中的意义。近年来,关于PFO相关疾病的研究逐渐增多,认识进一步加深,同时国内PFO封堵治疗的例数也增长明显。本文盘点了2023年度PFO领域最新研究进展,主要包括PFO相关疾病谱的扩展(癫痫、不明原因晕厥等),发病机制的探究以及风险评估的手段;针对PFO封堵治疗,本文介绍了关于封堵效果与预后的最新研究结果,以及封堵治疗与心房颤动之间关系。国内在PFO封堵新器械的研发上一直处于领先地位,本文也对该方面的最新成果进行了介绍。