Modern technology-based exploration of mechanism of traditional Chinese medicine in prevention and treatment of gastric cancer

This review comments on the article“To explore the mechanism of Yigong San anti-gastric cancer and immune regulation”.We are interested that the article applied network pharmacology and bioinformatics techniques to elucidate the mechanism of action of Yigong Sang,a traditional Chinese medicine(TCM),in the treatment of gastric cancer(GC).The mechanism of action of Yigong Sang in the treatment of GC has not yet been elucidated because it is composed of multiple Chinese medicines with multiple components and multiple targets.The emergence of network pharmacology and bioinformatics analysis helps explain the mechanism of action of TCM in preventing and treating GC,and provides a possibility for TCM to transform from empirical to evidence-based medicine.This is of great significance for the application of TCM in oncology,new drug development,formula optimization,and the improvement of clinical efficacy.

Study on Influencing Factors and Mechanism of Scientific and Technological Innovation Talents Gathering in Zhejiang Province

This paper systematically studies the influencing factors and mechanism of the agglomeration of scientific and technological innovation talents in Zhejiang Province. The findings are as follows: Firstly, environmental factors such as marketization level, financial development, opening to the outside world, infrastructure construction, medical resources, educational resources, cultural resources and policy support have a positive impact on the agglomeration of scientific and technological talents in Zhejiang Province;Secondly, in the transmission mechanism of the influence of various environmental factors on the concentration of scientific and technological talents in Zhejiang, economic development plays an intermediary role, and the effect is obvious. Various environmental factors indirectly affect the concentration of scientific and technological talents in Zhejiang through economic development. Finally, although both the level and quality of economic development have significant effect on the total concentration of scientific and technological talents in Zhejiang, the mediating effect of economic development level is more significant. These studies are for Zhejiang Province. It provides a theoretical basis for cultivating high-end talents and realizing the agglomeration of scientific and technological innovation talents.

Research on the Coupling Mechanism of Creative Spirit Cultivation and Scientific and Technological Innovation Development

Migration and innovation is the driving force of scientific and technological development.By analyzing the coupling relationship between the two,this paper finds out the common elements shared by the two factors,and constructs the coupling guarantee mechanism between them,so as to provide suggestions for the coordination,win-win and synchronous benign development of the spirit of makers and the development of scientific and technological innovation,and promote the sustainable development of the national innovation system.

Study on Driving Technology Innovation Using Patent Management Mechanism

In order to improve the cigarette enterprise technology innovation and patent management status, the macro work should start from the four aspects of patent ideology introduction, patent organization design, perfecting patent system and implementation of specific measures, and attention should be attached to strengthen the cooperation of the cigarette enterprise management departments. On the other hand, Jn the microscopic work level, it should build the culture atmosphere of the entire tobacco industry respect intellectual property rights, actively cultivate the na- tional patent agents and patent engineers, and gradually promote the patent work to develop in the direction of specialization, self-independence, so as to construct a scientific mechanism for patent management, and enhance the core competitiveness of the tobacco industry.

Mechanism and monitoring and early warning technology for rockburst in coal mines

On the basis of the massive amount of published literature and the long-term practice of our research group in the field of prevention and control of rockburst,the research progress and shortcomings in understanding the rockburst phenomenon have been comprehensively in-vestigated.This study focuses on the occurrence mechanism and monitoring and early warning technology for rockburst in coal mines.Results showed that the prevention and control of rockburst had made significant progress.However,with the increasing mining depth,several unre-solved concerns remain challenging.From the in-depth research and analysis,it can be inferred that rockburst disasters involve three main problems,i.e.,the induction factors are complicated,the mechanism is still unclear,and the accuracy of the monitoring equipment and multi-source stereo monitoring technology is insufficient.The monitoring and warning standards of rockburst need to be further clarified and im-proved.Combined with the Internet of Things,cloud computing,and big data,a study of the trend of rockburst needs to be conducted.Further-more,the mechanism of multiphase and multi-field coupling induced by rockburst on a large scale needs to be explored.A multisystem and multiparameter integrated monitoring and early warning system and remote monitoring cloud platform for rockburst should be explored and developed.High-reliability sensing technology and equipment and perfect monitoring and early warning standards are considered to be the de-velopment direction of rockburst in the future.This research will help experts and technicians adopt effective measures for controlling rock-burst disasters.

Failure mechanism of bolting support and high-strength bolt-grouting technology for deep and soft surrounding rock with high stress

In deep underground mining, the surrounding rocks are very soft with high stress. Their deformation and destruction are serious, and frequent failures occur on the bolt support. The failure mechanism of bolt support is proposed to solve these problems. A calculation theory is established on the bond strength of the interface between the anchoring agent and surrounding rocks. An analysis is made on the influence law of different mechanical parameters of surrounding rocks on the interfacial bond strength. Based on the research, a new high-strength bolt-grouting technology is developed and applied on site. Besides, some helpful engineering suggestions and measures are proposed. The research shows that the serious deformation and failure, and the lower bond strength are the major factors causing frequent failures of bolt support. So, the bolt could not give full play to its supporting potential. It is also shown that as the integrity, strength, interface dilatancy and stress of surrounding rocks are improved, the bond strength will increase. So, the anchoring force on surrounding rocks can be effectively improved by employing an anchoring agent with high sand content, mechanical anchoring means, or grouting reinforcement. The new technology has advantages in a high strength, imposing pre-tightening force, and giving full play to the bolt supporting potential. Hence, it can improve the control effect on surrounding rocks. All these could be helpful references for the design of bolt support in deep underground mines.

Instability mechanism and control technology of soft rock roadway affected by mining and high confined water

Based on deformation and failure characteristics of the second belt conveyor roadway at level II of Zhuxianzhuang coal mine, laboratory experiments, numerical calculation and field test were adopted to analyze the composition and microstructure of mudstone, the law of mudstone hydration and its strength weakening induced by water, the characteristics of surrounding rock deformation and failure under the action of confined water. Results showed that montmorillonite clay minerals accounted for as much as 76% of mudstone, with a large number of pores existing in the microstructure. Besides, as the molecular structure of montmorillonite changed, mudstone microstructure damage occurred with the macroscopic manifestation of its theological instability. Weakening degree of confined water on residual strength of mudstone was almost 50%. The instability mechanism of soft rock roadway caused by high confined water is that surrounding rock circulates the process of ＂fracture-seepage-mud ding-closed＂ twice, which weakens its strength and leads to roadway instability. A combined support technology, namely the, ＂high-toughness sealing layer ＋ hollow grouting cables ＋ full-length anchoring bolts with deep borehole＂ was proposed. Based on field observation, the soft rock roadway was controlled effectively, which also verified the effectiveness of new control technology for surrounding rock.

Research progress on permeability improvement mechanisms and technologies of coalbed deep-hole cumulative blasting

Coalbed gas extraction is an important means of exploiting and utilizing gas resources,as well as a means of preventing coal mine disasters.In view of the low gas extraction rate from coalbeds with high gas content and low permeability,a method of improving permeability through deep-hole cumulative blasting is applied to develop initial directional fractures using a jet flow.Under the action of the blasting stress wave and detonation gas wedge,the fractures extend over a large range within the coal,thereby improving coalbed permeability.This study focuses on the criteria of cumulative blasting-induced coalbed fracturing based on a literature review of the penetration effect of cumulative blasting.On this basis,we summarize the coal fracturing zone,crack extension process,and the key technologies of charging and hole sealing for cumulative blasting.In addition,the latest research progress in the optimization of field test drilling and blasting parameters for cumulative blasting is introduced.Research findings indicate that the permeability improvement mechanism of cumulative blasting could be further enhanced,and the technology and technical equipment are in urgent need of improvement.Finally,development trends in the cumulative blasting permeability improvement technique are identified.

Comparison and analysis of the main technological factors of influencing mechanical properties of scrimber and PSL

The main mechanical properties of scrimber and Parallel Strand Lumber (PSL) were researched through techno-logical test. Experimental materials of scrimber are small log of Aspen, Dahurian larch and Birch. Experimental materials of PSL come from fishtail veneer strips at plywood plant of Aspen and Birch. In the laboratory conditions low quality small log and wood residues can yield scrimber and PSL with high strength. After the technological conditions of scrimber were compared with that of PSL, the main factors of influencing their properties were separately pointed out and the reasons influencing proper-ties have been analyzed in this paper. The results showed that the hot-pressing pressure is an important technological factor for scrimber. The ratio of veneer-strand length to thickness is a key technological factor for PSL.

The application of label-free imaging technologies in transdermal research for deeper mechanism revealing

The penetration behavior of topical substances in the skin not only relates to the transdermal delivery efficiency but also involves the safety and therapeutic effect of topical products,such as sunscreen and hair growth products.Researchers have tried to illustrate the transdermal process with diversified theories and technologies.Directly observing the distribution of topical substances on skin by characteristic imaging is the most convincing approach.Unfortunately,fluorescence labeling imaging,which is commonly used in biochemical research,is limited for transdermal research for most topical substances with a molecular mass less than 500 Da.Label-free imaging technologies possess the advantages of not requiring any macromolecular dyes,no tissue destruction and an extensive substance detection capability,which has enabled rapid development of such technologies in recent years and their introduction to biological tissue analysis,such as skin samples.Through the specific identification of topical substances and endogenous tissue components,label-free imaging technologies can provide abundant tissue distribution information,enrich theoretical and practical guidance for transdermal drug delivery systems.In this review,we expound the mechanisms and applications of the most popular label-free imaging technologies in transdermal research at present,compare their advantages and disadvantages,and forecast development prospects.

Joint Bearing Mechanism of Coal Pillar and Backfilling Body in Roadway Backfilling Mining Technology

In the traditional mining technology,the coal resources trapped beneath surface buildings,railways,and water bodies cannot be mined massively,thereby causing the lower coal recovery and dynamic disasters.In order to solve the aforementioned problems,the roadway backfilling mining technology is developed and the joint bearing mechanism of coal pillar and backfilling body is presented in this paper.The mechanical model of bearing system of coal pillar and backfilling body is established,by analyzing the basic characteristics of overlying strata deformation in roadway backfilling mining technology.According to the Ritz method in energy variation principle,the elastic solution expression of coal pillar deformation is deduced in roadway backfilling mining technology.Based on elastic-viscoelastic correspondence principle,combining with the burgers rheological constitutive model and Laplace transform theory,the viscoelastic solution expression of coal pillar deformation is obtained in roadway backfilling mining technology.By analyzing the compressive mechanical property of backfilling body,the time formula required for coal pillar and backfilling body to play the joint bearing function in roadway backfilling mining technology is obtained.The example analysis indicates that the time is 140 days.The results can be treated as an important basis for theoretical research and process design in roadway backfilling mining technology.

Teaching Experiment in Engineering Mechanics Based on Simulation Technology:A Case Study

This paper explores the integration of simulation technology in Engineering Mechanics(EM)teaching in vocational colleges.A case study was conducted using the tensile test as an example,and digital resources,such as colored Mises stress nephograms,were obtained.These resources were integrated into the original curriculum to conduct teaching experiments.The results show that the use of digital resources significantly improved the quality of teaching in EM.The integration of simulation technology in EM teaching provides a promising direction for the improvement of vocational education and the cultivation of high-quality skilled talents.The development and application of more simulation-based teaching cases should be studied by scholars.

Application Strategies of BIM Technology in Highway Electromechanical Engineering

The transportation system is vital for social and economic development.With the rapid economic development,the demand for highways has been increasing.Mechanical and electrical engineering is a crucial part of highway construction,affecting the expressway’s later use.Applying building information modeling(BIM)technology in highway electromechanical engineering allows for the visibility and simulation of mechanical and electrical engineering construction,providing scientific guidance for construction.In this research,the author analyzes the advantages of BIM technology in highway electromechanical engineering and the basic composition of electromechanical engineering.The research proposes strategies and cases for applying BIM technology in highway electromechanical engineering.The ultimate goal of this research is to improve the construction of highways in terms of electromechanical engineering.

Review of Power Supply and Distribution Construction Technology for Highway Electromechanical Engineering

In recent years,China has made significant progress in the construction of highways,resulting in an improved highway network that has provided robust support for economic and social development.However,the rapid expansion of highway construction,power supply,and distribution has led to several challenges in mechanical and electrical engineering technology.Ensuring the safe,stable,and cost-effective operation of the power supply and distribution system to meet the diverse requirements of highway operations has become a pressing issue.This article takes an example of a highway electromechanical engineering power supply and distribution construction project to provide insight into the construction process of highway electromechanical engineering power supply and distribution technology.

Mechanism and Preventive Technology of the Thaumasite Form of Sulfate Attack on Cement Mortars

The deterioration mechanism of thaumasite towards cement or concrete structure and the deterioration pattern of in-situ construction caused by the formation of thaumasite were studied in this paper. To improve the TSA (the thaumasite form of sulfate attack) resistance, the cement type, water to cement ratios, the mineral admixture and the circumstance factors should be taken into consideration.

Study on Technology and Mechanism of Purifying Scandium Metal by Vacuum Distillation Method

The evaporation coefficients alpha(i) of impurity elements Al, Cu, Cr, Co, Fe, Ni, Si in liquid scandium metal of purity 99.9% were measured at 1550 degrees C and 6.7 x 10(-3) Pa. The separating coefficients beta(i) and activity coefficients gamma(i)(o) of these impurity elements were calculated and the separation possibility between these impurity elements and Sc was discussed from thermodynamics. Then the new technology in preparation of high purity scandium metal was proposed and its purification mechanism was discussed.

Mechanism of realizing industrial structure upgrading through technology-driven regional innovation capacity

Based on the analysis of the formation process of regional innovation capacity, this paper expatiates that the technology is the basis for industrial structure upgrading, while technological innovation is the power of regional innovation capacity. It points out that the essential of regional industrial structure upgrading is the transition of regional technology structure from one balance to another. The mechanism of realizing industrial structure upgrading through technology-driven regional innovation capacity is also discussed briefly.

Research on the Communication Mechanism of Online Rumors Under the Empowerment of New Media Technology-Take the“Nabobess Having an Affair With Courier”Rumor Incident as an Example

As new media communication becomes popular and the technological threshold of personal expression has been lowered,the phenomenon of online rumors has also emerged with new communication characteristics as individuals are continuously empowered to communicate.This paper quantifies a rumor spreading event from 2020 to 2021 that generated a lot of discussion.Using a content analysis approach,we examined how different subjects in the online public opinion chaos have influenced the spreading process of the event,and used the study of online rumor spreading mechanism to gain insight into the public opinion governance in the new media era.The study found that media platforms,the parties involved,and the general public as important participants have fully utilized the voice channel of the online communication platform to play a role behind the rumor event.

Research on the potential mechanism of Huashi Baidu Recipe against novel coronavirus pneumonia(COVID-19)by network pharmacology and molecular docking technology

Objective:Use network pharmacology to explore the anti-COVID-19 mechanism of Huashi Baidu Recipe,supplemented by molecular docking verification.Methods:Thorugh databases such as TCMSP,GeneCard,String,and software such as Cytoscape,AutoDockVina,network relationships was established,and the binding ability of active ingredients and targets is calculated through molecular docking,and biological function enrichment analysis was conducted.Result:The ingredients in Huashi Baidu Recipe that had strong affinity with SARS-CoV-23CL hydrolase(3CLpro)and angiotensin converting enzyme 2(ACE2)receptors include Quercetin,Baicalein,Astragaloside IV,Wogonin and other ingredients;25 active ingredients which obtained by screening had strong affinity with targets such as IL6,IL1B,NOS2 and CCL2.The biological function enrichment analysis mainly focused on Th17,Th1 and Th2 cell differentiation,NF-κB,MAPK,TNF,IL-17signaling pathway,etc.Conclusion:The active ingredients of Huashi Baidu Recipe may inhibit the infection and replication of SARS-CoV-2 virus,regulate RAS system’balance,inhibit excessive immune inflammatory response,and prevent inflammatory storm from appearing to fight COVID-19.

Research on Incentive Mechanism and Analysis of the Obstacles in the Application of Low-carbon Logistics Technology

Low-carbon logistics technology is a modem technology with green environmental protection concept as the core, which can effectively reduce the carbon emissions of all links in logistics activities, and thus achieve the goal of maximizing the use of resources and reducing environmental pollution. With the deepening of the concept of environmental protection, the application of low-carbon logistics technology is not only an inevitable choice for adapting to social development and responding to environmental protection slogans, but also an inevitable choice for the logistics industry to achieve sustainable development goals. Based on the brief introduction of low-carbon logistics technology, this paper analyzes the main obstacles of the application of the technology, and proposes corresponding incentive mechanism according to the obstacle factors, aiming at alleviating the resistance in the practical application of low-carbon logistics technology and promoting the realization of low-carbon logistics development.