Effect of Modulen vs budesonide on clinical response and mucosal healing in Crohn’s patients

BACKGROUND Mucosal healing has become an important goal of Crohn’s disease(CD)treat-ments.Modulen,enriched with transforming growth factor-beta 2,and budeso-nide are commonly accepted treatments for mild-moderate CD.However,their effects on the small bowel(SB)mucosa remain underexplored.AIM To prospectively assess clinical and mucosal responses to Modulen vs budesonide in adults with CD,using SB capsule endoscopy.METHODS Thirty patients were divided into two groups:Modulen+home-based diet(21 patients)and budesonide(9 patients)for an eight-week intervention followed by four weeks of follow-up.Clinical,laboratory,and endoscopic responses were evaluated.The mucosal changes were assessed through SB capsule endoscopy.RESULTS Results indicated significant clinical improvement in the Modulen group with reduced CD activity index(P=0.041)and improved inflammatory bowel disease questionnaire score(P=0.016).Moreover,Modulen was associated with a signifi-cant SB mucosal improvement,evidenced by a decrease in Lewis score(P=0.027).No significant changes were observed in calprotectin or other laboratory parame-ters.Conversely,budesonide exhibited more modest clinical effects,but it improved calprotectin,hemoglobin,and C-reactive protein levels(P=0.051,P=0.014,and P=0.038,respectively).The capsule endoscopy did not reveal a significant mucosal response in the budesonide group.CONCLUSION Both interventions have a role in CD treatment.Yet,their effects differ and may complement each other:Modulen yields clinical and mucosal improvements,while budesonide primarily leads mainly to laboratory improvements.

THE NON-AXISYMMETRICAL DYNAMIC RESPONSE OF TRANSVERSELY ISOTROPIC SATURATED POROELASTIC MEDIA

The Blot's wave equations of transversely isotropic saturated poroelastic media excited hy non-axisymmetrical harmonic source were solved by means of Fourier expansion and Hankel transform. Then the components of total stress in porous media are expressed with the solutions of Biot's wave equations. The method of research on non-axisymmetrical dynamic response of saturated porous media is discussed, and a numerical result is presented.

Elastoplastic bridge deck response spectra of high-speed railway simply-supported girder bridge with CRTS Ⅱ track system

The seismic damage to ancillary facilities on high-speed railway(HSR)bridges can affect the normal movement of trains.To propose the bridge deck acceleration response spectra of the typical HSR simply-supported girder bridge for simplifying the seismic responses analysis of the facilities on bridges,the finite element models of the HSR multi-span simply-supported girder bridges with CRTSII track were established,and the numerical model was validated by tests.Besides,the effects of the span number,peak ground acceleration(PGA),pier height on the seismic acceleration and response spectra of the bridge deck were investigated.Afterward,the bridge acceleration amplification factor curves and bridge deck response spectra with different PGAs and pier heights were obtained.The formula for bridge deck acceleration amplification factor,with a 95%guarantee rate,was fitted.Moreover,the finite element models of the overhead contact lines(OCL)mounted on rigid base and bridges were established to validate the fitted formula.The results indicated that the maximum seismic acceleration response is in the midspan of the beam.The proposed formula for the bridge deck acceleration response spectra can be used to analyze the earthquake response of the OCL and other ancillary facilities on HSR simply-supported girder bridges.The bridge deck acceleration response spectra are conservative in terms of structural safety and can significantly improving the analysis efficiency.

PENALTY FINITE ELEMENT METHOD FOR NONLINEAR DYNAMIC RESPONSE OF VISCOUS FLUID-SATURATED BIPHASE POROUS MEDIA

The governing equations as well as boundary land initial conditions for nonlinear dynamic response problems of viscous fluid-saturated biphase porous medium model, based on mixture theory, are presented. With Galerkin weighted residual method the corresponding nonlinear dynamic penalty finite element equation, in which the dependencies of volume fraction and permeation coefficients an deformation are included, is obtained. The iteration solution method of the nonlinear system equation is also discussed. As a numerical example, the dynamic response of a porous medium column under impulsive loading action is analyzed with the developed finite element program. The numerical results demonstrate the efficiency and correctness of the method.

W/Cu/S簇基超分子大环及其三阶非线性光学性质

以前驱簇[Et_(4)N][Tp*WS_(3)(CuCl)_(3)]与三氟甲烷磺酸银(AgOTf)及3个有机桥联配体2,5‑二(吡啶‑4‑基)噻吩(L1)、5,5'‑双(4‑吡啶基)‑2,2'‑双噻吩(L_(2))和2,7‑双(4‑吡啶基)芘(L_(3))分别反应,得到了3个阳离子型W/Cu/S簇基超分子大环化合物[(Tp*WS_(3)Cu_(3))_(2)(μ‑Cl)_(2)(μ_(4)‑Cl)(L_(1))]_(2)(OTf)_(2)(1)、[(Tp*WS_(3)Cu_(3))_(2)(μ‑Cl)_(2)(μ_(4)‑Cl)(L_(2))]_(2)(OTf)_(2)·2CHCl_(3)(2·2CHCl_(3))和[(Tp*WS_(3)Cu_(3))_(2)(μ‑Cl)_(2)(μ_(4)‑Cl)(L_(3))]_(2)(OTf)_(2)·2DMF(3·2DMF),其中Tp*=hydridotris(3,5‑dimethylpyrazol‑1‑yl)borate。对3个化合物分别进行了单晶X射线衍射、核磁、质谱、红外光谱、紫外可见光谱和元素分析等结构表征。单晶X射线衍射结果表明,3个大环的主体均是由2个L1、L_(2)和L_(3)配体和3个氯桥连接的[(Tp*WS_(3)Cu_(3))_(2)(μ‑Cl)_(2)(μ_(4)‑Cl)]^(2+)阳离子簇核组成。3个大环通过不同方式堆叠形成三维结构。核磁氢谱(^(1)H NMR)和电喷雾飞行质谱(ESI‑TOF MS)结果表明这些化合物在溶液中有较好的稳定性。Z扫描测试结果表明,3个化合物的溶液有一定的三阶非线性光学响应。

Azimuthal moveout response of seismic waves in two-phase anisotropic media

Dispersion and attenuation occur while seismic wave travels through cracks filled with fluids,which lead to the anisotropism of seismic azimuthal travel time.Based on latest rock physics models,this study aims to simulate seismic azimuthal moveout responses(AMR) and analyze the factors affecting this attribute.By numerical modeling,it is found that the AMR is very sensitive to the parameters of the cracks,especially these related to fluid;therefore AMR has the potential to qualitatively or even quantitatively identify cracks.

日本海沟S-net台网水平向海域浅地壳和上地幔地震动预测模型

地震动衰减关系是地震灾害研究和评估建筑结构可能遭受地震作用的一个重要工具.基于日本大型海底观测台网S-net的海域浅地壳和上地幔地震动记录,应用随机效应模型和回归分析构建了日本海沟地区的水平向海域浅地壳和上地幔地震动预测模型,对比了海域和陆地浅地壳和上地幔地震动预测模型在反应谱和衰减率上的差异.由于海底台站的埋设方式不同,在模型中将台站按埋设和未埋设进行区分,通过回归分析和参数平滑建立了考虑矩震级、断层距、震源深度、震源类型、水深、沉积层厚度和埋设方式的水平向海域浅地壳和上地幔地震动预测模型.通过与日本陆地预测模型的比较发现,海域地震动的长周期分量非常丰富,远大于陆域的预测值;在衰减率方面,短周期段低于陆地模型的衰减率.本文建立的海域浅地壳和上地幔地震动预测模型可为考虑震源分类的海域区划和地震危险性分析提供参考.

Trends in Corporate Social Responsibility Among Public Service Media in Europe

Corporate Social Responsibility （CSR） is the voluntary commitment taken over by companies in social, economic, and environmental terms. The aim is to counteract impacts generated by their activity. While the concept is genuinely linked to the private sector, this self-regulated system has been steadily introduced in some European public service media. Indeed, CSR is one of the mechanisms to face the challenges of the sector, both the financial crisis and the lack of trust. Seven public service media from the European Union are reporting--via their websites--on their CSR strategies. Annual reports on their performance are issued by the German ZDF, the Spanish RTVE, the Portuguese RTP, the British BBC, the Irish RTI~, the Finnish YLE, and the Italian RAI. Also, four other corporations--VRT and RTBF from Belgium, FT from France, and DR from Denmark include a section on corporate social responsibility on their annual reports. The aim of this paper is to know which of the trends in CSR are dominant among public service media in Europe, namely economy, environment, and society. The content analysis of corporate reports is the method used for the research.

COUPLED LINEAR-RESPONSE OF INHOMOGENEOUS MEDIA:A GENERAL THEORY AND ITS APPLICATIONS

A generally exact theory for predicting the effec-tive behavior of coupled linear-response for inhomogeneous me-dia is developed. The general solutions for the coupled problems of two fields and three fields are given. The applications of the theory in the magnetic-electric (.magnetoelectricity) properties and the thermal-electric-mechanical properties (thermoelasti-city, piezoelectricity, and pyroelectricity) are discussed. The firstorder approximations of the thermal-electric-mechanical properties of binary transversely isotropic composites are de-rived.

Responsibilities of the State Intellectual Property Office of the People's Republic of China (SIPO)

According to the "Notice on OrganizationStructure of the State Council", the formerChina Patent Office was changed into StateIntellectual Property Office of P. R. China(SIPO). SIPO falls within the category ofdirect authorities under State Council and isresponsible for patent work andcomprehensively coordination of the foreignrelated affairs in the field of intellectualproperty.

The Evaluation and Analysis of the Government’s Entity Responsibilities of Promoting Gender Equality and Women’s Development

During the past 40 years of reform and opening-up,the chinese government,on the basis of adhering to the constitutional principle of equality between men and women,has proposed and resolutely implemented the basic state policy of equality between men and women,and constantly explored and implemented ways and measures to promote gender equality and the women’s all-round development.in enacting laws,formulating policies,drawing up plans and deploying work,the chinese government has taken into account the practical differences between the genders and the special interests of women,promoted women’s equal exercising of their democratic rights,equal participation in economic and social development and equal enjoyment of the fruits of reform and development,and provided stronger systematic and institutional guarantees for women’s development.

响应面优化1T/2H O-MoS_(2)@S-pCN光催化去除Cr(Ⅵ)及环丙沙星

为光催化同步处理Cr(Ⅵ)和环丙沙星(CIP),文章采用一步水热反应法合成1T/2HO-MoS_2@S-pCN复合材料,通过响应面实验,研究不同条件(催化剂添加量、pH、Cr^(6+)浓度、CIP浓度)下光催化还原Cr(Ⅵ)和氧化CIP的效率。研究结果表明,单因素分析可知催化剂用量、pH值、CIP浓度和Cr(Ⅵ)浓度对光催化Cr(Ⅵ)和CIP的转化效率影响较大。建立了响应面优化实验模型,模型的P<0.0001,失拟项大于0.05,决定系数R^(2)均接近于1,说明实际值和模型预测值相关性较高。根据预测,当pH为3.00、催化剂添加量为60.00 mg、Cr(Ⅵ)初始浓度为5.01 mg/L、CIP浓度为5.04 mg/L时,Cr(Ⅵ)和CIP的去除率达最高。

基于B/S架构的防汛防旱抢险数字化管理系统研究

针对传统的防汛防旱抢险管理方式难以实现高效、精准、及时响应的问题,研究了一种基于B/S架构的防汛防旱抢险数字化管理系统。分析了该系统的技术特性,探讨了系统的框架体系、通用业务组件、应用管理平台和开发功能结构等。

Analysis of rock physics response of gas-bearing volcanic reservoir based on three-phase poroelastic theory

Unlike previous theories with velocity and/or elastic modulus averaging, we use a three-phase porous rock physics model developed by Santos for analyzing the seismic response of two immiscible fluids in saturated porous media. Considering reservoir reference pressure and coupling drag of two fluids in pores, the effects of frequency, porosity, and gas saturation on the phase velocities of the P-and S-waves are discussed in detail under field conditions. The effects of porosity and gas saturation on Vp/Vs are also provided. The data for our numerical experiments are from a sample of deep volcanic rock from Daqing. The numerical results show that the frequency dispersion effect can be ignored for deep volcanic rocks with low porosity and low permeability. It is concluded that for deep volcanic rocks the effect of gas content in pores on Vp/Vs is negligible but the effect of porosity is significant when there is a certain amount of water contained in the pores. The accurate estimate of lithology and porosity in this case is relatively more important.

Isolation and Identification of a Taxol-producing Endophytic Fungus Identified from Taxus media

[Objective] The aim was to isolate and identify a taxol-producing endophytic fungus from Taxus media. [Method] 32 strains of endophytic fungi were identified form the inner bark of T. media,and their fermentation products were detected by high performance liquid chromatography (HPLC). [Result] Through the screening,a strain of taxol-producing endophytic fungi M57 was obtained,which could produce 45-50 μg/L of taxol,and M57 was defined as Rhizopus sp. through morphological observation and 18S rDNA sequence analysis. [Conclusion] The finding of Rhizopus sp. M57 provided a promising strain for producing taxol with taxol-producing fungi fermentation process.

三维各向异性TI介质中的P/S波快速解耦技术及在弹性波逆时偏移中的应用

随着多分量采集技术的发展,弹性波逆时偏移技术在三维各向异性介质复杂地质构造成像中得到了广泛的应用.然而耦合的P波场和S波场,会在传播过程中产生串扰噪声,降低弹性波逆时偏移的成像精度.为了解决这一问题,本研究针对具有倾斜各向异性对称轴的三维横向各向同性(Transverse Isotropy,TI)介质,提出了一种矢量弹性波场快速解耦方法,可以有效提高偏移剖面的成像质量.该方法首先通过坐标转换,将观测系统坐标系的垂直轴旋转到TI介质的对称轴方向,在新坐标系下,根据具有垂直对称轴的三维横向各向同性(Vertical Transverse Isotropy,VTI)介质中的分解算子,推导出三维TI介质解耦算子表达式.接着引入一种在空间域快速计算分解波场的方法,来实现空间域矢量P波场和S波场分离,极大地提高了计算效率.最后,通过点积成像条件,将提出的P/S波分解方法引入到三维TI介质弹性波逆时偏移中,得到高精度的PP和PS成像.与以往的波场分解方法相比,本文方法具有数值稳定和计算效率高的特点.数值算例表明,应用上述三维TI分解算子得到的偏移剖面有效压制了噪声,提高了成像质量.

A Model of Spontaneous Chronic Otitis Media with Effusion in Mice with ENU Induced Mutations

Background Chronic otitis media(COM) is a significant clinical problem.Understanding the mechanisms of COM is critical for its control and treatment.However,little is known of the processes leading to COM as a result of lack of animal models of N-ethyl-N-nitrosourea(ENU) induced mutations in otitis media with effusion(OME).Methods Otoscopy and auditory brain response(ABR) evaluation were carried out under sedation in Nmf391nmf/nmf mice of 2,4,6 and 8 months of age.The mice were killed for study of middle and inner ear pathology.Results Tympanic membrane visualization and ABR thresholds in 1-to 8-month-old Nmf391nmf/nmf mice showed spontaneous OME and inner ear diseases in approximately 100% of the animals.The significant elevation of ABR thresholds suggested a sensorineural component in hearing loss in addition to the conductive loss.Middle and inner ear histology showed various degrees of outer hair cells loss and middle ear inflammation in all the mice,but no inflammation cells in the inner ear.The ABR threshold at 32 kHz was significantly elevated.Conclusions This study shows histopathologic changes in the Nmf391nmf/nmf mouse model of COM with effusion that have not been reported in human COM.This ENU induced mutation model of COM will be valuable for the characterization of middle ear inflammation and inner ear disease processes that are induced by middle ear infections.We propose that COM with effusion in this ENU induced mutation model is the cause of the cochlea hair cells damage.

Baeyer-Villiger oxidation of cyclic ketones utilizing potassium peroxydisulfate(K_2S_2O_8) or sodium perborate(NaBO_3) in acidic media

The efficient, green, facile, mild and straightforward conversion procedure for the oxidation of cyclic ketones to lactones at room temperature utilizing potassium peroxydisulfate （K2S2O8） in acidic media is satisfactory to high yields without using traditional chlorinated solvents is reported. This oxidative reagent is cheap and friendly environmental procedure for industrial purposes than use of organic peracids.

Modeling the efects of fracture infll on frequency‑dependent anisotropy and AVO response of a fractured porous layer

In a fractured porous hydrocarbon reservoir,wave velocities and refections depend on frequency and incident angle.A proper description of the frequency dependence of amplitude variations with ofset(AVO)signatures should allow efects of fracture inflls and attenuation and dispersion of fractured media.The novelty of this study lies in the introduction of an improved approach for the investigation of incident-angle and frequency variations-associated refection responses.The improved AVO modeling method,using a frequency-domain propagator matrix method,is feasible to accurately consider velocity dispersion predicted from frequency-dependent elasticities from a rock physics modeling.And hence,the method is suitable for use in the case of an anisotropic medium with aligned fractures.Additionally,the proposed modeling approach allows the combined contributions of layer thickness,interbedded structure,impedance contrast and interferences to frequency-dependent refection coefcients and,hence,yielding seismograms of a layered model with a dispersive and attenuative reservoir.Our numerical results show bulk modulus of fracture fuid signifcantly afects anisotropic attenuation,hence causing frequencydependent refection abnormalities.These implications indicate the study of amplitude versus angle and frequency(AVAF)variations provides insights for better interpretation of refection anomalies and hydrocarbon identifcation in a layered reservoir with vertical transverse isotropy(VTI)dispersive media.

Estimating peak response frequencies in a tidal band in the seas adjacent to China with a numerical model

A numerical method is designed to examine the response properties of real sea areas to open ocean forcing. The application of this method to modeling the China＇s adjacent seas shows that the Bohai Sea has a highest peak response frequency （PRF） of 1.52 d^-1; the northern Yellow Sea has a PRF of 1.69 d^-1; the Gyeonggi Bay has a high amplitude gain plateau in the frequency band roughly from 1.7 to 2.7 d^-1; the Yellow Sea （includ- ing the Gyeonggi Bay）, the East China Sea shelf and the Taiwan Strait have a common high amplitude gain band with frequencies around 1.76 to 1.78 d^-1 and are shown to be a system that responds to the open ocean forcing in favor of amplifying the waves with frequencies in this band; the Beibu Gulf, the Gulf of Thailand and the South China Sea deep basin have PRFs of 0.91, 1.01 and 0.98 d^-1 respectively. In addition, the East China Sea has a Poincare mode PRF of 3.91 d^-1. The PRFs of the Bohal Sea, the northern Yellow Sea, the Bei- bu Gulf and the South China Sea can be explained by a classical quarter （half for the Bohai Sea） wavelength resonance theory. The results show that further investigations are needed for the response dynamics of the Yellow Sea-East China Sea-Taiwan Strait system, the East China Sea Poincare mode, the Talwan Strait, and the Gulf of Thailand.