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Characterization of Rebound Depolarization in Neurons of the Rat Medial Geniculate Body In Vitro 被引量:2
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作者 Xin-Xing Wang Yan Jin +4 位作者 Hui Sun Chunlei Ma Jinsheng Zhang Ming Wang Lin Chen 《Neuroscience Bulletin》 SCIE CAS CSCD 2016年第1期16-26,共11页
Rebound depolarization (RD) is a response to the offset from hyperpolarization of the neuronal mem- brane potential and is an important mechanism for the synaptic processing of inhibitory signals. In the present stu... Rebound depolarization (RD) is a response to the offset from hyperpolarization of the neuronal mem- brane potential and is an important mechanism for the synaptic processing of inhibitory signals. In the present study, we characterized RD in neurons of the rat medial geniculate body (MGB), a nucleus of the auditory thala- mus, using whole-cell patch-clamp and brain slices. RD was proportional in strength to the duration and magnitude of the hyperpolarization; was effectively blocked by Ni2+ or Mibefradil; and was depressed when the resting membrane potential was hyperpolarized by blocking hyperpolarization-activated cyclic nucleotide-gated (HCN) channels with ZD7288 or by activating G-protein-gated inwardly-rectifying K+ (GIRK) channels with baclofen. Our results demonstrated that RD in MGB neurons, which is carried by T-type Ca2+ channels, is critically regulated by HCN channels and likely by GIRK channels. 展开更多
关键词 medial geniculate body Brain sliceRebound depolarizationchannel GIRK channel-type calcium channel - HCNResting membrane potential
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