BACKGROUND Calcifying fibrous tumor (CFT) is a rare benign mesenchymal tumor that often occurs in deep soft tissue of children and young adults.CFT rarely occurs in the mediastinum.CASE SUMMARY In this paper,we descri...BACKGROUND Calcifying fibrous tumor (CFT) is a rare benign mesenchymal tumor that often occurs in deep soft tissue of children and young adults.CFT rarely occurs in the mediastinum.CASE SUMMARY In this paper,we describe a 31-year-old male patient with CFT in the mediastinum.The patient did not have any symptoms,and the posterior mediastinal lesion was unintentionally found during routine re-examination of thyroid cancer.The tumor had no adhesion to the surrounding tissue and was successfully and completely removed.Pathology showed a large amount of collagen-rich fibrous connective tissue.There was scattered dystrophic calcification and gravel in the fibrous tissue and a small amount of lymphocyte and plasma cell infiltration and lymphoid follicle formation in the interstitial fluid.In addition,findings showed 20 IgG4+ plasma cells per high-powered field of the diseased tissue,an IgG4+/IgG ratio of about 20%,and normal serum IgG4 levels.The final diagnosis was CFT of the mediastinum (CFTM).No evidence of tumor recurrence was observed by computed tomography at 3 mo after surgery.CONCLUSION IgG4+ plasma cell enlargement may occur in CFTM,but clinical manifestations and serological tests suggest that it is not IgG4-related disease.We speculate that it may be an independent tumor subtype.展开更多
基金Supported by Natural Science Foundation of Liaoning Province in China,No.81572621 and No.2019-MS-370
文摘BACKGROUND Calcifying fibrous tumor (CFT) is a rare benign mesenchymal tumor that often occurs in deep soft tissue of children and young adults.CFT rarely occurs in the mediastinum.CASE SUMMARY In this paper,we describe a 31-year-old male patient with CFT in the mediastinum.The patient did not have any symptoms,and the posterior mediastinal lesion was unintentionally found during routine re-examination of thyroid cancer.The tumor had no adhesion to the surrounding tissue and was successfully and completely removed.Pathology showed a large amount of collagen-rich fibrous connective tissue.There was scattered dystrophic calcification and gravel in the fibrous tissue and a small amount of lymphocyte and plasma cell infiltration and lymphoid follicle formation in the interstitial fluid.In addition,findings showed 20 IgG4+ plasma cells per high-powered field of the diseased tissue,an IgG4+/IgG ratio of about 20%,and normal serum IgG4 levels.The final diagnosis was CFT of the mediastinum (CFTM).No evidence of tumor recurrence was observed by computed tomography at 3 mo after surgery.CONCLUSION IgG4+ plasma cell enlargement may occur in CFTM,but clinical manifestations and serological tests suggest that it is not IgG4-related disease.We speculate that it may be an independent tumor subtype.
