BACKGROUND Speech disorders have a substantial impact on communication abilities and quality of life.Traditional treatments such as speech and psychological therapies frequently demonstrate limited effectiveness and p...BACKGROUND Speech disorders have a substantial impact on communication abilities and quality of life.Traditional treatments such as speech and psychological therapies frequently demonstrate limited effectiveness and patient compliance.Transcranial electrical stimulation(TES)has emerged as a promising non-invasive treatment to improve neurological functions.However,its effectiveness in enhancing language functions and serum neurofactor levels in individuals with speech disorders requires further investigation.AIM To investigate the impact of TES in conjunction with standard therapies on serum neurotrophic factor levels and language function in patients with speech disorders.METHODS In a controlled study spanning from March 2019 to November 2021,81 patients with speech disorders were divided into a control group(n=40)receiving standard speech stimulation and psychological intervention,and an observation group(n=41)receiving additional TES.The study assessed serum levels of ciliary neurotrophic factor(CNTF),glial cell-derived neurotrophic factor(GDNF),brainderived neurotrophic factor(BDNF),and nerve growth factor(NGF),as well as evaluations of motor function,language function,and development quotient scores.RESULTS After 3 wk of intervention,the observation group exhibited significantly higher serum levels of CNTF,GDNF,BDNF,and NGF compared to the control group.Moreover,improvements were noted in motor function,cognitive function,language skills,physical abilities,and overall development quotient scores.It is worth mentioning that the observation group also displayed superior perfor CONCLUSION This retrospective study concluded that TES combined with traditional speech and psychotherapy can effectively increase the levels of neurokines in the blood and enhance language function in patients with speech disorders.These results provide a promising avenue for integrating TES into standard treatment methods for speech disorders.展开更多
Background:The present investigation tested the efficacy of the Tennant Biomodulator,a novel pain management intervention that uses biofeedback-modulated electrical stimulation,to reduce chronic pain and its psychosoc...Background:The present investigation tested the efficacy of the Tennant Biomodulator,a novel pain management intervention that uses biofeedback-modulated electrical stimulation,to reduce chronic pain and its psychosocial sequelae in a sample of current and former military service members.The Tennant Biomodulator used on its most basic setting was compared to two commonly used,non-pharmacological pain treatments—traditional Chinese acupuncture and transcutaneous electrical nerve stimulation(TENS)—in a comparative efficacy,randomized,open-label trial.Methods:Participants included 100 active duty and retired service men and women with chronic pain undergoing treatment at the Brooke Army Medical Center in Texas,USA,randomly assigned to receive six,weekly sessions of either Tennant Biomodulator treatment,traditional Chinese acupuncture,or TENS,in addition to usual care.Recruitment was conducted between May 2010 to September 2013.Outcome measures were collected at intake,before and after each treatment session,and at a 1-month follow-up.Intent-to-treat analyses were used throughout,with mixed models used to investigate main effects of group,time,and group×time interactions with consideration given to quadratic effects.Outcomes measured included ratings of chronic pain,pain-related functional disability,and symptoms of post-traumatic stress disorder(PTSD)and depression.Results:On average,regardless of their treatment group,participants exhibited a 16%reduction in pain measured by the Brooke Army Medical Center’s Clinic Pain Log[F(1,335)=55.7,P<0.0001]and an 11%reduction in pain-related disability measured by the Million Visual Analog Scale[MVAS:F(1,84)=28.3,P<0.0001]from baseline to the end of treatment,but no one treatment performed better than the other,and the reductions in pain and pain-related disability were largely lost by 1-month follow-up.Symptoms of PTSD and depression did not change significantly as a function of time or group.Conclusions:Findings build on previous work suggesting that traditional Chinese acupuncture and TENS can reduce pain and its functional sequelae without risks associated with pharmacological pain management.The Tennant Biomodulator used on its most basic setting performs as well as these other interventions.Based on the present findings,large,randomized controlled trials on the Tennant Biomodulator are indicated.Future work should test this device using its full range of settings for pain-related psychological health.Trial registration:Clincialtrials.gov(NCT01752010);registered December 14,2012.展开更多
目的观察头电针联合低频经颅重复磁刺激(low frequency repetitive transcranial magnetic stimulation,LF-rTMS)治疗脑梗死后Broca失语的临床疗效。方法将符合纳入标准的63例脑梗死后Broca失语患者用随机数字表法分为观察组(n=31)、对...目的观察头电针联合低频经颅重复磁刺激(low frequency repetitive transcranial magnetic stimulation,LF-rTMS)治疗脑梗死后Broca失语的临床疗效。方法将符合纳入标准的63例脑梗死后Broca失语患者用随机数字表法分为观察组(n=31)、对照组(n=32),每组30例完成所有结果评价。两组均予以临床对症支持治疗、语言康复训练及右侧大脑半球LF-r TMS治疗,观察组另行左侧大脑半球头电针治疗,对照组行左侧大脑半球头针治疗。治疗前后,均进行西方失语症成套测验(the Western aphasia battery,WAB)评分、中国式功能性言语沟通能力检查法(chinese functional communication profile,CFCP)评分及波士顿诊断性失语症检查(Boston diagnostic aphasia examination,BDAE)评级测试,并根据BDAE评级结果计算出显愈、显效和总有效率以判定临床疗效。结果治疗6周后,观察组总有效率为96.67%,显著高于对照组的76.67%(P<0.05);两组患者的自发言语、听理解、复述、命名评分及言语沟通能力的评分均明显上升(P<0.05),且观察组高于对照组(P<0.05);两组患者的失语症等级皆提高(P<0.05),且观察组高于对照组(P<0.05)。结论头电针联合LF-rTMS治疗脑梗死后Broca失语患者可有效改善其语言功能,值得临床推广应用。展开更多
目的通过数据挖掘技术分析穴位刺激改善结直肠癌术后胃肠功能的选穴规律。方法检索中国知网(CNKI)、维普资讯中文期刊服务平台(VIP)、万方数据知识服务平台(Wanfang Data)、中国生物医学文献服务系统(SinoMed)、PubMed、Web of Science...目的通过数据挖掘技术分析穴位刺激改善结直肠癌术后胃肠功能的选穴规律。方法检索中国知网(CNKI)、维普资讯中文期刊服务平台(VIP)、万方数据知识服务平台(Wanfang Data)、中国生物医学文献服务系统(SinoMed)、PubMed、Web of Science、Cochrane Library建库至2023年7月1日收录的穴位刺激改善结直肠癌术后胃肠功能的临床研究文献。采用Excel2021对数据进行提取与分析,采用R语言进行关联规则分析与聚类分析。结果最终纳入文献197篇,腧穴配伍242条,涉及69个腧穴,总频次为878;使用频次前3位的腧穴是足三里、上巨虚和内关;所用经络主要为足阳明胃经、任脉和足太阴脾经;腧穴多分布于下肢部;最常使用的干预方法是针刺;关联规则分析得到以足三里为中心配伍上巨虚、内关、三阴交等腧穴组合;聚类分析发现4类有效聚类组合。结论穴位刺激改善结直肠癌术后胃肠功能选穴采用多种配穴思想,本研究总结的选穴配伍规律可为临床研究与运用提供参考。展开更多
目的分析早期康复训练与经颅磁刺激(Transcranial Magnetic Stimulation,TMS)联合应用于脑性瘫痪(Cerebral Palsy,CP)合并语言发育障碍患儿中的效果。方法选取2021年7月—2023年6月通辽市医院收治的90例CP合并语言发育障碍患儿为研究对...目的分析早期康复训练与经颅磁刺激(Transcranial Magnetic Stimulation,TMS)联合应用于脑性瘫痪(Cerebral Palsy,CP)合并语言发育障碍患儿中的效果。方法选取2021年7月—2023年6月通辽市医院收治的90例CP合并语言发育障碍患儿为研究对象,参照随机数表法分为对照组和研究组,每组45例。对照组采取早期康复训练,研究组在对照组基础上联用TMS治疗。比较两组的临床疗效、Frenchay构音障碍评定法评分、Gesell发育诊断量表(Gesell Developmental Schedule,GDS)评分。结果研究组的总有效率为91.11%,高于对照组的71.11%,差异有统计学意义(χ^(2)=5.874,P<0.05)。研究组的Frenchay构音障碍评定法评分、GDS评分均高于对照组,差异有统计学意义(P均<0.05)。结论早期康复训练与TMS联合治疗CP合并语言发育障碍患儿效果确切,能够有效改善其语言功能与构音能力,促进智力发育。展开更多
Essential language sites and the arcuate fasciculus（AF） have been extensively researched. However, the relationship between them remains insufficiently studied,especially in healthy people. Navigated transcranial ma...Essential language sites and the arcuate fasciculus（AF） have been extensively researched. However, the relationship between them remains insufficiently studied,especially in healthy people. Navigated transcranial magnetic stimulation（n TMS） is increasingly used in language mapping. While enjoying the advantage of non-invasiveness, it is also capable of inducing a virtual lesion in the brain. Thus, it offers the possibility of using the virtuallesion method to study the healthy brain. This study combined n TMS and diffusion tensor imaging（DTI）tractography to investigate the relationship between essential language sites and the AF in 30 healthy right-handedvolunteers. A total of 143 essential language sites were identified using n TMS, and a total of 175 AF terminations were identified using DTI tractography. Sixty-six sites had a direct correlation with the AF, accounting for 46% of the total essential language sites. Forty-seven AF terminations harbored essential language sites, accounting for 27% of the total AF terminations. Upon data rendering to the cortical parcellation system, a region-related heterogeneity of the correlation rate was found. This study provides the first data on the relationship between essential language sites and the AF in healthy adults.展开更多
文摘BACKGROUND Speech disorders have a substantial impact on communication abilities and quality of life.Traditional treatments such as speech and psychological therapies frequently demonstrate limited effectiveness and patient compliance.Transcranial electrical stimulation(TES)has emerged as a promising non-invasive treatment to improve neurological functions.However,its effectiveness in enhancing language functions and serum neurofactor levels in individuals with speech disorders requires further investigation.AIM To investigate the impact of TES in conjunction with standard therapies on serum neurotrophic factor levels and language function in patients with speech disorders.METHODS In a controlled study spanning from March 2019 to November 2021,81 patients with speech disorders were divided into a control group(n=40)receiving standard speech stimulation and psychological intervention,and an observation group(n=41)receiving additional TES.The study assessed serum levels of ciliary neurotrophic factor(CNTF),glial cell-derived neurotrophic factor(GDNF),brainderived neurotrophic factor(BDNF),and nerve growth factor(NGF),as well as evaluations of motor function,language function,and development quotient scores.RESULTS After 3 wk of intervention,the observation group exhibited significantly higher serum levels of CNTF,GDNF,BDNF,and NGF compared to the control group.Moreover,improvements were noted in motor function,cognitive function,language skills,physical abilities,and overall development quotient scores.It is worth mentioning that the observation group also displayed superior perfor CONCLUSION This retrospective study concluded that TES combined with traditional speech and psychotherapy can effectively increase the levels of neurokines in the blood and enhance language function in patients with speech disorders.These results provide a promising avenue for integrating TES into standard treatment methods for speech disorders.
基金funding source was grant#W81XWH-06-2-0279 from the United States Army Medical Research Acquisition Activity through the Telemedicine and Advanced Technology Research Centerwhich was provided to the Samueli Institutefunding was provided as a gift to the Samueli Institute by an anonymous donor with no conflicts of interest to declare。
文摘Background:The present investigation tested the efficacy of the Tennant Biomodulator,a novel pain management intervention that uses biofeedback-modulated electrical stimulation,to reduce chronic pain and its psychosocial sequelae in a sample of current and former military service members.The Tennant Biomodulator used on its most basic setting was compared to two commonly used,non-pharmacological pain treatments—traditional Chinese acupuncture and transcutaneous electrical nerve stimulation(TENS)—in a comparative efficacy,randomized,open-label trial.Methods:Participants included 100 active duty and retired service men and women with chronic pain undergoing treatment at the Brooke Army Medical Center in Texas,USA,randomly assigned to receive six,weekly sessions of either Tennant Biomodulator treatment,traditional Chinese acupuncture,or TENS,in addition to usual care.Recruitment was conducted between May 2010 to September 2013.Outcome measures were collected at intake,before and after each treatment session,and at a 1-month follow-up.Intent-to-treat analyses were used throughout,with mixed models used to investigate main effects of group,time,and group×time interactions with consideration given to quadratic effects.Outcomes measured included ratings of chronic pain,pain-related functional disability,and symptoms of post-traumatic stress disorder(PTSD)and depression.Results:On average,regardless of their treatment group,participants exhibited a 16%reduction in pain measured by the Brooke Army Medical Center’s Clinic Pain Log[F(1,335)=55.7,P<0.0001]and an 11%reduction in pain-related disability measured by the Million Visual Analog Scale[MVAS:F(1,84)=28.3,P<0.0001]from baseline to the end of treatment,but no one treatment performed better than the other,and the reductions in pain and pain-related disability were largely lost by 1-month follow-up.Symptoms of PTSD and depression did not change significantly as a function of time or group.Conclusions:Findings build on previous work suggesting that traditional Chinese acupuncture and TENS can reduce pain and its functional sequelae without risks associated with pharmacological pain management.The Tennant Biomodulator used on its most basic setting performs as well as these other interventions.Based on the present findings,large,randomized controlled trials on the Tennant Biomodulator are indicated.Future work should test this device using its full range of settings for pain-related psychological health.Trial registration:Clincialtrials.gov(NCT01752010);registered December 14,2012.
文摘目的观察头电针联合低频经颅重复磁刺激(low frequency repetitive transcranial magnetic stimulation,LF-rTMS)治疗脑梗死后Broca失语的临床疗效。方法将符合纳入标准的63例脑梗死后Broca失语患者用随机数字表法分为观察组(n=31)、对照组(n=32),每组30例完成所有结果评价。两组均予以临床对症支持治疗、语言康复训练及右侧大脑半球LF-r TMS治疗,观察组另行左侧大脑半球头电针治疗,对照组行左侧大脑半球头针治疗。治疗前后,均进行西方失语症成套测验(the Western aphasia battery,WAB)评分、中国式功能性言语沟通能力检查法(chinese functional communication profile,CFCP)评分及波士顿诊断性失语症检查(Boston diagnostic aphasia examination,BDAE)评级测试,并根据BDAE评级结果计算出显愈、显效和总有效率以判定临床疗效。结果治疗6周后,观察组总有效率为96.67%,显著高于对照组的76.67%(P<0.05);两组患者的自发言语、听理解、复述、命名评分及言语沟通能力的评分均明显上升(P<0.05),且观察组高于对照组(P<0.05);两组患者的失语症等级皆提高(P<0.05),且观察组高于对照组(P<0.05)。结论头电针联合LF-rTMS治疗脑梗死后Broca失语患者可有效改善其语言功能,值得临床推广应用。
文摘目的通过数据挖掘技术分析穴位刺激改善结直肠癌术后胃肠功能的选穴规律。方法检索中国知网(CNKI)、维普资讯中文期刊服务平台(VIP)、万方数据知识服务平台(Wanfang Data)、中国生物医学文献服务系统(SinoMed)、PubMed、Web of Science、Cochrane Library建库至2023年7月1日收录的穴位刺激改善结直肠癌术后胃肠功能的临床研究文献。采用Excel2021对数据进行提取与分析,采用R语言进行关联规则分析与聚类分析。结果最终纳入文献197篇,腧穴配伍242条,涉及69个腧穴,总频次为878;使用频次前3位的腧穴是足三里、上巨虚和内关;所用经络主要为足阳明胃经、任脉和足太阴脾经;腧穴多分布于下肢部;最常使用的干预方法是针刺;关联规则分析得到以足三里为中心配伍上巨虚、内关、三阴交等腧穴组合;聚类分析发现4类有效聚类组合。结论穴位刺激改善结直肠癌术后胃肠功能选穴采用多种配穴思想,本研究总结的选穴配伍规律可为临床研究与运用提供参考。
基金supported in part by grants from the National Natural Science Foundation of China(81272782 and 81472352)the Chinese Society of Neuro-oncology,Chinese AntiCancer Association(CSNO2014MSD01)Special Funds for Instruments of the National Natural Science Foundation of China(81127003)
文摘Essential language sites and the arcuate fasciculus（AF） have been extensively researched. However, the relationship between them remains insufficiently studied,especially in healthy people. Navigated transcranial magnetic stimulation（n TMS） is increasingly used in language mapping. While enjoying the advantage of non-invasiveness, it is also capable of inducing a virtual lesion in the brain. Thus, it offers the possibility of using the virtuallesion method to study the healthy brain. This study combined n TMS and diffusion tensor imaging（DTI）tractography to investigate the relationship between essential language sites and the AF in 30 healthy right-handedvolunteers. A total of 143 essential language sites were identified using n TMS, and a total of 175 AF terminations were identified using DTI tractography. Sixty-six sites had a direct correlation with the AF, accounting for 46% of the total essential language sites. Forty-seven AF terminations harbored essential language sites, accounting for 27% of the total AF terminations. Upon data rendering to the cortical parcellation system, a region-related heterogeneity of the correlation rate was found. This study provides the first data on the relationship between essential language sites and the AF in healthy adults.
