Crystallization is a fundamental separation technology used for the production of particulate solids.Accurate nucleation and growth process control are vitally important but difficult.A novel controlling technology th...Crystallization is a fundamental separation technology used for the production of particulate solids.Accurate nucleation and growth process control are vitally important but difficult.A novel controlling technology that can simultaneously intensify the overall crystallization process remains a significant challenge.Membrane crystallization(MCr),which has progressed significantly in recent years,is a hybrid technology platform with great potential to address this goal.This review illustrates the basic concepts of MCr and its promising applications for crystallization control and process intensification,including a state-of-the-art review of key MCr-utilized membrane materials,process control mechanisms,and optimization strategies based on diverse hybrid membranes and crystallization processes.Finally,efforts to promote MCr technology to industrial use,unexplored issues,and open questions to be addressed are outlined.展开更多
Membrane distillation crystallization (MDC) is a promising hybrid separation process that has been applied to seawater desalination, brine treatment and wastewater recovery. In recent years, great progress has been ...Membrane distillation crystallization (MDC) is a promising hybrid separation process that has been applied to seawater desalination, brine treatment and wastewater recovery. In recent years, great progress has been made in MDC technologies including the promotion of nucleation and better control of crystallization and crystal size distribution. These advances are useful for the accurate control of the degree of supersaturation and for the control of the nucleation kinetic processes. This review focuses on the development of MDC process models and on crystallization control strategies. In addition, the most important innovative applications of MDC in the last five years in crystal engineering and pharmaceutical manufac- turing are summarized.展开更多
High-end crystal manufacture has drawn a permanent concern on the high-efficient manufacture of crystal particles,especially in fine chemical,pharmaceutical,electronics,biological and relative engineering fields.In re...High-end crystal manufacture has drawn a permanent concern on the high-efficient manufacture of crystal particles,especially in fine chemical,pharmaceutical,electronics,biological and relative engineering fields.In recent years,a series of microscale process intensification(MPI)technologies have been widely used in crystal particles preparation via addressing the control of nucleation and growth process.Herein,we review the research progresses of microscale process intensification technology from three aspects,microfluidics devices,microscale force field technology and membrane-based microchannels and interface transfer process.Firstly,the principle of microfluidic and relative microscale device on improving micro-mixing and mass transfer are briefly described.The advantage of microfluidic in continuous nano particle preparation is outlined.Microscale external force field(ultrasonic,high-gravity,electric and magnetic fields)is then introduced as another novel approach for ultrafine nanoparticles and continuous drug crystallization process.Further,in view of the micro-scale intensified mass transfer and microscale interfacial force field established on membrane technology,the basic mechanism of membrane crystallization(microscale 2D supersaturation degree control,auto seed detachment,microporous membrane dispersion,etc.)is reviewed.The process coupling and design strategy aiming for enhancing the manufacture capacity is also illustrated.Finally,the developing tendency and key challenges of high-efficient crystal particle preparation technology via microscale processes are overviewed.展开更多
基金We acknowledge the financial contributions from the National Natural Science Foundation of China(21978037,21676043,21527812,and U1663223)the Ministry of Science and Technology of the People’s Republic of China innovation team in key area(2016RA4053)Fundamental Research Funds for the Central Universities(DUT19TD33).
文摘Crystallization is a fundamental separation technology used for the production of particulate solids.Accurate nucleation and growth process control are vitally important but difficult.A novel controlling technology that can simultaneously intensify the overall crystallization process remains a significant challenge.Membrane crystallization(MCr),which has progressed significantly in recent years,is a hybrid technology platform with great potential to address this goal.This review illustrates the basic concepts of MCr and its promising applications for crystallization control and process intensification,including a state-of-the-art review of key MCr-utilized membrane materials,process control mechanisms,and optimization strategies based on diverse hybrid membranes and crystallization processes.Finally,efforts to promote MCr technology to industrial use,unexplored issues,and open questions to be addressed are outlined.
文摘Membrane distillation crystallization (MDC) is a promising hybrid separation process that has been applied to seawater desalination, brine treatment and wastewater recovery. In recent years, great progress has been made in MDC technologies including the promotion of nucleation and better control of crystallization and crystal size distribution. These advances are useful for the accurate control of the degree of supersaturation and for the control of the nucleation kinetic processes. This review focuses on the development of MDC process models and on crystallization control strategies. In addition, the most important innovative applications of MDC in the last five years in crystal engineering and pharmaceutical manufac- turing are summarized.
基金We acknowledge the financial contribution from Science Fund for Creative Research Groups of the National Natural Science Foundation of China(22021005)National Natural Science Foundation of China(Grant No.21978037)+3 种基金Fundamental Research Funds for the Central Universities(DUT19TD33)National Key Research and Development Program of China(Grant No.2019YFE0119200)Support Plan of Innovative Talents of Liaoning Province(XLYC1901005,XLYC1907149)Dalian Innovative Science and Technology Fund(2020JJ26SN064).
文摘High-end crystal manufacture has drawn a permanent concern on the high-efficient manufacture of crystal particles,especially in fine chemical,pharmaceutical,electronics,biological and relative engineering fields.In recent years,a series of microscale process intensification(MPI)technologies have been widely used in crystal particles preparation via addressing the control of nucleation and growth process.Herein,we review the research progresses of microscale process intensification technology from three aspects,microfluidics devices,microscale force field technology and membrane-based microchannels and interface transfer process.Firstly,the principle of microfluidic and relative microscale device on improving micro-mixing and mass transfer are briefly described.The advantage of microfluidic in continuous nano particle preparation is outlined.Microscale external force field(ultrasonic,high-gravity,electric and magnetic fields)is then introduced as another novel approach for ultrafine nanoparticles and continuous drug crystallization process.Further,in view of the micro-scale intensified mass transfer and microscale interfacial force field established on membrane technology,the basic mechanism of membrane crystallization(microscale 2D supersaturation degree control,auto seed detachment,microporous membrane dispersion,etc.)is reviewed.The process coupling and design strategy aiming for enhancing the manufacture capacity is also illustrated.Finally,the developing tendency and key challenges of high-efficient crystal particle preparation technology via microscale processes are overviewed.