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Ringing in the Changes Unprecedented State Council restructuring sees creation, cuts and merges of ministries
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作者 Yuan Yuan 《ChinAfrica》 2018年第4期16-17,共2页
China's Xinhua News Agency calls it the "biggest government reshuffle in years" in what is seen as a dra matic continuation of the previous seven rounds of cabinet restructuring that began in 1982.
关键词 Ringing in the Changes Unprecedented State Council restructuring sees creation cuts and merges of ministries
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3D MERGE与3D SPACE STIR序列在腰椎间盘突出症检查中的应用比较 被引量:1
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作者 李兰 殷小丹 +2 位作者 李旭雪 吴海燕 张滔 《中国医学物理学杂志》 CSCD 2024年第1期27-31,共5页
目的:对比三维多回波恢复梯度回波(3D MERGE)、三维可变反转角快速自旋回波(3D SPACE STIR)序列在腰椎间盘突出症(LDH)检查中的应用效果。方法:选择2020年1月~2022年11月收治的135例LDH患者,回顾性分析患者临床和磁共振成像(MRI)资料,... 目的:对比三维多回波恢复梯度回波(3D MERGE)、三维可变反转角快速自旋回波(3D SPACE STIR)序列在腰椎间盘突出症(LDH)检查中的应用效果。方法:选择2020年1月~2022年11月收治的135例LDH患者,回顾性分析患者临床和磁共振成像(MRI)资料,所有患者均接受常规MRI扫描及3D MERGE、3D SPACE STIR序列扫描,对比3D MERGE、3D SPACE STIR序列测量神经根直径的一致性,评价两种序列的图像质量参数[信噪比(SNR)、对比噪声比(CNR)]、图像清晰度评分。结果:3D MERGE和3D SPACE STIR序列测量的L3~S1神经根直径比较差异无统计学意义(P>0.05),且两组序列测量的L3、L4、L5和S1直径均显示出较高相关性(r=0.957,0.986,0.975,0.972,P<0.05);3D MERGE序列的SNR及CNR均高于3D SPACE STIR序列,神经根显示分级、图像清晰度评分优于3D SPACE STIR序列,差异有统计学意义(P<0.05)。结论:3D MERGE、3D SPACE STIR序列在LDH神经根直径测量中具有极高一致性,3D MERGE序列较3D SPACE STIR序列能够更清晰显示神经跟的解剖形态,图像质量更好。 展开更多
关键词 腰椎间盘突出症 3D MERGE 3D SPACE STIR 神经根直径 图像质量
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中医药多元证据整合方法学MERGE框架 被引量:4
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作者 赖鸿皓 王浙 +12 位作者 李滢 唐文静 王蓓蓓 孙培栋 孙铭谣 黄嘉杰 肖志攀 李颖 赵晨 商洪才 杨克虎 刘杰 葛龙 《协和医学杂志》 CSCD 北大核心 2024年第1期172-182,共11页
在循证医学时代下,依托规范的技术方法和标准化的操作规程发掘中医药独特优势,是实现中医药现代化、国际化发展并惠泽人类的必由之路。中医理论、人用经验和研究证据三结合证据体系的提出标志着中医药特色评价体系思维方法取得了重要进... 在循证医学时代下,依托规范的技术方法和标准化的操作规程发掘中医药独特优势,是实现中医药现代化、国际化发展并惠泽人类的必由之路。中医理论、人用经验和研究证据三结合证据体系的提出标志着中医药特色评价体系思维方法取得了重要进步,经过恰当方法整合后的多元证据体是中医药临床指南推荐意见和循证卫生决策的有力支撑。本文基于当前国际证据合成与分级方法学前沿进展,初步提出中医药多元证据整合的方法学框架——MERGE(Merge Evidence-based Research and artificial intelliGence to support smart dEcision)框架,以期为中医药循证医学方法学体系的完善和发展提供借鉴和参考。 展开更多
关键词 循证医学 中医药 多元证据 证据整合 MERGE框架
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A New Merged Product Reveals Precipitation Features over Drylands in China
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作者 Min LUO Yuzhi LIU +5 位作者 Jie GAO Run LUO Jinxia ZHANG Ziyuan TAN Siyu CHEN Khan ALAM 《Advances in Atmospheric Sciences》 SCIE CAS CSCD 2024年第10期2079-2091,共13页
Due to the considerable uncertainties inherent in the datasets describing the spatiotemporal distributions of precipitation in the drylands of China,this study presents a new merged monthly precipitation product with ... Due to the considerable uncertainties inherent in the datasets describing the spatiotemporal distributions of precipitation in the drylands of China,this study presents a new merged monthly precipitation product with a spatial resolution of approximately 0.2°×0.2°during 1980–2019.The newly developed precipitation product was validated at different temporal scales(e.g.,monthly,seasonally,and annually).The results show that the new product consistently aligns with the spatiotemporal distributions reported by the Chinese Meteorological Administration Land Data Assimilation System(CLDAS)product and Multi-Source Weighted Ensemble Precipitation(MSWEP).The merged product exhibits exceptional quality in describing the drylands of China,with a bias of–2.19 mm month^(–1)relative to MSWEP.In addition,the annual trend of the merged product(0.09 mm month^(–1)yr^(−1))also closely aligns with that of the MSWEP(0.11 mm month^(–1)yr^(−1))during 1980–2019.The increasing trend indicates that the water cycle and wetting process intensified in the drylands of China during this period.In particular,there was an increase in wetting during the period from 2001–2019.Generally,the merged product exhibits potential value for improving our understanding of the climate and water cycle in the drylands of China. 展开更多
关键词 PRECIPITATION merged dataset DRYLANDS water cycle
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Optimization of High-Concurrency Conflict Issues in Execute-Order-Validate Blockchain
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作者 MA Qianli ZHANG Shengli +2 位作者 WANG Taotao YANG Qing WANG Jigang 《ZTE Communications》 2024年第2期19-29,共11页
With the maturation and advancement of blockchain technology,a novel execute-order-validate(EOV)architecture has been proposed,allowing transactions to be executed in parallel during the execution phase.However,parall... With the maturation and advancement of blockchain technology,a novel execute-order-validate(EOV)architecture has been proposed,allowing transactions to be executed in parallel during the execution phase.However,parallel execution may lead to multi-version concurrency control(MVCC)conflicts during the validation phase,resulting in transaction invalidation.Based on different causes,we categorize conflicts in the EOV blockchain into two types:within-block conflicts and cross-block conflicts,and propose an optimization solution called FabricMan based on Fabric v2.4.For within-block conflicts,a reordering algorithm is designed to improve the transaction success rate and parallel validation is implemented based on the transaction conflict graph.We also merge transfer transactions to prevent triggering multiple version checks.For cross-block conflicts,a cache-based version validation mechanism is implemented to detect and terminate invalid transactions in advance.Experimental comparisons are conducted between FabricMan and two other systems,Fabric and Fabric++.The results show that FabricMan outperforms the other two systems in terms of throughput,transaction abort rate,algorithm execution time,and other experimental metrics. 展开更多
关键词 blockchain MVCC conflict REORDERING parallel validation transaction merging
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Controlling Congestion in Al-Seeb Highway Using Ramp Metering (Case Study)
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作者 Zahra Al Habsi Mohamed Al Qanaii 《Journal of Transportation Technologies》 2024年第3期308-335,共28页
This paper represents a case study of traffic congestion within a section on Al Seeb Street highway due to the on-ramp merging of vehicles that causes a bottleneck in the mainline road. It studies the efficiency of in... This paper represents a case study of traffic congestion within a section on Al Seeb Street highway due to the on-ramp merging of vehicles that causes a bottleneck in the mainline road. It studies the efficiency of installing ramp metering within a ramp within the selected study zone. This is done by simulating the collected data using Vissim software by drawing three one-hour-long scenarios;the first scenario reflects the data collected for 30 minutes duration and is used as a base scenario to draw the other two scenarios, which are reflected as factored-up scenarios to create a situation observed in the early morning in the study zone at 6:00-7:00 in which slowing down of speeds exist, and breakdown is raised in working days. The two factoring-up scenarios were as follows: one without ramp metering and the other without ramp metering. Each scenario was calibrated and run five times with random seeds, and then the average was considered. The simulation examines the ability of RM to smooth traffic in mainline and reduce queuing on on-ramp roads within the selected study zone by comparing the performance of the network for the scenarios and comparing them in terms of the overall delays, number of stops and the average speeds for the vehicles within the mainline. The results showed a good performance reflected by the scenario with ramp metering with a reduction of the overall delay, a decrease in stops number and an increase of the average speed were achieved. For the base scenario, a visualization (video extracted from Vissim software) was extracted, showing no need to install RM with an associated table showing a number of stops equal to zero with an average speed of 102.74 km/h and a total delay of 6045 seconds. For the second scenario with no RM, a visualization was extracted showing a slowing down of speeds for vehicles within the mainline while vehicles merging from the on-ramp and need to be controlled with a table showing a number of stops equal to 16 and an average speed equal to 58 km/h and a total delay of 916,874 seconds. For the third scenario with RM, a visualization was extracted showing good control of the second scenario with a table showing the number of stops equal to 6, an average speed equal to 61 km/h and a total delay equal to 484,466 seconds. Ten literatures in regard to this study have been reviewed. The data collected are quantitative, which are collected using an indirect manual counting method and then the data is used to feed the software for simulation. 展开更多
关键词 On-Ramp Merge Ramp-Metering Vissim Simulation
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加勒比海的水下雕塑
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作者 李畅 《疯狂英语(新读写)》 2024年第5期11-13,74,共4页
主题语境:雕塑篇幅:332词建议用时:7分钟1 Nearly two decades ago,the worlds first underwater sculpture garden opened off the coast of Grenada to much acclaim and wonder.Now,artists have expanded the unique installation b... 主题语境:雕塑篇幅:332词建议用时:7分钟1 Nearly two decades ago,the worlds first underwater sculpture garden opened off the coast of Grenada to much acclaim and wonder.Now,artists have expanded the unique installation by submerging 31 new sculptures under the waters of the Caribbean. 展开更多
关键词 expanded UNDERWATER MERGING
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North Korea Merges Into East Asia
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作者 SHI YONGMING The author is an Associate Researcher at the China Institute of International Studies 《Beijing Review》 2008年第34期10-11,共2页
As North Korea becomes more involved in regional cooperation, East Asian countries adjust to their new parther 0n July 24, North Korea signed the Treaty of Amity and Cooperation in Southeast Asia (TAC), marking the st... As North Korea becomes more involved in regional cooperation, East Asian countries adjust to their new parther 0n July 24, North Korea signed the Treaty of Amity and Cooperation in Southeast Asia (TAC), marking the strengthened relations between 展开更多
关键词 North Korea merges Into East Asia ASEAN
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基于患者满意度的紧密型县域医疗共同体建设评价:以广西为例 被引量:4
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作者 管文博 黄葭燕 梁笛 《中国卫生资源》 CSCD 北大核心 2023年第1期71-75,共5页
目的分析广西紧密型县城医疗共同体(以下简称“医共体”)试点县前后患者对居民就医体验和服务质量的满意度变化,评价紧密型县域医共体建设的实施成效。方法在2020年与2022年,分别对试点县和非试点县的医共体门诊患者、住院患者进行满意... 目的分析广西紧密型县城医疗共同体(以下简称“医共体”)试点县前后患者对居民就医体验和服务质量的满意度变化,评价紧密型县域医共体建设的实施成效。方法在2020年与2022年,分别对试点县和非试点县的医共体门诊患者、住院患者进行满意度基线调查和终末调查,采用描述性分析、双重差分法比较前后满意度差异。结果2022年的患者满意度较2020年有不同程度的提升(P<0.05)。试点县住院患者的总体满意度、就医环境、等候时间、服务态度、技术水平、医疗费用满意度与非试点县相比,分别提升了0.306分、0.361分、0.462分、0.377分、0.273分、0.404分(P<0.05),但医共体建设对门诊患者满意度影响不大。结论广西“三二”医联体(三级公立医院与县级二级医疗机构组成的医疗联合体)取得了一定成效,牵头医院住院患者就医体验不断改善。应促进“三二”医联体和县域医共体有机衔接和融合,提高县域整体医疗服务能力。 展开更多
关键词 患者满意度satisfaction of patient 紧密型县域医共体merged county medical alliance 评价evaluation 广西Guangxi
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Honghe Chemical Merges into ChemChina
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《China Chemical Reporter》 2005年第34期7-7,共1页
Zigong Honghe Chemical Group Co.,Ltd.was formally merged into ChinaHaohua Chemical Industrial(Group)Corporation of ChemChina on Novem-ber 11th,2005.Owning Asian largest synthetic in-dustrial unit for producing sodiumb... Zigong Honghe Chemical Group Co.,Ltd.was formally merged into ChinaHaohua Chemical Industrial(Group)Corporation of ChemChina on Novem-ber 11th,2005.Owning Asian largest synthetic in-dustrial unit for producing sodiumbicarbonate,Honghe Chemical has to-tal asset of RMB2.5 billion with eco-nomic growth above 30% in the pastthree years.It realized the sales revenueof RMB450 million and profit of morethan RMB43 million in the fiscal 2004.During the Eleventh Five-year 展开更多
关键词 morethan FORMALLY producing PROFIT FISCAL ASSET OWNED merged realized VENUE
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Super Typhoon Hinnamnor(2022)with a Record-Breaking Lifespan over the Western North Pacific 被引量:2
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作者 Qian WANG Dajun ZHAO +4 位作者 Yihong DUAN Shoude GUAN Lin DONG Hongxiong XU Hui WANG 《Advances in Atmospheric Sciences》 SCIE CAS CSCD 2023年第9期1558-1566,共9页
Super Typhoon Hinnamnor(2022)was a rare and unique western North Pacific typhoon,and throughout its lifespan,it exhibited all of the major features that pose current challenges in typhoon research.Specifically,during ... Super Typhoon Hinnamnor(2022)was a rare and unique western North Pacific typhoon,and throughout its lifespan,it exhibited all of the major features that pose current challenges in typhoon research.Specifically,during different stages of its lifespan,it experienced a sudden change of track,underwent rapid intensification,interacted and merged with another vortex,expanded in size,underwent rapid weakening,produced a strong cold wake,exhibited eyewall replacement,and underwent extratropical transition.Therefore,a timely identification and review of these features of Hinnamnor(2022),as reported in this article,will help update and enrich the case sets for each of these scientific issues and provide a background for more in-depth mechanistic studies of typhoon track,intensity,and structural changes in the future.We also believe that Hinnamnor(2022)can serve as an excellent benchmark to quickly evaluate the overall performance of different numerical models in predicting typhoon’s track,intensity,and structural changes. 展开更多
关键词 sudden track change rapid intensification rapid weakening vortex merging extratropical transition
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基于VVC的多方向细化Merge模式优化算法
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作者 唐健翔 熊淑华 +1 位作者 孙伟恒 何小海 《电子测量技术》 北大核心 2023年第10期189-196,共8页
针对多功能视频编码标准VVC帧间预测中,Merge模式未充分考虑运动存在的多种方向性从而降低了预测精度的问题,提出了一种基于VVC的多方向细化Merge模式优化算法。本算法在分析带运动矢量差的Merge技术的基础上,首先调整了步长选择范围并... 针对多功能视频编码标准VVC帧间预测中,Merge模式未充分考虑运动存在的多种方向性从而降低了预测精度的问题,提出了一种基于VVC的多方向细化Merge模式优化算法。本算法在分析带运动矢量差的Merge技术的基础上,首先调整了步长选择范围并增加多种搜索方向,然后根据步长自适应选择色度块的运动补偿方式,并最终根据率失真代价准则选择最优的运动矢量信息。实验结果表明,本文算法与VTM-12.0参考模型相比,在低延迟P帧配置下Y、U、V三分量的BD-rate分别平均下降了0.57%、0.62%、0.25%,在随机接入配置下的BD-rate中Y分量下降了0.27%、U分量仅提高了0.11%、V分量降低了0.04%,有效地提升了Merge模式的编码性能。 展开更多
关键词 多功能视频编码 帧间预测 多方向细化 Merge模式 编码性能
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A Large-Scale Scheduling Method for Multiple Agile Optical Satellites
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作者 Zheng Liu Wei Xiong Minghui Xiong 《Computer Modeling in Engineering & Sciences》 SCIE EI 2023年第8期1143-1163,共21页
This study investigates the scheduling problem ofmultiple agile optical satelliteswith large-scale tasks.This problem is difficult to solve owing to the time-dependent characteristic of agile optical satellites,comple... This study investigates the scheduling problem ofmultiple agile optical satelliteswith large-scale tasks.This problem is difficult to solve owing to the time-dependent characteristic of agile optical satellites,complex constraints,and considerable solution space.To solve the problem,we propose a scheduling method based on an improved sine and cosine algorithm and a task merging approach.We first establish a scheduling model with task merging constraints and observation action constraints to describe the problem.Then,an improved sine and cosine algorithm is proposed to search for the optimal solution with the maximum profit ratio.An adaptive cosine factor and an adaptive greedy factor are adopted to improve the algorithm.Besides,a taskmerging method with a task reallocation mechanism is developed to improve the scheduling efficiency.Experimental results demonstrate the superiority of the proposed algorithm over the comparison algorithms. 展开更多
关键词 Multiple agile optical satellites scheduling task merging sine and cosine algorithm task reallocation
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Validation of the multi-satellite merged sea surface salinity in the South China Sea
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作者 Huipeng WANG Junqiang SONG +3 位作者 Chengwu ZHAO Xiangrong YANG Hongze LENG Nan ZHOU 《Journal of Oceanology and Limnology》 SCIE CAS CSCD 2023年第6期2033-2044,共12页
Sea surface salinity(SSS)is an essential variable of ocean dynamics and climate research.The Soil Moisture and Ocean Salinity(SMOS),Aquarius,and Soil Moisture Active Passive(SMAP)satellite missions all provide SSS mea... Sea surface salinity(SSS)is an essential variable of ocean dynamics and climate research.The Soil Moisture and Ocean Salinity(SMOS),Aquarius,and Soil Moisture Active Passive(SMAP)satellite missions all provide SSS measurements.The European Space Agency(ESA)Climate Change Initiative Sea Surface Salinity(CCI-SSS)project merged these three satellite SSS data to produce CCI L4SSS products.We validated the accuracy of the four satellite products(CCI,SMOS,Aquarius,and SMAP)using in-situ gridded data and Argo floats in the South China Sea(SCS).Compared with in-situ gridded data,it shows that the CCI achieved the best performance(RMSD:0.365)on monthly time scales.The RMSD of SMOS,Aquarius,and SMAP(SMOS:0.389;Aquarius:0.409;SMAP:0.391)are close,and the SMOS takes a slight advantage in contrast with Aquarius and SMAP.Large discrepancies can be found near the coastline and in the shelf seas.Meanwhile,CCI with lower RMSD(0.295)perform better than single satellite data(SMOS:0.517;SMAP:0.297)on weekly time scales compared with Argo floats.Overall,the merged CCI have the smallest RMSD among the four satellite products in the SCS on both weekly time scales and monthly time scales,which illustrates the improved accuracy of merged CCI compared with the individual satellite data. 展开更多
关键词 sea surface salinity(SSS) South China Sea(SCS) ARGO multi-satellite merged data VALIDATION
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Novel layout design of 4H-SiC merged PiN Schottky diodes leading to improved surge robustness
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作者 陈嘉豪 王颖 +2 位作者 费新星 包梦恬 曹菲 《Chinese Physics B》 SCIE EI CAS CSCD 2023年第9期552-558,共7页
A method to improve the surge current capability of silicon carbide(SiC)merged PiN Schottky(MPS)diodes is presented and investigated via three-dimensional electro-thermal simulations.When compared with a conventional ... A method to improve the surge current capability of silicon carbide(SiC)merged PiN Schottky(MPS)diodes is presented and investigated via three-dimensional electro-thermal simulations.When compared with a conventional MPS diode,the proposed structure has a more uniform current distribution during bipolar conduction due to the help of the continuous P+surface,which can avoid the formation of local hotspots during the surge process.The Silvaco simulation results show that the proposed structure has a 20.29%higher surge capability and a 15.06%higher surge energy compared with a conventional MPS diode.The bipolar on-state voltage of the proposed structure is 4.69 V,which is 56.29%lower than that of a conventional MPS diode,enabling the device to enter the bipolar mode earlier during the surge process.Furthermore,the proposed structure can suppress the occurrence of‘snapback'phenomena when switching from the unipolar to the bipolar operation mode.In addition,an analysis of the surge process of MPS diodes is carried out in detail. 展开更多
关键词 merged PiN Schottky(MPS)diode silicon carbide(SiC) surge capability surge energy reliability
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Homogeneous Batch Memory Deduplication Using Clustering of Virtual Machines
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作者 N.Jagadeeswari V.Mohan Raj 《Computer Systems Science & Engineering》 SCIE EI 2023年第1期929-943,共15页
Virtualization is the backbone of cloud computing,which is a developing and widely used paradigm.Byfinding and merging identical memory pages,memory deduplication improves memory efficiency in virtualized systems.Kern... Virtualization is the backbone of cloud computing,which is a developing and widely used paradigm.Byfinding and merging identical memory pages,memory deduplication improves memory efficiency in virtualized systems.Kernel Same Page Merging(KSM)is a Linux service for memory pages sharing in virtualized environments.Memory deduplication is vulnerable to a memory disclosure attack,which uses covert channel establishment to reveal the contents of other colocated virtual machines.To avoid a memory disclosure attack,sharing of identical pages within a single user’s virtual machine is permitted,but sharing of contents between different users is forbidden.In our proposed approach,virtual machines with similar operating systems of active domains in a node are recognised and organised into a homogenous batch,with memory deduplication performed inside that batch,to improve the memory pages sharing efficiency.When compared to memory deduplication applied to the entire host,implementation details demonstrate a significant increase in the number of pages shared when memory deduplication applied batch-wise and CPU(Central processing unit)consumption also increased. 展开更多
关键词 Kernel same page merging memory deduplication virtual machine sharing content-based sharing
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Quantifying Operational Impacts of Variations in Work Zone Setups, Traffic Demand, and Traffic Composition: A Case Study
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作者 A B M Tausif Ullah Chy Virginia P. Sisiopiku 《Journal of Transportation Technologies》 2023年第1期18-37,共20页
The presence of work zones due to pavement repair and rehabilitation is very common in highway facilities. Lane closures associated with work zones result in capacity reduction, which, in turn, often leads to increase... The presence of work zones due to pavement repair and rehabilitation is very common in highway facilities. Lane closures associated with work zones result in capacity reduction, which, in turn, often leads to increased congestion at such locations. This paper documents findings from a study that investigated the performance of freeway facilities in the presence of work zones under various Temporary Traffic Control (TTC) and lane closure scenarios while taking under consideration traffic composition and driving behaviors. The study site was an approximately 10-mile freeway segment of Interstate 65 (I-65) located in Birmingham, AL. The testbed was coded in PTV VISSIM, a microscopic simulation analysis platform, for: 1) baseline conditions (i.e., no work zone presence) and 2) work zone conditions with single lane closure (i.e., 3-to-2 lane closure). Work zone scenarios were coded for two TTC strategies, namely, early merge and late merge control and for three different positions of the lane closure (i.e., left, right, and center lane closures). The length of the work zones varied from 1000 to 2000, and 3000 ft. Sensitivity analysis was performed to document the operational impacts of varying heavy vehicle percentages, changes in drivers’ aggressiveness, and projected traffic demand changes. The impacts were quantified using linked-based measures of effectiveness (MOEs) such as travel time, and travel time index. The study results show that there is no significant change in travel time index due to the variation of work zone length across the study corridor. Under similar traffic control and demand conditions, a center lane closure consistently results in significantly higher travel time index than a left or right lane closure and should be avoided. Consideration of operational impacts of changes in truck percentage indicates that the corridor can absorb an increase in truck percentage from 10% to 15%, while performance rapidly deteriorates when a higher percentage of trucks is present in the traffic stream. The study findings can be used to guide transportation agencies in their future efforts to develop strategic lane closure plans that minimize congestion. 展开更多
关键词 Work Zone Placement Late Merge Control PTV VISSIM
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Construction and Evaluation of Merged Pharmacophore Based on Peroxisome Proliferator Receptor-Alpha Agonists 被引量:3
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作者 乔连生 贺昱甦 +5 位作者 霍晓乾 蒋芦荻 陈艳昆 陈茜 张燕玲 李贡宇 《Chinese Journal of Chemical Physics》 SCIE CAS CSCD 2016年第4期508-516,I0002,共10页
Pharmacophore is a commonly used method for molecular simulation, including ligand-based pharmacophore (LBP) and structure-based pharmacophore (SBP). LBP can be utilized to identify active compounds usual with low... Pharmacophore is a commonly used method for molecular simulation, including ligand-based pharmacophore (LBP) and structure-based pharmacophore (SBP). LBP can be utilized to identify active compounds usual with lower accuracy, and SBP is able to use for distin- guishing active compounds from inactive compounds with frequently higher missing rates. Merged pharmacophore (MP) is presented to integrate advantages and avoid shortcomings of LBP and SBP. In this work, LBP and SBP models were constructed for the study of per- oxisome proliferator receptor-alpha (PPARα) agonists. According to the comparison of the two types of pharmacophore models, mainly and secondarily pharmacological features were identified. The weight and tolerance values of these pharmacological features were adjusted to construct MP models by single-factor explorations and orthogonal experimental design based on SBP model. Then, the reliability and screening efficiency of the best MP model were validated by three databases. The best MP model was utilized to compute PPARα activity of compounds from traditional Chinese medicine. The screening efficiency of MP model outperformed individual LBP or SBP model for PPARα agonists, and was similar to combinatorial screening of LBP and SBP. However, MP model might have an advantage over the combination of LBP and SBP in evaluating the activity of compounds and avoiding the inconsistent prediction of LBP and SBP, which would be beneficial to guide drug design and optimization. 展开更多
关键词 Merged pharmacophore Ligand-based pharmacophore Structure-based pharmaeophore Peroxisome proliferator receptor-alpha DOCKING Combinatorial screening
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融合的三维卷积神经网络的视频流分类研究 被引量:5
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作者 裴颂文 杨保国 顾春华 《小型微型计算机系统》 CSCD 北大核心 2018年第10期2266-2270,共5页
三维数学模型擅长描述连续性视频流数据的多维度信息,是视频分类研究中的重要手段.将多个顺序模型融合(Merge)后通过全连接(Dense)的方式构建了融合的三维卷积神经网络模型(3DConvNet_Ensemble),解决了单个三维卷积神经网络模型训练不... 三维数学模型擅长描述连续性视频流数据的多维度信息,是视频分类研究中的重要手段.将多个顺序模型融合(Merge)后通过全连接(Dense)的方式构建了融合的三维卷积神经网络模型(3DConvNet_Ensemble),解决了单个三维卷积神经网络模型训练不充分性和低相关性问题.对UCF-101视频流数据集的101类场景进行动作行为分类实验,结果表明该模型在UCF-101数据集上获得了87. 7%的分类准确率,相比二维ConvNet和三维ConvNet模型的分类准确率分别提高了32%和17%. 展开更多
关键词 三维卷积神经网络 MERGE DENSE UCF-101数据集
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多焦视网膜电图的增龄变化 被引量:7
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作者 谭浅 夏朝华 +2 位作者 丁芝祥 刘双珍 许雪亮 《国际眼科杂志》 CAS 2005年第2期275-277,共3页
目的:探讨不同年龄正常人多焦视网膜电图(mul-ticalelectroretinogrammERG)在视网膜的分布特征,以获得正常参考值。方法:应用法国Metrovision公司生产的VisionMonitor视觉诱发系统检测20例(28眼)正常人mERG,分为2组,其中年龄≥50岁者,... 目的:探讨不同年龄正常人多焦视网膜电图(mul-ticalelectroretinogrammERG)在视网膜的分布特征,以获得正常参考值。方法:应用法国Metrovision公司生产的VisionMonitor视觉诱发系统检测20例(28眼)正常人mERG,分为2组,其中年龄≥50岁者,为10例(15眼),年龄<50岁者;为10例(13眼)。检测视野的水平视角±30°,垂直视角±23°,采用ERG-jet接触镜电极,于5min记录61个视网膜部位的反应。结果:黄斑中心凹第1环及第2环N1波、P1波、N2波的振幅密度值两组比较差异有显著意义(P<0.05),而潜伏期值P1波两组比较差异有显著意义(P<0.05)。第3、第4环N1波、P1波、N2波的潜伏期均较其他各区缩短。结论:随着年龄的增长mERG的各波振幅密度值及潜伏期值的变化,与视网膜感光细胞功能逐渐减低有关。 展开更多
关键词 多焦视网膜电图 增龄变化 Vision mERG 正常参考值 视网膜部位 P1波 潜伏期 不同年龄 系统检测 细胞功能 正常人 50岁 密度值 接触镜 中心凹 视角 振幅 N2
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