Diagnostic Accuracy of Computerized Bowel Sound Analysis with Non-Invasive Devices for Irritable Bowel Syndrome:A Systematic Review and Meta-Analysis

Objective To assess the diagnostic accuracy of bowel sound analysis for irritable bowel syndrome(IBS)with a systematic review and meta-analysis.Methods We searched MEDLINE,Embase,the Cochrane Library,Web of Science,and IEEE Xplore databases until September 2023.Cross-sectional and case-control studies on diagnostic accuracy of bowel sound analysis for IBS were identified.We estimated the pooled sensitivity,specificity,positive likelihood ratio,negative likeli-hood ratio,and diagnostic odds ratio with a 95% confidence interval(CI),and plotted a summary receiver operat-ing characteristic curve and evaluated the area under the curve.Results Four studies were included.The pooled diagnostic sensitivity,specificity,positive likelihood ratio,nega-tive likelihood ratio,and diagnostic odds ratio were 0.94(95%CI,0.87‒0.97),0.89(95%CI,0.81‒0.94),8.43(95%CI,4.81‒14.78),0.07(95%CI,0.03‒0.15),and 118.86(95%CI,44.18‒319.75),respectively,with an area under the curve of 0.97(95%CI,0.95‒0.98).Conclusions Computerized bowel sound analysis is a promising tool for IBS.However,limited high-quality data make the results'validity and applicability questionable.There is a need for more diagnostic test accuracy studies and better wearable devices for monitoring and analysis of IBS.

Retrospective analysis of pathological types and imaging features in pancreatic cancer: A comprehensive study

BACKGROUND Pancreatic cancer remains one of the most lethal malignancies worldwide,with a poor prognosis often attributed to late diagnosis.Understanding the correlation between pathological type and imaging features is crucial for early detection and appropriate treatment planning.AIM To retrospectively analyze the relationship between different pathological types of pancreatic cancer and their corresponding imaging features.METHODS We retrospectively analyzed the data of 500 patients diagnosed with pancreatic cancer between January 2010 and December 2020 at our institution.Pathological types were determined by histopathological examination of the surgical spe-cimens or biopsy samples.The imaging features were assessed using computed tomography,magnetic resonance imaging,and endoscopic ultrasound.Statistical analyses were performed to identify significant associations between pathological types and specific imaging characteristics.RESULTS There were 320(64%)cases of pancreatic ductal adenocarcinoma,75(15%)of intraductal papillary mucinous neoplasms,50(10%)of neuroendocrine tumors,and 55(11%)of other rare types.Distinct imaging features were identified in each pathological type.Pancreatic ductal adenocarcinoma typically presents as a hypodense mass with poorly defined borders on computed tomography,whereas intraductal papillary mucinous neoplasms present as characteristic cystic lesions with mural nodules.Neuroendocrine tumors often appear as hypervascular lesions in contrast-enhanced imaging.Statistical analysis revealed significant correlations between specific imaging features and pathological types(P<0.001).CONCLUSION This study demonstrated a strong association between the pathological types of pancreatic cancer and imaging features.These findings can enhance the accuracy of noninvasive diagnosis and guide personalized treatment approaches.

Diagnostic Analysis on A Hail Storm Occurred in Dalian Area

By using regular meteorological data and Doppler radar data,causes for a hail storm over northern area of Dalian on Oct.13,2009 were analyzed from several aspects,including synoptic background,T-LnP charts and the characteristics of radar reflectivity factor evolution.The results showed that the hail storm occurred in downstream of 500 hPa trough.The 500 hPa cold trough turned zonally and triggered the formation of shear line on lower level.Before the hail event,instability energy and moisture supply were observed.The shear line on lower level intensified the atmospheric instability,promoted the release of potential energy,caused the hail event.The cooperation of upper and lower level jet streams provided favorable dynamic condition for strong convection development.The Doppler radar analysis showed that strong convection was comprised of multiple convection cells,which demonstrated 'L' and 'V' shapes during mature stage,with peak intensity of 50-60 dBz.

Diagnostic model construction and example analysis of habitat degradation in enclosed bay: II. spatiotemporal variations in habitat degradation in Sansha Bay

The process of habitat degradation varies in habitat type and driving force which shows certain spatial and temporal heterogeneity on regional scales. In the present study, a new diagnostic model for enclosed bay habitat degradation was established, with which the spatial and temporal variation patterns of habitat degradation during 1991–2012 in Sansha Bay, Fujian, China was investigated. The results show that anthropogenic disturbance is the major controlling factor for the habitat degradation in large temporal heterogeneity in the bay. On the other hand, the habitat degradation experienced signifi cant spatial variations among six sub-bays. Under the joint action of temporal and spatial heterogeneity, the degradation trend in growing scale shows a more signifi cant correlation with the distribution of local leading industries along shorelines. Therefore, we quantifi ed the main characters of habitat degradation in Sansha Bay, and have understood the relationship between the status of habitats spatio-temporal variation value and the main controlling factor leading to the changes. However, a defi ciency of this research is the lack of or inaccessible to the detailed data, which shall be better solved in the future study for accessing more data from more sources.

THE DIAGNOSTIC ANALYSIS OF THE TRACK AND PRECIPITATION OF TYPHOON “RANANIM” AFTER LANDFALL

Over the past few years, landfall and track,intensity, sustaining mechanisms of tropical cyclones （hereafter TCs） and associated weather changes have become heated topics of research, From the viewpoints of energy transformation, moisture transfer, midlatitude baroclinic frontal zones and ambient wind fields, Chen et al.Le et al.and Zeng et al.studied the sustaining mechanism of TCs that have made landfall. Li et al.also pointed out that the intensification of TCs during transition was associated with the disturbance and downward transportation of high-level potential vortexes, low-level frontal zones and low-pressure circulation around TCs, after explaining the difference in TCs transition following the theory of wet potential vortexes. With large-scale diagnostic study of two types of TCs that unexpectedly weaken or enhance just before landfall in southern China, Hu et al.noted that enhancing TCs were usually to the southwest or south of the subtropical high with low levels featured by well-defined southwesterly inflow inside TCs and sufficient supply of water vapor. Liang et al.not only analyzed the changes in convective cloud bands, precipitation, track and temperature and humidity structure in the course of TC Vongfang landfall, but the effect of cold air and Southwest Monsoon on its intensity in particular. As also shown in numerical experiments conducted both at home and abroad and relevant studies,saturated humidity and large-sized bodies of water are favorable for the maintenance and enhancement of landfall TCs circulation. All of the above research achievements not only help broaden the understanding of the patterns by which TCs behave but are positive in improving the forecast of the track, winds and rains after landfall. It is.however, not much addressed in the field or evounon of landfall TCs when they are with special underlying surface and circulation background. TC Rananim （0414） was the most serious typhoon that ever affected Zhejiang province after landfall in the 48 years from 1956 to 2004, which was also the storm that caused heavy rains in the most widespread area in Jiangxi province in the past 20 years. There are two points about Rananim that stand out from the other storms. The first was the sudden westward turning of its track and the second the significant enhancement of precipitation after moving above the Boyang Lake.What kind of mechanism caused such remarkable change in the storm？ With 6-hourly 1×1°NECP global reanalysis data, real-time upper-level observations and TCs location reports by the Central Observatory, the above two points and possible causes are studied in terms large-scale circulation background, underlying surface, cold air and diagnosis of physical quantity fields. New understanding has been made about the behavioral pattern of landfall TCs and related results will offer effective help in operational forecast.

DIAGNOSTIC ANALYSIS ON THE DISTRIBUTION OF RAINFALL ASSOCIATED WITH TYPHOON"MOLAVE"(0906)

This work examines the mechanism of rainfall associated with typhoon Molave(0906)in Guangdong province and Guangxi Zhuang Autonamous Region with rainfall observations,radar mosaics from China National Meteorological Center and the final analysis data of National Center of Environmental Prediction(FNL/NCEP,USA).The result shows that the mechanism is different for the rainfall in the these areas.The rainfall in eastern Guangdong is mainly associated with a convective line to the front-right of the typhoon.The convective line is about 200 km away from the typhoon center.The rainfall in western Guangdong and Guangxi appear ahead of or to the left of the typhoon and is very close to the typhoon center.Both rainfall moves forward with the typhoon anticlockwise.It was also found that the rainfall occurred in the boundary between unstable and low-level convergent areas and closer to the convergent area.The unstable area is located in the downstream of rainfall and ahead of the convective line.It is an important factor to the development and convection.Strong frontogenesis is observed in the backward or upstream convective area of rainfall and is thus an important lifting condition for the formation of rainfall.When the low-level convergent area moves to the unstable area ahead of it,the unstable energy is left behind and as a result the convection is strengthened.

Structural Design and Force Analysis for Equatorial Diagnostic Port Plug of ITER

The structural design of equatorial diagnostic port plug for international thermonuclear experimental reactor （ITER） was discussed in this paper. The induced electromagnetic （EM） loads of port plug and blanket shielding module （BSM） were presented. The finite element analysis （FEA） and numerical calculation of the system were performed under the maximum loads. According to the American Society of Mechanical Engineers （ASME） criteria, the EM stress is far below the admissible failure boundary, which indicates that the system can resist the cooperative action of EM loads and device deadweight. The analysis could provide technical data and references for further analysis and optimized design of the system.

Metabonomic analysis of hepatitis B virus-induced liver failure:identification of potential diagnostic biomarkers by fuzzy support vector machine

Hepatitis B virus （HBV）-induced liver failure is an emergent liver disease leading to high mortality. The severity of liver failure may be reflected by the profile of some metabolites. This study assessed the potential of using metabolites as biomarkers for liver failure by identifying metabolites with good discriminative performance for its phenotype. The serum samples from 24 HBV-indueed liver failure patients and 23 healthy volunteers were collected and analyzed by gas chromatography-mass spectrometry （GC-MS） to generate metabolite profiles. The 24 patients were further grouped into two classes according to the severity of liver failure. Twenty-five eommensal peaks in all metabolite profiles were extracted, and the relative area values of these peaks were used as features for each sample. Three algorithms, F-test, k-nearest neighbor （KNN） and fuzzy support vector machine （FSVM） combined with exhaustive search （ES）, were employed to identify a subset of metabolites （biomarkers） that best predict liver failure. Based on the achieved experimental dataset, 93.62% predictive accuracy by 6 features was selected with FSVM-ES and three key metabolites, glyeerie acid, cis-aeonitie acid and citric acid, are identified as potential diagnostic biomarkers.

Diagnostic Analysis on a Regional Rainstorm Weather in North-central Henan Province

[Objective] The research aimed to analyze a regional rainstorm weather process in north-central Henan Province. [Method] Based on the conventional meteorological observation data and the rainfall data of Henan Meteorological Station, the diagnostic analysis of atmospheric thermodynamics and dynamics on a rainstorm weather process in north-central Henan Province on July 19, 2010 was carried out. The characteristics of physical quantity field and the evolution of weather situation in north-central Henan Province when the rainstorm happened were studied. [Result] Western Pacific subtropical high strengthened to extend westward. The dynamic uplifting of low vortex at the middle and low layers, the strong water vapor transportation of southwest low-level jet caused the regional rainstorm weather process in north-central Henan Province. The diagnostic results of physical quantity showed that the deep, thick wet layer and the sustained water vapor convergence provided the abundant water vapor for rainstorm generation. The positive vorticity advection center developed and spread from northwest to southeast, which was favorable for the development of vertical movement. The structure maintenance of positive vorticity at the middle and low layers, negative vorticity at the middle and high levels provided the power condition for the regional rainstorm generation. The pumping effect of convergence at the middle and low layers, divergence at the high layer was favorable for the strengthening of vertical ascending motion at the low layer. The uplifting effect of dew point front at the middle and low layers triggered the release of unstable energy. The confrontation of warm and cold air was one of the important reasons for the regional rainstorm. TBB characteristic analysis showed that TBB was from -60 to -50 ℃ in north-central Henan Province in the whole strong precipitation time, and the moving speed was equivalent to that of southwest vortex. The low-value belt of TBB corresponded with the rainstorm occurrence zone in Henan, and the minimum-value center of TBB was basically consistent with the strongest center of precipitation. [Conclusion] The research provided the scientific basis for the short-term forecast of rainstorm.

Diagnostic Analysis of Rainstorm and Backward Trajectory Simulation of Water Vapor in Jilin Province in July,2010

[Objective] The research aimed to analyze the rainstorm process and backward trajectory simulation of water vapor condition in Jilin Province in July,2010.[Method] Based on the actual situation data of routine weather chart,NCEP (2.5°×2.5°) reanalysis data per 6 h and GBL data of NOAA,the rainstorm process was carried out the diagnostic analysis of physical quantity in Jilin Province in July,2010.Moreover,HYSPLIT backward trajectory mode was used to simulate the water vapor source.[Result] The coexistence of upper-level divergence and low-level convergence generated the ascending motion,which was the dynamic condition of rainstorm appearance.The unstable energy induced by the low-level shear promoted the generation of heavy rainstorm.The water vapor source of precipitation process was divided into the water vapor in the southern sea area,northern high-altitude water vapor transportation and local water vapor source.[Conclusion] The research provided some reference basis for the forecast and analysis of rainstorm.

Application of Automatic Diagnostic Analysis on Atmospheric Horizontal Inversion Area and Freezing Rain Falling Area

The automatic diagnostic analysis on atmospheric horizontal inversion area is realized through changing the single atmospheric inversion into horizontal one based on the sounding data in Micaps system;the basic conceptual model INCLUDING atmospheric horizontal inversion area,ground 0 ℃ line,high altitude wet area,extreme point 0 ℃ line in inversion layer is buillt after the research on relationship between atmospheric horizontal inversion area and freezing rain falling area;automatic diagnostic analysis on freezing rain falling area is developed based on the conceptual model,the method is in accord well with the actual situation (freezing rain disaster weather occurred in most part of the south in beginning of 2008) and fitting rate reaches 94.4%,quantitative correlation coefficient between the area of freezing rain falling area and stations reporting freezing rain is 0.839.

Seismic response analysis for equatorial diagnostic port plug of international thermonuclear experimental reactor

Modal analysis and seismic response analysis were carried out for the equatorial diagnostic port plug of international thermonuclear experimental reactor (ITER). The aim of the theoretical analysis is to verify structural strength and reliability of the device. The working condition includes one-dimensional seismic wave and two-dimensional seismic wave. Modal analysis of the device shows that primary vibration is inclined to occur in low-order modes. The horizontal (X-direction, Y-direction) maximum vibration appears at the first and the fourth eigen modes, with the natural frequency of 70.59 and 215.88 Hz respectively, and the vertical (Z-direction) primary vibration appears at the second eigen mode with the natural frequency of 82.85 Hz. According to the results of the finite element analysis (FEA) program, the weak portions of the device are distributed in the joint of port body with blanket shielding module (BSM) and inner side wall of ribbed plate for lifting flange, the maximum von Mises stress is 14.8 MPa with the Y-direction seismic wave. In accordance with the design criteria, the destructive effect is far below the failure boundary, and the structural reliability of the equatorial diagnostic port plug can meet the requirements of the design specifications.

Diagnostic Analysis of a Snowfall Weather in Beijing,Tianjin and Hebei in 2010

[ Objective] The research aimed to analyze a local snowstorm weather process which happened in Beijing, Tianjin and Hebei during I - 4 January, 2010. [ Method] Based on routine meteorological observation data and NCEP/NCAR 2.5° ×2.5° grid data （four times every day）, a lo- cal snowstorm weather process which happened in Beijing, Tianjin and Hebei during 1 -4 January, 2010 was carried out diagnostic analysis by using composite analysis method. [Result] Circumfluence on the ground and strong cold advection in the rear of upper trough were the main weath- er system of the snowfall. The deep thick wet layer and strong water vapor convergence provided sufficient water vapor for snowfall. The divergence field of low-level convergence and high^level divergence, dynamic coupling effect of vorticity provided favorable dynamic condition upwardly for the occurrence of strong snowfall. The steep dense area of Oso, low temperature at the ground layer and inversion temperature at the high layer provided certain energy condition for the development of snowfall weather. [ Conclusion] The research provided theoretical basis for snowfall forecast in future.

Immunodiagnostic efficacy of detection of Schistosoma japonicum human infections in China:a meta analysis

Objective:To assess the diagnostic efficacy of the currently most widely used indirect hemagglutination assay(IHA) and enzyme-linked immunosorbent assay(ELISA) for detection of Schistosoma japonicum human infections.Methods:A comprehensive search was undertaken from China National Knowledge Infrastructure,Wanfang Database.VIP Database,PubMed. Cochrane Library,Science Citation Index Expanded.Proquest,and the inclusion and exclusion criteria were strictly settled.The funnel plot was used to assess the publication bias.Cochran’s Q test was employed to measure the homogeneity between studies,a summary receiver operating characteristic(SROC) curve was used to compare the diagnostic accuracy between the IHA and ELISA qualitatively by means of the Weighted Least Square method,the Ordinary Least Square method and the Robust regression method,and the diagnostic odds ratio(DOR) was drawn to compare the accuracy quantitatively.Results:Out of 785 publications,19 papers were eventually selected for analysis.Literature finality assessment indicated that minor publication bias existed in studies pertaining IHA test,but no bias was found in literatures regarding ELISA test.The heterogeneity test showed a heterogeneity between studies was present(χ~2 =466.07 and 34.67. both P values【0.0001).The areas under the SROC curves of IHA were all higher than that of ELISA test using the three methods(Weighted Least Square method:0.766 vs.0.695.Ordinary Least Square method:0.826 vs.0.741.Robust regression:0.815 vs.0.715).The TPR* values for IHA and EUSA were 0.710.0.759.0.749.and 0.650.0.686 and 0.666.respectively,and OR values were 5.997.9.937.8.893.and 3.432.4.784 and 3.959.respectively.The DOR of IHA was 9.41(95% CI:4.88-18.18).and 4.78(95%CI:3.21-7.13) for ELISA.Conclusions:All above results revealed that the diagnostic performance of IHA is better than that of ELISA.However,taking into account their unsatisfactory diagnostic value in areas with low infection intensity,a search for a better diagnostic test that can be applied in field situations in China should be given high priority.

DIAGNOSTIC ANALYSIS AND VERIFICATION OF PREDICTION OF THE TROPICAL PACIFIC SEA SURFACE TEMPERATURE ANOMALIES DURING 1997～1998

By comparing with ENSO events that ever happened in the history, the basic features and probable causes of the anomalous sea surface temperature of the tropical Pacific Ocean during 1997 and 1998 have been analyzed diagnostically. It is found that the 1997/1998 El Nino had significant abnormalities and peculiarities. It differs from the previous El Ni駉 events falling into the simple eastern pattern or western pattern. The predictions of 1997/1998 El Ni駉 event have also been tested with an intermediate ocean-atmosphere coupled dynamic model. The results show that the skills of the 0～24 lead month forecasts for the warm event are all above 0.5. The predictions of the mature phase and the later stages of the warm event are better than those of the beginning phase.

Baking Analysis of the ITER Equatorial Diagnostic Port Plug

In this study both electric heating and fluid heating were proposed to bakeout the port plug structure being inserted in the middle of the international thermonuclear experimental reactor （ITER） vacuum vessel. The coupled thermal and structural analyses were carried out. The results, such as the distributions of the temperature field, thermal stress and thermal deformation of the port plug, were obtained. Based on the American Society of Mechanical Engineers （ASME） criteria, the reliability and feasibility of the heating technique were verified. The results provide detailed information on the selection of a preferable method for future engineering experiments.

A Reinterpretation of Historic Aquifer Tests of Two Hydraulically Fractured Wells by Application of Inverse Analysis, Derivative Analysis, and Diagnostic Plots

Aquifer test methods have greatly improved in recent years with the advent of inverse analysis, derivative analysis, and diagnostic plots. Updated analyses of past aquifer tests allow for improved interpretations of the data to enhance the knowledge and the predictive capabilities of the flow system. This work thoroughly reanalyzes a series of pre- and post-hydraulic fracturing, single-well aquifer tests conducted in two crystalline rock wells in New Hampshire as part of an early 1970’s study. Previous analyses of the data had relied on older manual type-curve methods for predicting the possible effects of hydraulic fracturing. This work applies inverse analysis, derivative analysis, and diagnostic plots to reanalyze the 1970’s aquifer test data. Our results demonstrate that the aquifer tests were affected by changes in flow regimes, dewatering of the aquifer and discrete fractures, and changes due to well development. Increases in transmissivities are related to well development prior to hydraulic fracturing, propagation of a single, vertical fracture hydraulically connecting the two wells after stimulation and expansion of troughs of depression. After hydraulic fracturing, the estimated total yield of the individual wells increased by 2.5 times due to the hydraulic fracturing. However, the wells may be receiving water from the same source, and well interference may affect any significant increase in their combined yield. Our analyses demonstrate the value in applying inverse analysis, derivative analysis, and diagnostic plots over the conventional method of manual type-curve analysis. In addition, our improvement in the aquifer test interpretation of the 1970’s test data has implications for more reliable estimates of sustained well yields.

Diagnostic Analysis of a Rainstorm Process in Chongqing

[Objective] The research aimed to analyze a rainstorm process in Chongqing. [Methed] Based on precipitation product datasets and NCEP reanalysis data, synoptic situation and diagnostic analysis of a heavy rain process during 11 -12 May, 2012 in Chongqing were made, and the diagnostic analysis included dynamic and vapor conditions, instability index, vapor helicity and vapor divergence flux. [ Result] The east-south moving short wave trough and east-north moving southwest vortex were the main synoptic systems causing the heavy rain; the positive vorticity advection before trough and after ridge helped the ascending motion from surface; the southwest stream at 700 hPa provided vapor and energy, promoting and maintaining the intense development of convection; the higher vapor helicity and lower vapor divergence flux were well corresponding with higher precipitation area, and had well temporal correlation, which was significant for forecast of precipitation area and its development; the ascended warm wet stream on the lower air came across the cold air on the upper air, triggering the heavy rain; the Kindex and A index were significant for the heavy rain forecasting. [ Conclusion] The research could provide some references for research and forecast of future rainstorm process in Sichuan and Chongqing.

Diagnostic Analysis on Physical Quantities of Spring Hail Weather in Hunan

Based on hail weather cases in Chenzhou of Hunan in 2016,environmental conditions and physical quantity characteristics of hail generation were analyzed and studied from circulation field,low level jet,stability,dynamic and thermal fields,and some conclusions with the guiding significance of prediction were obtained,which had an active effect on guiding prewarning of hail weather in Hunan,forecast business in falling region,disaster prevention and mitigation.

Rolling Element Bearing Diagnostics by Combination of Envelope Analysis and Wavelet Transform

Rolling element-bearing diagnostics has been studied over the last thirty years, and envelope analysis is widely recognized as being the best approach for detection and diagnosis of rolling element bearing incipient failure. But one of the on-going difficulties with envelope technique is to determine the best frequency band to envelop. Here, wavelet transform technique is introduced into envelope analysis to solve the problem by capturing bearing defects-sensory scales (i.e. frequency bands). A modulated Gaussian function is chosen to be the analytical wavelet because it coincides well with bearing defect-induced vibration signal patterns. Vibration signals measured from railway bearing tests were studied by the proposed method. Cases of bearings with single and multiple defects on inner and outer race under different testing conditions are presented. Experimental results showed that the proposed method allowed a more accurate local description and separation of transient signal part, which were caused by impacts between defects and the mating surfaces in the bearing. The combination method provides an effective signal detection technique for rolling element-bearing diagnostics.