目的系统评价扶正化瘀散结法联合西药治疗厌食-恶病质综合征的有效性。方法系统检索维普(VIP)、中国知网(CNKI)、万方数据知识服务平台(Wan Fang)、中国生物医学文献数据库(CBM)、PubMed、Web of Science、Embase数据库、Cochrane Libr...目的系统评价扶正化瘀散结法联合西药治疗厌食-恶病质综合征的有效性。方法系统检索维普(VIP)、中国知网(CNKI)、万方数据知识服务平台(Wan Fang)、中国生物医学文献数据库(CBM)、PubMed、Web of Science、Embase数据库、Cochrane Library数据库,利用Jadad、Cochrane协作网RCT质量评价标准对纳入文献的研究质量进行评价,Meta分析提取数据。结果1)共纳入17个随机对照研究(RCT),患者1423例,纳入研究质量一般;2)Meta分析合并RR值包括体重变化[RR=1.36,95%CI(1.08,1.71),P=0.009]、KPS评分变化[RR=1.44,95%CI(1.29,1.60),P<0.00001]、进食量变化[RR=1.33,95%CI(1.15,1.55),P=0.0002]、白蛋白变化[MD=3.01,95%CI(2.10,3.93),P<0.00001]以及血红蛋白变化[MD=10.74,95%CI(1.91,19.58),P=0.02]。结论本研究证实扶正化瘀散结法在厌食-恶病质综合征应用的有效性优于单纯西药治疗或结合营养支持治疗。展开更多
目的:评价γ-干扰素诱导蛋白10(IP-10)鉴别结核分枝杆菌不同感染状态的诊断效能.方法:检索Cochrane Library、PubMed、Web of Science、中国知网、维普、万方等数据库,检索自建库至2023年1月的相关文献,进行数据提取和质量评价,采用RevM...目的:评价γ-干扰素诱导蛋白10(IP-10)鉴别结核分枝杆菌不同感染状态的诊断效能.方法:检索Cochrane Library、PubMed、Web of Science、中国知网、维普、万方等数据库,检索自建库至2023年1月的相关文献,进行数据提取和质量评价,采用RevMan 5.3和Stata 17.0软件进行统计分析.结果:共纳入75篇文献,96项研究,共11116例患者.Meta分析结果为IP-10用于鉴别结核感染和非结核感染的合并敏感度为0.82(95%CI:0.79~0.84),特异度为0.87(95%CI:0.84~0.90),阳性似然比为6.40(95%CI:5.20~8.00),阴性似然比为0.21(95%CI:0.18~0.24),诊断比数比为31(95%CI:23~420),受试者工作曲线的曲线下面积为0.91(95%CI:0.88~0.93).结论:IP-10有助于鉴别结核不同感染状态,但最终确诊需要结合病史、症状等进行综合诊断.展开更多
目的:探讨体力活动、久坐行为与成年人高尿酸血症(Hyperuricemia,HUA)风险关联及剂量-反应关系,为高尿酸血症的预防提供循证依据。方法:检索PubMed、Cochrane Library、EMbase、Web of Science、中国知网(CNKI)、万方(Wanfang)、中国生...目的:探讨体力活动、久坐行为与成年人高尿酸血症(Hyperuricemia,HUA)风险关联及剂量-反应关系,为高尿酸血症的预防提供循证依据。方法:检索PubMed、Cochrane Library、EMbase、Web of Science、中国知网(CNKI)、万方(Wanfang)、中国生物医学文献服务系统(SinoMed)等数据库2023年7月15日前发表的体力活动、久坐行为与高尿酸血症风险关联性的相关文献,运用Cochrane偏倚风险评估工具进行文献质量评价、Stata 15.0软件进行Meta分析和剂量-反应关系Meta分析。研究结果:共纳入13项前瞻性队列研究或病例对照研究,包含750678名受访者,平均随访年限5.9年。风险关系Meta分析结果表明:①MVPA显著降低成年人发病风险。女性、≥45岁、亚洲人群HUA发病风险可能对MVPA更敏感。②久坐行为显著增加成年人发病风险。男性、≥45岁、欧美人群HUA发病风险可能对久坐行为最敏感。剂量-反应Meta分析发现:①MVPA与HUA发病风险存在负相关非线性剂量-反应关系。MVPA与罹患HUA的风险阈值为15MET-h/w。②久坐行为与HUA存在正相关非线性剂量-反应关系。久坐时间与罹患HUA的风险阈值为25h/w。研究结论:MVPA与HUA存在负相关“对数”剂量-反应关系,久坐行为与HUA存在正相关“指数”剂量-反应关系。展开更多
A new phloretin derivative 1 3-[2-(4-hydroxy-phenyl)-ethyl]-benzo[d] isoxazole-4,6-diol (yield 63%) was synthesized from phloretin by carbonyl nucleophilic addition condensation reaction. Its structure was characteriz...A new phloretin derivative 1 3-[2-(4-hydroxy-phenyl)-ethyl]-benzo[d] isoxazole-4,6-diol (yield 63%) was synthesized from phloretin by carbonyl nucleophilic addition condensation reaction. Its structure was characterized by 1H NMR, 13C NMR and HR-MS. The phloretin, compound 1, resveratrol and acetylated resveratrol were determined by comparing them with paclitaxel. Anti-tumor activity of alcohol on SPC-A1, EC109, A549, MCF-7 and MDA-MB-231 cell lines. Compound 1 showed better antitumor activity than docetaxel against A549 tumor cells.展开更多
Objective: Nurses play important roles in caring for dying patients and their families. Difficulties students confronted when facing dying patients challenge the quality of nursing education. A better understanding of...Objective: Nurses play important roles in caring for dying patients and their families. Difficulties students confronted when facing dying patients challenge the quality of nursing education. A better understanding of students' experiences would enhance teachers' ability in helping students. This study aims to describe available evidence about nursing students' experiences when caring for dying patients and their families.Methods: A review of qualitative studies published between 2005 and 2017 was undertaken using the following databases: MEDLINE, CINAHL, ProQuest Central, ScienceDirect, and CNKI. The keywords included were nursing students, experience, care, end-of-life, and dying. Qualitative Assessment and Review Instrument was used to assess the quality of the studies by two independent reviewers. The data from the studies were analyzed by meta-synthesis.Results: Eighteen English and two Chinese studies were selected in this review. Four themes were emerged:(1) Students with dying patients: students did not have enough ability in symptoms control, comfort supply, and therapeutic communication for dying patients.(2) Students with the patients' families: students advocated more caring for patients' families.(3) Students with the surroundings: professional medical staffs, especially the nursing preceptors, were key roles in constructing a supporting system for students.(4) Students with themselves: nursing students underwent various negative feelings and adopted both negative and positive strategies to cope with such feelings;students experienced professional and personal development during the caring for dying patients.Conclusions: Nursing students' abilities in terminal symptom control, comfort supply, and therapeutic communication should be improved by more theoretic learning and simulation practice. The nursing preceptors were key roles in constructing a supporting system for students and helping them to control the negative emotions when facing dying patients.展开更多
This meta-synthesis presents the results of qualitative studies on puerperal perception concerning woman’s care in the post-partum period. Four databases were researched using keywords such as “postnatal care” (or)...This meta-synthesis presents the results of qualitative studies on puerperal perception concerning woman’s care in the post-partum period. Four databases were researched using keywords such as “postnatal care” (or) “postpartum period”, (and) “care”, “women”, “perception”, “qualitative research”, “women’s health services”, “community health services”, “allied health personnel”, “primary health care”, resulting in 9 articles for analysis. Six themes were identified: interpersonal relationship, information, communication, attending the necessities, service organization and other supports. Results report mainly on the unsatisfactory professional care for women, appreciating the form of dealing with promptness and the timing to be attended;trust;content, coherence and the way to inform;clarification of doubts;friendly conversation and clinical assistance. The professional workload was restricted on postpartum period care quality. There were gaps found in clinical practice and in dialogical communication and information on women’s health necessities.展开更多
This research is a meta-synthesis study of Massive online open course(MOOC) literature on students' learning.It aims to investigate key components for the design of a MOOC as well as the benefits and challenged en...This research is a meta-synthesis study of Massive online open course(MOOC) literature on students' learning.It aims to investigate key components for the design of a MOOC as well as the benefits and challenged engaged in MOOCs' learning.It is found that in MOOC's all stages,discussion forum,video features and instructor's teaching are well connected to each other.展开更多
目的系统评价护理人员利用移动健康进行慢性病管理的体验,为改善移动健康管理服务提供依据。方法计算机检索Medline(Ovid)、Embase、Cochrane Library、Web of Science、CINAHL、中国知网、万方数据库和维普数据库,检索有关护理人员利...目的系统评价护理人员利用移动健康进行慢性病管理的体验,为改善移动健康管理服务提供依据。方法计算机检索Medline(Ovid)、Embase、Cochrane Library、Web of Science、CINAHL、中国知网、万方数据库和维普数据库,检索有关护理人员利用移动健康进行慢性病管理体验的质性研究,检索时限为建库至2023年2月。依据JBI质性研究质量评价标准评价文献质量,采用Meta整合方法对原始研究结果进行整合。结果共纳入8篇文献,提炼出66个原始研究结果,归纳为10个新类别,综合为2个整合。护士使用移动健康进行慢性病管理感知益处;护士使用移动健康进行慢性病管理感知障碍。结论移动健康有助于护理人员进行慢性病管理,但其使用仍存在一些障碍,应从移动健康的易用性、移动健康与传统管理手段的融合、健全相关制度保障等方面完善。展开更多
目的:系统评价和整合我国产后返岗护士工作体验的质性研究,为帮助其更好地进行工作适应提供干预依据。方法:计算机检索PubMed、Web of Science、Embase、中国知网、万方数据库、维普数据库、中国生物医学文献数据库等中英文数据库,收集...目的:系统评价和整合我国产后返岗护士工作体验的质性研究,为帮助其更好地进行工作适应提供干预依据。方法:计算机检索PubMed、Web of Science、Embase、中国知网、万方数据库、维普数据库、中国生物医学文献数据库等中英文数据库,收集有关我国产后返岗护士工作体验相关的质性研究,检索时限为建库至2023年3月。采用澳大利亚Joanna Briggs Institute(JBI)循证卫生保健中心质性研究质量评价标准(2020版)评价纳入文献,采用Meta整合方法对结果进行整合分析。结果:共纳入8项研究,归纳成8个新的类别,综合成产后返岗护士的身心体验、产后返岗护士面临多重压力、产后返岗护士期望多方面的支持帮助3个整合结果。结论:我国产后返岗护士不良身心体验较多,存在多重压力。提示管理者应重视产后返岗护士的情感体验,动态关注其身心健康,给予更多人文关怀,并通过积极建立有效的外部支持系统,采取有效措施帮助产后返岗护士应对多重挑战和压力。展开更多
目的系统评价和整合有关实习护生针刺伤体验的质性研究,以期为制定针对性预防策略提供参考。方法计算机检索中国知网、万方、维普、中国生物医学文献数据库、PubMed、Web of Science、Embase、EBSCO等中英文数据库,收集有关实习护生针...目的系统评价和整合有关实习护生针刺伤体验的质性研究,以期为制定针对性预防策略提供参考。方法计算机检索中国知网、万方、维普、中国生物医学文献数据库、PubMed、Web of Science、Embase、EBSCO等中英文数据库,收集有关实习护生针刺伤相关的质性研究,检索时限均为建库至2023年10月。采用澳大利亚Joanna Briggs研究所循证卫生保健中心质性研究质量评价标准对纳入文献进行质量评价,并采用汇集性整合方法对结果进行整合。结果共纳入10篇文献,提炼出22个研究结果,归纳为3个整合结果(实习护生针刺伤发生的原因、针刺伤发生后的感受、希望获得的帮助),共8个类别。结论管理者应重视实习护生针刺伤后真实感受,并加强专业指导,学校和医院共同做好职业安全教育培训,完善实习护生职业防护支持系统,给予护生更多人文关怀,有效降低针刺伤风险。展开更多
背景了解老年慢性病患者在医院-家庭过渡期的真实经历和对护理服务的体验与期望,可以促进过渡期护理服务的改善和质量的提升。近年来,有关老年慢性病患者医院-家庭过渡期真实经历和对护理服务体验的质性研究逐渐增多,但单一的质性研究...背景了解老年慢性病患者在医院-家庭过渡期的真实经历和对护理服务的体验与期望,可以促进过渡期护理服务的改善和质量的提升。近年来,有关老年慢性病患者医院-家庭过渡期真实经历和对护理服务体验的质性研究逐渐增多,但单一的质性研究结果可能不具有概括性和代表性。目的系统评价老年慢性病患者从医院到家庭的过渡时期的真实感受和对护理服务的体验。方法于2022年5月,计算机检索PubMed、Web of Science核心合集、EmBase、CINAHL、中国知网和万方数据知识服务平台等中英文数据库,搜索关于老年慢性病患者医院-家庭过渡期真实感受和对护理服务体验的质性研究,检索时限均为建库至2022年5月。由两名研究者独立筛选文献、提取资料,并根据英国牛津大学循证医学中心制定的文献质量评价项目(CASP)对纳入文献质量进行评价,运用Meta整合法对研究结果进行整合。结果共纳入13篇文献,提炼出45个研究结果,将相似的研究结果归纳为8个类别,并综合得出3个整合结果,分别为:老年慢性病患者医院-家庭过渡期护理的障碍因素;老年慢性病患者医院-家庭过渡期护理的促进因素;老年慢性病患者对医院-家庭过渡期护理的期待。结论老年慢性病患者从医院到家庭的过渡是一个充满挑战的过程,过渡期护理服务质量仍有较大的提升空间。家庭、社区、医疗机构、政府、社会应积极改善老年慢性病患者在个人、家庭、社区、社会等层面的过渡条件。可通过强化对过渡期患者的教育、提升患者自我管理能力、提供护士主导的过渡期护理服务等举措,帮助老年慢性病患者实现从医院到家庭的安全过渡。展开更多
文摘目的系统评价扶正化瘀散结法联合西药治疗厌食-恶病质综合征的有效性。方法系统检索维普(VIP)、中国知网(CNKI)、万方数据知识服务平台(Wan Fang)、中国生物医学文献数据库(CBM)、PubMed、Web of Science、Embase数据库、Cochrane Library数据库,利用Jadad、Cochrane协作网RCT质量评价标准对纳入文献的研究质量进行评价,Meta分析提取数据。结果1)共纳入17个随机对照研究(RCT),患者1423例,纳入研究质量一般;2)Meta分析合并RR值包括体重变化[RR=1.36,95%CI(1.08,1.71),P=0.009]、KPS评分变化[RR=1.44,95%CI(1.29,1.60),P<0.00001]、进食量变化[RR=1.33,95%CI(1.15,1.55),P=0.0002]、白蛋白变化[MD=3.01,95%CI(2.10,3.93),P<0.00001]以及血红蛋白变化[MD=10.74,95%CI(1.91,19.58),P=0.02]。结论本研究证实扶正化瘀散结法在厌食-恶病质综合征应用的有效性优于单纯西药治疗或结合营养支持治疗。
文摘目的:探讨体力活动、久坐行为与成年人高尿酸血症(Hyperuricemia,HUA)风险关联及剂量-反应关系,为高尿酸血症的预防提供循证依据。方法:检索PubMed、Cochrane Library、EMbase、Web of Science、中国知网(CNKI)、万方(Wanfang)、中国生物医学文献服务系统(SinoMed)等数据库2023年7月15日前发表的体力活动、久坐行为与高尿酸血症风险关联性的相关文献,运用Cochrane偏倚风险评估工具进行文献质量评价、Stata 15.0软件进行Meta分析和剂量-反应关系Meta分析。研究结果:共纳入13项前瞻性队列研究或病例对照研究,包含750678名受访者,平均随访年限5.9年。风险关系Meta分析结果表明:①MVPA显著降低成年人发病风险。女性、≥45岁、亚洲人群HUA发病风险可能对MVPA更敏感。②久坐行为显著增加成年人发病风险。男性、≥45岁、欧美人群HUA发病风险可能对久坐行为最敏感。剂量-反应Meta分析发现:①MVPA与HUA发病风险存在负相关非线性剂量-反应关系。MVPA与罹患HUA的风险阈值为15MET-h/w。②久坐行为与HUA存在正相关非线性剂量-反应关系。久坐时间与罹患HUA的风险阈值为25h/w。研究结论:MVPA与HUA存在负相关“对数”剂量-反应关系,久坐行为与HUA存在正相关“指数”剂量-反应关系。
文摘A new phloretin derivative 1 3-[2-(4-hydroxy-phenyl)-ethyl]-benzo[d] isoxazole-4,6-diol (yield 63%) was synthesized from phloretin by carbonyl nucleophilic addition condensation reaction. Its structure was characterized by 1H NMR, 13C NMR and HR-MS. The phloretin, compound 1, resveratrol and acetylated resveratrol were determined by comparing them with paclitaxel. Anti-tumor activity of alcohol on SPC-A1, EC109, A549, MCF-7 and MDA-MB-231 cell lines. Compound 1 showed better antitumor activity than docetaxel against A549 tumor cells.
基金supported by the Macao Science and Technology Development Fund(No.FDCT 276/2017/P)
文摘Objective: Nurses play important roles in caring for dying patients and their families. Difficulties students confronted when facing dying patients challenge the quality of nursing education. A better understanding of students' experiences would enhance teachers' ability in helping students. This study aims to describe available evidence about nursing students' experiences when caring for dying patients and their families.Methods: A review of qualitative studies published between 2005 and 2017 was undertaken using the following databases: MEDLINE, CINAHL, ProQuest Central, ScienceDirect, and CNKI. The keywords included were nursing students, experience, care, end-of-life, and dying. Qualitative Assessment and Review Instrument was used to assess the quality of the studies by two independent reviewers. The data from the studies were analyzed by meta-synthesis.Results: Eighteen English and two Chinese studies were selected in this review. Four themes were emerged:(1) Students with dying patients: students did not have enough ability in symptoms control, comfort supply, and therapeutic communication for dying patients.(2) Students with the patients' families: students advocated more caring for patients' families.(3) Students with the surroundings: professional medical staffs, especially the nursing preceptors, were key roles in constructing a supporting system for students.(4) Students with themselves: nursing students underwent various negative feelings and adopted both negative and positive strategies to cope with such feelings;students experienced professional and personal development during the caring for dying patients.Conclusions: Nursing students' abilities in terminal symptom control, comfort supply, and therapeutic communication should be improved by more theoretic learning and simulation practice. The nursing preceptors were key roles in constructing a supporting system for students and helping them to control the negative emotions when facing dying patients.
文摘This meta-synthesis presents the results of qualitative studies on puerperal perception concerning woman’s care in the post-partum period. Four databases were researched using keywords such as “postnatal care” (or) “postpartum period”, (and) “care”, “women”, “perception”, “qualitative research”, “women’s health services”, “community health services”, “allied health personnel”, “primary health care”, resulting in 9 articles for analysis. Six themes were identified: interpersonal relationship, information, communication, attending the necessities, service organization and other supports. Results report mainly on the unsatisfactory professional care for women, appreciating the form of dealing with promptness and the timing to be attended;trust;content, coherence and the way to inform;clarification of doubts;friendly conversation and clinical assistance. The professional workload was restricted on postpartum period care quality. There were gaps found in clinical practice and in dialogical communication and information on women’s health necessities.
文摘This research is a meta-synthesis study of Massive online open course(MOOC) literature on students' learning.It aims to investigate key components for the design of a MOOC as well as the benefits and challenged engaged in MOOCs' learning.It is found that in MOOC's all stages,discussion forum,video features and instructor's teaching are well connected to each other.
文摘目的系统评价护理人员利用移动健康进行慢性病管理的体验,为改善移动健康管理服务提供依据。方法计算机检索Medline(Ovid)、Embase、Cochrane Library、Web of Science、CINAHL、中国知网、万方数据库和维普数据库,检索有关护理人员利用移动健康进行慢性病管理体验的质性研究,检索时限为建库至2023年2月。依据JBI质性研究质量评价标准评价文献质量,采用Meta整合方法对原始研究结果进行整合。结果共纳入8篇文献,提炼出66个原始研究结果,归纳为10个新类别,综合为2个整合。护士使用移动健康进行慢性病管理感知益处;护士使用移动健康进行慢性病管理感知障碍。结论移动健康有助于护理人员进行慢性病管理,但其使用仍存在一些障碍,应从移动健康的易用性、移动健康与传统管理手段的融合、健全相关制度保障等方面完善。
文摘目的:系统评价和整合我国产后返岗护士工作体验的质性研究,为帮助其更好地进行工作适应提供干预依据。方法:计算机检索PubMed、Web of Science、Embase、中国知网、万方数据库、维普数据库、中国生物医学文献数据库等中英文数据库,收集有关我国产后返岗护士工作体验相关的质性研究,检索时限为建库至2023年3月。采用澳大利亚Joanna Briggs Institute(JBI)循证卫生保健中心质性研究质量评价标准(2020版)评价纳入文献,采用Meta整合方法对结果进行整合分析。结果:共纳入8项研究,归纳成8个新的类别,综合成产后返岗护士的身心体验、产后返岗护士面临多重压力、产后返岗护士期望多方面的支持帮助3个整合结果。结论:我国产后返岗护士不良身心体验较多,存在多重压力。提示管理者应重视产后返岗护士的情感体验,动态关注其身心健康,给予更多人文关怀,并通过积极建立有效的外部支持系统,采取有效措施帮助产后返岗护士应对多重挑战和压力。
文摘目的系统评价和整合有关实习护生针刺伤体验的质性研究,以期为制定针对性预防策略提供参考。方法计算机检索中国知网、万方、维普、中国生物医学文献数据库、PubMed、Web of Science、Embase、EBSCO等中英文数据库,收集有关实习护生针刺伤相关的质性研究,检索时限均为建库至2023年10月。采用澳大利亚Joanna Briggs研究所循证卫生保健中心质性研究质量评价标准对纳入文献进行质量评价,并采用汇集性整合方法对结果进行整合。结果共纳入10篇文献,提炼出22个研究结果,归纳为3个整合结果(实习护生针刺伤发生的原因、针刺伤发生后的感受、希望获得的帮助),共8个类别。结论管理者应重视实习护生针刺伤后真实感受,并加强专业指导,学校和医院共同做好职业安全教育培训,完善实习护生职业防护支持系统,给予护生更多人文关怀,有效降低针刺伤风险。
文摘背景了解老年慢性病患者在医院-家庭过渡期的真实经历和对护理服务的体验与期望,可以促进过渡期护理服务的改善和质量的提升。近年来,有关老年慢性病患者医院-家庭过渡期真实经历和对护理服务体验的质性研究逐渐增多,但单一的质性研究结果可能不具有概括性和代表性。目的系统评价老年慢性病患者从医院到家庭的过渡时期的真实感受和对护理服务的体验。方法于2022年5月,计算机检索PubMed、Web of Science核心合集、EmBase、CINAHL、中国知网和万方数据知识服务平台等中英文数据库,搜索关于老年慢性病患者医院-家庭过渡期真实感受和对护理服务体验的质性研究,检索时限均为建库至2022年5月。由两名研究者独立筛选文献、提取资料,并根据英国牛津大学循证医学中心制定的文献质量评价项目(CASP)对纳入文献质量进行评价,运用Meta整合法对研究结果进行整合。结果共纳入13篇文献,提炼出45个研究结果,将相似的研究结果归纳为8个类别,并综合得出3个整合结果,分别为:老年慢性病患者医院-家庭过渡期护理的障碍因素;老年慢性病患者医院-家庭过渡期护理的促进因素;老年慢性病患者对医院-家庭过渡期护理的期待。结论老年慢性病患者从医院到家庭的过渡是一个充满挑战的过程,过渡期护理服务质量仍有较大的提升空间。家庭、社区、医疗机构、政府、社会应积极改善老年慢性病患者在个人、家庭、社区、社会等层面的过渡条件。可通过强化对过渡期患者的教育、提升患者自我管理能力、提供护士主导的过渡期护理服务等举措,帮助老年慢性病患者实现从医院到家庭的安全过渡。
