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Robustness Study and Superior Method Development and Validation for Analytical Assay Method of Atropine Sulfate in Pharmaceutical Ophthalmic Solution
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作者 Md. Nazmus Sakib Chowdhury Sreekanta Nath Dalal +4 位作者 Md. Ariful Islam Md. Anwar Hossain Pranab Kumar Das Shakawat Hossain Parajit Das 《American Journal of Analytical Chemistry》 CAS 2024年第5期151-164,共14页
Background: The robustness is a measurement of an analytical chemical method and its ability to contain unaffected by little with deliberate variation of analytical chemical method parameters. The analytical chemical ... Background: The robustness is a measurement of an analytical chemical method and its ability to contain unaffected by little with deliberate variation of analytical chemical method parameters. The analytical chemical method variation parameters are based on pH variability of buffer solution of mobile phase, organic ratio composition changes, stationary phase (column) manufacture, brand name and lot number variation;flow rate variation and temperature variation of chromatographic system. The analytical chemical method for assay of Atropine Sulfate conducted for robustness evaluation. The typical variation considered for mobile phase organic ratio change, change of pH, change of temperature, change of flow rate, change of column etc. Purpose: The aim of this study is to develop a cost effective, short run time and robust analytical chemical method for the assay quantification of Atropine in Pharmaceutical Ophthalmic Solution. This will help to make analytical decisions quickly for research and development scientists as well as will help with quality control product release for patient consumption. This analytical method will help to meet the market demand through quick quality control test of Atropine Ophthalmic Solution and it is very easy for maintaining (GDP) good documentation practices within the shortest period of time. Method: HPLC method has been selected for developing superior method to Compendial method. Both the compendial HPLC method and developed HPLC method was run into the same HPLC system to prove the superiority of developed method. Sensitivity, precision, reproducibility, accuracy parameters were considered for superiority of method. Mobile phase ratio change, pH of buffer solution, change of stationary phase temperature, change of flow rate and change of column were taken into consideration for robustness study of the developed method. Results: The limit of quantitation (LOQ) of developed method was much low than the compendial method. The % RSD for the six sample assay of developed method was 0.4% where the % RSD of the compendial method was 1.2%. The reproducibility between two analysts was 100.4% for developed method on the contrary the compendial method was 98.4%. 展开更多
关键词 ROBUSTNESS method Validation HPLC Compendial method method development GDP LOQ
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Analytical Method Development and Validation of Some Biosimilar Drugs by High Performance Thin Layer Chromatography
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作者 Husna Kanwal Qureshi Ciddi Veeresham 《American Journal of Analytical Chemistry》 2023年第3期121-133,共13页
A simple and rapid HPTLC analytical method has been developed and validated for the determination of Etanercept and Filgrastim in pure form and in marketed formulation. Both the drugs were chromatographed on silica ge... A simple and rapid HPTLC analytical method has been developed and validated for the determination of Etanercept and Filgrastim in pure form and in marketed formulation. Both the drugs were chromatographed on silica gel 60 F254s HPTLC plates, as stationary phase. The mobile phase optimized for Filgrastim and Etanercept was Water: n-butanol (7.5:2.5 v/v) and Isopropyl alcohol: water (6.5:4.5 v/v), respectively. The chromatogram obtained was scanned at 225 nm and 222 nm for filgrastim and etanercept which resulted in a retention factor of 0.45 ± 0.07 and 0.32 ± 0.03, respectively. The method was validated for parameters like linearity, accuracy, precision, specificity and robustness. Recovery studies were performed at three concentration levels, to demonstrate suitability, accuracy and precision of proposed method. Statistical analysis proved that the proposed method is accurate and reproducible with linearity in the range of 500 to 3000 ng/band for filgrastim and 200 to 1200 ng/band for etanercept. The limit of detection and limit of quantification for filgrastim was found to be 63.418 ng/band and 192.177 ng/band. For etanercept, LOD and LOQ were found to be 33.381 ng/band and 101.153 ng/band, respectively. The proposed method can be employed for the routine analysis of selected biosimilars. 展开更多
关键词 BIOSIMILARS ETANERCEPT FILGRASTIM method development Validation
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A Stability Indicating Reverse Phase-HPLC Method Development and Validation for the Estimation of Rucaparib in Bulk and Pharmaceutical Dosage Form 被引量:1
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作者 D. Suchitra Satyanarayana Battu 《American Journal of Analytical Chemistry》 2021年第4期96-107,共12页
The research was carried out for establishing a new reverse phase-HPLC stability indicating method for the quantification of Rucaparib. The experiment was determined on Waters HPLC instrument using 996 photo-diode arr... The research was carried out for establishing a new reverse phase-HPLC stability indicating method for the quantification of Rucaparib. The experiment was determined on Waters HPLC instrument using 996 photo-diode array detector. The separation was done by using symmetry C-18 ODS (25 cm × 0.46 cm internal diameter) 5 μm analytical column containing mobile phase of Phosphate buffer (0.02 M) and methanol [65:35% v/v] adjusted pH to 4.8 by adding dilute ortho phosphoric acid. The method was run at 1 ml·min<sup>-1</sup> at 286 nm detection. The drug was eluted at 5.484 min. After developing the method, it was assured for the intended use by validation which was done according to ICH Q2B guidelines. The analytical parameters checked were linearity, accuracy, repeatability, intermediate precision, limit of detection, limit of quantitation, ruggedness and robustness. It was observed that the response of the detector was linear in the range of 6 - 14 μg/ml with correlation coefficient of 0.999. The results of all the parameters were found to be within the acceptance criteria. The stability indicating assay method was established by using the samples generated by forced degradation process. The forced degradation was carried out by subjecting the drug to acid, alkali, thermal, oxidative and photolytic degradation and the results showed that the degradation products were successfully separated from the drug. Hence, this can be applied perfectly later for the analysis of quality of the rucaparib drug. 展开更多
关键词 Rucaparib Reverse-Phase High Performance Liquid Chromatography method development VALIDATION
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Analytical Method Development and Validation of Filgrastim by UV and RP-UFLC Methods 被引量:1
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作者 Husna Kanwal Qureshi Ciddi Veeresham Chinta Srinivas 《American Journal of Analytical Chemistry》 2021年第10期333-346,共14页
The research work was carried out for establishing a new Ultra Violet (UV)— Visible spectroscopy and Reverse phase-Ultra Fast Liquid Chromatography (RP-UFLC) method for the analysis and quantification of a biosimilar... The research work was carried out for establishing a new Ultra Violet (UV)— Visible spectroscopy and Reverse phase-Ultra Fast Liquid Chromatography (RP-UFLC) method for the analysis and quantification of a biosimilar drug, Filgrastim. Filgrastim or recombinant methionyl granulocyte colony stimulating factor (rGCSF) is a glycoprotein. It has a biological action essential for proliferation and differentiation of hematopoetic and progenitor cells. The UV and RP-UFLC work was carried on a Shimadzu UV1800 Spectrophotometer and Shimadzu Prominence LC-20AD UFLC systems, respectively. The <i>λ</i><sub>max</sub> of filgrastim was found to be 215 nm. The correlation coefficient by UV spectroscopy was found to be 0.9994 for the concentration range of 1 to 3 μg/ml in double distilled water. The Reverse phase UFLC was done by using Phenomenex C4 (25 cm × 0.46 cm internal diameter) 15 μ, 300 A° analytical column. The optimized mobile phase for binary elution was Acetonitrile and double distilled water (80:20) with a flow rate of 1 ml/min. The retention time of drug was at 3.2 min. It was observed that the response of the detector was linear in the range of 5 - 15 μg/ml with correlation coefficient value of 0.999. After developing the methods, it was assured for the intended use by validation of the analytical parameters like linearity, accuracy, precision, limit of detection, limit of quantitation, ruggedness and robustness. The results of all the parameters for both the methods were found to be within the acceptance criteria as per the International Council for Harmonisation (ICH) guidelines. 展开更多
关键词 BIOSIMILARS Filgastim method development RP-UFLC UV Visible Spectroscopy VALIDATION
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A Stability Indicating Reverse Phase-HPLC Method Development and Validation for the Estimation of Bimatoprost 0.3% &Timolol 0.5% Pharmaceutical Ophthalmic Dosage Form
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作者 Md. S. Amin Muhammad T. Islam 《American Journal of Analytical Chemistry》 CAS 2022年第12期506-530,共25页
The research was carried out to establish a new reverse phase-HPLC stability indicating method for quantifying Bimatoprost & Timolol in ophthalmic solution. The experiment of Bimatoprost & Timolol in ophthalmi... The research was carried out to establish a new reverse phase-HPLC stability indicating method for quantifying Bimatoprost & Timolol in ophthalmic solution. The experiment of Bimatoprost & Timolol in ophthalmic solution method development was determined on Waters HPLC instrument using a UV Detector. The separation was done by using L11, Zorbex SB phenyl (4.6 mm × 250 mm internal diameter) 5 μm analytical column, containing mobile phase of Phosphate buffer (0.02 M), methanol, and acetonitrile [50:30:20 % v/v]. The method was run at 1 ml·min<sup>-1</sup> at 210 nm for Bimatoprost and 295 nm for Timolol for detection. The drug was eluted at 10.81 min for Bimatoprost and 3.77 min for Timolol. After developing the method, it was assured for the intended use by validation, which was done according to ICH Q2B guidelines. The analytical parameters checked were Specificity/Selectivity, linearity, Range, accuracy, ruggedness, and robustness. It was observed that the response of the detector was linear in the range of 6 - 18 μg/ml with a correlation coefficient of 0.999. The results of all the parameters were found to be within the acceptance criteria. The stability-indicating assay method was established by using the samples generated by the forced degradation process. The forced degradation was carried out by subjecting the drug to acid, alkali, thermal, oxidative, and photolytic degradation, and the results showed that the degradation products were successfully separated from the drug. Hence, this can be applied perfectly later for the quantitative analysis of Bimatoprost 0.3% + Timolol 0.5% Ophthalmic Solution drugs for pharmaceutical use. Currently, there is no official method for Bimatoprost & Timolol combination products in USP or BP. Available research work related to single Bimatoprost or Timolol products was not suitable for testing Bimatoprost and Timolol combination drugs. Additionally, there is no stability-indicating method to test Bimatoprost & Timolol combination products which insist us to do research and develop a new reverse phase-HPLC indicating method which will be faster and more accurate. 展开更多
关键词 BIMATOPROST TIMOLOL Reverse-Phase High Performance Liquid Chromatography method development Validation Stability Indicating
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Development and Validation of a UPLC Method for the Determination of Docetaxel and Its Related Substances in Pharmaceutical Dosage Forms, an Antineoplastic Agent
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作者 Srinivasulu Kasa Sreenivas Pippalla +1 位作者 Mopidevi Narasimha Naidu Dipak Goyal 《American Journal of Analytical Chemistry》 CAS 2024年第10期333-346,共14页
A novel, simple, and sensitive Ultra Performance Liquid Chromatography (UPLC) method was developed and validated for the quantification of process-related impurities and degradants, as well as the assay of Docetaxel. ... A novel, simple, and sensitive Ultra Performance Liquid Chromatography (UPLC) method was developed and validated for the quantification of process-related impurities and degradants, as well as the assay of Docetaxel. The stability-indicating capability of the method was demonstrated through forced degradation studies and a comprehensive mass balance evaluation. Chromatographic separation was achieved using an ACQUITY UPLC BEH C18 column (100 × 2.1 mm, 1.7 µm), with gradient elution. The mobile phase A comprised a mixture of water, methanol, and acetonitrile (500:300:200, v/v/v), while mobile phase B was acetonitrile and water (800:200, v/v). The flow rate was set at 0.4 mL/min, with detection at 232 nm using a photodiode array detector. The method exhibited excellent performance, with a tailing factor of 1.10 for Docetaxel. The method was rigorously validated for precision, accuracy, linearity, LOD, LOQ, ruggedness, specificity, and robustness. Forced degradation studies confirmed the method’s suitability for stability analysis. Stability testing on the drug substance was conducted following ICH guidelines. 展开更多
关键词 UPLC method development VALIDATION DOCETAXEL IMPURITIES ICH
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Agile Development Methods in Software Engineering and Their Efficiency Analysis
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作者 Shuntao Tang Wei Chen 《计算机科学与技术汇刊(中英文版)》 2024年第1期8-11,共4页
This paper delves into Agile Development Methods in Software Engineering,contrasting them with the traditional Waterfall model and analyzing their efficiency.Agile methods,known for their adaptability and customer-cen... This paper delves into Agile Development Methods in Software Engineering,contrasting them with the traditional Waterfall model and analyzing their efficiency.Agile methods,known for their adaptability and customer-centric approach,have gained prominence in the fast-paced software development industry.These methods,including Scrum,Kanban,and Extreme Programming(XP),are characterized by iterative cycles,collaborative efforts,and a focus on rapid delivery and quality improvement.The paper compares these agile methodologies to the sequential and rigid Waterfall model,highlighting agile’s superior flexibility,adaptability,and responsiveness to changing requirements.It emphasizes the importance of customer involvement in agile processes,which leads to higher satisfaction and better alignment with user expectations.The analysis reveals that agile methods not only enhance the speed of delivery but also improve the overall quality of the software product.The paper concludes that agile methodologies are more effective in today's dynamic software development environment,providing a robust framework for managing complex projects and ensuring the delivery of high-quality,relevant software solutions. 展开更多
关键词 Agile development methods Software Engineering SCRUM KANBAN Extreme Programming
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Construction of the Curriculum System of Software Engineering Based on the Agile Development Method
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作者 Ziyi Wang 《Journal of Contemporary Educational Research》 2024年第10期121-127,共7页
Under the background of“new engineering”construction,software engineering teaching pays more attention to cultivating students’engineering practice and innovation ability.In view of the inconsistency between develo... Under the background of“new engineering”construction,software engineering teaching pays more attention to cultivating students’engineering practice and innovation ability.In view of the inconsistency between development and demand design,team division of labor,difficult measurement of individual contribution,single assessment method,and other problems in traditional practice teaching,this paper proposes that under the guidance of agile development methods,software engineering courses should adopt Scrum framework to organize course project practice,use agile collaboration platform to implement individual work,follow up experiment progress,and ensure effective project advancement.The statistical data of curriculum“diversity”assessment show that there is an obvious improvement effect on students’software engineering ability and quality. 展开更多
关键词 Agile development method Software engineering Practical teaching Curriculum system Experimental project
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Gas Chromatographic Method for Identification and Quantification of Commonly Used Residual Solvents in Pharmaceuticals Products
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作者 Sreekanta Nath Dalal Pranab Kumar Das 《American Journal of Analytical Chemistry》 CAS 2024年第8期241-252,共12页
Background: Impurities are not expected in the final pharmaceutical products. All impurities should be regulated in both drug substances and drug products in accordance with pharmacopeias and ICH guidelines. Three dif... Background: Impurities are not expected in the final pharmaceutical products. All impurities should be regulated in both drug substances and drug products in accordance with pharmacopeias and ICH guidelines. Three different types of impurities are generally available in the pharmaceutical’s product specification: organic impurities, inorganic impurities, and residual solvents. Residual solvents are organic volatile chemicals used or generated during the manufacturing of drug substances or drug products. Purpose: The aim of this study is to develop a cost-effective gas chromatographic method for the identification and quantification of some commonly used solvents—methanol, acetone, isopropyl alcohol (IPA), methylene chloride, ethyl acetate, tetrahydrofuran (THF), benzene, toluene, and pyridine—in pharmaceutical product manufacturing. This method will be able to identify and quantify the multiple solvents within a single gas chromatographic procedure. Method: A gas chromatography (GC) equipped with a headspace sampler and a flame ionization detector, and a column DB 624, 30-meter-long × 0.32-millimeter internal diameter, 1,8 μm-thick, Brand-Agilent was used to develop this method. The initial GC oven temperature was 40°C and held for 5 minutes. It was then increase to 80˚C at a rate of 2˚C per minute, followed by a further increase to 225˚C at a rate of 30˚C per minute, with a final hold at 225˚C for 10 minutes. Nitrogen was used as a carrier gas at a flow rate of 1.20 mL per minute. Dimethyl sulfoxide (DMSO) was selected as sample solvent. Results: The developed method is precise and specific. The percent RSD for the areas of six replicate injections of this gas chromatographic method was within 10.0 and the recovery result found within 80.0% to 120.0%. 展开更多
关键词 method development Gas Chromatography Compendial method GDP SPECIFICITY RECOVERY
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Development of a rapid GC-FID method to simultaneously determine triethylamine, diisopropylamine, and 1,1,3,3-tetramethylguanidine residues in an active pharmaceutical ingredient 被引量:2
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作者 Minshan Shou Haixiao Qiu 《Journal of Pharmaceutical Analysis》 SCIE CAS CSCD 2021年第2期251-256,共6页
A rapid GC-FID method was developed to simultaneously determine residual levels of triethylamine(TEA), 1,1,3,3-tetramethylguanidine(TMG), and diisopropylamine(DIPA) in the synthetic route of an active pharmaceutical i... A rapid GC-FID method was developed to simultaneously determine residual levels of triethylamine(TEA), 1,1,3,3-tetramethylguanidine(TMG), and diisopropylamine(DIPA) in the synthetic route of an active pharmaceutical ingredient(API). Due to the severe absorption of amines on GC stationary phases,GC columns with various stationary phases were evaluated for optimal peak shape and reproducibility.The final conditions used the Agilent CP-Volamine column to resolve the three amines in 12 min. Various inlet liners were also screened to further improve the sensitivity of the analysis. The Restek Siltek~? liner was selected to achieve the desired detectability for the method. The quantitation limits were 4, 3, and 4 mg/mL for TEA, DIPA, and TMG in the presence of API, respectively. All three amines showed good linearity(r > 0.999) and recoveries(> 90%) over the concentration range of 3 to 16 mg/mL. The testing of residual amines was initially performed at the penultimate stage of the synthesis. However, this work demonstrates that TMG can act as a proton sponge to react with salicylic acid, the counter ion of the penultimate, to form a volatile component that elutes at a different retention time. Consequently, in the final method, these three amines were monitored in the final API to circumvent the matrix interference.Key parameters of the method were qualified per method validation requirements in ICH guidelines. The method was successfully applied for batch testing during development and implemented as an inprocess control procedure at manufacturing sites. 展开更多
关键词 GC-FID AMINES API method development method qualification
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Quality Control of Tramadol in Kisangani: Development, Validation, and Application of a UV-Vis Spectroscopic Method 被引量:4
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作者 Marguerite Borive Amani Jérémie Mbinze Kindenge +4 位作者 Emile Tweni Baruti Elodie Nsasi Bakiantima Salomon Batina Agasa Philippe Hubert Roland Marini Djang’eing’a 《American Journal of Analytical Chemistry》 2021年第8期295-309,共15页
<strong>Context:</strong> Substandard and falsified medicines are circulating in low-income countries mostly without any control. We availed a simple and not expensive UV-Vis spectroscopic method to evalua... <strong>Context:</strong> Substandard and falsified medicines are circulating in low-income countries mostly without any control. We availed a simple and not expensive UV-Vis spectroscopic method to evaluate the quality of tramadol in Kisangani before and during the Covid-19 period. <strong>Methods:</strong> For the analytical quantitative method, an experimental design was applied to set up the optimal levels of the selected factors, namely, pH of dissolution medium, type of cuvette, and wavelength. Taking into account the capsule pharmaceutical formulation within 80 - 120 μg&middotmL<sup>-1</sup> concentration range, we analyzed 89 tramadol samples from pharmacies and hospitals of the six Kisangani municipalities. <strong>Results:</strong> pH showed a significant effect on absorbance, whereas quartz cuvette and wavelength did not. A typical 100 μg&middotmL<sup>-1</sup> tramadol solution gave an absorbance of 0.64 at 272 nm. Validation highlighted a matrix effect observed with a 6% bias. A correction factor of 0.9372 allowed to improve the accuracy profile, which were then totally included within the 10% acceptance limits. Quality control revealed that 25 samples out of 89 were not compliant in terms of manufacturing license, registration status in DRC and content as well. <strong>Conclusion:</strong> This study showed that the strengthening of analytical strategy in Kisangani is a need. 展开更多
关键词 TRAMADOL UV-Vis Spectroscopy method development VALIDATION Quality Control
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A review of development methods and EOR technologies for carbonate reservoirs 被引量:14
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作者 Zheng-Xiao Xu Song-Yan Li +3 位作者 Bin-Fei Li Dan-Qi Chen Zhong-Yun Liu Zhao-Min Li 《Petroleum Science》 SCIE CAS CSCD 2020年第4期990-1013,共24页
Carbonate reservoirs worldwide are complex in structure,diverse in form,and highly heterogeneous.Based on these characteristics,the reservoir stimulation technologies and fluid flow characteristics of carbonate reserv... Carbonate reservoirs worldwide are complex in structure,diverse in form,and highly heterogeneous.Based on these characteristics,the reservoir stimulation technologies and fluid flow characteristics of carbonate reservoirs are briefly described in this study.The development methods and EOR technologies of carbonate reservoirs are systematically summarized,the relevant mechanisms are analyzed,and the application status of oil fields is catalogued.The challenges in the development of carbonate reservoirs are discussed,and future research directions are explored.In the current development processes of carbonate reservoirs,water flooding and gas flooding remain the primary means but are often prone to channeling problems.Chemical flooding is an effective method of tertiary oil recovery,but the harsh formation conditions require high-performance chemical agents.The application of emerging technologies can enhance the oil recovery efficiency and environmental friendliness to a certain extent,which is welcome in hard-to-recover areas such as heavy oil reservoirs,but the economic cost is often high.In future research on EOR technologies,flow field control and flow channel plugging will be the potential directions of traditional development methods,and the application of nanoparticles will revolutionize the chemical EOR methods.On the basis of diversified reservoir stimulation,combined with a variety of modern data processing schemes,multichannel EOR technologies are being developed to realize the systematic,intelligent,and cost-effective development of carbonate reservoirs. 展开更多
关键词 Carbonate reservoir Reservoir stimulation Flow characteristic development method EOR technology
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Oil oxidation in the whole temperature regions during oil reservoir air injection and development methods 被引量:1
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作者 LIAO Guangzhi WANG Hongzhuang +7 位作者 WANG Zhengmao TANG Junshi WANG Bojun PAN Jingjun YANG Huaijun LIU Weidong SONG Qiang PU Wanfen 《Petroleum Exploration and Development》 2020年第2期357-364,共8页
The oil oxidation characteristics of the whole temperature regions from 30 ℃ to 600 ℃ during oil reservoir air injection were revealed by experiments. The whole oil oxidation temperature regions were divided into fo... The oil oxidation characteristics of the whole temperature regions from 30 ℃ to 600 ℃ during oil reservoir air injection were revealed by experiments. The whole oil oxidation temperature regions were divided into four different parts: dissolving and inflation region, low temperature oxidation region, medium temperature oxidation region and high temperature oxidation region. The reaction mechanisms of different regions were explained. Based on the oil oxidation characteristics and filed tests results, light oil reservoirs air injection development methods were divided into two types: oxygen-reducing air flooding and air flooding;heavy oil reservoirs air injection in-situ combustion development methods were divided into two types: medium temperature in-situ combustion and high temperature in-situ combustion. When the reservoir temperature is lower than 120 ℃, oxygen-reducing air flooding should be used for light oil reservoir development. When the reservoir temperature is higher than 120 ℃, air flooding method should be used for light oil reservoir development. For a normal heavy oil reservoir, when the combustion front temperature is lower than 400 ℃, the development method is medium temperature in-situ combustion. For a heavy oil reservoir with high oil resin and asphalting contents, when the combustion front temperature is higher than 450 ℃, the development method at this condition is high temperature in-situ combustion. Ten years field tests of air injection carried out by PetroChina proved that air has advantages in technical, economical and gas source aspects compared with other gas agents for oilfield gas injection development. Air injection development can be used in low/super-low permeability light oil reservoirs, medium and high permeability light oil reservoirs and heavy oil reservoirs. Air is a very promising gas flooding agent. 展开更多
关键词 air injection full temperature regions oil oxidation reaction characteristics coke formation reservoir types development methods
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Priority-sequence of mineral resources' development and utilization based on grey relational analysis method 被引量:3
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作者 Wang Ying Zhang Chang Jiang Gaopeng 《International Journal of Mining Science and Technology》 SCIE EI CSCD 2016年第3期395-400,共6页
Generally, the sequence decision of the development and utilization of Chinese mineral resources is based on national and provincial overall plan of the mineral resources. Such plan usually cannot reflect the relative... Generally, the sequence decision of the development and utilization of Chinese mineral resources is based on national and provincial overall plan of the mineral resources. Such plan usually cannot reflect the relative size of the suitability of the development and utilization of mineral resources. To solve the problem, the paper has selected the gift condition, the market condition, the technological condition,socio-economic condition and environmental condition as the starting-points to analyze the influential factors of the priority-sequence of mineral resources' development and utilization. The above 5 conditions are further specified into 9 evaluative indicators to establish an evaluation indicator system. At last,we propose a decision model of the priority sequence based on grey relational analysis method, and figure out the observation objects by the suitability index of development. Finally, the mineral resources of a certain province in China were analyzed as an example. The calculation results indicate that silver(2.0057), coal(1.9955), zinc(1.9442), cement limestone(1.9077), solvent limestone(1.5624) and other minerals in the province are suitable for development and utilization. 展开更多
关键词 Mineral resources development and utilization Priority-sequence Grey relational analysis method
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Qualitative Research Methods in Spatial Urban Development: A Methodological Investigation of Approaches into Urban Development Based on Centralities in the Context of a Medium-Sized European City
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作者 Martin Brabant 《Journal of Civil Engineering and Architecture》 2016年第11期1288-1296,共9页
Dispersed and peripheral spaces in the urban core are influenced both by the trend towards constant growth as well as social ways of life which are constantly evolving. Following a connotation, these two factors there... Dispersed and peripheral spaces in the urban core are influenced both by the trend towards constant growth as well as social ways of life which are constantly evolving. Following a connotation, these two factors therefore play a crucial role in defining the alternation of urban space--in particular, that of the centers. The main focus of this research article is on the methodology used in the survey and evaluation of "centralities" as well as their developments over the past four decades (1974-2014) in approaches to urban development that has been developed in Graz.~ The analysis has drawn on the four editions ("evolution") of approaches to urban development as conceived by the city of Graz in order to examine their verbal characteristics in regard to centralities. At the same time, the analysis does not examine presentations of plans which exist in supplementary forms (e.g., explanatory reports and supplemented plans)--it restricts itself solely to the various plans set out in the STEKs.2 The highest degree of accuracy has been applied to the notion of "centralis" in approaches to urban development. The goal of the research project was to depict the modulation of the notion of "centrality" in the urban context as a space-forming dimension. Furthermore, it clearly shows the extent to which the notion of the "centre" (in the widest sense of the word) has become distanced from qualitative, spatial development and at the current time of urban development is experiencing a sort of Renaissance. In the field of "urban development", architectural references in the context of"centrality" have scarcely been researched. This has led to the opening-up of a complex interdisciplinary research field. In order to make the complex architectural determinants of "centrality" more accessible to the participating disciplines, approaches to urban development have been explored in the form of a social and spatial analysis. 展开更多
关键词 Social space analysis qualitative research methods in urban development processes classification of city sizes URBAN centre.
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Effects of Different Enucleation Methods on Developmental Potency of Pig Handmade Clone Reconstructed Embryos
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作者 Lv Lingyan Lu Xingrong +5 位作者 Sun Junming Pan Cuiling Lan Haien Wang Yanling Cui Kuiqing Xie Bingkun 《Animal Husbandry and Feed Science》 CAS 2016年第3期134-138,共5页
Effects of different enucleation methods on developmental potency of pig handmade clone(HMC)reconstructed embryo was investigated in the paper.We compared enucleation efficiency of blind cut method,first polar body... Effects of different enucleation methods on developmental potency of pig handmade clone(HMC)reconstructed embryo was investigated in the paper.We compared enucleation efficiency of blind cut method,first polar body(Pb1)positioning method and demecolcine(DM)assisted enucleation,as well as their effects on development of HMC reconstructed embryos.The results showed that overall enucleation efficiency of Pb1 positioning method was significantly higher than that of blind cut method(P〈0.05).The protuberance rate and overall enucleation efficiency of 0.4μg/mL DM treated group for 60 min was significantly higher than that of other concentrations and time treatment groups(P〈0.05).For effects on development of HMC reconstructed embryos,there was no significant difference between DM-assisted enucleation and Pb1 positioning method.In conclusion,appropriate addition of DM could enhance enucleation efficiency of HMC,which had no significant influence on developmental potency of reconstructed embryos. 展开更多
关键词 Enucleation methods Pig Handmade clone developmental potency
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The Principles and Methods of Power Development Planning in the Market Economic Situation of China
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《Electricity》 1999年第1期7-9,24,共4页
关键词 The Principles and methods of Power development Planning in the Market Economic Situation of China
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Bee-like Oil Production Technology──Development of Low Permeability Oilfield by Oil Bailing Method in Jilin Oilfield
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《China Oil & Gas》 CAS 1999年第3期168-169,共2页
关键词 development of Low Permeability Oilfield by Oil Bailing method in Jilin Oilfield Bee-like Oil Production Technology
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SOME DEVELOPMENTS IN VISCOUS FLUID DYNAMICS AND ITS NUMERICAL METHODS
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作者 GaoZhi(The CAS Institute of Mechanics) Wang Ruquan(CAS Institute of Computational Mathematics & Scientific/Engineering Computing) 《Bulletin of the Chinese Academy of Sciences》 1999年第2期104-106,共3页
Viscous fluid flows contain abundant "physical phenomena and the viscous fluid dynamics is of wide applications in the fields of natural and engineering sciences. After the basic equations of viscousfluiddynamics... Viscous fluid flows contain abundant "physical phenomena and the viscous fluid dynamics is of wide applications in the fields of natural and engineering sciences. After the basic equations of viscousfluiddynamics (i.e., the Navier-Stokes equations) came out, one of the most important contributions to the discipline was the boundary layer (BL) theory and the BL equations presented by Prandtl 展开更多
关键词 SOME developmentS IN VISCOUS FLUID DYNAMICS AND ITS NUMERICAL methodS ITS
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档案袋评价法在高校发展型资助育人机制中的应用
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作者 邵明颖 《泰州职业技术学院学报》 2024年第1期29-32,共4页
新时期高校资助工作理念从保障型向发展型转变是时代发展的必然趋势。但是,当前高校发展型资助育人工作存在育人理念的理解不够深入、育人机制不够完善、缺少有效的学生评价方法等问题。档案袋评价法作为较为成熟的评价方法,其区别于传... 新时期高校资助工作理念从保障型向发展型转变是时代发展的必然趋势。但是,当前高校发展型资助育人工作存在育人理念的理解不够深入、育人机制不够完善、缺少有效的学生评价方法等问题。档案袋评价法作为较为成熟的评价方法,其区别于传统的量性评价,重视多元化、个性化及人的全面和谐发展,优势明显。为此,在分析学生发展中的需求后,将“档案袋评价法”引入高校发展型资助育人机制中,设计应用“发展型学生档案袋”,为提升家庭困难学生未来发展能力,完善资助育人机制提供了新的理论方向和实践路径。 展开更多
关键词 档案袋评价法 发展型资助 育人机制
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