Effect of Chinese Drugs for Supplementing Qi,Nourishing Yin and Activating Blood Circulation on Myocardial Perfusion in Patients with Acute Myocardial Infarction after Revascularization

Objective:To observe the effects of Chinese drugs for supplementing qi,nourishing yin and activating blood circulation on the myocardial perfusion in acute myocardial infarction(AMI) patients after revascularization.Methods:Eighty patients with anterior or inferior ventricular wall AMI,who had received revascularization by intravenous thrombolysis or coronary bypass,were randomized into the treated group and the control group equally,both treated with conventional Western medical treatment,but combined,resp...

Effect of Chinese Herbal Medicine for Nourishing Yin,Supplementing Qi,and Activating Blood on the Th1/Th2 Immune Balance in Peripheral Blood in Patients with Primary Sjogren's Syndrome

Objective： To observe the effect of Chinese herbal medicine for nourishing yin, supplementing qi, and activating blood on the expression of interferen- γ （IFN-γ,）/interleukin-4 （IL-4） in peripheral blood and disease activity in primary Sjogren＇s syndrome （pSS） patients, and to study the relationship between the immune balance of Th1/Th2 and the disease activity. Methods： A total of 66 pSS patients were randomized with tossing coins method into two groups： the integrative therapy group （34 cases） and the control group （32 cases）; and 28 healthy subjects were taken as the normal group. The integrative therapy group was treated by Chinese herbal medicines for nourishing yin, supplementing qi, and activating blood combined with hydroxychloroquine sulfate tablets and the control group was treated with hydroxychloroquine sulfate tablets. The treatment course was 3 months for both groups. The levels of serum immunoglobulin G （IgG）, erythrocyte sedimentation rate （ESR）, IFN-γand IL-4 in peripheral blood were measured before and after treatment. Results： Compared with the normal group, the levels of IgG, ESR, IFN- γ and IL-4 were significantly increased in pSS patients （P〈0.05）. Remarkably, after 3 months of treatment, these levels were dramatically decreased in both the integrative therapy group and the control group, although still higher than the normal group. The levels of IgG, ESR, IFN- and IL-4 in the integrative therapy group were lower than the control group and the same group before treatment （P〈0.05）. The ratio of IFN-γ/IL-4 also significantly decreased after treatment. Moreover, the level of IFN- γ, and the ratio of IFN- γ/IL-4 in the integrative theraphy group were significantly lower than the control group （P〈0.05）. For all patients the ratio of IFN-γ/IL-4 before and after treatment was positive correlated with the levels of IgG and ESR. Conclusion： Chinese herbal medicine for nourishing yin, supplementing qi, and activating blood can alleviate the disease activity of pSS by regulating the immune balance of Th1/Th2.

Effect of Chinese Herbal Medicines for Nourishing Yin,Supplementing Qi,and Activating Blood on Reproductive Endocrine Activity and Immune Functions in Patients with Primary Sjogren's Syndrome

ABSTRACT Objective： To investigate the effect of Chinese herbal medicines for nourishing yin, supplementing qi, and activating blood on the reproductive endocrine-immune network and its mechanisms in patients with primary Sjogren＇s syndrome （pSS）. Methods： Seventy pSS patients were randomly assigned to two groups using a randomized digital table： the integrative therapy group （36 cases） and the control group （34 cases）. Thirty healthy subjects were taken as a normal group. The control group was treated with hydroxychloroquine sulfate tablets alone, and the integrative therapy group was treated by Chinese herbal medicines for nourishing yin, supplementing qi, and activating blood combined with hydroxychloroquine sulfate tablets. The treatment course was 6 months for both groups. Before and after treatment, serum estradiol （E2）, testosterone （T）, luteinizing hormone （LH）, prolactin （PRL） by radioimmunoassay and immunoglobulin （IgG） by immunodiffusion, erythrocyte sedimentation rate （ESR） by Westergren, interferon-γ （IFN-γ） and interleukin-4 （IL-4） by enzyme linked immunosorbent assay were determined. Results： E2 and T levels in all patients were lower than those of normal subjects before treatment （P〈0.05） and were increased significantly after 6-month treatment （P〈0.05）. ESR, FSH, LH, IgG, IFN - γ, IL - 4 and ratios of E2/T, and IFN --γ/IL in the patients were higher than those of normal subjects before the treatments （P〈0.05）, and were reduced significantly after the treatments （P〈0.05）. The T and IFN -γ levels and E2/T ratio in the patients treated with integrative therapy were reduced significantly compared with the control group （P〈0.05）. However, the PRL levels before and after treatment were not significantly changed in the two groups （P〉0.05）. The ratios of E2/T and IFN -γ/IL-4, and levels of IgG and ESR were positively correlated before and after treatment （P〈0.05）. Conclusions： The ratios of E2/T and IFN - γ/ IL-4 might be used as indicators of pSS activity. Chinese herbal medicines for nourishing yin, supplementing qi, and activating blood combined with Western medicine could improve the therapeutic effect by regulating the reproductive endocrine-immune network in pSS patients.

Protective Effect of Chinese Herbs for Supplementing Qi,Nourishing Yin and Activating Blood Circulation on Heart Function of Patients with Acute Coronary Syndrome after Percutaneous Coronary Intervention

Objective： To investigate the effects of Chinese herbs for supplementing qi, nourishing yin and activating blood circulation on heart function of patients with acute coronary syndrome （ACS） after successful percutaneous coronary intervention （PCI）. Methods： One hundred patients with ACS after successful PCI were randomly assigned to a Western medicine （WM） treatment group （WMG） and a combined treatment group （CMG） treated by Chinese herbs for supplementing qi, nourishing yin and activating blood circulation, besides Western medicine treatment, with 50 cases in each group. Both treatment courses were 6 months. The follow- up was scheduled at baseline, 6 months and 1 year after PCI, and New York Heart Association （NYHA） functional class, Chinese medicine （CM） symptom scores, blood stasis syndrome scores, and major adverse cardiovascular events （MACE） were observed, serum levels of N-terminal pro-brain natriuretic peptide （NT-proBNP） and hyper-sensitivity C-reactive protein （Hs-CRP） were measured, an echocardiogram was conducted to examine left ventricular ejection fraction （LVEF）, left ventricular end-diastolic volume （LVEDV）, left ventricular end-systolic volume （LVESV）, inter-ventricular septal thickness （IVST）, left ventricular posterior wall thickness （LVPWT）, and ventricular wall motion index （VWMI）. Results： Compared with the baseline, LVEF significantly increased （P〈0.01）, and CM symptom scores, blood stasis syndrome scores, VWMI, LVEDV, LVESV, NT-proBNP, and Hs-CRP all decreased （P〈0.01） in both groups at 6 months and at 1 year after PCI. There were no significant differences in all the above parameters at 1 year vs those at 6 months after PCI （P〉0.05）. VWMI, LVEDV, LVESV, NT-proBNP, Hs-CRP, LVEF, and CM symptom and blood stasis syndrome scores were all improved obviously in CMG than those in WMG （P〈0.05 or P〈0.01） at 6 months and at 1 year after PCI. There were no significant differences in NYHA functional class between CMG and WMG at different follow-up timepoints; it was notable that P value was 0.054 when comparing the cases of NYHA functional class between the two groups at 1-year follow-up. During the 1-year follow-up, 3 MACE and 11 MACE occurred in CMG and WMG, respectively; the MACE rate in CMG was lower than that in WMG （6% vs 22%, P〈0.05）. Conclusion： Chinese herbs for supplementing qi, nourishing yin and activating blood circulation could improve heart function, reduce the CM symptom scores and blood stasis syndrome scores, and decrease the incidence of MACE in patients with ACS after successful PCI.

Effects of Chinese herbs capable of replenishing qi, nourishing yin and activating blood circulation and their compatibility on differentially expressed genes of ischemic myocardium

This study was conducted to investigate the effects of Chinese herbs capable of replenishing qi, nourishing yin and activating blood circulation and their compatibility on differentially expressed genes of ischemic myocardium which were selected from differential expression profile we had established before, and to explore the underlying mechanism. The acute myocardial infarction (AMI) model was established by ligating the left anterior descending (LAD) coronary artery, then the model rats were randomly divided into the model group, the Metoprolol group, the replenishing qi nourishing yin (RN) group, the activating blood circulation (AB) group, and the replenishing qi, nourishing yin and activating blood circulation (RA) group. In addition, the normal group and the sham group were set up. The rats of medication groups were administered by intragastric gavage with corresponding drugs on the second day after operations, and the rats of the normal group and the sham group were given normal saline as the same time.Then the ischemic hearts were harvested on the 8th day after operation. The myocardial pathomorphological changes were observed under a light microscope. The mRNA changes of target genes such as COX5a and ATP5e were detected using Realtime fluorescence quantitative PCR (QPCR), and the activities of related enzymes were detected by colorimetric assay. The main results were as follows: the histological changes were observed by HE staining, and cardiocyte swelling, inflammatory cell infiltration and cytolysis were showed in regional ischemic myocardium of the model group, while the pathomorphological changes in all medication groups did not show obvious changes. Two genes related to energy metabolism, COX5a and ATP5e, were selected as the target genes which were downregulated at the mRNA level in the medication groups. The activities of correlative functional enzymes also decreased in the RA group compared to that in the model group accordingly (P<0.05). The results indicated that the abnormal expression of genes involved in energy metabolism pathways could be one of the molecular mechanisms of AMI. The compatibility of Chinese herbs capable of replenishing qi, nourishing yin and activating blood circulation affects the expression of energyrelative gene COX5a, ATP5e, which is probably the mechanism of myocardial preservation, and is more effective than single herb of replenishing qi and nourishing yin or activating blood circulation.

益气养阴化痰祛瘀法对甲状腺机能亢进症激素抗体及氧化应激因子表达的影响

目的研究益气养阴化痰祛瘀法对甲状腺机能亢进症(Hyperthyroidism,简称甲亢)患者激素抗体和氧化应激因子表达的影响。方法选取2022年1月—2023年12月收治的76例甲亢患者,按照随机数字表法分组,对照组(38例)采用常规西药治疗,观察组(38例)在对照组基础上加用益气养阴化痰祛瘀方治疗;治疗2个月后对比两组临床疗效、中医证候积分、甲状腺功能(各项激素水平)、氧化应激因子、促甲状腺激素受体抗体(TRAb)、甲状腺过氧化物酶抗体(TPOAb)的表达。结果观察组治疗总有效率为94.74%(36/38),高于对照组(76.32%,29/38),差异有统计学意义(P<0.05)。治疗后,两组主症积分、次症积分和舌脉积分均降低,观察组低于对照组;两组促甲状腺激素(TSH)上升,游离三碘甲状腺原氨酸(FT3)、游离甲状腺素(FT4)下降(P<0.05),观察组改善高于对照组;两组超氧化物歧化酶(SOD)升高,观察组SOD水平高于对照组,差异有统计学意义(P<0.05)。结论益气养阴化痰祛瘀法用于甲亢患者的治疗取得确切治疗成果,可以有效改善甲状腺功能,通过调控甲状腺激素水平、TRAb、TPOAb以及氧化应激因子的表达以改善病情,缓解症状。

基于气阴两虚夹瘀运用五参汤治疗肺癌术后发热浅析

肺癌术后发热有非感染性发热与感染性发热之分,在气虚、阴虚、瘀血阻滞病理状态下形成热蕴状态,是为非感染性发热;而术中感染或外感风寒入里化热则形成感染性发热表现。其基本病机均可概括为气阴两虚夹瘀。五参汤具有益气养阴、清热解毒之功,为证属正气亏虚、外感邪毒者而设,用于肺癌术后发热契合其病机。

活血通络类方剂治疗糖尿病肾脏疾病的研究进展

糖尿病肾脏疾病(DKD)是导致慢性肾脏病和终末期肾病的首要病因,严重危害人类健康。中医认为血瘀是贯穿DKD全病程的重要病机,多项研究拟定了多个活血通络类方治疗DKD患者,其临床症状好转、蛋白尿减少、肾功能保护、治疗有效率提高和疾病进展延缓等方面均有成效。

毛静远教授治疗心肌桥致难治性心绞痛经验

心肌桥导致的难治性心绞痛常给患者带来沉重的躯体和精神负担,中医药治疗能够进一步改善症状,提高生活质量。现总结毛静远教授治疗心肌桥致难治性心绞痛经验,毛教授认为该病病机以血瘀为始动环节,因实致虚,本虚以阴虚为主,血瘀、痰热为标,治疗应注重养阴,兼用活血、化痰、清热,同时须注意顾护调理,避免心衰等并发症的发生。

近10年中医辨治胃癌前病变的研究进展

对近10年来有关中医辨治胃癌前病变(precancerous lesions of gastric cancer,PLGC)的研究进行综述。PLGC是指在慢性萎缩性胃炎基础上出现的胃黏膜肠上皮化生和异型增生,作为慢性萎缩性胃炎与胃癌的中间阶段,PLGC的病程较缓慢。中医辨治PLGC具有一定的优势。PLGC主要可分为脾胃虚弱证、脾胃湿热证、肝胃气滞证、胃络瘀阻证、胃阴不足证5种证型。胃镜技术的普及促进了胃病微观辨证的发展,微观辨证与宏观辨证的结合为PLGC的中医辨证论治提供了更加丰富的理论支持。PLGC根本病机为脾胃虚弱,脾胃气机不畅,兼有湿热、瘀毒、痰湿等病理因素蕴结,日久胃阴亏耗。中药治疗PLGC的临床研究开展较多,治疗主要采用以益气健脾为主,兼以疏肝活血、化湿消瘀、化瘀解毒、养阴益胃,从而防止PLGC向胃癌进一步发展。针灸治疗胃癌前病变的研究开展较少。今后需开展更多严格且规范的多中心、大样本的临床随机对照试验,深入研究针灸治疗胃癌前病变机制,以期为中医辨治PLGC提供更多高级别的循证依据。

益气养阴活血法治疗2型糖尿病合并慢性心力衰竭患者的疗效观察

目的 探讨中医益气养阴活血法辨证治疗2型糖尿病(Type 2 diabetes, T2DM)合并慢性心力衰竭(Chronic heart failure, CHF)患者的临床疗效。方法 选取2021年1月—2022年1月期间唐山市中医医院内分泌一科收治的T2DM合并CHF患者102例作为研究对象,按随机数字表法分为对照组与治疗组,每组各51例。对照组给予常规西医治疗,治疗组在对照组基础上联合中医益气养阴活血法辨证治疗,均治疗12周。观察比较两组患者西医疗效、中医证候疗效、安全性及治疗前后血糖水平[空腹血糖(Fasting blood glucose, FPG)、餐后2 h血糖(Blood glucose 2 h after a meal, 2 h PG)、糖化血红蛋白(Glycosylated hemoglobin, HbAlc)]、心功能指标[6分钟步行试验距离(6 min walking test, 6MWT)、左室射血分数(Left ventricular ejection fraction, LVEF)、N末端B型脑钠肽前体(N-terminal B-type brain natriuretic peptide precursor, NT-pro BNP)]、生活质量评分[T2DM生活质量(Quality of life specific scale for diabetes patients, DSQL)、CHF生活质量(Minnesota Living with Heart Failure Questionnaire, MLHFQ)]变化。结果 临床疗效:治疗后治疗组西医疗效总有效率96.08%(49/51)高于对照组82.35%(42/51),差异有统计学意义(P<0.05);治疗组中医证候疗效总有效率92.16%(47/51)高于对照组68.63%(35/51),差异有统计学意义(P<0.05)。血糖水平:治疗后两组患者血糖FPG、2 h PG及HbAlc水平均较治疗前降低,差异有统计学意义(P<0.05);且治疗组血糖FPG、2 h PG及HbAlc水平均明显低于对照组,差异有统计学意义(P<0.05)。心功能指标:治疗后两组患者心功能6MWT、LVEF水平较治疗前升高,NT-pro BNP水平较治疗前降低,差异有统计学意义(P<0.05);且治疗组6MWT、LVEF水平高于对照组,NT-pro BNP水平低于对照组,差异有统计学意义(P<0.05)。生活质量:治疗后两组患者DSQL、MLHFQ评分均较治疗前降低,差异有统计学意义(P<0.05);且治疗组DSQL、MLHFQ评分均明显低于对照组,差异有统计学意义(P<0.05)。安全性:治疗期间,两组患者不良反应均为轻度或一过性,未影响治疗,且不良反应发生率组间比较,差异无统计学意义(P>0.05)。结论 中医益气养阴活血法辨证治疗T2DM合并CHF效果显著、安全性高,有利于控制患者血糖,改善心功能与生活质量。

滋阴化瘀法治疗妊娠晚期羊水偏少临床观察

目的探讨滋阴化瘀法治疗妊娠晚期羊水偏少的临床效果。方法随机将60例2021年9月—2022年9月该院收治的妊娠晚期羊水偏少患者分为对照组(30例)和治疗组(30例)。对照组给予常规治疗,治疗组在对照组基础上给予滋阴化瘀法进行治疗,两组均持续治疗4周,并随访至分娩结束。比较两组治疗4周后的疗效,治疗前、治疗4周后羊水、胎盘血液灌注情况、性激素水平,治疗前、治疗1、4周后的中医证候评分,分娩结束时的新生儿窒息情况及随访期间的妊娠结局。结果治疗4周后,治疗组总有效率为90.00%(27/30),高于对照组的66.67%(20/30)(P<0.05)。与治疗前比较,治疗1、4周后,两组中医证候评分均呈逐渐降低趋势,且治疗组治疗1、4周后的中医证候评分均低于对照组(P<0.05)。与治疗前比较,治疗4周后,两组AFI及血清雌激素(E_(2))、前列腺素E(PGE)水平均升高,治疗组高于对照组(P<0.05);两组肾动脉收缩期最大血流速度/舒张期末血流速度(S/D)、脐动脉S/D及血清孕酮(P)水平均降低,治疗组低于对照组(P<0.05)。分娩结束时,治疗组新生儿窒息发生率为3.33%(1/30),低于对照组的23.33%(7/30)(P<0.05)。随访期间,治疗组不良妊娠发生率为6.67%(2/30),低于对照组的26.67%(8/30)(P<0.05)。结论滋阴化瘀法可有效调节妊娠晚期羊水偏少患者性激素水平,改善羊水、胎盘血液灌注情况及中医证候,进而可减少新生儿窒息情况的发生,改善妊娠结局,疗效显著。

张仲景复脉法探析

复脉法出自《伤寒论》,指通过益气、养血、温阳、滋阴、通阳以平衡脉之气血阴阳,使脉象返之如常的治法。张仲景以复脉法治疗多种严重脉象失常,具体形式体现为益气复脉、养血复脉、温阳复脉、滋阴复脉、气血阴阳并补复脉以及通阳复脉。在临床中应根据患者病情选择相应的复脉法,从而实现“脉复”的治疗预期。此外,“脉复”的表现应视具体情况而论。

滋阴疏肝清瘀法联合达格列净治疗女性2型糖尿病性功能障碍的临床研究

目的:分析滋阴疏肝清瘀法联合达格列净治疗女性2型糖尿病(T2DM)性功能障碍的疗效。方法:选择2023年1~4月就诊于医院的60例女性T2DM性功能障碍患者,按随机对照原则分为对照组与研究组,各30例。对照组接受达格列净+二甲双胍治疗,研究组接受达格列净联合二甲双胍及中药滋阴疏肝清瘀法治疗,两组均治疗3个月。对比两组血糖指标、性激素水平、肝肾功能、性功能障碍情况及不良反应情况。结果:治疗3个月后研究组女性性功能指数(FSFI)评分比对照组高,糖化血红蛋白(HbA1c)、空腹血糖(FPG)水平比对照组低(P<0.05);治疗3个月后,研究组血清卵泡刺激素(FSH)、黄体生成激素(LH)、雌二醇(E2)水平与对照组相比,差异无统计学意义(P>0.05),但相比本组治疗前,血清E2水平升高,LH、FSH水平下降(P<0.05);研究组血清丙氨酸转氨酶(ALT)、血清天冬氨酸转氨酶(AST)、血肌酐(SCr)、尿素氮(BUN)水平、尿路感染发生率与对照组相比,差异无统计学意义(P<0.05)。结论:滋阴疏肝清瘀法联合达格列净治疗女性T2DM性功能障碍,能有效降低患者血糖水平,减轻性功能障碍程度,且不会影响肝肾功能及增加药物不良反应,可保证用药安全性。

益气养阴补肾活血方治疗早期糖尿病肾病临床研究

目的:观察益气养阴补肾活血方治疗早期糖尿病肾病的临床疗效。方法:将成都市双流区中医医院治疗的60例早期糖尿病肾病患者作为研究对象,按照随机数字表法分为常规组和观察组,每组30例。常规组给予西药常规疗法治疗,观察组在常规组治疗的基础上加用益气养阴补肾活血方治疗。观察两组治疗前后血糖[空腹血糖(Fasting blood glucose,FBG)、餐后2 h血糖(2 hours postprandial blood glucose,2 hPG)、糖化血红蛋白(glycosylated hemoglobin,HbA1c)]、血脂[三酰甘油(three acyl glycerin,TG)、总胆固醇(total cholesterol,TC)]、肾功能指标[24 h尿蛋白、β2-微球蛋白(β2-Microglobulin,β2-MG)、血肌酐(serum creatinine,Scr)、尿白蛋白排泄率(urinary albumin excretion rates,UAER)]和不良反应的变化情况。结果:常规组有效率为86.67%,观察组有效率为93.33%,观察组有效率高于常规组,差异有统计学意义(P<0.05)。两组治疗后FBG、2 hPG、HbA1c均低于治疗前,且观察组低于常规组,但组间比较,差异无统计学意义(P<0.05)。观察组治疗后TC、TG低于常规组,差异有统计学意义(P<0.05)。观察组治疗后24 h尿蛋白定量、β2-MG、UAER水平低于常规组,差异有统计学意义(P<0.05),观察组治疗后Scr也低于常规组,但差异无统计学意义(P>0.05)。观察组不良反应发生率为13.33%,常规组不良反应发生率为23.33%,观察组不良反应发生率低于常规组,差异有统计学意义(P<0.05)。结论:益气养阴补肾活血方治疗早期糖尿病肾病,能降低患者血糖、血脂水平,改善患者肾功能,且不良反应少。

益气固本汤联合运动干预对糖尿病模型大鼠血糖的调节

目的探究益气固本汤对糖尿病模型大鼠的血糖调节作用,并进一步研究其对血糖调节激素水平的影响。方法使用高脂饲料及链脲霉素建立糖尿病大鼠模型,实验设置运动组、益气固本汤组及益气固本汤+运动组,观察运动组、益气固本汤+运动组对糖尿病大鼠一般情况、空腹血糖(FBG)、空腹胰岛素水平、胰高血糖素水平、皮质醇及肝糖原水平的影响。结果与模型组比较,运动组、益气固本汤组及益气固本汤+运动组大鼠FBG,血清胰高血糖素、皮质醇水平降低显著,差异具有统计学意义(P<0.01,P<0.05);空腹胰岛素及肝糖原水平升高,差异具有统计学意义(P<0.01,P<0.05),益气固本汤+运动组对大鼠FBG,空腹胰岛素水平、胰高血糖素水平、皮质醇及肝糖原水平改变有协同作用(P<0.05)。结论益气固本汤联合运动干预可有效改善糖尿病大鼠其一般状态,降低糖尿病大鼠血糖并维持其血糖稳态,对糖尿病大鼠胰岛功能具有恢复作用。这可能与益气固本汤增加胰岛素分泌、降低及调节血清胰高血糖素和皮质醇分泌、增加肝糖原含量有关。

运用活血利水法治疗糖尿病气阴两虚脉络瘀阻型眼底出血的体会

糖尿病眼底出血属于糖尿病视网膜病变(DR),能迅速导致视力下降,病情较急,本着“急则治其标”的原则,此时应当以眼内出血论治为主。廖品正教授认为其证本虚而标实,应分期论治,“血不利则为水”,以活血利水为大法。

益气养阴活血法对早期糖尿病肾病患者一氧化氮的影响

目的:观察以益气养阴活血法为主治疗早期糖尿病肾病(DN)患者的疗效及对一氧化氮(NO)的影响。方法:将入选的65例患者随机分为对照组(31例)和治疗组(34例),对照组予糖尿病教育、常规降血糖及对症处理,治疗组加用以益气养阴活血为主的中药治疗。结果:早期糖尿病肾病患者NO明显升高,治疗8周后,两组均能较好地降低症状积分、空腹血糖(FBG)及24h尿微量白蛋白排泄量(UAE)。治疗组在改善患者症状、降低UAE及N0水平方面,疗效明显优于对照组(P<0.05或P<0.01),对照组对NO改善不明显。结论:提示DN早期高N0生成与肾小球高滤过有关,益气养阴活血法为主可能通过降低肾脏NO水平,改善肾小球的高滤过。

养阴活血方对鼻咽癌放疗减毒增效的临床观察

目的:观察中药养阴活血方对鼻咽癌放疗减毒增效的作用。方法:将100例初治鼻咽癌住院患者随机分为A、B两组,A组为中药养阴活血方配合常规放疗组50例,B组为单纯常规放疗组50例,观察两组的急性放射反应及放疗按时完成率、鼻咽原发灶及颈部肿大淋巴结的消退情况、放疗后1、3年生存率、复发率与转移率。结果:放疗后两组的口咽粘膜急性放射反应总的发生率基本相似,但A组的程度比B组轻,因此放疗按时完成率A组为98％,B组为84％(X2=4.40,P<O.05)。外照射剂量达50Gy时鼻咽原发灶消失率:A组为74％、B组为52％;前者高于后者(X2=4.29,P<O.05)。治疗后1、3年生存率两组比较差异无显著性。但两组3年生存者复发及转移率:A组为17.95％、B组为33.33％,组间比较差异有显著性(X2=4.92,P<0.05)。结论:中药养阴活血方配合鼻咽癌放疗可以减轻放疗反应,提高放疗按时完成率,从而减少放疗后复发及转移。

活血生津中药对头颈部肿瘤患者放疗中唾液腺的影响

目的 :探讨活血生津中药制剂对头颈部肿瘤患者放疗中唾液腺功能的保护作用。方法 :将 5 0例首程放疗的头颈部肿瘤患者随机分为观察组 (中药加放疗 ,2 4例 ) ,对照组(单纯放疗 ,2 6例 )。对放疗前及放疗不同剂量时的口干程度、唾液流速及淀粉酶分泌速度进行比较。结果 :随放疗剂量的增加 ,两组口干程度增加 ,唾液流速与淀粉酶分泌速度下降。放疗中观察组口干程度曲线较对照组明显平坦。放疗至 2 0、40、60Gy时观察组唾液流速及淀粉酶分泌速度均较对照组为高。结论 :头颈部肿瘤患者放疗过程中辅以活血生津中药制剂可改善口干症状 ,明显的保护其唾液腺的分泌功能。