Objective:To study the diagnostic value of MicroPure imaging for malignant thyroid nodule microcalcification and its correlation with the oncogene expression in nodules.Methods:Patients with thyroid nodules confirmed ...Objective:To study the diagnostic value of MicroPure imaging for malignant thyroid nodule microcalcification and its correlation with the oncogene expression in nodules.Methods:Patients with thyroid nodules confirmed by ultrasound in Dongtai People's Hospital between June 2014 and October 2016 were selected and divided into those with malignant thyroid nodules and benign thyroid nodules according to the pathological results, and MicroPure imaging technology was used to judge the microcalcification and further divide the malignant thyroid nodules into microcalcification (+) and microcalcification (-). The biopsy tissue was collected to detect the expression of cyclin, cell invasion molecules and angiogenesis molecules.Results: CyclinD1, CyclinE, MCM7, MMP2, MMP13, Vimentin, N-cadherin, Twist, HIF-1α, VEGF-C,VEGFR-2, VEGFR-3, Ang-2 and Tie-2 expression in malignant thyroid nodules of microcalcification (+) group and microcalcification (-) group were significantly higher than those of benign group while CyclinG2 and P53 expression were significantly lower than those of benign group;CyclinD1, CyclinE, MCM7, MMP2, MMP13, Vimentin, N-cadherin, Twist, HIF-1α, VEGF-C, VEGFR-2, VEGFR-3, Ang-2 and Tie-2 expression in malignant thyroid nodules of microcalcification (+) group were significantly higher than those of microcalcification (-) group while CyclinG2 and P53 expression were significantly lower than those of microcalcification (-) group.Conclusion: Malignant thyroid nodule microcalcification detected by MicroPure imaging has a good correlation with cancer cell proliferation, invasion and angiogenesis.展开更多
乳腺癌发病率的日益增长严重威胁着女性患者的身心健康。乳腺微钙化的形成与乳腺癌的发生发展关系密切。超声检查是中国女性乳腺筛查的主要模式之一。乳腺影像报告和数据系统(Breast Imaging Report And Date System,BI-RADS)的出现,进...乳腺癌发病率的日益增长严重威胁着女性患者的身心健康。乳腺微钙化的形成与乳腺癌的发生发展关系密切。超声检查是中国女性乳腺筛查的主要模式之一。乳腺影像报告和数据系统(Breast Imaging Report And Date System,BI-RADS)的出现,进一步规范化了超声对乳腺病变的描述,超声新技术如MicroPure成像技术、超声弹性成像、超声造影、三维超声等的进一步发展,显著提高了超声对乳腺病变的诊断价值。本文就超声诊断技术对伴钙化乳腺肿块结合BI-RADS分类的诊断价值进行综述。展开更多
文摘Objective:To study the diagnostic value of MicroPure imaging for malignant thyroid nodule microcalcification and its correlation with the oncogene expression in nodules.Methods:Patients with thyroid nodules confirmed by ultrasound in Dongtai People's Hospital between June 2014 and October 2016 were selected and divided into those with malignant thyroid nodules and benign thyroid nodules according to the pathological results, and MicroPure imaging technology was used to judge the microcalcification and further divide the malignant thyroid nodules into microcalcification (+) and microcalcification (-). The biopsy tissue was collected to detect the expression of cyclin, cell invasion molecules and angiogenesis molecules.Results: CyclinD1, CyclinE, MCM7, MMP2, MMP13, Vimentin, N-cadherin, Twist, HIF-1α, VEGF-C,VEGFR-2, VEGFR-3, Ang-2 and Tie-2 expression in malignant thyroid nodules of microcalcification (+) group and microcalcification (-) group were significantly higher than those of benign group while CyclinG2 and P53 expression were significantly lower than those of benign group;CyclinD1, CyclinE, MCM7, MMP2, MMP13, Vimentin, N-cadherin, Twist, HIF-1α, VEGF-C, VEGFR-2, VEGFR-3, Ang-2 and Tie-2 expression in malignant thyroid nodules of microcalcification (+) group were significantly higher than those of microcalcification (-) group while CyclinG2 and P53 expression were significantly lower than those of microcalcification (-) group.Conclusion: Malignant thyroid nodule microcalcification detected by MicroPure imaging has a good correlation with cancer cell proliferation, invasion and angiogenesis.
文摘乳腺癌发病率的日益增长严重威胁着女性患者的身心健康。乳腺微钙化的形成与乳腺癌的发生发展关系密切。超声检查是中国女性乳腺筛查的主要模式之一。乳腺影像报告和数据系统(Breast Imaging Report And Date System,BI-RADS)的出现,进一步规范化了超声对乳腺病变的描述,超声新技术如MicroPure成像技术、超声弹性成像、超声造影、三维超声等的进一步发展,显著提高了超声对乳腺病变的诊断价值。本文就超声诊断技术对伴钙化乳腺肿块结合BI-RADS分类的诊断价值进行综述。
