Intranasal administration of stem cell-derived exosomes for central nervous system diseases

Exosomes,lipid bilayer-enclosed small cellular vesicles,are actively secreted by various cells and play crucial roles in intercellular communication.These nanosized vesicles transport internalized proteins,mRNA,miRNA,and other bioactive molecules.Recent findings have provided compelling evidence that exosomes derived from stem cells hold great promise as a therapeutic modality for central nervous system disorders.These exosomes exhibit multifaceted properties including antiapoptotic,anti-inflammatory,neurogenic,and vasculogenic effects.Furthermore,exosomes offer several advantages over stem cell therapy,such as high preservation capacity,low immunogenicity,the ability to traverse the blood-brain barrier,and the potential for drug encapsulation.Consequently,researchers have turned their attention to exosomes as a novel therapeutic avenue.Nonetheless,akin to the limitations of stem cell treatment,the limited accumulation of exosomes in the injured brain poses a challenge to their clinical application.To overcome this hurdle,intranasal administration has emerged as a non-invasive and efficacious route for delivering drugs to the central nervous system.By exploiting the olfactory and trigeminal nerve axons,this approach enables the direct transport of therapeutics to the brain while bypassing the blood-brain barrier.Notably,exosomes,owing to their small size,can readily access the nerve pathways using this method.As a result,intranasal administration has gained increasing recognition as an optimal therapeutic strategy for exosomebased treatments.In this comprehensive review,we aim to provide an overview of both basic and clinical research studies investigating the intranasal administration of exosomes for the treatment of central nervous system diseases.Furthermore,we elucidate the underlying therapeutic mechanisms and offer insights into the prospect of this approach.

Impact of COVID-19 Pandemic on Mental Health of Healthcare Workers–A Perception of Indian Hospital Administrators

Since the coronavirus pandemic,many factors led to the change in the mental well-being of hospital administrators and their staff.The pandemic negatively impacted the availability and capability of health professionals to deliver essential services and meet rising demand.Therefore,this study aimed to understand the perspective of hospital administrators about issues and challenges that negatively impacted their staff’s mental health and hospital administrators’coping response to mitigate those challenges and issues.An exploratory qualitative study was conducted with 17 hospital administrators(superintendents,deputy superintendents,nursing in charge and hospital in charge)working in a government district hospital of Rajasthan state during September 2022 and October 2022.This study revealed various emerging themes on mental health-related issues,challenges and coping strategies reported by the administrators.Themes and sub-themes that emerged from this study were 1)Perceived mental health of HCWs-perceived importance of mental health,2)Impact of COVID-19 on the mental health of HCWs–common mental health issues,changes in mental health pre and post-pandemic,3)Impact of COVID-19 on health behavior of HCWs-increased self-care and awareness,4)Challenges responsible for poor mental health of HCWs-organizational,ethical and societal challenges and 5)Strategies to retain mental health of HCWs-effective coping strategies.The most common problems were increased levels of stress,feeling fatigued,tiredness,weak and anxiety among the HCWs.Keeping their staff motivated was the biggest challenge reported.Social support,counseling through professionals and demystifying myths were the most effective coping strategies adopted by the participants.In conclusion,this study reported poor mental health-related issues,challenges faced by the HCWs and effective strategies adopted by hospital administrators during tough situations.This study will assist hospital administrators in developing interventions such as regular training programs and workshops to teach effective coping skills to address poor mental health during crises.

Adjustment of Administrative Divisions and Upgrading of Industrial Structure in Hefei Metropolitan Area:Taking"Partitions of Chaohu"as a Quasi-natural Experiment

Administrative regions are an important environment for the operation of China's market economy.The relevant economic subjects cannot predict the policy of adjustment of administrative divisions and carry out conscious migration behavior,adjustment of administrative divisions can be regarded as a quasi-natural experiment.The three cities of Hefei,Wuhu,and Ma'anshan,which are directly related to the adjustment of the administrative division of Chaohu,are taken as the treatment group,and the seven adjacent cities of Lu'an,Huainan,Chuzhou,Bengbu,Anqing,Chizhou,and Tongling are taken as the control group.Differences-in-Differences method and relevant control variables affecting the upgrading of industrial structure are used to test.The test results show that"Partitions of Chaohu"has a significant industrial structure upgrading effect by promoting the optimization of spatial layout,the cross-regional flow of production factors and the effective management of Chaohu Lake Basin.At the same time,the increase of total retail sales of consumer goods,urban fixed assets investment,public utility expenses in science,education,culture and health,and population plays a significant positive role in promoting the upgrading of industrial structure,while foreign direct investment plays a certain inhibition role in the upgrading of industrial structure.In order to meet the ever-developing space demands and enhance the impact on surrounding areas,the Hefei metropolitan area should be driven by technological innovation,strengthen the integration of industrial chains,improve the business environment and transportation network,and continuously promote the upgrading of industrial structure and the formation and development of new productive forces.

The Development Trend of Enterprise Business Administration and the Innovation of Management Mode

In the context of the new period,the continuous growth of social and economic levels and the rapid update of information technology have significantly impacted the business management of Chinese enterprises,presenting substantial challenges.The intensification of market competition exerts development pressure on many enterprises,and coupled with the unstable strength of some businesses,numerous problems in business management arise.These issues hinder the smooth execution of various business activities.Therefore,it is crucial to ensure effective business administration to conduct different business activities in an orderly manner,promptly avoid adverse risks,and strengthen control over multiple factors.The innovation and improvement of business administration are of great significance for enhancing the management level and market competitiveness of modern enterprises,accelerating their healthy development,and creating numerous opportunities.Consequently,this paper analyzes and explores the development trends of enterprise business administration and the innovation of management models for reference.

Exploring Corporate Tax Compliance in the Era of Digital Tax Collection and Administration:Insights from the“Golden Tax Phase Four”Project

This article primarily examines the current state of tax collection and management,alongside other associated issues.It integrates insights from China’s“14th Five-Year Plan”and anticipates the imminent implementation of the“Golden Tax Phase Four.”With this backdrop,the article offers recommendations for advancing the reform of the tax collection and management system,fostering the development of intelligent taxation,and accelerating the modernization of tax collection and management in China.

Research on Monitoring and Early-warning Standards of Ancient and Famous Trees Protection in the Humble Administrator's Garden

Based on the current situation and symptoms of the trees' growth in the Humble Administrator's Garden,this paper put forward corresponding monitoring and early-warning standards and technical measures of the ancient and famous trees protection in the Humble Administrator's Garden specifically.The aim of doing this is to establish a scientific basis for the protection of the ancient and famous trees in the Humble Administrator's Garden by setting up systematic fundamental data,dynamic protection standard grades and technique measures of protecting the trees.The main symptom of trees in the Humble Administrator's Garden is the erosion and decay of the tree trunks.Fifteen tree trunks need technical protection,which holds 65.22% of the total sum of trees in the Humble Administrator's Garden.Therefore,much more emphasis should be paid in strengthening technical protection procedures of monitoring and early warning of the tree trunks in the future protection of the ancient and famous trees in the garden.Besides,the rejuvenation technique of rooting zone and rooting system,tree pruning technique as well as tree supporting measures according to the specific condition and symptom of the trees should be concerned with in order to protect the ancient and famous trees in the Humble Administrator's Garden in a more scientific and effective way.

Improved Smartphone Application for Remote Access by Network Administrators

This research attempts the implementation of an improved smartphone application for remote system administration. The work was motivated by the inability of network administrators to access their virtual servers from a remote location without worrying about the security implications, inaccurate and unreliable reports from a third party whenever he is out of town. The cloud server can be monitored and administered because various task such as creating users, manage users (grant access, block or delete users), restart server and shutdown server can be handled by the remote system administrator. This will involve of securing the system with a one-way hashing of encrypted password and a device ID for only whitelisted devices to be granted access. It will be observed that remote access for system administration can be implemented using a smartphone app based on a Point-to-Point Protocol and also reveal the advantages of PPP protocol, therefore making the enormous responsibilities of a remote system administrator much easier to accomplish.

介绍一个相当好的远程控制软件——Remote Administrator

以前一直是用Pcanywhere,没有比较也就不知道差异,也没有觉得Pcanywhere有什么不好,近日听别人说起另一个远程控制软件,Remote administrator(RADMIN),用了一下,竟然爱不释手,于是就把我的使用心得告诉大家。

Ji Zhengkun,Administrator of Standardization Administration of the People's Republic of China(SAC)

Mr, Ji Zhengkun is the Administrator of the SAC, serves as a member of the Party Leadership Group of the General Administration of Quality Supervision,Inspection and Quarantine （AQSIQ）, he has appointed to this position since 2008. Mr. Ji is a senior engineer, graduated from Tianjin Universit34, majoring in precision instrument. He ever took the positions of the deputy director in the department of policies and regulations and the department of quality in the State Bureau of Quality and Technical Supervision respectively. Then he took on the secretary-general for the CPC Committee of China Jiliang University After that, he acted as the director of the department of supervision,

如何在用户选项中恢复Administrator？

我使用电脑的时候注销了Administrator账户后，在用户选项里再也找不到Administrator了。而以前在注销Administrator后，能够重新以Administrator账户登录，很方便。请问，应该怎么恢复呢？

深挖潜力,打造更强Administrator账户

提起Administrator账户，可谓是大名鼎鼎。只要安装完Windows，Administmtor贝长户就拥有与生俱来的系统管理大权。虽然Administrator地位特殊，不过大家一般只是简单的使用该账户登录系统，执行各种普通的操作，

Administrator账户加密码后登录慢

我给WindowsXP的Administrator账户添加密码后自动登录，发现用该账户启动到桌面时非常慢，请问这是怎么回事呢？

《卡巴斯基》与Remote Administrator共存

我的系统是Windows Server 2003企业版，在安装了Remote Administrator 2．1后，只要《卡巴斯基》一启动，就会把Remote Administrator 2．1删除。请问如何设置，才能让它们共存？

用Access Administrator Pro守住隐私

不少朋友都有过和别人共用一台计算机的经历，这样自己安装的各种程序、保存在硬盘中的文件都有可能被别人使用，安全性自然大打折扣。那么怎样才能有针对性地防止别人随意使用这些文件程序呢？只要有了Access Administrator Pro的帮助，这一切都不是难题了。

我正在使用Data Protection Manager（DPM）2010，但我查看恢复点时一个都没有显示，即使DPM Administrator控制台显示了机器上受保护的内容。哪里出问题了？

您必须是DPM客户端机器的本地管理员才能使用DPM客户端applet访问恢复点。此外，本地管理员权限必须是显式的——您的账户必须明确成为客户端本地Administrators组的成员。只成为本地Administrators组的分组（如Domain Admins）的成员是不够的，

Exploring Paths for Substantive Settlement of Administrative Disputes:An Empirical Analysis Based on Practice in Weiyuan County,Sichuan Province

As an effective means of addressing social contradictions,the substantive settlement of administrative disputes refers to the timely,impartial,and effective handling of such disputes.It embodies the essence of the modern governance system enabled by the principles and methodologies of the rule of law.Administrative reconsideration,the main channel for settling administrative disputes,is an inevitable consequence of its effective role in settling such disputes.The efficient adjudication of administrative litigation is an indispensable prerequisite for achieving the substantive settlement of administrative disputes,while the diverse approaches employed in settling these disputes contribute to achieving source governance of such disputes.Along with the efficient adjudication of administrative litigation and the multiple approaches to settling administrative disputes,the effectiveness of administrative reconsideration decisions constitutes a comprehensive system that ensures the substantive settlement of administrative disputes.