This study sought to investigate late-onset hypogonadism （LOH） in old and middle-aged males in Shanghai communities, using symptom score evaluation systems and measurements of sex hormone levels. One thousand cases ...This study sought to investigate late-onset hypogonadism （LOH） in old and middle-aged males in Shanghai communities, using symptom score evaluation systems and measurements of sex hormone levels. One thousand cases of males aged 40-70 years were investigated. The aging male symptoms （AMS） scale and androgen deficiency in aging males （ADAM） questionnaire were used at the beginning of the investigation, followed by measurement of the sex hormone-related factors （total testosterone （TT）, free testosterone （fT）, sex hormone-binding globulin （SHBG） and bioavailability of testosterone （Bio-T））. There were 977 valid questionnaires. The LOH-positive rates shown by AMS and ADAM were 59.88% and 84.65%, respectively; values increased with the age of the patients. There were 946 results related to sex hormone measurements, which showed the following results： TT was not related to aging （P〉O.05）; levels of SHBG increased with age; and fT and Bio-T decreased with age. There was a significant difference in fT between LOH-positive and LOH-negative patients, as shown by the ADAM. In summary, TT levels were not related to aging, even though SHBG did increase while fT and Bio-T decreased with aging. Clinically, the diagnosis of LOH cannot be based on serum TT level.展开更多
Objective: To understand the correlation between different degrees of obesity and bone mineral density (BMD). Methods: 772 cases (300 men and 472 females) of Zhuang over 40 years old were randomly selected. The BMD an...Objective: To understand the correlation between different degrees of obesity and bone mineral density (BMD). Methods: 772 cases (300 men and 472 females) of Zhuang over 40 years old were randomly selected. The BMD and T score were calculated by measuring the right heel bone using a quantitative-ultrasound densitometer. Body composition index of body weight, waist circumference (WC), waist height ratio (WtHR), body fat percentage (BFP) and visceral fat (VF) were measured using a bioelectrical impedance method. Results: The BMI, WC, and WtHR of the male osteoporosis group were lower than those of the normal bone mass (NBM) group (P Conclusion: BMI is positively correlated with BMD in Zhuang. BFP has a greater correlation with female BMD, and a small reduction in BFP can result in a significant decrease in BMD. BMD of male was positively correlated with abdominal obesity indicators (WC, WtHR, VF). However, abdominal obesity has no obvious effect on the promotion of BMD in women, and increased WtHR can lead to a decrease in BMD. Zhuang can appropriately increase the amount of fat within the normal weight range. At the same time, reasonable exercise and balanced nutrition to avoid excessive obesity or low body weight can reduce the incidence of osteoporosis and osteoporosis fractures.展开更多
On aging, spatial memory declines to some degree in both, rodents and humans. It is unknown, however, whether aging brings about a decline of encoding and retrieval of spatial information in parallel. The present stud...On aging, spatial memory declines to some degree in both, rodents and humans. It is unknown, however, whether aging brings about a decline of encoding and retrieval of spatial information in parallel. The present study examined spatial encoding and retrieval in male CD-1 mice at 4, 9, and 12 months of age in a complex dry-land maze. The total time to reach the goal zone was age-dependent favoring mice at 4 months of age. We showed previously that moving time represents encoding of spatial information and resting time represents recall of previously learned spatial information. The average moving time decreased from 69.8 ± 5.3 s (mean ± SEM), 69.7 ± 8.0 s, and 78.9 ± 4.9 s to 17.0 ± 2.3 s (p < 0.001 ), 24.7 ± 2.7 s (p < 0.001), and 31.0 ± 3.5 s (p < 0.001) at 4, 9, and 12 months of age, respectively. The average resting time decreased from 34.9 ± 5.6 s, 22.2 ± 4.2 s, and 41.7 ± 5.3 s to 3.6 ± 1.2 s (p < 0.001), 5.3 ± 1.8 s (p = 0.009), and 22.7 ± 4.9 s (p = 0.007) at 4, 9, and 12 months of age, respectively. We conclude that age-related deficits of spatial memory in mice manifest with an encoding deficit prior to a retrieval deficit.展开更多
文摘This study sought to investigate late-onset hypogonadism （LOH） in old and middle-aged males in Shanghai communities, using symptom score evaluation systems and measurements of sex hormone levels. One thousand cases of males aged 40-70 years were investigated. The aging male symptoms （AMS） scale and androgen deficiency in aging males （ADAM） questionnaire were used at the beginning of the investigation, followed by measurement of the sex hormone-related factors （total testosterone （TT）, free testosterone （fT）, sex hormone-binding globulin （SHBG） and bioavailability of testosterone （Bio-T））. There were 977 valid questionnaires. The LOH-positive rates shown by AMS and ADAM were 59.88% and 84.65%, respectively; values increased with the age of the patients. There were 946 results related to sex hormone measurements, which showed the following results： TT was not related to aging （P〉O.05）; levels of SHBG increased with age; and fT and Bio-T decreased with age. There was a significant difference in fT between LOH-positive and LOH-negative patients, as shown by the ADAM. In summary, TT levels were not related to aging, even though SHBG did increase while fT and Bio-T decreased with aging. Clinically, the diagnosis of LOH cannot be based on serum TT level.
文摘Objective: To understand the correlation between different degrees of obesity and bone mineral density (BMD). Methods: 772 cases (300 men and 472 females) of Zhuang over 40 years old were randomly selected. The BMD and T score were calculated by measuring the right heel bone using a quantitative-ultrasound densitometer. Body composition index of body weight, waist circumference (WC), waist height ratio (WtHR), body fat percentage (BFP) and visceral fat (VF) were measured using a bioelectrical impedance method. Results: The BMI, WC, and WtHR of the male osteoporosis group were lower than those of the normal bone mass (NBM) group (P Conclusion: BMI is positively correlated with BMD in Zhuang. BFP has a greater correlation with female BMD, and a small reduction in BFP can result in a significant decrease in BMD. BMD of male was positively correlated with abdominal obesity indicators (WC, WtHR, VF). However, abdominal obesity has no obvious effect on the promotion of BMD in women, and increased WtHR can lead to a decrease in BMD. Zhuang can appropriately increase the amount of fat within the normal weight range. At the same time, reasonable exercise and balanced nutrition to avoid excessive obesity or low body weight can reduce the incidence of osteoporosis and osteoporosis fractures.
文摘On aging, spatial memory declines to some degree in both, rodents and humans. It is unknown, however, whether aging brings about a decline of encoding and retrieval of spatial information in parallel. The present study examined spatial encoding and retrieval in male CD-1 mice at 4, 9, and 12 months of age in a complex dry-land maze. The total time to reach the goal zone was age-dependent favoring mice at 4 months of age. We showed previously that moving time represents encoding of spatial information and resting time represents recall of previously learned spatial information. The average moving time decreased from 69.8 ± 5.3 s (mean ± SEM), 69.7 ± 8.0 s, and 78.9 ± 4.9 s to 17.0 ± 2.3 s (p < 0.001 ), 24.7 ± 2.7 s (p < 0.001), and 31.0 ± 3.5 s (p < 0.001) at 4, 9, and 12 months of age, respectively. The average resting time decreased from 34.9 ± 5.6 s, 22.2 ± 4.2 s, and 41.7 ± 5.3 s to 3.6 ± 1.2 s (p < 0.001), 5.3 ± 1.8 s (p = 0.009), and 22.7 ± 4.9 s (p = 0.007) at 4, 9, and 12 months of age, respectively. We conclude that age-related deficits of spatial memory in mice manifest with an encoding deficit prior to a retrieval deficit.
