Percutaneous microwave ablation and transcatheter arterial chemoembolization for serum tumor markers and prognostics of middle-late primary hepatic carcinoma

BACKGROUND Primary hepatic carcinoma(PHC)has an insidious onset and is usually diagnosed in the middle and late stages.Although transcatheter arterial chemoembolization(TACE)is the preferred option for treating middle-and advanced-stage PHC,it has limited efficacy in killing tumor cells and poor long-term efficacy.TACE plus percutaneous microwave coagulation therapy(PMCT)is more effective than interventional therapy alone and can improve survival time.However,there are few reports on the effects of TACE and PMCT on serum marker levels and the prognosis of patients with advanced PHC.AIM To investigate the effect of PMCT+TACE on serum tumor markers and the prognosis of middle-late PHC.METHODS This retrospective study included 150 patients with middle-late PHC admitted to Zhongshan People’s Hospital between March 2018 and February 2021.Patients were divided into a single group(treated with TACE,n=75)and a combined group(treated with TACE+PMCT,n=75).Before and after treatment,the clinical efficacy and serum tumor marker levels[carbohydrate antigen 19-9(CA19-9),alpha-fetoprotein(AFP),and carcinoembryonic antigen(CEA)]of both groups were observed.The 1-year survival rates and prognostic factors of the two groups were analyzed.RESULTS The combined group had 21 and 35 cases of complete remission(CR)and partial remission(PR),respectively.The single group had 13 and 25 cases of CR and PR,decreased,with the decrease in the combined group being more significant(P<0.05).The 1-year survival rate of the combined group(80.00%)was higher than that of the single group(60.00%)(P<0.05).The average survival time within 1 year in the combined group was 299.38±61.13 d,longer than that in the single group(214.41±72.97 d,P<0.05).COX analysis revealed that tumor diameter,tumor number,and the treatment method were prognostic factors for patients with middle-late PHC(P<0.05).CONCLUSION TACE+PMCT is effective in treating patients with mid-late PHC.It reduces the levels of tumor markers,prolongs survival,and improves prognosis.

An Updated Review of the Middle-Late Jurassic Yanliao Biota: Chronology,Taphonomy,Paleontology and Paleoecology

The northeastern Chinese Yanliao Biota （sometimes called the Daohugou Biota） comprises numerous, frequently spectacular fossils of non-marine organisms, occurring in Middle-Upper Jurassic strata in western Liaoning, northern Hebei, and southeastern Inner Mongolia. The biota lasted for about 10 million years, divided into two phases： the Bathonian-Callovian Daohugou phase （about 168-164 million years ago） and the Oxfordian Linglongta phase （164-159 million years ago）. The Yanliao fossils are often taphonomically exceptional （many vertebrate skeletons, for example, are complete and accompanied by preserved integumentary features）, and not only are taxonomically diverse but also include the oldest known representatives of many groups of plants, invertebrates, and vertebrates. These fossils have provided significant new information regarding the origins and early evolution of such clades as fleas, birds, and mammals, in addition to the evolution of some major biological structures such as feathers, and have demonstrated the existence of a complex terrestrial ecosystem in northeast China around the time of the Middle-Late Jurassic boundary.

Field Efficacy Trial and Optimum Control Period of Rice False Smut(Ustilaginoidea virens) in Single Cropping Middle-late Rice

[Objective]The paper was to study optimum chemical agents and control periods against rice false smut( Ustilaginoidea virens) in single cropping middle-late rice. [Method]Taking chemical agents( triadimefon,armure,Jinggangmycin) as main treatments and spraying periods( within 7 d before initial heading stage,within 7 d before initial heading stage + initial heading stage,initial heading stage) as assisted treatments,the field efficacy trial and optimum control period of U. virens in single cropping middle-late rice were studied using Huanghuazhan and Jinnongsimiao as experimental materials in 2013. [Result] Three chemical agents,triadimefon,armure,Jinggangmycin,extremely reduced diseased panicle rate and disease index of U. virens,but there was no significant difference among three chemical agents. Spraying period did not have significant impact on diseased panicle rate and disease index of U. virens,whereas spraying within7 d before initial heading stage and during initial heading stage had relatively good control effect. Yield increased significantly after application of three chemical agents,and armure led to greater increase. The reason for yield increase was that seed setting rate was significantly increased,and the number of filled grains per panicle was significantly increased. Although spraying period influenced yield,the difference was not significant. [Conclusion] Triadimefon,armure and Jinggangmycin had good control effects against U. virens in single cropping middle-late rice,of which armure had better control effects. Spraying chemical agents increased seed setting rate,and further increased the number of filled grains per panicle and yield. Spraying within 7 d before initial heading stage and during initial heading stage had relatively better control effect against U. virens.

The Shishugou Fauna of the Middle-Late Jurassic Transition Period in the Junggar Basin of Western China

The Middle-Late Jurassic transition period is a critical period for the evolution of terrestrial vertebrates,but the global fossil record from this time is relatively poor.The Shishugou Fauna of this period has recently produced significant fossil remains of dinosaurs and other vertebrate groups,some representing the earliest known members of several dinosaurian groups and other vertebrate groups and some representing the best-known specimens of their group.These discoveries are significant for our understanding of the origin and evolution of several vertebrate lineages.Radiometric dating indicates that the fauna is aged approximately 159-164 Ma.Comparisons with other similarly-aged terrestrial faunas such as Shaximiao and Yanliao show both taxonomic similarities and differences between these faunas and indicate that the Junggar deposits might have preserved the most complete vertebrate fossil record for a Middle-Late Jurassic Laurasian terrestrial fauna.

Analysis of Sedimentary Environment and Sequence Stratigraphy of Middle-Late Permian Sediments in Coastal Fars, Iran (Zireh Gas Field, Well ZH-A)

The current paper is focused on the facies, sedimentary environment and depositional cycles study of the Middle-Late Permian sediments in the South Fars Zireh Gas Field, the subsurface section of well ZH-A. Four hundred thin-sections obtained from cores and cuttings were examined under standard petrographic microscope. For this study research, Corel Draw X6, Corel Photo-Paint, DN2 Microscopy Image Processing System, Scope Photo, Autodesk Map, Geocalc and Auto Cad 2014 were utilized. Based on microfacies analysis and significant founa and flora, fourteen major facies in four facies associations comprising tidal flat (A), lagoon (B), shoal (C) and open marine (D) identified in the well ZH-A. This formation was deposited in inner part of a homoclinal ramp. Based on depositional cycles, seven main 3rd order sequences were revealed in the Well ZH-A. The ooid grainstone facies with interparticle and oomoldic porosity has high reservoir potential. The diagenetic processes like dolomitization and dissolution have significant effect in the reservoir quality. Based on research results, a major framework can be weaved and used to correlate reservoir layering.

Middle-late Holocene environment change induced by climate and human based on multi-proxy records from the middle and lower reaches of Yangtze River,eastern China

Our knowledge about the interaction between human activities and the environment in the middle-late Holocene remains incomplete.Core C1 in Lake Chaohu from the middle and lower reaches of Yangtze River (MLYR),eastern China,provides an opportunity to investigate vegetation and climate changes,human activities,and East Asian summer monsoon(EASM) evolution since 5100 cal.yr BP.These variables are assessed based on radiocarbon dating,pollen and charcoal records,and magnetic susceptibility (χ_(lf)),median grain size and TP.Results reveal a hiatus in sedimentation between 2080 and 730 cal.yr BP in the western part of Lake Chaohu,which is common in most lakes in the MLYR.Evergreen and deciduous broadleaved mixed forest retreated gradually after 3650 cal.yr BP,and was replaced by secondary Pinus forest after at least 730 cal.yr BP.Intense agricultural activities and vegetation clearance are first detected at 2520 cal.yr BP.Human settlements expanded from the lake front wetlands (during the period 2520–2080 cal.yr BP) to remote high-altitude areas(2080–400 cal.yr BP),and then returned to the lake front to reclaim the wetlands and lake (after 400 cal.yr BP).A gradual trend of recessional EASM strength from 4300 cal.yr BP and centennial-scale variations of EASM during the period5100–3650 cal.yr BP are revealed.The reduction of summer insolation,southward shift of the ITCZ,and El Ni?o Southern Oscillation may control the intensity of EASM and climate on a large regional scale.

Properties of middle-late Proterozoic volcanic rocks in South Qinling and the Precambrian continental break-up

In South Qinling, the volcanic series of the middle-late Proterozoic Yunxi Group, Yaolinghe Group, Xi.xiang Group and Bikou Group have characteristics of the continental rift volcanic rocks or continental flood basalts and are formed in continental intraplate tensional setting. The enrichment of incompatible elements, high εNd values and low-medium 87Sr/86Sr initial ratios of these volcanic rocks indicate that they were derived from asthenospheric plume. Under the action of the intense pull-apart in lithosphere, the mantle plume upwelled, quickly decompressed and melted, and finally produced magma. This tensional process made the continental crust break and eventually led to an oceanic basin in late Proterozoic. The middle-late Proterozoic volcanism is a precursor of Precarabrian continental break-up in the South Qinling.

Sequence framework of two different kinds of margins and their response to tectonic activity during the Middle-Late Triassic, Ordos Basin

Two kinds of margin respectively occur in the Ordos Basin during the Middle-Late Triassic (Yanchang Age), one is foreland margin developed under the background of flexural subsidence by thrusting intensively in the southwest margin, and the other is intracratonic basin margin by stable subsidence in northern and central parts of the basin. The Middle-Late Triassic Yanchang Formation can be divided into four regional third-order sequences, which are separated by gentle angular unconformity or regional erosion surface, made up of lowstand system tract (LST), expanding system tract (EST) and highstand system tract (HST) from lower to upper within a sequence. But there are distinct differences of the sequence framework between the southwest margin and northern and central parts of the basin. The southwest margin develops heavy conglomerate layer and unconformity as a result of orogeny by thrusting, and the intracratonic basin margin by stable subsidence in the northern and central parts grows aggradational sandstone, conglomerate in fluvio-delta system and parallel unconformity. The depositional framework of southwest margin reflects the tectonic evolution from flexural subsidence by thrusting to rebounded uplift. The formation of sequence boundary is related to the resilient uplift and erosion. The sequence stratigraphic framework and depositional system tract configuration in the foreland basin are controlled by structural activity of the fold and thrust belt, and the sequence succession reflects episodic thrusting of the Middle-Late Triassic toward the foreland basin. The sequence evolution in northern and central parts reflects the depositional succession of fluvio-delta system under intracratonic background, composed of coarse-grained sediment in braided channel deposit at the lower, meandering channel deposit in the middle and fine-grained sediment in the flood plain at the upper, dominated by lake level fluctuation. During the deposit of the LST in the intracraton basin, accommodation space is limited, and results in abundant fluvial sediment migration laterally, erosion and transport, forming laterally sandstone composite and aggradational deposit on the alluvial plain, which constitutes specific erosion unconformity boundary.

Comparison of Middle-Late Holocene environment between the coastal areas of South China and California

1 Geographical setting The coast of South China, on the west Pacific front in low latitudes, is a coast of marginal sea on continental plate with a wide shelf and under tropical and south-subtropical climates: with great rainfall and many rivers running into sea. The river activities play an important role in coastal development.

Geochronology,Eruption Sequence and Geochemistry of Mid-Late Jurassic Volcanics South of Manzhouli:Petrogenesis and Implications for Mesozoic Tectonic Regime Transformation

To the south of Manzhouli,Hulunbuir,Inner Mongolia,experienced a tectonic regime transformation from compression to extension in the mid-Mesozoic.Based on systematic research of the volcanics,petrology,volcanic facies,chronology and geochemistry of rocks in the Buridun area,two stages of volcanics are identified.The first stage named the trachyte series was formed in the late Middle Jurassic(167-163 Ma),its eruption rhythm is pyroxene trachyandesite-trachyandesite-trachyte,and its origin rock is basic volcanics from thickened lower crust,with a tectonic setting in the collision orogeny after the closure of the Mongolia Okhotsk Ocean(MOO).The second stage is a bimodal volcanic rock,formed in the early Late Jurassic(163-160 Ma).The eruption rhythm of basic volcanics in this stage is basaltic andesite-basalt-olivine basalt,which comes from the metasomatized lithospheric mantle,the acidic volcanics of which being characterized by the eruption rhythm of sedimentary-explosive-overflow facies,which came from the partial melting of newly formed lower crust,and this shows the characteristics of A-type granite;the tectonic setting is extension of the lithosphere after collision and closure of the MOO.The changes in the formation age and tectonic setting of the two stages of volcanics demonstrate that the transition time from the compressive system to the extensional system south of Manzhouli is about 163 Ma.

The Late Mesozoic Orogenic Processes of Mongolia-Okhotsk Orogen: Evidence from Field Investigations into Deformation of the Mohe Area, NE China

Based on field investigation in 1999, two deformational domains with d ifferent dynamics have been distinguished from the Jurassic geological outcrops in the Mohe area of NE China, i.e. northern ductile and southern plastic-brittl e ones. Their deformational features are stated in this paper. And then, three st ages of structural deformation of the area relative to the late Mesozoic orogeni c processes of Mongolian-Okhotsk orogen are reconstructed as follows, (1) south w ards thrusting in the middle-late Jurassic, (2) eastwards thrusting and strike -s lipping parallel to the orogen in the late Jurassic, and (3) southeastwards thru sting in the early Cretaceous.

Morphological and Phylogenetic Study Based on New Materials ofAnchiornis huxleyi (Dinosauria, Theropoda) from Jianchang, Western Liaoning, China

Anchiornis huxleyi, which is a member of the Middle-Late Jurassic Yanliao Biota, is the smallest feathered dinosaur ever known. It has been described as a critical link between feathered dinosaurs and birds. Recent studies, including those of Anchiornis, Xiaotingia, Eosinopteryx and Aurornis, challenged Archaeopteryx as the most basal bird. The new Anchiornis huxleyi specimens that are described in this paper show some minor different characters compared to previously reported Anchiornis specimens, which has revised the character list of Anchiornis and indicates a different phylogenetic point from former opinions.

Chemical Weeding in Dry Direct Seeding Fields of Single Cropping Middlelate Rice

Chemical weeding in dry direct seeding fields of single cropping middle-late rice was studied in Huida vegetable farm of Huizhou City in 2012. The main treatment was herbicide（ pretilachlor ＋ bensulfuron-methyl,Yangguo and butachlor）,and the sub-treatment was application method（ soil treatments,seedling treatment and integrated treatment）. The results showed that 80 g pretilachlor ＋ bensulfuron-methyl（ 36% pretilachlor ＋ 4% bensulfuron-methyl） diluted with 50 kg water could be sprayed or 200 g Yangguo（ 23. 9% butachlor ＋ 1. 1% bensulfuron-methyl） mixed with 15 kg sandy soil could be broadcasted per 667 m2 on the sowing day or the second day under moist condition of soil,which could effectively control weeds in dry direct seeding fields of single cropping middle-late rice.

Geological age of Chouniukou Formation

Studies demonstrate that the Chouniukou Formation of the Qilian Mountains represents a lithostratigraphical unit across series, with its lower part belonging to the Middle-Late Visean, middle part to E-zone of the Early Namunan, and upper part to the Middle-Late Namurian. The Mid-Carboniferous boundary passes through the bedding plane between the middle and upper parts of this formation.