Developing the high biosafety,effective and wearable devices for fast wound healing is highly desired but remains a challenge.Here,we propose a“win–win co-operation”strategy to potentiate effective skin wound heali...Developing the high biosafety,effective and wearable devices for fast wound healing is highly desired but remains a challenge.Here,we propose a“win–win co-operation”strategy to potentiate effective skin wound healing at the wound site by constructing robust and ecofriendly composite patch under opto-electric stimulation.The wearable patch is composed of ionic gel doped with Ti3C2Tx(MXene),which possesses good photothermal response to kill the bacteria via effective inhibition of the expression of inflammatory factors,preventing wound infection.Importantly,the composite ionogel patch is capable of providing green and on-demand electrical stimulation for wound site,guiding cell migration and proliferation by improved bioenergy and expression up-regulation of growth factor.In mice wound models,the treatment group healed~31%more rapidly.Mechanistically,the wearable devices could enable visual and real-time supervising treatment effect due to their good transmittance.The proposed strategy would be promising for future clinical treatment of wound healing.展开更多
基金supported by the National Natural Science Foundation of China(grant No.22004117 and 21675146)Chinese Academy of Sciences for Special Research Assistant Grant.
文摘Developing the high biosafety,effective and wearable devices for fast wound healing is highly desired but remains a challenge.Here,we propose a“win–win co-operation”strategy to potentiate effective skin wound healing at the wound site by constructing robust and ecofriendly composite patch under opto-electric stimulation.The wearable patch is composed of ionic gel doped with Ti3C2Tx(MXene),which possesses good photothermal response to kill the bacteria via effective inhibition of the expression of inflammatory factors,preventing wound infection.Importantly,the composite ionogel patch is capable of providing green and on-demand electrical stimulation for wound site,guiding cell migration and proliferation by improved bioenergy and expression up-regulation of growth factor.In mice wound models,the treatment group healed~31%more rapidly.Mechanistically,the wearable devices could enable visual and real-time supervising treatment effect due to their good transmittance.The proposed strategy would be promising for future clinical treatment of wound healing.
