Identical-by-descent(IBD)is a fundamental genomic characteristic in population genetics and has been widely used for population history reconstruction.However,limited by the nature of IBD,which could only capture the ...Identical-by-descent(IBD)is a fundamental genomic characteristic in population genetics and has been widely used for population history reconstruction.However,limited by the nature of IBD,which could only capture the relationship between two individuals/haplotypes,existing IBD-based history inference is constrained to two populations.In this study,we propose a framework by leveraging IBD sharing in multipopulation and develop a method,MatrixiBD,to reconstruct recent multi-population migration history.Specifically,we employ the structured coalescent theory to precisely model the genealogical process and then estimate the IBD sharing across multiple populations.Within our model,we establish a theoretical connection between migration history and IBD sharing.Our method is rigorously evaluated through simulations,revealing its remarkable accuracy and robustness.Furthermore,we apply MatrixiBD to Central and South Asia in the Human Genome Diversity Project and successfully reconstruct the recent migration history of three closely related populations in South Asia.By taking into account the IBD sharing across multiple populations simultaneously,MatrixlBD enables us to attain clearer and more comprehensive insights into the history of regions characterized by complex migration dynamics,providing a holistic perspective on intricate patterns embedded within the recent population migration history.展开更多
The geographical information reflected in a traditional genealogy mainly has two aspects.On the one hand,it is the administrative division,human geography,and other general environmental conditions of the ethnic group...The geographical information reflected in a traditional genealogy mainly has two aspects.On the one hand,it is the administrative division,human geography,and other general environmental conditions of the ethnic group.On the other hand,it points to the specific origin and migration of family members in the family tree.In addition to affecting the formation and evolution of language,these factors will also affect the development trend of language behavior by promoting the psychology of people’s geographic identity.From these data,we find that geographic factors in the genealogy have a non-negligible relationship with the geographical spread of the language of the genealogy.展开更多
基金supported by the Fundamental Research Funds for the Central Universities(2023JBMC011)the National Natural Science Foundation of China(NSFC)Grant(12271026)the Beijing Natural Science Foundation Grant(L222051).
文摘Identical-by-descent(IBD)is a fundamental genomic characteristic in population genetics and has been widely used for population history reconstruction.However,limited by the nature of IBD,which could only capture the relationship between two individuals/haplotypes,existing IBD-based history inference is constrained to two populations.In this study,we propose a framework by leveraging IBD sharing in multipopulation and develop a method,MatrixiBD,to reconstruct recent multi-population migration history.Specifically,we employ the structured coalescent theory to precisely model the genealogical process and then estimate the IBD sharing across multiple populations.Within our model,we establish a theoretical connection between migration history and IBD sharing.Our method is rigorously evaluated through simulations,revealing its remarkable accuracy and robustness.Furthermore,we apply MatrixiBD to Central and South Asia in the Human Genome Diversity Project and successfully reconstruct the recent migration history of three closely related populations in South Asia.By taking into account the IBD sharing across multiple populations simultaneously,MatrixlBD enables us to attain clearer and more comprehensive insights into the history of regions characterized by complex migration dynamics,providing a holistic perspective on intricate patterns embedded within the recent population migration history.
文摘The geographical information reflected in a traditional genealogy mainly has two aspects.On the one hand,it is the administrative division,human geography,and other general environmental conditions of the ethnic group.On the other hand,it points to the specific origin and migration of family members in the family tree.In addition to affecting the formation and evolution of language,these factors will also affect the development trend of language behavior by promoting the psychology of people’s geographic identity.From these data,we find that geographic factors in the genealogy have a non-negligible relationship with the geographical spread of the language of the genealogy.
