Facial bone, as the frame to support maxillofacial region and with several sinuses and cavities, is structurally complicated and the maxillofacial tumors,benign or malignant, in this region usually grows into the deep...Facial bone, as the frame to support maxillofacial region and with several sinuses and cavities, is structurally complicated and the maxillofacial tumors,benign or malignant, in this region usually grows into the deep tissues, sinus-cav-ities and orbit and destroys the bone. In this study, the maxillofacial tumors were subjected to a mimic operation on a computer following CT scanning and 3-dimen-sional reconstruction. The data similar to those of real operation were obtained,which could be used for developing operative plans. As compared with data on the basis of conditions in the real operation, computerized mimic operation reflected the real conditions during operation. Computerized mimic operation is valuable for the preoperative planning and the prediction of probable intraoperative events.展开更多
In recent years,network attacks have been characterized by diversification and scale,which indicates a requirement for defense strategies to sacrifice generalizability for higher security.As the latest theoretical ach...In recent years,network attacks have been characterized by diversification and scale,which indicates a requirement for defense strategies to sacrifice generalizability for higher security.As the latest theoretical achievement in active defense,mimic defense demonstrates high robustness against complex attacks.This study proposes a Function-aware,Bayesian adjudication,and Adaptive updating Mimic Defense(FBAMD)theory for addressing the current problems of existing work including limited ability to resist unknown threats,imprecise heterogeneous metrics,and over-reliance on relatively-correct axiom.FBAMD incorporates three critical steps.Firstly,the common features of executors’vulnerabilities are obtained from the perspective of the functional implementation(i.e,input-output relationships extraction).Secondly,a new adjudication mechanism considering Bayes’theory is proposed by leveraging the advantages of both current results and historical confidence.Furthermore,posterior confidence can be updated regularly with prior adjudication information,which provides mimic system adaptability.The experimental analysis shows that FBAMD exhibits the best performance in the face of different types of attacks compared to the state-of-the-art over real-world datasets.This study presents a promising step toward the theo-retical innovation of mimic defense.展开更多
Lesion mimic often exhibits leaf disease-like symptoms even in the absence of pathogen infection,and is characterized by a hypersensitive-response(HR)that closely linked to plant disease resistance.Despite this,only a...Lesion mimic often exhibits leaf disease-like symptoms even in the absence of pathogen infection,and is characterized by a hypersensitive-response(HR)that closely linked to plant disease resistance.Despite this,only a few lesion mimic genes have been identified in wheat.In this investigation,a lesion mimic wheat mutant named je0297 was discovered,showing no alteration in yield components when compared to the wild type(WT).Segregation ratio analysis of the F_(2)individuals resulting from the cross between the WT and the mutant revealed that the lesion mimic was governed by a single recessive gene in je0297.Using Bulked segregant analysis(BSA)and exome capture sequencing,we mapped the lesion mimic gene designated as lm6 to chromosome 6BL.Further gene fine mapping using 3315 F_(2)individuals delimited the lm6 within a 1.18 Mb region.Within this region,we identified 16 high-confidence genes,with only two displaying mutations in je0297.Notably,one of the two genes,responsible for encoding flavonol synthase,exhibited altered expression levels.Subsequent phenotype analysis of TILLING mutants confirmed that the gene encoding flavonol synthase was indeed the causal gene for lm6.Transcriptome sequencing analysis revealed that the DEGs between the WT and mutant were significantly enriched in KEGG pathways related to flavonoid biosynthesis,including flavone and flavonol biosynthesis,isoflavonoid biosynthesis,and flavonoid biosynthesis pathways.Furthermore,more than 30 pathogen infection-related(PR)genes exhibited upregulation in the mutant.Corresponding to this expression pattern,the flavonoid content in je0297 showed a significant decrease in the 4^(th)leaf,accompanied by a notable accumulation of reactive oxygen,which likely contributed to the development of lesion mimic in the mutant.This investigation enhances our comprehension of cell death signaling pathways and provides a valuable gene resource for the breeding of disease-resistant wheat.展开更多
目的探讨关节外科临床教学中医学影像控制系统(materialise's interactive medical image control syste,Mimics)数字化软件辅助教学的可行性与效果。方法选取2023年3月—2024年3月第二医科大学附属医院的54名实习医学生作为研究对...目的探讨关节外科临床教学中医学影像控制系统(materialise's interactive medical image control syste,Mimics)数字化软件辅助教学的可行性与效果。方法选取2023年3月—2024年3月第二医科大学附属医院的54名实习医学生作为研究对象,按教学模式不同分为参照组与研究组,各27例,参照组采取传统教学模式,研究组实施Mimics数字化软件辅助教学模式,比较两组考核成绩、教学效果与教学满意度。结果研究组医学生出科考核成绩(理论知识、临床操作技能)优于参照组,差异有统计学意义(P均<0.05)。研究组教学效果(帮助理解解剖位置关系、帮助理解截骨方法及角度、提升学习兴趣、操作难易程度、增强职业认同感、增强思维能力)评分高于参照组,差异有统计学意义(P均<0.05)。研究组医学生对教学的满意度为96.30%(26/27),高于参照组的74.07%(20/27),差异有统计学意义(χ^(2)=5.283,P<0.05)。结论关节外科临床教学中,基于Mimics数字化软件联合3D建模打印技术展开教学,可以有效地调动实习医学生积极性,使医学生对假肢放置方式和操作过程有更好的理解,切实提升实习医学生学习效果,并保证其对临床教学工作的认可与满意。展开更多
介绍了Mimics(Materiaise's interactive medical image control system)软件及医学图像三维重建的方法,并对该软件在医学图像三维重建中的应用现状进行了分析。指出Mimics软件是连接二维断层扫描图像和三维图像的桥梁,其更重视实...介绍了Mimics(Materiaise's interactive medical image control system)软件及医学图像三维重建的方法,并对该软件在医学图像三维重建中的应用现状进行了分析。指出Mimics软件是连接二维断层扫描图像和三维图像的桥梁,其更重视实现可视化之后的后续研究,并且可以实现个人普通计算机上大规模数据的转换处理,无需专业工作站,将二维扫描的数据(CT、MRI)输入该软件可快速生成三维模型并进行编辑,为医生日常临床诊疗以及科研工作使用提供帮助。最后对其应用前景进行了展望。展开更多
文摘Facial bone, as the frame to support maxillofacial region and with several sinuses and cavities, is structurally complicated and the maxillofacial tumors,benign or malignant, in this region usually grows into the deep tissues, sinus-cav-ities and orbit and destroys the bone. In this study, the maxillofacial tumors were subjected to a mimic operation on a computer following CT scanning and 3-dimen-sional reconstruction. The data similar to those of real operation were obtained,which could be used for developing operative plans. As compared with data on the basis of conditions in the real operation, computerized mimic operation reflected the real conditions during operation. Computerized mimic operation is valuable for the preoperative planning and the prediction of probable intraoperative events.
基金supported by the National Key Research and Development Program of China(Grant No.2020YFB1804604).
文摘In recent years,network attacks have been characterized by diversification and scale,which indicates a requirement for defense strategies to sacrifice generalizability for higher security.As the latest theoretical achievement in active defense,mimic defense demonstrates high robustness against complex attacks.This study proposes a Function-aware,Bayesian adjudication,and Adaptive updating Mimic Defense(FBAMD)theory for addressing the current problems of existing work including limited ability to resist unknown threats,imprecise heterogeneous metrics,and over-reliance on relatively-correct axiom.FBAMD incorporates three critical steps.Firstly,the common features of executors’vulnerabilities are obtained from the perspective of the functional implementation(i.e,input-output relationships extraction).Secondly,a new adjudication mechanism considering Bayes’theory is proposed by leveraging the advantages of both current results and historical confidence.Furthermore,posterior confidence can be updated regularly with prior adjudication information,which provides mimic system adaptability.The experimental analysis shows that FBAMD exhibits the best performance in the face of different types of attacks compared to the state-of-the-art over real-world datasets.This study presents a promising step toward the theo-retical innovation of mimic defense.
基金supported by the National Key Research and Development Program of China(2022YFD1200700)the Nuclear Energy Development Research Program of the State Administration of Science,Technology,and Industry for National Defense(Crop Varietal Improvement and Insect Pests Control by Nuclear Radiation)the China Agriculture Research System of MOF and MARA(CARS-03)。
文摘Lesion mimic often exhibits leaf disease-like symptoms even in the absence of pathogen infection,and is characterized by a hypersensitive-response(HR)that closely linked to plant disease resistance.Despite this,only a few lesion mimic genes have been identified in wheat.In this investigation,a lesion mimic wheat mutant named je0297 was discovered,showing no alteration in yield components when compared to the wild type(WT).Segregation ratio analysis of the F_(2)individuals resulting from the cross between the WT and the mutant revealed that the lesion mimic was governed by a single recessive gene in je0297.Using Bulked segregant analysis(BSA)and exome capture sequencing,we mapped the lesion mimic gene designated as lm6 to chromosome 6BL.Further gene fine mapping using 3315 F_(2)individuals delimited the lm6 within a 1.18 Mb region.Within this region,we identified 16 high-confidence genes,with only two displaying mutations in je0297.Notably,one of the two genes,responsible for encoding flavonol synthase,exhibited altered expression levels.Subsequent phenotype analysis of TILLING mutants confirmed that the gene encoding flavonol synthase was indeed the causal gene for lm6.Transcriptome sequencing analysis revealed that the DEGs between the WT and mutant were significantly enriched in KEGG pathways related to flavonoid biosynthesis,including flavone and flavonol biosynthesis,isoflavonoid biosynthesis,and flavonoid biosynthesis pathways.Furthermore,more than 30 pathogen infection-related(PR)genes exhibited upregulation in the mutant.Corresponding to this expression pattern,the flavonoid content in je0297 showed a significant decrease in the 4^(th)leaf,accompanied by a notable accumulation of reactive oxygen,which likely contributed to the development of lesion mimic in the mutant.This investigation enhances our comprehension of cell death signaling pathways and provides a valuable gene resource for the breeding of disease-resistant wheat.
文摘目的探讨关节外科临床教学中医学影像控制系统(materialise's interactive medical image control syste,Mimics)数字化软件辅助教学的可行性与效果。方法选取2023年3月—2024年3月第二医科大学附属医院的54名实习医学生作为研究对象,按教学模式不同分为参照组与研究组,各27例,参照组采取传统教学模式,研究组实施Mimics数字化软件辅助教学模式,比较两组考核成绩、教学效果与教学满意度。结果研究组医学生出科考核成绩(理论知识、临床操作技能)优于参照组,差异有统计学意义(P均<0.05)。研究组教学效果(帮助理解解剖位置关系、帮助理解截骨方法及角度、提升学习兴趣、操作难易程度、增强职业认同感、增强思维能力)评分高于参照组,差异有统计学意义(P均<0.05)。研究组医学生对教学的满意度为96.30%(26/27),高于参照组的74.07%(20/27),差异有统计学意义(χ^(2)=5.283,P<0.05)。结论关节外科临床教学中,基于Mimics数字化软件联合3D建模打印技术展开教学,可以有效地调动实习医学生积极性,使医学生对假肢放置方式和操作过程有更好的理解,切实提升实习医学生学习效果,并保证其对临床教学工作的认可与满意。
文摘介绍了Mimics(Materiaise's interactive medical image control system)软件及医学图像三维重建的方法,并对该软件在医学图像三维重建中的应用现状进行了分析。指出Mimics软件是连接二维断层扫描图像和三维图像的桥梁,其更重视实现可视化之后的后续研究,并且可以实现个人普通计算机上大规模数据的转换处理,无需专业工作站,将二维扫描的数据(CT、MRI)输入该软件可快速生成三维模型并进行编辑,为医生日常临床诊疗以及科研工作使用提供帮助。最后对其应用前景进行了展望。
