目的探讨关节外科临床教学中医学影像控制系统(materialise's interactive medical image control syste,Mimics)数字化软件辅助教学的可行性与效果。方法选取2023年3月—2024年3月第二医科大学附属医院的54名实习医学生作为研究对...目的探讨关节外科临床教学中医学影像控制系统(materialise's interactive medical image control syste,Mimics)数字化软件辅助教学的可行性与效果。方法选取2023年3月—2024年3月第二医科大学附属医院的54名实习医学生作为研究对象,按教学模式不同分为参照组与研究组,各27例,参照组采取传统教学模式,研究组实施Mimics数字化软件辅助教学模式,比较两组考核成绩、教学效果与教学满意度。结果研究组医学生出科考核成绩(理论知识、临床操作技能)优于参照组,差异有统计学意义(P均<0.05)。研究组教学效果(帮助理解解剖位置关系、帮助理解截骨方法及角度、提升学习兴趣、操作难易程度、增强职业认同感、增强思维能力)评分高于参照组,差异有统计学意义(P均<0.05)。研究组医学生对教学的满意度为96.30%(26/27),高于参照组的74.07%(20/27),差异有统计学意义(χ^(2)=5.283,P<0.05)。结论关节外科临床教学中,基于Mimics数字化软件联合3D建模打印技术展开教学,可以有效地调动实习医学生积极性,使医学生对假肢放置方式和操作过程有更好的理解,切实提升实习医学生学习效果,并保证其对临床教学工作的认可与满意。展开更多
The atmospheric corrosion monitoring(ACM)technique has been widely employed to track the real-time corrosion behavior of metal materials.However,limited studies have applied ACM to the corrosion protection properties ...The atmospheric corrosion monitoring(ACM)technique has been widely employed to track the real-time corrosion behavior of metal materials.However,limited studies have applied ACM to the corrosion protection properties of organic coatings.This study compared a bare epoxy coating with one containing zinc phosphate corrosion inhibitors,both applied on ACM sensors,to observe their corrosion protection properties over time.Coatings with artificial damage via scratches were exposed to immersion and alternating dry and wet environments,which allowed for monitoring galvanic corrosion currents in real-time.Throughout the corrosion tests,the ACM currents of the zinc phosphate/epoxy coating were considerably lower than those of the blank epoxy coating.The trend in ACM current variations closely matched the results obtained from regular electrochemical tests and surface analysis.This alignment highlights the potential of the ACM technique in evaluating the corrosion protection capabilities of organic coatings.Compared with the blank epoxy coating,the zinc phosphate/epoxy coating showed much-decreased ACM current values that confirmed the effective inhibition of zinc phosphate against steel corrosion beneath the damaged coating.展开更多
BACKGROUND Proton pump inhibitors(PPIs)are widely used,including among cancer patients,to manage gastroesophageal reflux and other gastric acid-related disorders.Recent evidence suggests associations between long-term...BACKGROUND Proton pump inhibitors(PPIs)are widely used,including among cancer patients,to manage gastroesophageal reflux and other gastric acid-related disorders.Recent evidence suggests associations between long-term PPI use and higher risks for various adverse health outcomes,including greater mortality.AIM To investigate the association between PPI use and all-cause mortality among cancer patients by a comprehensive analysis after adjustment for various confounders and a robust methodological approach to minimize bias.METHODS This retrospective cohort study used data from the TriNetX research network,with electronic health records from multiple healthcare organizations.The study employed a new-user,active comparator design,which compared newly treated PPI users with non-users and newly treated histamine2 receptor antagonists(H2RA)users among adult cancer patients.Newly prescribed PPIs(esomeprazole,lansoprazole,omeprazole,pantoprazole,or rabeprazole)users were compared to non-users or newly prescribed H2RAs(cimetidine,famotidine,nizatidine,or ranitidine)users.The primary outcome was all-cause mortality.Each patient in the main group was matched to a patient in the control group using 1:1 propensity score matching to reduce confounding effects.Multivariable Cox regression models were used to estimate hazard ratios(HRs)and 95% confidence interval(CI).RESULTS During the follow-up period(median 5.4±1.8 years for PPI users and 6.5±1.0 years for non-users),PPI users demonstrated a higher all-cause mortality rate than non-users after 1 year,2 years,and at the end of follow up(HRs:2.34-2.72).Compared with H2RA users,PPI users demonstrated a higher rate of all-cause mortality HR:1.51(95%CI:1.41-1.69).Similar results were observed across sensitivity analyses by excluding deaths from the first 9 months and 1-year post-exposure,confirming the robustness of these findings.In a sensitivity analysis,we analyzed all-cause mortality outcomes between former PPI users and individuals who have never used PPIs,providing insights into the long-term effects of past PPI use.In addition,at 1-year follow-up,the analysis revealed a significant difference in mortality rates between former PPI users and non-users(HR:1.84;95%CI:1.82-1.96).CONCLUSION PPI use among cancer patients was associated with a higher risk of all-cause mortality compared to non-users or H2RA users.These findings emphasize the need for cautious use of PPIs in cancer patients and suggest that alternative treatments should be considered when clinically feasible.However,further studies are needed to corroborate our findings,given the significant adverse outcomes in cancer patients.展开更多
介绍了Mimics(Materiaise's interactive medical image control system)软件及医学图像三维重建的方法,并对该软件在医学图像三维重建中的应用现状进行了分析。指出Mimics软件是连接二维断层扫描图像和三维图像的桥梁,其更重视实...介绍了Mimics(Materiaise's interactive medical image control system)软件及医学图像三维重建的方法,并对该软件在医学图像三维重建中的应用现状进行了分析。指出Mimics软件是连接二维断层扫描图像和三维图像的桥梁,其更重视实现可视化之后的后续研究,并且可以实现个人普通计算机上大规模数据的转换处理,无需专业工作站,将二维扫描的数据(CT、MRI)输入该软件可快速生成三维模型并进行编辑,为医生日常临床诊疗以及科研工作使用提供帮助。最后对其应用前景进行了展望。展开更多
文摘目的探讨关节外科临床教学中医学影像控制系统(materialise's interactive medical image control syste,Mimics)数字化软件辅助教学的可行性与效果。方法选取2023年3月—2024年3月第二医科大学附属医院的54名实习医学生作为研究对象,按教学模式不同分为参照组与研究组,各27例,参照组采取传统教学模式,研究组实施Mimics数字化软件辅助教学模式,比较两组考核成绩、教学效果与教学满意度。结果研究组医学生出科考核成绩(理论知识、临床操作技能)优于参照组,差异有统计学意义(P均<0.05)。研究组教学效果(帮助理解解剖位置关系、帮助理解截骨方法及角度、提升学习兴趣、操作难易程度、增强职业认同感、增强思维能力)评分高于参照组,差异有统计学意义(P均<0.05)。研究组医学生对教学的满意度为96.30%(26/27),高于参照组的74.07%(20/27),差异有统计学意义(χ^(2)=5.283,P<0.05)。结论关节外科临床教学中,基于Mimics数字化软件联合3D建模打印技术展开教学,可以有效地调动实习医学生积极性,使医学生对假肢放置方式和操作过程有更好的理解,切实提升实习医学生学习效果,并保证其对临床教学工作的认可与满意。
基金financially supported by the National Natural Science Foundation of China(No.52371049)the Young Elite Scientists Sponsorship Program by the China Association for Science and Technology(YESS,No.2020QNRC001)the National Science and Technology Resources Investigation Program of China(Nos.2021FY100603 and 2019FY101404)。
文摘The atmospheric corrosion monitoring(ACM)technique has been widely employed to track the real-time corrosion behavior of metal materials.However,limited studies have applied ACM to the corrosion protection properties of organic coatings.This study compared a bare epoxy coating with one containing zinc phosphate corrosion inhibitors,both applied on ACM sensors,to observe their corrosion protection properties over time.Coatings with artificial damage via scratches were exposed to immersion and alternating dry and wet environments,which allowed for monitoring galvanic corrosion currents in real-time.Throughout the corrosion tests,the ACM currents of the zinc phosphate/epoxy coating were considerably lower than those of the blank epoxy coating.The trend in ACM current variations closely matched the results obtained from regular electrochemical tests and surface analysis.This alignment highlights the potential of the ACM technique in evaluating the corrosion protection capabilities of organic coatings.Compared with the blank epoxy coating,the zinc phosphate/epoxy coating showed much-decreased ACM current values that confirmed the effective inhibition of zinc phosphate against steel corrosion beneath the damaged coating.
文摘BACKGROUND Proton pump inhibitors(PPIs)are widely used,including among cancer patients,to manage gastroesophageal reflux and other gastric acid-related disorders.Recent evidence suggests associations between long-term PPI use and higher risks for various adverse health outcomes,including greater mortality.AIM To investigate the association between PPI use and all-cause mortality among cancer patients by a comprehensive analysis after adjustment for various confounders and a robust methodological approach to minimize bias.METHODS This retrospective cohort study used data from the TriNetX research network,with electronic health records from multiple healthcare organizations.The study employed a new-user,active comparator design,which compared newly treated PPI users with non-users and newly treated histamine2 receptor antagonists(H2RA)users among adult cancer patients.Newly prescribed PPIs(esomeprazole,lansoprazole,omeprazole,pantoprazole,or rabeprazole)users were compared to non-users or newly prescribed H2RAs(cimetidine,famotidine,nizatidine,or ranitidine)users.The primary outcome was all-cause mortality.Each patient in the main group was matched to a patient in the control group using 1:1 propensity score matching to reduce confounding effects.Multivariable Cox regression models were used to estimate hazard ratios(HRs)and 95% confidence interval(CI).RESULTS During the follow-up period(median 5.4±1.8 years for PPI users and 6.5±1.0 years for non-users),PPI users demonstrated a higher all-cause mortality rate than non-users after 1 year,2 years,and at the end of follow up(HRs:2.34-2.72).Compared with H2RA users,PPI users demonstrated a higher rate of all-cause mortality HR:1.51(95%CI:1.41-1.69).Similar results were observed across sensitivity analyses by excluding deaths from the first 9 months and 1-year post-exposure,confirming the robustness of these findings.In a sensitivity analysis,we analyzed all-cause mortality outcomes between former PPI users and individuals who have never used PPIs,providing insights into the long-term effects of past PPI use.In addition,at 1-year follow-up,the analysis revealed a significant difference in mortality rates between former PPI users and non-users(HR:1.84;95%CI:1.82-1.96).CONCLUSION PPI use among cancer patients was associated with a higher risk of all-cause mortality compared to non-users or H2RA users.These findings emphasize the need for cautious use of PPIs in cancer patients and suggest that alternative treatments should be considered when clinically feasible.However,further studies are needed to corroborate our findings,given the significant adverse outcomes in cancer patients.
文摘介绍了Mimics(Materiaise's interactive medical image control system)软件及医学图像三维重建的方法,并对该软件在医学图像三维重建中的应用现状进行了分析。指出Mimics软件是连接二维断层扫描图像和三维图像的桥梁,其更重视实现可视化之后的后续研究,并且可以实现个人普通计算机上大规模数据的转换处理,无需专业工作站,将二维扫描的数据(CT、MRI)输入该软件可快速生成三维模型并进行编辑,为医生日常临床诊疗以及科研工作使用提供帮助。最后对其应用前景进行了展望。
