期刊文献+
共找到211篇文章
< 1 2 11 >
每页显示 20 50 100
Miniaturized power detection module operating in millimeter wave band
1
作者 Xiang Zhou Zhi-Yong Zhong 《Journal of Electronic Science and Technology》 EI CAS CSCD 2024年第2期69-76,共8页
The miniaturized broadband detection module can be embedded into the microwave application system such as the front end of the transmitter to detect the power or other parameters in real time.It is highly prospective ... The miniaturized broadband detection module can be embedded into the microwave application system such as the front end of the transmitter to detect the power or other parameters in real time.It is highly prospective in military and scientific research.In this paper,a broadband power detection module operating at 26.5 GHz-40.0 GHz is designed by using low-barrier Schottky diode as the detector and a comparator for threshold output.This module can dynamically detect the power range between-10 dBm and 10 dBm with the detection accuracy of 0.1 dB.Further,the temperature compensation circuit is also applied to improve the measurement error.As a result,the resulted error low to±1 dB in the temperature range of -55℃ to +85℃ is achieved.The designed module is encapsulated by a Kovar alloy with a small volume of 9 mm×6 mm×3 mm.This endows the designed module the advantages of small size,easy integration,and low cost,and even it is applicable to high-reliability environments such as satellites. 展开更多
关键词 DIODE MINIATURIZATION Power detection Temperature compensation
下载PDF
An AuNPs/Mesoporous NiO/Nickel Foam Nanocomposite as a Miniaturized Electrode for Heavy Metal Detection in Groundwater 被引量:1
2
作者 Boyuan Xue Qian Yang +4 位作者 Kaidong Xia Zhihong Li George Y.Chen Dayi Zhang Xiaohong Zhou 《Engineering》 SCIE EI CAS CSCD 2023年第8期199-208,共10页
Heavy metals,notably Pb2+and Cu^(2+),are some of the most persistent contaminants found in groundwater.Frequent monitoring of these metals,which relies on efficient,sensitive,cost-effective,and reliable methods,is a n... Heavy metals,notably Pb2+and Cu^(2+),are some of the most persistent contaminants found in groundwater.Frequent monitoring of these metals,which relies on efficient,sensitive,cost-effective,and reliable methods,is a necessity.We present a nanocomposite-based miniaturized electrode for the concurrent measurement of Pb2+and Cu^(2+)by exploiting the electroanalytical technique of square wave voltammetry.We also propose a facile in situ hydrothermal calcination method to directly grow binder-free mesoporous Ni O on a three-dimensional nickel foam,which is then electrochemically seeded with gold nanoparticles(Au NPs).The meticulous design of a low-barrier Ohmic contact between mesoporous Ni O and Au NPs facilitates target-mediated nanochannel-confined electron transfer within mesoporous Ni O.As a result,the heavy metals Pb2+(0.020 mg.L^(-1)detection limit;2.0–16.0 mg.L^(-1)detection range)and Cu^(2+)(0.013 mg.L^(-1)detection limit;0.4–12.8 mg.L^(-1)detection range)can be detected simultaneously with high precision.Furthermore,other heavy metal ions and common interfering ions found in groundwater showed negligible impacts on the electrode’s performance,and the recovery rate of groundwater samples varied between 96.3%±2.1%and 109.4%±0.6%.The compactness,flexible shape,low power consumption,and ability to remotely operate our electrode pave the way for onsite detection of heavy metals in groundwater,thereby demonstrating the potential to revolutionize the field of environmental monitoring. 展开更多
关键词 AuNPs Mesoporous NiO miniaturized electrode Heavy metal ions GROUNDWATER Square wave voltammetry
下载PDF
Retrograde intrarenal surgery vs miniaturized percutaneous nephrolithotomy to treat lower pole renal stones 1.5-2.5 cm in diameter 被引量:7
3
作者 Mao-Mao Li Hou-Meng Yang +2 位作者 Xiao-Ming Liu Hong-Gang Qi Guo-Bin Weng 《World Journal of Clinical Cases》 SCIE 2018年第15期931-935,共5页
AIM To compare the outcomes of retrograde intrarenal surgery(RIRS) and miniaturized percutaneous nephrolithotomy(mini-PCNL) in treating lower pole(LP) renal stones with a diameter of 1.5-2.5 cm.METHODS A total of 216 ... AIM To compare the outcomes of retrograde intrarenal surgery(RIRS) and miniaturized percutaneous nephrolithotomy(mini-PCNL) in treating lower pole(LP) renal stones with a diameter of 1.5-2.5 cm.METHODS A total of 216 patients who underwent mini-PCNL(n = 103) or RIRS n = 113) for LP stones with a diameter of 1.5-2.5 cm were enrolled between December 2015 and April 2017 at the Urology Department of Ningbo Urology and Nephrology Hospital.RESULTS Significant differences were found in the hospital stay(9.39 ± 4.01 vs 14.08 ± 5.26, P < 0.0001) and hospitalization costs(2624.5 ± 513.36 vs 3255.2 ± 976.5, P < 0.0001) between the RIRS and mini-PCNL groups. The mean operation time was not significantly different between the RIRS group(56.48 ± 24.77) and the mini-PCNL group(60.04 ± 30.38, P = 0.345). The stone-free rates at the first postoperative day(RIRS vs mini-PCNL: 90.2% vs 93.2%, P = 0.822) and the second month postoperatively(RIRS vs mini-PCNL: 93.8% vs 95.1%, P = 0.986) were not significantly different.CONCLUSION RIRS and mini-PCNL are both safe and effective methods for treating LP stones with a diameter of 1.5-2.5 cm. RIRS can be considered as an alternative to PCNL for the treatment for LP stones of 1.5-2.5 cm. 展开更多
关键词 RETROGRADE intrarenal surgery PERCUTANEOUS nephrolithotripsy LOWER POLE kidney stones miniaturizeD PERCUTANEOUS NEPHROLITHOTOMY
下载PDF
Emerging miniaturized energy storage devices for microsystem applications:from design to integration 被引量:6
4
作者 Huaizhi Liu Guanhua Zhang +2 位作者 Xin Zheng Fengjun Chen Huigao Duan 《International Journal of Extreme Manufacturing》 EI 2020年第4期1-28,共28页
The rapid progress of micro/nanoelectronic systems and miniaturized portable devices has tremendously increased the urgent demands for miniaturized and integrated power supplies.Miniaturized energy storage devices(MES... The rapid progress of micro/nanoelectronic systems and miniaturized portable devices has tremendously increased the urgent demands for miniaturized and integrated power supplies.Miniaturized energy storage devices(MESDs),with their excellent properties and additional intelligent functions,are considered to be the preferable energy supplies for uninterrupted powering of microsystems.In this review,we aim to provide a comprehensive overview of the background,fundamentals,device configurations,manufacturing processes,and typical applications of MESDs,including their recent advances.Particular attention is paid to advanced device configurations,such as two-dimensional(2D)stacked,2D planar interdigital,2D arbitrary-shaped,three-dimensional planar,and wire-shaped structures,and their corresponding manufacturing strategies,such as printing,scribing,and masking techniques.Additionally,recent developments in MESDs,including microbatteries and microsupercapacitors,as well as microhybrid metal ion capacitors,are systematically summarized.A series of on-chip microsystems,created by integrating functional MESDs,are also highlighted.Finally,the remaining challenges and future research scope on MESDs are discussed. 展开更多
关键词 microsystems miniaturized energy storage devices MICROBATTERIES microsupercapacitors microhybrid metal ion capacitors
下载PDF
A miniaturized 2.45 GHz ECR ion source at Peking University 被引量:1
5
作者 Jia-Mei Wen Shi-Xiang Peng +6 位作者 Hai-Tao Ren Tao Zhang Jing-Feng Zhang Wen-Bin Wu Jiang Sun Zhi-Yu Guo Jia-Er Chen 《Chinese Physics B》 SCIE EI CAS CSCD 2018年第5期374-377,共4页
A miniaturized 2.45 GHz permanent magnet electron cyclotron resonance(PMECR) ion source, which has the ability of producing a tens-m A H+beam, has been built and tested at Peking University(PKU). Its plasma chamb... A miniaturized 2.45 GHz permanent magnet electron cyclotron resonance(PMECR) ion source, which has the ability of producing a tens-m A H+beam, has been built and tested at Peking University(PKU). Its plasma chamber dimension is Φ30 mm×40 mm and the whole size of the ion source is Φ180 mm×130 mm. This source has a unique structure with the whole source body embedded into the extraction system. It can be operated in both continuous wave(CW) mode and pulse mode. In the CW mode, more than 20 m A hydrogen ion beam at 40 k V can be obtained with the microwave power of 180 W and about 1 m A hydrogen ion beam is produced with a microwave power of 10 W. In the pulse mode, more than50 m A hydrogen ion beam with a duty factor of 10% can be extracted when the peak microwave power is 1800 W. 展开更多
关键词 miniaturized ECR ion source hydrogen plasma continuous wave (CW) beam pulse beam
下载PDF
Calculating Model of Interference Amount for Miniaturized Gear and Shaft Shrink Fit
6
作者 金鑫 张之敬 +1 位作者 叶鑫 李忠新 《Journal of Beijing Institute of Technology》 EI CAS 2006年第2期138-143,共6页
Based on miniaturized components' characteristics, the method of assembling miniaturized gear and shaft together with corresponding calculating model of the interference amount are proposed. On the basis of main effe... Based on miniaturized components' characteristics, the method of assembling miniaturized gear and shaft together with corresponding calculating model of the interference amount are proposed. On the basis of main effecting factors analysis on the gear and shaft assembling interference amount, calculating formula including all factors effective on the interference amount necessary for reliable system running was built up. The methods of reverse calculating theoretical model was used to build up the equivalent simulation model of the theoretical one, together with simulation verification and case study for calculating formula. The results show that the cold assembling method is applicable for miniaturized gear and shaft, but in the assembling process, the interference amount compensating the shape error of contacting surfaces takes a large proportion, which is the main cause of stress variance on contacting surfaces. 展开更多
关键词 miniaturizeD interference amount calculating model cold assembling simulation model
下载PDF
Study on the High Conductive Polymer as the Miniaturized Reference Electrode
7
作者 Jung-Chuan Chou Chien-Cheng Chen 《稀有金属材料与工程》 SCIE EI CAS CSCD 北大核心 2006年第A03期254-255,共2页
The polypyrrole is the high conductive polymer which was coated onto indium tin oxide (ITO) glass substrate by electroplated technique to fabricate a miniaturized reference electrode.Besides,the morphology of the ITO... The polypyrrole is the high conductive polymer which was coated onto indium tin oxide (ITO) glass substrate by electroplated technique to fabricate a miniaturized reference electrode.Besides,the morphology of the ITO glass reference electrode electroplated with pyrrole has been studied through the instrumental analysis utilizing cyclic voltammetry (CV). Furthermore,the sensing characteristics of the reference electrode have been measured by using commercial instrumental amplifier as the readout circuit.Using the high conductive polymer as miniaturized reference electrode has many advantages such as easy fabrication of coating polymer,without any expensive fabricating equipment,easy carry by the miniaturized technique.Hence,it is suitable for the reference electrode production. 展开更多
关键词 miniaturized reference electrode POLYPYRROLE conductive polymer cyclic voltammetry
下载PDF
Experience with Miniaturized Cardiopulmonary Bypass in Cardiac Surgery: A Prospective Comparison of the NovoSCI Ready System to Off-Pump and Conventional Coronary Artery Bypass Grafting
8
作者 Dominic Emerson Debbie Baldwin +3 位作者 Miguel Pinales Michael Greenberg Melissa Mattes Gregory Trachiotis 《World Journal of Cardiovascular Surgery》 2014年第12期232-238,共7页
The major source of morbidity following cardiopulmonary bypass (CPB) is the systemic inflammatory response (SIRS response) which leads to multiple derangements in different organ systems. To combat this, miniaturized ... The major source of morbidity following cardiopulmonary bypass (CPB) is the systemic inflammatory response (SIRS response) which leads to multiple derangements in different organ systems. To combat this, miniaturized cardiopulmonary bypass circuits (MCPBC) have been created to lessen the inflammatory response to CPB. Here we examine early outcomes following coronary artery bypass grafting (CABG) using a MCPBC system compared to conventional bypass techniques at a single institution. Methods: 60 consecutive patients undergoing elective CABG were prospectively enrolled. Nine patients underwent coronary artery bypass grafting (CABG) with conventional CPB (cCABG), 33 underwent off-pump CABG (OPCAB), and the remaining 18 patients underwent CABG with a MCPBC system. Demographics and outcomes were compared between groups and statistical analyses applied. Results: No significant difference was observed in mortality between groups, with only one death reported in total. Morbidity was also low, totaling only 6.7%, with none occurring in the MCPBC group. The MCPBC group required less PRBC and total blood product transfusion than the cCABG and OPCABG groups (p = 0.05), but changes in PLT and Hct over time were not different between groups. Conclusions: The MCPBC system was shown to be comparable to conventional bypass and OPCABG in terms of postoperative complications and mortality. Furthermore, the MCPBC system had the advantage of a decreased transfusion requirement. Based on our preliminary observations, this mini-cardiopulmonary bypass circuit provides a safe alternative to conventional bypass techniques. 展开更多
关键词 miniaturizeD Circuits Coronary Artery BYPASS GRAFT Outcomes
下载PDF
Broadband Miniaturized Bandpass Filter with Circular Stubs for Compact Wireless and Mobile Communication Systems
9
作者 Yulan Zhang Heather Song 《Journal of Electromagnetic Analysis and Applications》 2013年第3期109-113,共5页
A miniaturized square resonator bandpass filter with circular stubs is designed, fabricated, and characterized. Analytical calculations were carried out to determine the critical filter parameters and the design was o... A miniaturized square resonator bandpass filter with circular stubs is designed, fabricated, and characterized. Analytical calculations were carried out to determine the critical filter parameters and the design was optimized using a 3D electromagnetic finite-element solver. The measured results were in good agreement with the designed results. The proposed filter exhibits significant improvement in bandwidth compared to the conventional square resonator bandpass filters. 展开更多
关键词 miniaturizeD SQUARE Resonator BANDPASS Filter CIRCULAR STUB Electromagnetic Simulation
下载PDF
Design of Miniaturized Band-Pass Filter with Composite Right/Left-Handed Transmission Line
10
作者 Meng Zhang Fang Zhang Xingfang Luo 《Journal of Computer and Communications》 2015年第3期44-48,共5页
In this paper, a new miniaturized wide-pass-band filter at U band based on composite right/left- handed transmission line (CRLH TL) is implemented. The CRLH TL contributed to a broadband filter is a balanced structure... In this paper, a new miniaturized wide-pass-band filter at U band based on composite right/left- handed transmission line (CRLH TL) is implemented. The CRLH TL contributed to a broadband filter is a balanced structure with a small size of only 1.428 mm*0.5530 mm. The frequency characteristics are simulated and the results show that the 3 dB band width of the proposed filter is about 13.5 GHz from 45.8 GHz to 59.3 GHz. The insertion loss is quite flat through the pass-band and the return loss is relatively low. 展开更多
关键词 miniaturizeD Composite Right/Left-Handed Transmission Line BANDPASS FILTER METAMATERIAL
下载PDF
China APMT to Launch 50 Miniaturized Satellites
11
《Aerospace China》 2012年第3期24-24,共1页
China Asia-Pacific Mobile Telecommunications Satellite Co., Ltd. (China APMT) has signed a QB50 Project Memorandum of Understanding with the Von Karman Institute for Fluid Dynamics (VKI). According to the agreement, C... China Asia-Pacific Mobile Telecommunications Satellite Co., Ltd. (China APMT) has signed a QB50 Project Memorandum of Understanding with the Von Karman Institute for Fluid Dynamics (VKI). According to the agreement, China APMT will launch 50 miniaturized satellites for VKI from 2014-15. 展开更多
关键词 APMT China APMT to Launch 50 miniaturized Satellites PROJECT
下载PDF
MINIATURIZED MICROSTRIP BRANCH-LINE COUPLER WITH GOOD HARMONIC SUPPRESSION PERFORMANCE 被引量:2
12
作者 Yang Guo Li Bo +1 位作者 Kang Wei Ge Sheng 《Journal of Electronics(China)》 2012年第1期132-136,共5页
This paper presents a miniaturized microstrip branch-line coupler with good harmonic suppression performance. The proposed coupler consists of four branch-line sections, each of which is loaded by open-circuit stubs b... This paper presents a miniaturized microstrip branch-line coupler with good harmonic suppression performance. The proposed coupler consists of four branch-line sections, each of which is loaded by open-circuit stubs both at the center and the two ends. This type of loading can realize size reduction and harmonic suppression. As an example, a proposed branch-line coupler operating at 1.0 GHz is designed, fabricated and measured. The results show that the proposed branch-line coupler occupies 67% size of a conventional one and has better than 20 dB suppression from 1.9 to 5.8 GHz. Furthermore, the high slop of the transition band ensures good selectivity of the coupler. 展开更多
关键词 Branch-line coupler MINIATURIZATION Harmonic suppression
下载PDF
Novel Methodology for Designing Frequency Selective Surfaces with Miniaturized Cells
13
作者 Guo-Hui Yang Wan-Lu Li +2 位作者 Tong Zhang Qun Wu Xue-Mai Gu 《Journal of Harbin Institute of Technology(New Series)》 EI CAS 2013年第2期1-6,共6页
Miniaturization of Frequency Selective Surface's ( FSS's) size is significant for its application in the limited space. In this paper, a novel methodology for designing low-profile FSS is discussed, and a corr... Miniaturization of Frequency Selective Surface's ( FSS's) size is significant for its application in the limited space. In this paper, a novel methodology for designing low-profile FSS is discussed, and a corresponding multi-layer structure with lumped elements for band-pass response is presented. Based on the equivalent circuit theory,the inductive designed center layer is firstly discussed. Then different numbers of additional capacitive designed layers are added and their performances are presented. Finally,the lumped elements are added both between adjacent layers and between adjacent cells of the additional layers so that the miniaturization performance can be further improved. The simulations for each structure in waves of different polarizations and incident angles are conducted,and the results are presented,which demonstrate the claimed characteristics of the proposed structure. 展开更多
关键词 FSS MINIATURIZATION MULTI-LAYER polarization stability
下载PDF
Design of a low-frequency miniaturized piezoelectric antenna based on acoustically actuated principle
14
作者 Yong Zhang Zhong-Ming Yan +3 位作者 Tian-Hao Han Shuang-Shuang Zhu Yu Wang Hong-Cheng Zhou 《Chinese Physics B》 SCIE EI CAS CSCD 2022年第7期565-572,共8页
An acoustically actuated piezoelectric antenna is proposed for low frequency(LF)band in this paper.The proposed antenna is theoretically calculated,numerically optimized by the finite element method(FEM),and experimen... An acoustically actuated piezoelectric antenna is proposed for low frequency(LF)band in this paper.The proposed antenna is theoretically calculated,numerically optimized by the finite element method(FEM),and experimentally analyzed.The measurement results show that the near-field radiation pattern of the piezoelectric antenna is similar to that of the electric dipole antenna.The radiation efficiency of the piezoelectric antenna is 3-4 orders of magnitude higher than that of electrically small antenna(ESA),with their sizes being the same size,and the maximum transmission distance obtained experimentally is 100 cm,which can be improved by increasing the input power.In addition,the gain,directivity,and quality factor of piezoelectric antenna are also analyzed.In this paper,traditional antenna parameters are creatively used to analyze the performance of piezoelectric antenna.The research conclusions can provide reliable theoretical basis for realizing LF antenna miniaturization. 展开更多
关键词 piezoelectric low frequency antenna resonance frequency radiation quality factor antenna miniaturization
下载PDF
Miniaturized Fiber-Optic Fabry-Perot Interferometer for Highly Sensitive Refractive Index Measurement
15
作者 Ming Deng Tao Zhu +1 位作者 Yun-Jiang Rao Hong Li 《Journal of Electronic Science and Technology of China》 2008年第4期365-368,共4页
This paper presents a novel miniaturized fiber-optic Fabry-Peort interferometer (FPI) for highly sensitive refractive index measurement. This device was tested for the refractive indices of various liquids including... This paper presents a novel miniaturized fiber-optic Fabry-Peort interferometer (FPI) for highly sensitive refractive index measurement. This device was tested for the refractive indices of various liquids including acetone and ethanol at room temperature. The sensitivity for measurement of refractive index change of ethanol is 1138 nm/RIU at the wavelength of 1550 nm. In addition, the sensor fabrication is simple including only cleaving, splicing, and etching. The signal is stable with high visibility. Therefore, it provides a valuable tool in biological and chemical applications. 展开更多
关键词 Fiber optic sensors Fabry-Perot miniature sensor photonic crystal fiber refractive indexmeasurement.
下载PDF
New progress of the miniaturized microwave ion source at Peking University
16
作者 S.X.Peng T.H.Ma +5 位作者 W.B.Wu B.J.Cui A.L.Zhang Y.X.Jiang Z.Y.Guo J.E.Chen 《Radiation Detection Technology and Methods》 CSCD 2023年第4期545-549,共5页
The generation of plasma in a microwave ion source involves confining electrons using a static magnetic field and energizing them with an electromagnetic field that transmitted into the plasma chamber.However,accordin... The generation of plasma in a microwave ion source involves confining electrons using a static magnetic field and energizing them with an electromagnetic field that transmitted into the plasma chamber.However,according to electromagnetics theory,there is always a cut-off size in circular wave guides for a given frequency.For a 2.45 GHz microwave,this dimension is 72 mm,which should theoretically prevent transmission of the microwave into the discharge chamber and no plasma can be generated.Since 2006 Peking University(PKU)has successfully developed a series of permanent magnet 2.45 GHz microwave ion sources(PKU PMECRs)with a discharge chamber less than 50 mm,capable of delivering tens of mA beams for accelerators.To explain this anomalous phenomenon,a hybrid discharge heating(HDH)mode that combines surface wave plasma and electron cyclotron heating has been proposed.This HDH mode not only successfully explains PKU PMECRs,but also predicts that the optimized inner diameter of the plasma chamber is 24 mm,which is confirmed by experiments involving different liners in the miniaturized microwave ion source. 展开更多
关键词 miniaturized 2.45 GHz ECR source Hybrid discharge mode Hydrogen plasma
原文传递
Identifying the enhancement mechanism of Al/MoO_(3) reactive multilayered films on the ignition ability of semiconductor bridge using a one-dimensional gas-solid two-phase flow model
17
作者 Jianbing Xu Yuxuan Zhou +3 位作者 Yun Shen Yueting Wang Yinghua Ye Ruiqi Shen 《Defence Technology(防务技术)》 SCIE EI CAS CSCD 2024年第3期168-179,共12页
Energetic Semiconductor bridge(ESCB)based on reactive multilayered films(RMFs)has a promising application in the miniature and intelligence of initiator and pyrotechnics device.Understanding the ignition enhancement m... Energetic Semiconductor bridge(ESCB)based on reactive multilayered films(RMFs)has a promising application in the miniature and intelligence of initiator and pyrotechnics device.Understanding the ignition enhancement mechanism of RMFs on semiconductor bridge(SCB)during the ignition process is crucial for the engineering and practical application of advanced initiator and pyrotechnics devices.In this study,a one-dimensional(1D)gas-solid two-phase flow ignition model was established to study the ignition process of ESCB to charge particles based on the reactivity of Al/MoO_(3) RMFs.In order to fully consider the coupled exothermic between the RMFs and the SCB plasma during the ignition process,the heat release of chemical reaction in RMFs was used as an internal heat source in this model.It is found that the exothermal reaction in RMFs improved the ignition performance of SCB.In the process of plasma rapid condensation with heat release,the product of RMFs enhanced the heat transfer process between the gas phase and the solid charge particle,which accelerated the expansion of hot plasma,and heated the solid charge particle as well as gas phase region with low temperature.In addition,it made up for pressure loss in the gas phase.During the plasma dissipation process,the exothermal chemical reaction in RMFs acted as the main heating source to heat the charge particle,making the surface temperature of the charge particle,gas pressure,and gas temperature rise continuously.This result may yield significant advantages in providing a universal ignition model for miniaturized ignition devices. 展开更多
关键词 Ignition enhancement mechanism 1D gas-solid two-phase flow Al/MoO_(3)reactive multilayered films Semiconductor bridge miniaturized ignition device
下载PDF
Forebrain excitatory neuron-specific loss of Brpf1 attenuates excitatory synaptic transmission and impairs spatial and fear memory 被引量:3
18
作者 Baicheng Zhao Hang Zhang +5 位作者 Ying Liu Gaoyu Zu Yuxiao Zhang Jiayi Hu Shuai Liu Linya You 《Neural Regeneration Research》 SCIE CAS CSCD 2024年第5期1133-1141,共9页
Bromodomain and plant homeodomain(PHD)finger containing protein 1(Brpf1)is an activator and scaffold protein of a multiunit complex that includes other components involving lysine acetyltransferase(KAT)6A/6B/7.Brpf1,K... Bromodomain and plant homeodomain(PHD)finger containing protein 1(Brpf1)is an activator and scaffold protein of a multiunit complex that includes other components involving lysine acetyltransferase(KAT)6A/6B/7.Brpf1,KAT6A,and KAT6B mutations were identified as the causal genes of neurodevelopmental disorders leading to intellectual disability.Our previous work revealed strong and specific expression of Brpf1 in both the postnatal and adult forebrain,especially the hippocampus,which has essential roles in learning and memory.Here,we hypothesized that Brpf1 plays critical roles in the function of forebrain excitatory neurons,and that its deficiency leads to learning and memory deficits.To test this,we knocked out Brpf1 in forebrain excitatory neurons using CaMKIIa-Cre.We found that Brpf1 deficiency reduced the frequency of miniature excitatory postsynaptic currents and downregulated the expression of genes Pcdhgb1,Slc16a7,Robo3,and Rho,which are related to neural development,synapse function,and memory,thereby damaging spatial and fear memory in mice.These findings help explain the mechanisms of intellectual impairment in patients with BRPF1 mutation. 展开更多
关键词 behavioral test Brpf1 CAMKIIa-Cre intellectual disability miniature excitatory postsynaptic current MRNA-SEQ
下载PDF
Miniature tunable Airy beam optical meta-device 被引量:3
19
作者 Jing Cheng Zhang Mu Ku Chen +6 位作者 Yubin Fan Qinmiao Chen Shufan Chen Jin Yao Xiaoyuan Liu Shumin Xiao Din Ping Tsai 《Opto-Electronic Advances》 SCIE EI CAS CSCD 2024年第2期5-12,共8页
Tunable Airy beams with controllable propagation trajectories have sparked interest in various fields,such as optical manipulation and laser fabrication.Existing research approaches encounter challenges related to ins... Tunable Airy beams with controllable propagation trajectories have sparked interest in various fields,such as optical manipulation and laser fabrication.Existing research approaches encounter challenges related to insufficient compactness and integration feasibility,or they require enhanced tunability to enable real-time dynamic manipulation of the propagation trajectory.In this work,we present a novel method that utilizes a dual metasurface system to surpass these limitations,significantly enhancing the practical potential of the Airy beam.Our approach involves encoding a cubic phase profile and two off-axis Fresnel lens phase profiles across the two metasurfaces.The validity of the proposed strategy has been confirmed through simulation and experimental results.The proposed meta-device addresses the existing limitations and lays the foundation for broadening the applicability of Airy beams across diverse domains,encompassing light-sheet microscopy,laser fabrication,optical tweezers,etc. 展开更多
关键词 metasurface miniature device tunable Airy beam tunable meta-device
下载PDF
Miniaturized electrochemical sensors and their point-of-care applications 被引量:2
20
作者 Wei Zhang Ruiguo Wang +2 位作者 Fang Luo Peilong Wang Zhenyu Lin 《Chinese Chemical Letters》 SCIE CAS CSCD 2020年第3期589-600,共12页
Most of the current analytical methods depend largely on laboratory-based analytical techniques that require expensive and bullky equipment,potentially incur costly testing,and involve lengthy detection processes.With... Most of the current analytical methods depend largely on laboratory-based analytical techniques that require expensive and bullky equipment,potentially incur costly testing,and involve lengthy detection processes.With increasing requirements for point-of-care testing(POCT),more attention has been paid to miniaturized analytical devices.Miniaturized electrochemical(MEC)sensors,including different material-based MEC sensors(such as DNA-,paper-,and screen electrode-based),have been in strong demand in analytical science due to their easy operation,portability,high sensitivity,as well as their short analysis time.They have been applied for the detection of trace amounts of target through measuring changes in electrochemical signal,such as current,voltage,potential,or impedance,due to the oxidation/reduction of chemical/biological molecules with the help of electrodes and electrochemical units.MEC sensors present great potential for the detection of targets including small organic molecules,metal ions,and biomolecules.In recent years,MEC sensors have been broadly applied to POCT in various fields,including health care,food safety,and environmental monitoring,owing to the excellent advantages of electrochemical(EC)technologies.This review summarized the state-of-the-art advancements on various types of MEC sensors and their applications in POCT.Furthermore,the future perspectives,opportunities,and challenges in this field are also discussed. 展开更多
关键词 miniaturizeD ELECTROCHEMICAL sensors POINT-OF-CARE testing DNA-based miniaturizeD ELECTROCHEMICAL SENSOR Paper-based ELECTROCHEMICAL SENSOR Microfluidics-based ELECTROCHEMICAL SENSOR miniaturizeD capillary electrophoresis-based SENSOR
原文传递
上一页 1 2 11 下一页 到第
使用帮助 返回顶部