Traditional craniotomy versus current minimally invasive surgery for spontaneous supratentorial intracerebral haemorrhage:A propensity-matched analysis

BACKGROUND Minimally invasive surgery(MIS)and craniotomy(CI)are the current treatments for spontaneous supratentorial cerebral haemorrhage(SSTICH).AIM To compare the efficacy and safety of MIS and CI for the treatment of SSTICH.METHODS Clinical and imaging data of 557 consecutive patients with SSTICH who underwent MIS or CI between January 2017 and December 2022 were retrospectively analysed.The patients were divided into two subgroups:The MIS group and CI group.Propensity score matching was performed to minimise case selection bias.The primary outcome was a dichotomous prognostic(favourable or unfavourable)outcome based on the modified Rankin Scale(mRS)score at 3 months;an mRS score of 0–2 was considered favourable.RESULTS In both conventional statistical and binary logistic regression analyses,the MIS group had a better outcome.The outcome of propensity score matching was unexpected(odds ratio:0.582;95%CI:0.281–1.204;P=0.144),which indicated that,after excluding the interference of each confounder,different surgical modalities were more effective,and there was no significant difference in their prognosis.CONCLUSION Deciding between MIS and CI should be made based on the individual patient,considering the hematoma size,degree of midline shift,cerebral swelling,and preoperative Glasgow Coma Scale score.

Prognostic value of intracranial pressure monitoring for the management of hypertensive intracerebral hemorrhage following minimally invasive surgery

BACKGROUND:The incidence of hypertensive intracerebral hemorrhage(HICH)has been increasing during the recent years in low-and middle-income countries.With high mortality and morbidity rates,it brings huge burden to the families.It lacks evidence regarding the application of intracranial pressure(ICP)monitoring in HICH.In the current study,the authors aimed to evaluate whether ICP monitoring could make any difference on the prognosis of HICH patients after minimally invasive surgery.METHODS:A retrospective review of 116 HICH patients admitted to the Second Affiliated Hospital of Zhejiang University School of Medicine,between 2014 and 2016,was performed.The effects of ICP monitoring on 6-month mortality and favorable outcomes were evaluated by univariate and logistic regression analysis.RESULTS:ICP monitors were inserted into 50 patients.Patients with ICP monitoring had a significantly better outcome(P<0.05).The average in-hospital duration in patients with ICP monitoring was shorter than that in the patients without ICP monitoring(16.68 days vs.20.47 days,P<0.05).Mortality rates between ICP monitoring and no ICP monitoring did not differ significantly(16.0%vs.15.1%,P=0.901).On univariate analysis,age,Glasgow Coma Scale(GCS)on admission and presence of ICP monitor were independent predictors of 6-month favorable outcomes.CONCLUSION:ICP monitoring is associated with a better 6-month functional outcome compared with no ICP monitoring.Future study is still needed to confirm our results and elucidate which subgroup of HICH patients will benefit most from the minimally invasive surgical intervention and ICP monitoring.

Association of Satellite Sign with Postoperative Rebleeding in Patients Undergoing Stereotactic Minimally Invasive Surgery for Hypertensive Intracerebral Haemorrhage

There are few studies regarding imaging markers for predicting postoperative rebleeding after stereotactic minimally invasive surgery(MIS)for hypertensive intracerebral haemorrhage(ICH),and little is known about the relationship between satellite sign on computed tomography(CT)scans and postoperative rebleeding after MIS.This study aimed to determine the value of the CT satellite sign in predicting postoperative rebleeding in patients with hypertensive ICH who undergo stereotactic MIS.We retrospectively examined and analysed 105 patients with hypertensive ICH who underwent standard stereotactic MIS for hematoma evacuation within 72 h following admission.Postoperative rebleeding occurred in 14 of 65(21.5%)patients with the satellite sign on baseline CT,and in 5 of the 40(12.5%)patients without the satellite sign.This diiTerence was statistically significant.Positive and negative values of the satellite sign for predicting postoperative rebleeding were 21.5%and 87.5%,respectively.Multivariate logistic regression analysis verified that baseline ICH volume and intraventricular rupture were independent predictors of postoperative rebleeding.In conclusion,the satellite sign on baseline CT scans may not predict postoperative rebleeding following stereotactic MIS for hypertensive ICH.

Short-term effect and long-term prognosis of neuroendoscopic minimally invasive surgery for hypertensive int-racerebral hemorrhage

BACKGROUND Hypertensive intracerebral hemorrhage is a common critical disease of the nervous system,comprising one fifth of all acute cerebrovascular diseases and has a high disability and mortality rate.It severely affects the patients’quality of life.AIM To analyze the short-term effect and long-term prognosis of neuroendoscopic minimally invasive surgery for hypertensive intracerebral hemorrhage.METHODS From March 2018 to May 2020,118 patients with hypertensive intracerebral hemorrhage were enrolled in our study and divided into a control group and observation group according to the surgical plan.The control group used a hard-channel minimally invasive puncture and drainage procedure.The observation group underwent minimally invasive neuroendoscopic surgery.The changes in the levels of serum P substances(SP),inflammatory factors[tumor necrosis factor-α,interleukin-6(IL-6),IL-10],and the National Hospital Stroke Scale(NIHSS)and Barthel index scores were recorded.Surgery related indicators and prognosis were compared between the two groups.RESULTS The operation time(105.26±28.35)of the observation group was min longer than that of the control group,and the volume of intraoperative bleeding was 45.36±10.17 mL more than that of the control group.The hematoma clearance rates were 88.58%±4.69%and 94.47%±4.02%higher than those of the control group at 48 h and 72 h,respectively.Good prognosis rate(86.44%)was higher in the observation group than in the control group,and complication rate(5.08%)was not significantly different from that of the control group(P>0.05).The SP level and Barthel index score of the two groups increased(P<0.05)and the inflam-matory factors and NIHSS score decreased(P<0.05).The cytokine levels,NIHSS score,and Barthel index score were better in the observation group than in the control group(P<0.05).CONCLUSION Neuroendoscopic minimally invasive surgery is more complicated than hard channel minimally invasive puncture drainage in the treatment of hypertensive intracerebral hemorrhage;however,hematoma clearance is more thorough,and the short-term effect and long-term prognosis are better than hard channel minimally invasive puncture drainage.

Effect of urokinase in combined with minimally invasive intracranial hematoma evacuation on serum ferritin, serum P substance, inflammatory factors and vascular endothelial function in patients with hypertensive intracerebral hemorrhage

Objective: To investigate the effects of minimally invasive evacuation of intracranial hematoma on serum SP, SF, vascular endothelial function and inflammatory factors of patients with hypertensive intracerebral hemorrhage. Methods: According to random data table method, a total of 120 patients with hypertensive cerebral hemorrhage from September 2016 to May 2017 were divided into observation group and the control group, 60 cases in each group. The control group was treated with conventional treatment;on the basis of conventional treatment, the observation group underwent minimally invasive evacuation of intracranial hematoma. The levels of serum SF, SP, vascular endothelial function and inflammatory factors changes were compared between the two groups before and after the treatment. Results: Before treatment, the levels of serum SP, SF, NO, ET-1, hs-CRP, IL-6, TNF-α in the two groups were not statistically significant. The levels of hs-CRP, IL-6, TNF-α, SF, ET-1 after treatment in two groups were significantly lower than those in the same group before treatment, and the observation group levels were significantly lower than those in the control group;the levels of SP, NO in the two groups after treatment were significantly higher than before treatment, and the observation group was higher than that the control group with significant difference. Conclusion: The minimally invasive intracranial hematoma evacuation for patients with HICH can effectively improve the levels of SP, SF, inflammatory factors and vascular endothelial function, which is helpful to relieve cerebral edema and lower intracranial pressure, and improve the quality of treatment.

Effect of urokinase in combined with minimally invasive hematoma puncture with YL-1 type needle on the blood sugar and serum CRP in patients with hypertensive cerebral hemorrhage

Objective:To observe the clinical efficacy of urokinase in combined with minimally invasive hematoma puncture with YL-1 type needle in the treatment of hypertensive cerebral hemorrhage and the effect on blood sugar and serum CRP.Methods:A total of 84 patients with hypertensive cerebral hemorrhage who were admitted in our hospital were included in the study and divided into the minimally invasive group (n=53) and the conservative group (n=31) according to different treatment protocols. The patients in the two groups were given routine drug treatments. The patients in the observation group were given urokinase in combined with minimally invasive hematoma puncture with YL-1 type needle. The blood sugar and serum CRP levels before and after treatment in the two groups were compared. CT was performed to reexamine the cerebral hematoma and edema volume.Results: The serum CRP and blood sugar levels 3, 7 and 14 d after treatment in the minimally invasive group were significantly lower than those in the conservative group (P<0.05). The cerebral hematoma and edema volume 1, 3, 7, and 14 d after treatment in the minimally invasive group was significantly lower than that in the conservative group (P<0.05).Conclusions: Urokinase in combined with minimally invasive hematoma puncture with YL-1 type needle in the treatment of hypertensive cerebral hemorrhage can significantly alleviate the brain tissue injury, reduce the systemic inflammatory reaction and blood sugar level, and contribute to the rehabilitation.

Intraclot Recombinant Tissue-type Plasminogen Activator Reduces Perihematomal Edema and Mortality in Patients with Spontaneous Intracerebral Hemorrhage

The study aimed to investigate the impact of intraclot recombinant tissue-type plasminogen activator （rt-PA） on perihematomal edema （PHE） development in patients with intracerebral hemorrhage （ICH） treated with minimally invasive surgery （MIS） and the effects of intraclot rt-PA on the 30-day survival. We reviewed the medical records of ICH patients undergoing MIS between October 2011 and July 2013. A volumetric analysis was done to assess the change in PHE and ICH volumes at pre-MIS （T1）, post-MIS （T2） and day 10-16 （T3） following diagnostic computed tomographic scans （To）. Forty-three patients aged 52.8±11.1 years with （n=30） or without rt-PA （n=13） were enrolled from our institutional ICH database. The median rt-PA dose was 1.5 （1） mg, with a maximum dose of 4.0 mg. The ratio of clot evacuation was significantly increased by intraclot rt-PA as compared with controls （77.9%±20.4% vs. 64%±15%; P=0.046）. From TI to T2, reduction in PHE volume was strongly associ- ated with the percentage of clot evacuation （p=0.34; P=-0.027）. In addition, PHE volume was positively correlated with residual ICH volume at the same day （p ranging from 0.39-0.56, P〈0.01）. There was no correlation between the cumulative dose of rt-PA and early （T2） PHE volume （p=0.24; P=0.12） or de- layed （T3） PHE volume （p=0.19; P=0.16）. The 30-day mortality was zero in this cohort. In the selected cohort of ICH patients treated with MIS, intraclot rt-PA accelerated clot removal and had no effects on PHE formation. MIS aspiration and low dose of rt-PA seemed to be feasible to reduce the 30-day mor- tality in patients with severe ICH. A large, randomized study addressing dose titration and long-term outcome is needed.

幕上高血压性脑出血微创颅内血肿抽吸引流术后早期神经功能恶化危险因素分析

目的分析幕上高血压性脑出血微创颅内血肿抽吸引流术后发生早期神经功能恶化(early neurological deterioration,END)的危险因素。方法本研究为回顾性病例研究,连续纳入2018年10月—2022年12月首都医科大学附属北京天坛医院急诊神经内科收治的微创颅内血肿抽吸引流术治疗的幕上高血压性脑出血患者,记录患者人口学特征和临床信息,以及血肿体积、部位、周围灌注等影像学信息。END定义为手术后24 h内NIHSS评分增加≥4分或GCS评分下降≥2分。将单因素分析中差异有统计学意义的变量纳入多因素logistic回归模型(后退法),分析影响患者END的独立危险因素。绘制独立危险因素预测END的ROC曲线并计算AUC,采取De Long检验比较不同独立危险因素的预测能力。结果共入组157例患者,平均年龄为(57.1±13.1)岁。20例(12.7%)患者出现END。多因素logistic回归分析显示,术前血肿体积(OR 1.024,95%CI 1.001~1.047,P=0.043)、术后血肿扩大(OR 41.605,95%CI 7.405~233.765,P<0.001)、术前低灌注体积(OR 1.011,95%CI 1.002~1.020,P=0.012)等3个因素可独立预测END的发生。其中术前低灌注体积ROC的AUC为0.921,敏感度为0.824,特异度为0.891,截断值为119.0 mL。De Long检验显示,术前低灌注体积对END的预测效力优于术前血肿体积及术后血肿扩大。结论术前低灌注体积与幕上高血压性脑出血患者微创颅内血肿抽吸引流术后发生END独立相关,低灌注体积越大,术后END发生的风险越高。

术前血清碱性磷酸酶、骨桥蛋白与基底节区脑出血患者神经内镜清除术预后的关系

目的分析术前血清碱性磷酸酶(ALP)与骨桥蛋白(OPN)与基底节区脑出血患者神经内镜清除术预后的关系,评估其对患者预后的预测价值。方法回顾性采集2019年1月至2023年6月于商丘市第一人民医院完成神经内镜下微创血肿清除术治疗的65例基底节区脑出血患者的资料。记录研究所需实验室指标结果数据,包括术前及术后血清ALP、OPN水平,统计术后1个月患者预后情况,分析脑出血患者术前血清ALP、OPN与预后的关系。结果65例基底节区脑出血患者预后不良14例,占比21.54%。术前及术后,预后不良组患者血清ALP、OPN高于预后良好组(P<0.05)。经过点二列相关性分析,术前血清ALP、OPN与脑出血患者预后不良呈正相关关系(r>0,P<0.05)。绘制受试者工作特征(ROC)曲线,结果显示,术前血清ALP、OPN预测脑出血患者预后不良的曲线下面积(AUC)均>0.70,联合预测的AUC>0.80,联合预测价值更高。结论基底节区脑出血患者神经内镜清除术前ALP、OPN越高,预后不良的可能性越大,术前ALP、OPN可以作为基底节区脑出血患者神经内镜清除术后预后不良的有效预测指标。

醒脑静注射液联合立体定向微创治疗对高血压脑出血患者的应用效果

目的探讨醒脑静注射液联合立体定向微创治疗对高血压脑出血患者的应用效果。方法选取2018年1月至2023年1月九江市第一人民医院神经外科收治的80例高血压脑出血患者作为研究对象,根据随机数字表法将患者分为对照组和观察组,每组各40例。对照组采用小骨窗开颅术治疗,观察组采用醒脑静注射液联合立体定向微创治疗。比较两组患者的手术时间、血肿清除率、并发症(包括肺部感染、消化道出血、二次出血)发生率及术后生活自理能力情况。结果观察组的手术时间短于对照组,血肿清除率>80%的比例高于对照组,差异有统计学意义(P<0.05)。观察组术后1个月的并发症总发生率低于对照组,差异有统计学意义(P<0.05)。观察组的术后生活自理能力评分高于对照组,差异有统计学意义(P<0.05)。结论醒脑静注射液联合立体定向微创治疗高血压脑出血患者,可以缩短手术时间,提高血肿清除率,且其并发症相对较少,同时术后患者日常生活自理水平提高明显,值得临床推广应用。

中等量高血压脑出血机器人辅助穿刺微创手术与保守治疗的临床研究

目的:探究中等量高血压脑出血机器人辅助穿刺微创手术与保守治疗比较。方法:选取2021年7月~2022年7月华中科技大学协和深圳医院100例中等量高血压脑出血患者,采用随机数字表法分为参照组(保守治疗)和试验组(机器人辅助穿刺微创手术)各50例,对干预效果进行比较。结果:试验组总有效率94.00%高于参照组72.00%,差异有统计学意义(P<0.05),试验组失血量、手术、血肿清除、脑脊液恢复、置管引流、住院时长均少于参照组,差异有统计学意义(P<0.05),手术后1 min、1 d、3 d试验组的颅内压小于参照组,差异有统计学意义(P<0.05),两组手术前的炎性因子比较,差异无统计学意义(P>0.05),试验组手术后的肿瘤坏死因子-α(TNF-α)、C反应蛋白(CRP)、白介素-6(IL-6)均小于参照组,差异有统计学意义(P<0.05),研究对象手术前的神经功能缺损(NIHSS)、日常生活能力(ADL)、格拉斯昏迷评分(GCS)、格拉斯哥预后评分(GOS)比较,差异无统计学意义(P>0.05),试验组手术后的NIHSS评分低于参照组,但ADL、GCS、GOS评分高于参照组,差异有统计学意义(P<0.05)。结论:机器人辅助穿刺微创手术能够快速降低患者颅内压,并清除血肿,缩短住院天数,促进炎性反应消失,改善患者神经功能,促进预后。

两种手术方式治疗高血压脑出血患者的临床效果及复发因素探讨

目的 探讨微创穿刺血肿引流术(MIPHD)与开颅血肿清除术治疗高血压脑出血(HICH)的效果以及复发的危险因素。方法 80例HICH患者根据治疗方案的不同分为MIPHD组和开颅手术组,比较两组的治疗效果和临床指标,分析影响HICH患者复发的危险因素。结果 治疗后,两组的NIHSS评分均显著低于治疗前(P <0.05)。Logistic回归分析显示,入院SBP、出血量、凝血机制异常是影响HICH患者术后复发的危险因素(P <0.05)。结论 微创穿刺血肿引流术和开颅血肿清除术均可改善HICH患者的神经缺损程度,对于术前SBP过高、出血量偏大、凝血机制异常的患者,应警惕术后HICH的复发。

微创法腋臭去除术患者的手术配合以及护理分析

目的研究微创法腋臭去除术患者的手术护理配合以及护理方案。方法于我院微创法腋臭去除术治疗期间实施综合护理前后各随机抽取32例患者中,并作为对照组(实施前,行常规护理)和观察组(实施后,行综合护理),对比两组护理效果。结果观察组依从率(100.00%)较对照组(81.25%)明显提高(P<0.05)。观察组SAS(42.68±4.74)分,SDS(40.69±5.76)分,低于对照组[SAS(54.39±4.60)分,SDS(52.46±4.92)分](P<0.05)。观察组皮肤瘀斑1例(3.13%),皮下积液1例(3.13%),未见切口感染、血肿,合计2例(6.25%),少于对照组[皮肤瘀斑2例(6.25%),皮下积液3例(9.38%),切口感染2例(6.25%),血肿2例(6.25%),合计9例(28.13%)](P<0.05)。观察组满意度(96.88%)高于对照组(71.88%)(P<0.05)。观察组GCQ(76.22±6.39)分,显著优于对照组[GCQ(68.19±4.57)分](P<0.05)。结论对于微创法腋臭去除术患者的手术配合采取综合护理,可以缓解患者不良情绪,预防并发症,提高患者配合度和满意度,具有较高临床价值。

神经内镜微创手术治疗高血压脑出血的效果分析

目的:分析神经内镜微创手术治疗高血压脑出血的效果。方法:选取2020年1月—2022年12月新疆生产建设兵团第一师医院收治的高血压脑出血患者120例作为研究对象,依据双色球法分为观察组与对照组,各60例。对照组采取开颅血肿清除术治疗,观察组采取神经内镜微创手术治疗。比较两组临床疗效。结果:观察组手术时间短于对照组,术中出血量少于对照组,血肿清除率高于对照组,差异有统计学意义(P<0.001)。观察组术后并发症发生率低于对照组,差异有统计学意义(P=0.031)。观察组治疗总有效率高于对照组,差异有统计学意义(P=0.028)。观察组重症监护室观察时间及整体治疗时间短于对照组,差异有统计学意义(P<0.001)。结论:神经内镜微创手术治疗高血压脑出血的效果较好,其手术时间短、术中出血量少、血肿清除率高,术后并发症发生率低,患者恢复速度快。

清震汤加减联合微创血肿清除术治疗高血压脑出血临床研究

目的:观察清震汤加减联合微创血肿清除术治疗高血压脑出血的治疗效果。方法:抽取98例高血压脑出血患者为研究对象,按照随机数字表法分为试验组和对照组各49例。对照组行微创血肿清除术,术后给予西医常规治疗,试验组在对照组基础上联合清震汤加减治疗。比较2组颅内压(ICP)、美国国立卫生院卒中量表(NIHSS)评分与格拉斯哥昏迷指数(GCS),脑水肿体积和持续时间,血清肿瘤坏死因子-α(TNF-α)、神经生长因子(NGF)、基质金属蛋白酶-9(MMP-9)水平及中医证候评分。结果:术前,2组ICP值比较,差异无统计学意义(P>0.05);术后即刻及24 h、72 h、1周,试验组相同时间点的ICP值均低于对照组(P<0.05)。术前,2组NIHSS、GCS指数评分比较,差异无统计学意义(P>0.05);术后14 d,试验组NIHSS评分低于对照组(P<0.05),GCS指数高于对照组(P<0.05)。术后,试验组脑水肿体积、脑水肿持续时间低于对照组,差异有统计学意义(P<0.05)。术前,2组血清TNF-α、MMP-9、NGF水平比较,差异无统计学意义(P>0.05)。术后14 d,2组血清TNF-α、MMP-9水平较术前下降(P<0.05),血清NGF水平较术前上升(P<0.05);且试验组血清TNF-α、MMP-9水平低于对照组(P<0.05),NGF水平高于对照组(P<0.05)。术前,2组半身不遂、口眼歪斜、神志昏蒙等中医证候评分比较,差异无统计学意义(P>0.05);术后14 d,试验组上述各项中医证候评分均低于对照组(P<0.05)。结论:微创血肿清除术联合清震汤加减治疗高血压脑出血可降低ICP,减轻卒中症状和昏迷指数,减轻脑水肿,改善中医证候及炎症反应。

CT定位辅助下微创穿刺引流术对高血压脑出血患者神经功能缺损评分与并发症发生情况的影响

目的探讨CT定位辅助下微创穿刺引流术对高血压脑出血(HICH)患者神经功能缺损评分与并发症发生情况的影响。方法选取2019年1月至2022年3月昌邑市人民医院收治的96例HICH患者作为研究对象,按照奇偶数法分为A组与B组,每组48例。A组行CT定位辅助下微创穿刺引流术治疗,B组行小骨窗开颅血肿清除术治疗,比较两组基本手术指标、神经功能损伤程度[神经功能缺损评分(NFDS)]及日常生活能力[Barthel指数评定量表(BI)]、生命质量[脑卒中影响量表(SIS)]、血管内皮功能[一氧化氮(NO)、内皮素-1(ET-1)]、并发症发生情况、不良事件发生情况。结果A组术中出血量少于B组,住院时间短于B组,血肿清除率高于B组,差异有统计学意义(P<0.05)。治疗后,两组NFDS评分均低于治疗前,BI评分均高于治疗前,且A组NFDS评分低于B组,BI评分高于B组,差异有统计学意义(P<0.05)。治疗后,两组交流、日常生活能力、移动能力、情感、参与、力气、手功能、记忆与思维评分均高于治疗前,且A组高于B组,差异有统计学意义(P<0.05)。治疗后,两组NO水平均高于治疗前,ET-1水平均低于治疗前,且A组NO水平高于B组,ET-1水平低于B组,差异有统计学意义(P<0.05)。A组并发症发生率低于B组,差异有统计学意义(P<0.05)。两组不良事件发生率比较差异无统计学意义。结论CT定位辅助下微创穿刺引流术疗效更佳,可有效减轻患者神经功能损伤,减少并发症发生,值得临床推广应用。

血肿微创清除联合脑血疏口服液治疗自发性脑出血的疗效及安全性的Meta分析与质量评价

目的:系统评价颅内血肿微创清除手术联合脑血疏口服液治疗自发性脑出血的疗效及安全性。方法:计算机检索从建库至2023年6月收录于中国期刊全文数据库(China National Knowledge Infrastructure,CNKI)、维普中文科技期刊数据库(VIP Chinese science and technology journal database,VIP)、万方数据库、中国生物医学文献数据库(The Chinese biomedical literature database,CBM)、PubMed、Embase、the Cochrane Library等中英文数据库,结合纳入与排除标准筛选出所有颅内血肿微创清除手术联合脑血疏口服液治疗自发性脑出血的临床随机对照试验,根据Cochrane系统评价手册对纳入研究进行偏倚风险评价,运用Revman5.4软件进行Meta分析,最后采用GRADE系统对结局指标进行证据质量评价。结果:共纳入9项研究,总样本量739例。其中,对照组371例,试验组368例。Meta分析结果显示,与血肿微创清除后仅予常规西医治疗相比,联合应用脑血疏口服液能够提高自发性脑出血患者临床治疗的总有效率[OR=5.47,95%CI=2.28,13.09,P=0.0001],在降低患者美国国立卫生研究所卒中量表评分[MD=−3.42,95%CI=−4.97,−1.87,P<0.0001]和中国脑卒中患者神经功能缺损程度评分[MD=−2.30,95%CI=−3.01,−1.58,P<0.00001],提高患者格拉斯哥昏迷量表(Glasgow coma scale,GCS)评分[MD=1.51,95%CI=1.13,1.89,P<0.00001]和Barthel指数(Barthel index,BI)评分[MD=6.88,95%CI=4.49,9.27,P<0.00001],降低血清S100蛋白[MD=−0.02,95%CI=−0.03,−0.02,P<0.00001]和水通道蛋白4水平[MD=−0.02,95%CI=−0.03,−0.01,P=0.002]方面均具有明显优势。安全性方面,所纳研究均无严重不良反应;2项研究报告有恶心、腹胀、腹泻的胃肠道不适症状,其余研究未报告不良反应发生。结论:现有证据表明,颅内血肿微创清除手术联合脑血疏口服液治疗自发性脑出血疗效确切,能够明显减轻患者神经功能缺损和意识障碍程度,提高患者日常生活能力,改善患者生活质量,且具有一定的安全性。

自发性脑出血微创血肿清除术的研究进展

自发性脑出血(SICH)是一种高病死率和致残率的脑卒中疾病,微创血肿清除术可降低SICH患者的病死率并改善其功能预后。目前,有多种微创颅内血肿清除术可供选择,但各种技术的难易程度和疗效参差不齐。选择适宜或最佳的脑出血微创治疗方案对改善SICH患者的预后有重要意义。本文回顾了关于SICH微创血肿清除术的文献,分析主要几种手术的优缺点,为神经科医生选择最佳的脑出血微创治疗方案提供参考。目前尚无公认的最佳脑出血微创血肿清除术,但正在进行的多项大型微创血肿清除术临床试验有望为脑出血的最佳微创治疗策略提供重要信息。

立体定向仪联合颅内血肿清除术对高血压脑出血患者术后并发症及神经功能的影响

目的探究立体定向仪联合颅内血肿清除术对高血压脑出血患者术后并发症及神经功能的影响。方法选取2023年1月至2024年1月本院收治的80例高血压脑出血患者作为研究对象,采用随机数字表法分为对照组和试验组,各40例,对两组患者的均开展颅内血肿清除术,其中对照组采用简易定位颅内血肿清除术,试验组采用立体定向下颅内血肿清除术,对比两组患者的相关临床指标。结果试验组患者的神经功能、日常生活评分及手术指标均优于对照组(P<0.05);试验组炎性因子水平指标及并发症发生率均低于对照组(P<0.05)。结论通过立体定向仪结合颅内血肿清除术的方式能够有效改善患者的神经功能,让患者的术后并发症得到减少,有效保障患者的预后水平。

机器人辅助下HICH患者颅内血肿穿刺引流术

高血压脑出血(HICH)是一种致死率和致残率均较高的脑卒中类型,外科手术作为HICH的重要治疗方式之一,能有效解除血肿压迫、缓解颅内高压。随着神经外科手术机器人的不断完善与升级,微创外科技术在HICH治疗中已取得重大突破,机器人辅助颅内血肿穿刺引流可有效提高引流管置入精准度并缩短手术时间,在治疗HICH患者中具有明显优势。本文将介绍机器人辅助下颅内血肿穿刺引流术的详细操作步骤,为HICH患者的临床治疗提供参考。