When watching someone performs an action, mirror neurons are activated in a way that is very similar to the activation that occurs when actually performing that action. Previous single-sample case studies indicate tha...When watching someone performs an action, mirror neurons are activated in a way that is very similar to the activation that occurs when actually performing that action. Previous single-sample case studies indicate that hand-action observation training may lead to activation and remodeling of mirror neuron systems, which include important language centers, and may improve language function in aphasia patients. In this randomized-block-design experiment, we recruited 24 aphasia patients from, Zhongda Hospital, Southeast University, China. The patients were divided into three groups where they underwent hand-action observation and repetition, dynamic-object observation and repetition, or conventional speech therapy. Training took place 5 days per week, 35 minutes per day, for 2 weeks. We assessed language function via picture naming tests for objects and actions and the Western Aphasia Battery. Among the participants, one patient, his wife and four healthy student volunteers underwent functional magnetic resonance imaging to analyze changes in brain activation during hand-action observation and dynamic-object observation. Results demonstrated that, compared with dynamic-object observation, hand-action observation led to greater performance with respect to the aphasia quotient and affiliated naming sub-tests and a greater Western Aphasia Battery test score. The overall effect was similar to that of conventional aphasia training, yet hand-action observation had advantages compared with conventional training in terms of vocabulary extraction and spontaneous speech. Thus, hand-action observation appears to more strongly activate the mirror neuron system compared with dynamic-object observation. The activated areas included Broca's area, Wernicke's area, and the supramarginal gyrus. These results suggest that hand-action observation combined with repetition might better improve language function in aphasia patients compared with dynamic-object observation combined with repetition. The therapeutic mechanism of this intervention may be associated with activation of additional mirror neuron systems, and may have implications for the possible repair and remodeling of damaged nerve networks. The study protocol was approved by the Ethical Committee of Nanjing Medical University, China(approval number: 2011-SRFA-086) on March 11, 2011. This trial has been registered in the ISRCTN Registry(ISRCTN84827527).展开更多
Introduction: Mental exercise using the mirror therapy (MT) improves the retention of newly acquired skills and the performance of sequential motor skills in subjects with post-stroke hemiparesis. Objectives: The stud...Introduction: Mental exercise using the mirror therapy (MT) improves the retention of newly acquired skills and the performance of sequential motor skills in subjects with post-stroke hemiparesis. Objectives: The study aimed to analyze the mirror therapy effect on the range of motion and the lower limb functionality in post-stroke hemiparesis subjects. Materials and Methods: Eleven participants with hemiparesis in the lower limb were subjected to the 10 sessions of a MT protocol. The interventions were three times per week per 30 minutes each day. Evaluation of active and passive ankle goniometry (dorsiflexion and eversion movements);Ascent and Descent Ladder Rate (ADLR);Time Up and Go test (TUG test);EFEI scale;and FAAM scale were performed. The data were collected before and after the intervention using MT, and then statistically compared. Results: The MT improved significantly (p < 0.01) the range of motion of the paretic lower limb both evaluated by active and passive ankle goniometry. An increase in the speed of gait and other functional tasks related to the paretic lower limbs were found through the TUG and ADLR tests. It also demonstrated a positive influence on the functionality of the paretic lower limb motor control through the analysis of the scores in the FAAM and EFEI scales. Conclusion: It is concluded that the MT therapy can help the patients with post-stroke hemiparesis in the improvement of several functions. Probably, the mirror therapy would aid in the repair of the injuries in the cortical areas.展开更多
目的观察针刺联合镜像疗法治疗脑卒中患者上肢运动功能障碍的临床疗效。方法将90例脑卒中上肢运动功能障碍患者按随机数字表法分为对照1组(30例,给予针刺治疗)、对照2组(30例,给予镜像疗法治疗)和观察组(30例,给予针刺联合镜像疗法治疗)...目的观察针刺联合镜像疗法治疗脑卒中患者上肢运动功能障碍的临床疗效。方法将90例脑卒中上肢运动功能障碍患者按随机数字表法分为对照1组(30例,给予针刺治疗)、对照2组(30例,给予镜像疗法治疗)和观察组(30例,给予针刺联合镜像疗法治疗),疗程均为2周。比较3组患者治疗前后Fugl-Meyer评估量表上肢板块(Fugl-Meyer assessment upper extremity,FMA-UE)评分,Wolf运动功能测试(Wolf motor function test,WMFT)量表评分,改良Barthel指数(modified Barthel index,MBI),国际功能、残疾和健康分类(international classification of functioning,disability and health,ICF)评分及伸腕主动运动范围(active range of motion,AROM)和基于FMA-UE评分判定临床疗效。结果观察组临床疗效优于对照1组和对照2组(P<0.05);治疗后3组患者FMA-UE评分、WMFT评分、MBI均较治疗前显著增加(P<0.05),ICF评分显著减少(P<0.05),且观察组FMA-UE评分、WMFT评分、MBI增加程度,ICF评分减少程度显著大于对照1组和对照2组(P<0.05);治疗后观察组患者伸腕AROM显著大于对照1组和对照2组(P<0.05)。结论针刺联合镜像疗法能有效改善脑卒中患者上肢运动功能障碍。展开更多
目的探讨基于镜像理论指导下的运动处方对断指再植术后患者再植断指恢复的影响。方法选取郑州市骨科医院2021年7月至2023年7月收治的89例断指再植术术后患者,使用信封随机抽取住院号方式分为两组。对照组44例患者给予常规康复训练运动处...目的探讨基于镜像理论指导下的运动处方对断指再植术后患者再植断指恢复的影响。方法选取郑州市骨科医院2021年7月至2023年7月收治的89例断指再植术术后患者,使用信封随机抽取住院号方式分为两组。对照组44例患者给予常规康复训练运动处方,研究组45例患者给予基于镜像理论指导下的运动处方,两组患者均干预12周。比较两组患者干预前后手指活动度[手指关节总主动活动度(total angle of motion,TAM)]、手功能[Michigan手功能评估量表(Michigan hand outcomes questionnaire,MHQ)]、断指再植功能(中华医学会手外科学会断指再植功能评定试用标准)、断指感觉功能[静态两点辨别觉(static two-point discrimination,S2PD)]及生活质量[Barthel评分(Barthel index,BI)]。结果两组患者干预前MHQ、TAM、S2PD评分及BI评分差异无统计学意义(P>0.05),干预后两组患者均有不同程度改善。研究组患者工作能力评分(72.41±5.26)分、整体手功能评分(79.63±3.81)分、日常活动评分(81.19±4.72)分、对手功能的满意度评分(73.69±5.38)分、外观评分(63.48±6.32)分,均高于对照组患者工作能力评分(61.28±6.38)分、整体手功能评分(74.35±4.68)分、日常活动评分(76.47±5.69)分、对手功能的满意度评分(67.35±5.64)分、外观评分(56.37±6.57)分,研究组疼痛评分(48.34±7.88)分低于对照组(54.48±7.61)分(P<0.05)。研究组患者干预后TAM评分(151.64±10.96)分、BI评分(77.58±5.48)分,高于对照组患者TAM评分(139.19±10.37)分、BI评分(73.49±5.36)分;研究组S2PD(9.56±2.14)mm低于对照组(12.69±2.43)mm(P<0.05)。两组患者干预前断指功能评分差异无统计学意义(P>0.05),干预后两组患者均有提升,研究组患者断指功能评分(82.68±6.51)分、干预后断指再植功能优秀率24.44%,高于对照组患者断指功能评分(75.39±6.34)分、干预后断指再植功能优秀率6.82%(P<0.05)。结论基于镜像理论指导下的运动处方可有效提升断指再植术后患者手指关节活动度及感觉功能,促进再植断指功能恢复,改善患者生活质量。展开更多
目的探讨脊柱微创通道镜系统辅助椎间孔腰椎椎体间融合术(TLIF)对腰椎退行性疾病患者脊髓功能及血清P物质(SP)、前列腺素E2(PGE2)水平的影响。方法选取51例腰椎退行性疾病患者,按照入院次序单双号法分为A组(n=25)及B组(n=26)。A组行脊...目的探讨脊柱微创通道镜系统辅助椎间孔腰椎椎体间融合术(TLIF)对腰椎退行性疾病患者脊髓功能及血清P物质(SP)、前列腺素E2(PGE2)水平的影响。方法选取51例腰椎退行性疾病患者,按照入院次序单双号法分为A组(n=25)及B组(n=26)。A组行脊柱微创通道镜系统辅助TLIF术治疗,B组行常规TLIF术治疗。比较两组手术指标,腰腿部疼痛与功能障碍状况,脊髓功能,血清P物质(SP)、前列腺素E2(PGE2)水平。结果A组术中失血量、术后引流量均少于B组,下床活动时间短于B组(P<0.05);术后4周两组腰腿部视觉模拟评分法(VAS)与Oswestry障碍指数(ODI)评分均较术前均明显改善(P<0.05);术后7 d两组各项脊髓功能指标较术前均明显改善,且A组改善幅度优于B组(P<0.05);术后3 d A组血清SP水平高于B组,而血清PGE2水平低于B组(P<0.05)。结论脊柱微创通道镜系统辅助TLIF术可显著改善腰椎退行性疾病患者脊髓功能以及疼痛介质水平。展开更多
基金supported by the National Natural Science Foundation of China,No.81472163,81874035(to CLS)the General Project of University Philosophy and Social Science Research of China,No.2016SJB740015(to QY)+1 种基金the Science and Technology Plan Project of Zhangjiagang city of China in 2016,No.ZKS1615(to WLC)the Youth Science and Technology Project of Suzhou Health Development through Scientific Research and Education in 2018,No.KJXW2018059(to WLC)
文摘When watching someone performs an action, mirror neurons are activated in a way that is very similar to the activation that occurs when actually performing that action. Previous single-sample case studies indicate that hand-action observation training may lead to activation and remodeling of mirror neuron systems, which include important language centers, and may improve language function in aphasia patients. In this randomized-block-design experiment, we recruited 24 aphasia patients from, Zhongda Hospital, Southeast University, China. The patients were divided into three groups where they underwent hand-action observation and repetition, dynamic-object observation and repetition, or conventional speech therapy. Training took place 5 days per week, 35 minutes per day, for 2 weeks. We assessed language function via picture naming tests for objects and actions and the Western Aphasia Battery. Among the participants, one patient, his wife and four healthy student volunteers underwent functional magnetic resonance imaging to analyze changes in brain activation during hand-action observation and dynamic-object observation. Results demonstrated that, compared with dynamic-object observation, hand-action observation led to greater performance with respect to the aphasia quotient and affiliated naming sub-tests and a greater Western Aphasia Battery test score. The overall effect was similar to that of conventional aphasia training, yet hand-action observation had advantages compared with conventional training in terms of vocabulary extraction and spontaneous speech. Thus, hand-action observation appears to more strongly activate the mirror neuron system compared with dynamic-object observation. The activated areas included Broca's area, Wernicke's area, and the supramarginal gyrus. These results suggest that hand-action observation combined with repetition might better improve language function in aphasia patients compared with dynamic-object observation combined with repetition. The therapeutic mechanism of this intervention may be associated with activation of additional mirror neuron systems, and may have implications for the possible repair and remodeling of damaged nerve networks. The study protocol was approved by the Ethical Committee of Nanjing Medical University, China(approval number: 2011-SRFA-086) on March 11, 2011. This trial has been registered in the ISRCTN Registry(ISRCTN84827527).
文摘Introduction: Mental exercise using the mirror therapy (MT) improves the retention of newly acquired skills and the performance of sequential motor skills in subjects with post-stroke hemiparesis. Objectives: The study aimed to analyze the mirror therapy effect on the range of motion and the lower limb functionality in post-stroke hemiparesis subjects. Materials and Methods: Eleven participants with hemiparesis in the lower limb were subjected to the 10 sessions of a MT protocol. The interventions were three times per week per 30 minutes each day. Evaluation of active and passive ankle goniometry (dorsiflexion and eversion movements);Ascent and Descent Ladder Rate (ADLR);Time Up and Go test (TUG test);EFEI scale;and FAAM scale were performed. The data were collected before and after the intervention using MT, and then statistically compared. Results: The MT improved significantly (p < 0.01) the range of motion of the paretic lower limb both evaluated by active and passive ankle goniometry. An increase in the speed of gait and other functional tasks related to the paretic lower limbs were found through the TUG and ADLR tests. It also demonstrated a positive influence on the functionality of the paretic lower limb motor control through the analysis of the scores in the FAAM and EFEI scales. Conclusion: It is concluded that the MT therapy can help the patients with post-stroke hemiparesis in the improvement of several functions. Probably, the mirror therapy would aid in the repair of the injuries in the cortical areas.
文摘目的观察针刺联合镜像疗法治疗脑卒中患者上肢运动功能障碍的临床疗效。方法将90例脑卒中上肢运动功能障碍患者按随机数字表法分为对照1组(30例,给予针刺治疗)、对照2组(30例,给予镜像疗法治疗)和观察组(30例,给予针刺联合镜像疗法治疗),疗程均为2周。比较3组患者治疗前后Fugl-Meyer评估量表上肢板块(Fugl-Meyer assessment upper extremity,FMA-UE)评分,Wolf运动功能测试(Wolf motor function test,WMFT)量表评分,改良Barthel指数(modified Barthel index,MBI),国际功能、残疾和健康分类(international classification of functioning,disability and health,ICF)评分及伸腕主动运动范围(active range of motion,AROM)和基于FMA-UE评分判定临床疗效。结果观察组临床疗效优于对照1组和对照2组(P<0.05);治疗后3组患者FMA-UE评分、WMFT评分、MBI均较治疗前显著增加(P<0.05),ICF评分显著减少(P<0.05),且观察组FMA-UE评分、WMFT评分、MBI增加程度,ICF评分减少程度显著大于对照1组和对照2组(P<0.05);治疗后观察组患者伸腕AROM显著大于对照1组和对照2组(P<0.05)。结论针刺联合镜像疗法能有效改善脑卒中患者上肢运动功能障碍。
文摘目的探讨基于镜像理论指导下的运动处方对断指再植术后患者再植断指恢复的影响。方法选取郑州市骨科医院2021年7月至2023年7月收治的89例断指再植术术后患者,使用信封随机抽取住院号方式分为两组。对照组44例患者给予常规康复训练运动处方,研究组45例患者给予基于镜像理论指导下的运动处方,两组患者均干预12周。比较两组患者干预前后手指活动度[手指关节总主动活动度(total angle of motion,TAM)]、手功能[Michigan手功能评估量表(Michigan hand outcomes questionnaire,MHQ)]、断指再植功能(中华医学会手外科学会断指再植功能评定试用标准)、断指感觉功能[静态两点辨别觉(static two-point discrimination,S2PD)]及生活质量[Barthel评分(Barthel index,BI)]。结果两组患者干预前MHQ、TAM、S2PD评分及BI评分差异无统计学意义(P>0.05),干预后两组患者均有不同程度改善。研究组患者工作能力评分(72.41±5.26)分、整体手功能评分(79.63±3.81)分、日常活动评分(81.19±4.72)分、对手功能的满意度评分(73.69±5.38)分、外观评分(63.48±6.32)分,均高于对照组患者工作能力评分(61.28±6.38)分、整体手功能评分(74.35±4.68)分、日常活动评分(76.47±5.69)分、对手功能的满意度评分(67.35±5.64)分、外观评分(56.37±6.57)分,研究组疼痛评分(48.34±7.88)分低于对照组(54.48±7.61)分(P<0.05)。研究组患者干预后TAM评分(151.64±10.96)分、BI评分(77.58±5.48)分,高于对照组患者TAM评分(139.19±10.37)分、BI评分(73.49±5.36)分;研究组S2PD(9.56±2.14)mm低于对照组(12.69±2.43)mm(P<0.05)。两组患者干预前断指功能评分差异无统计学意义(P>0.05),干预后两组患者均有提升,研究组患者断指功能评分(82.68±6.51)分、干预后断指再植功能优秀率24.44%,高于对照组患者断指功能评分(75.39±6.34)分、干预后断指再植功能优秀率6.82%(P<0.05)。结论基于镜像理论指导下的运动处方可有效提升断指再植术后患者手指关节活动度及感觉功能,促进再植断指功能恢复,改善患者生活质量。
文摘目的探讨脊柱微创通道镜系统辅助椎间孔腰椎椎体间融合术(TLIF)对腰椎退行性疾病患者脊髓功能及血清P物质(SP)、前列腺素E2(PGE2)水平的影响。方法选取51例腰椎退行性疾病患者,按照入院次序单双号法分为A组(n=25)及B组(n=26)。A组行脊柱微创通道镜系统辅助TLIF术治疗,B组行常规TLIF术治疗。比较两组手术指标,腰腿部疼痛与功能障碍状况,脊髓功能,血清P物质(SP)、前列腺素E2(PGE2)水平。结果A组术中失血量、术后引流量均少于B组,下床活动时间短于B组(P<0.05);术后4周两组腰腿部视觉模拟评分法(VAS)与Oswestry障碍指数(ODI)评分均较术前均明显改善(P<0.05);术后7 d两组各项脊髓功能指标较术前均明显改善,且A组改善幅度优于B组(P<0.05);术后3 d A组血清SP水平高于B组,而血清PGE2水平低于B组(P<0.05)。结论脊柱微创通道镜系统辅助TLIF术可显著改善腰椎退行性疾病患者脊髓功能以及疼痛介质水平。
