Inflammatory bowel disease(IBD)is a complex disease with variability in genetic,environmental,and lifestyle factors affecting disease presentation and course.Precision medicine has the potential to play a crucial role...Inflammatory bowel disease(IBD)is a complex disease with variability in genetic,environmental,and lifestyle factors affecting disease presentation and course.Precision medicine has the potential to play a crucial role in managing IBD by tailoring treatment plans based on the heterogeneity of clinical and temporal variability of patients.Precision medicine is a population-based approach to managing IBD by integrating environmental,genomic,epigenomic,transcriptomic,proteomic,and metabolomic factors.It is a recent and rapidly developing medicine.The widespread adoption of precision medicine worldwide has the potential to result in the early detection of diseases,optimal utilization of healthcare resources,enhanced patient outcomes,and,ultimately,improved quality of life for individuals with IBD.Though precision medicine is promising in terms of better quality of patient care,inadequacies exist in the ongoing research.There is discordance in study conduct,and data collection,utilization,interpretation,and analysis.This review aims to describe the current literature on precision medicine,its multiomics approach,and future directions for its application in IBD.展开更多
Different from conventional mechanical systems with single degree of freedom (DOF), the main idea of the system of hybrid-driven precision press is to combine the motion of a constant speed motor with a servomotor via...Different from conventional mechanical systems with single degree of freedom (DOF), the main idea of the system of hybrid-driven precision press is to combine the motion of a constant speed motor with a servomotor via a two-DOF mechanism to provide flexible output. In order to make the feasibility clear, this paper studies theoretically the dynamic characteristics of this hybrid-driven mechanical system.Firstly,the dynamics model of the whole electromechanical system is set up by combining dynamic equations of DC motors with those of two-DOF nine-bar mechanism deduced by the Lagrange′s formula. Secondly through the numerical solution with the fourth Runge-Kutta, computer simulation about the dynamics is done, which shows that the designed and optimized hybrid-driven precision press is feasible in theory. These provide theoretical basis for later experimental research.展开更多
The absolute frequency of 87Rb 5S1/2 （F=2）→5D5/2 （F＂ = 4） two-photon transition at 778nm is measured in an accuracy of 44kHz. A home-made erbium-doped fiber laser frequency comb with frequency stability of 5.0 ...The absolute frequency of 87Rb 5S1/2 （F=2）→5D5/2 （F＂ = 4） two-photon transition at 778nm is measured in an accuracy of 44kHz. A home-made erbium-doped fiber laser frequency comb with frequency stability of 5.0 × 10-13@1 s is employed for the light source. By using a periodically poled lithium niobate, the femtosecond pulse operating in 1556 nm is frequency-doubled to 778 nm to obtain the direct two-photon transition spectroscopy of thermal rubidium vapor. Through sweeping the carrier envelope offset frequency （fceo）, the 5S1/2 （F=2）→5D5/2 （F＂ = 4） two-photon transition line is clearly resolved and its absolute frequency is determined via the peak-finding of the fitting curve. After the frequency correction, the measured result agrees well with the previous experiment on this transition. The entire potential candidate of optical frequency standard for system configuration is compact and robust, providing a telecommunication applications.展开更多
In order to find stable, accurate, and computationally efficient methods for performing the inverse Laplace transform, a new double transformation approach is proposed. To validate and improve the inversion solution o...In order to find stable, accurate, and computationally efficient methods for performing the inverse Laplace transform, a new double transformation approach is proposed. To validate and improve the inversion solution obtained using the Gaver-Stehfest algorithm, direct Laplace transforms are taken of the numerically inverted transforms to compare with the original function. The numerical direct Laplace transform is implemented with a composite Simpson’s rule. Challenging numerical examples involving periodic and oscillatory functions, are investigated. The numerical examples illustrate the computational accuracy and efficiency of the direct Laplace transform and its inverse due to increasing the precision level and the number of terms included in the expansion. It is found that the number of expansion terms and the precision level selected must be in a harmonious balance in order for correct and stable results to be obtained.展开更多
This article describes China’s C802 shore-to-ship mobile missile system,especially its components,tactical and technical specifications,as well as the configuration and features of C802 missile.Besides,it also briefs...This article describes China’s C802 shore-to-ship mobile missile system,especially its components,tactical and technical specifications,as well as the configuration and features of C802 missile.Besides,it also briefs the weapon system’s launching and technical site facilities and their functions.展开更多
The paper describes the main tactical and technical performances as well as the leading features of China’s HY-2 shore-to-ship missile system.From this paper,the readers can get better understanding of the missile’s...The paper describes the main tactical and technical performances as well as the leading features of China’s HY-2 shore-to-ship missile system.From this paper,the readers can get better understanding of the missile’s aerodynamic configuration,guidance and control modes and its warhead,engines and follow-on versions The article also deals with the fire and technical position facilities and equipment of the weapon system.展开更多
This article introduces the composition and characteristics of China’s C601 air-to-ship missile weapon system and describes in detail the functions of the missile-borne equipment and launching process of the missile....This article introduces the composition and characteristics of China’s C601 air-to-ship missile weapon system and describes in detail the functions of the missile-borne equipment and launching process of the missile.The technical position and related airfield facilities of the system are also presented here briefly.展开更多
研究部署与任务期间导弹武器系统可用性建模方法与仿真实验设计。阐述了可用性概念,明确了量化指标,构建建模与仿真(modeling and simulation,M&S)一体化框架,利用分层组合的思想,提出了基于体系-实体-行为-状态(system-of-system,e...研究部署与任务期间导弹武器系统可用性建模方法与仿真实验设计。阐述了可用性概念,明确了量化指标,构建建模与仿真(modeling and simulation,M&S)一体化框架,利用分层组合的思想,提出了基于体系-实体-行为-状态(system-of-system,entity,behavior,state,SEBS)的可用性建模方法,即以体系组织集成建模为框架,以变结构实体建模为主体,以可用性为中心的行为建模为支撑,以基于故障与战损的可用状态建模为核心,并对模型的形式化描述展开研究。探讨了仿真实验设计的关键技术,提出基于测试-使用-维修-保障(test,operation,maintain,support,TOMS)的实验空间串联分割方法,并对随机变量建模、仿真优化设计、仿真系统可信度评估进行阐述。仿真结果表明,该分层组合评估方法快捷有效,仿真实验设计合理可行,极大地提高了可用性评估和分析的效率,为精确保障奠定了基础。展开更多
文摘Inflammatory bowel disease(IBD)is a complex disease with variability in genetic,environmental,and lifestyle factors affecting disease presentation and course.Precision medicine has the potential to play a crucial role in managing IBD by tailoring treatment plans based on the heterogeneity of clinical and temporal variability of patients.Precision medicine is a population-based approach to managing IBD by integrating environmental,genomic,epigenomic,transcriptomic,proteomic,and metabolomic factors.It is a recent and rapidly developing medicine.The widespread adoption of precision medicine worldwide has the potential to result in the early detection of diseases,optimal utilization of healthcare resources,enhanced patient outcomes,and,ultimately,improved quality of life for individuals with IBD.Though precision medicine is promising in terms of better quality of patient care,inadequacies exist in the ongoing research.There is discordance in study conduct,and data collection,utilization,interpretation,and analysis.This review aims to describe the current literature on precision medicine,its multiomics approach,and future directions for its application in IBD.
文摘Different from conventional mechanical systems with single degree of freedom (DOF), the main idea of the system of hybrid-driven precision press is to combine the motion of a constant speed motor with a servomotor via a two-DOF mechanism to provide flexible output. In order to make the feasibility clear, this paper studies theoretically the dynamic characteristics of this hybrid-driven mechanical system.Firstly,the dynamics model of the whole electromechanical system is set up by combining dynamic equations of DC motors with those of two-DOF nine-bar mechanism deduced by the Lagrange′s formula. Secondly through the numerical solution with the fourth Runge-Kutta, computer simulation about the dynamics is done, which shows that the designed and optimized hybrid-driven precision press is feasible in theory. These provide theoretical basis for later experimental research.
基金Supported by the National Natural Science Foundation of China under Grant Nos 61405002,91336103,10934010,61535001 and 61078026
文摘The absolute frequency of 87Rb 5S1/2 （F=2）→5D5/2 （F＂ = 4） two-photon transition at 778nm is measured in an accuracy of 44kHz. A home-made erbium-doped fiber laser frequency comb with frequency stability of 5.0 × 10-13@1 s is employed for the light source. By using a periodically poled lithium niobate, the femtosecond pulse operating in 1556 nm is frequency-doubled to 778 nm to obtain the direct two-photon transition spectroscopy of thermal rubidium vapor. Through sweeping the carrier envelope offset frequency （fceo）, the 5S1/2 （F=2）→5D5/2 （F＂ = 4） two-photon transition line is clearly resolved and its absolute frequency is determined via the peak-finding of the fitting curve. After the frequency correction, the measured result agrees well with the previous experiment on this transition. The entire potential candidate of optical frequency standard for system configuration is compact and robust, providing a telecommunication applications.
文摘In order to find stable, accurate, and computationally efficient methods for performing the inverse Laplace transform, a new double transformation approach is proposed. To validate and improve the inversion solution obtained using the Gaver-Stehfest algorithm, direct Laplace transforms are taken of the numerically inverted transforms to compare with the original function. The numerical direct Laplace transform is implemented with a composite Simpson’s rule. Challenging numerical examples involving periodic and oscillatory functions, are investigated. The numerical examples illustrate the computational accuracy and efficiency of the direct Laplace transform and its inverse due to increasing the precision level and the number of terms included in the expansion. It is found that the number of expansion terms and the precision level selected must be in a harmonious balance in order for correct and stable results to be obtained.
文摘This article describes China’s C802 shore-to-ship mobile missile system,especially its components,tactical and technical specifications,as well as the configuration and features of C802 missile.Besides,it also briefs the weapon system’s launching and technical site facilities and their functions.
文摘The paper describes the main tactical and technical performances as well as the leading features of China’s HY-2 shore-to-ship missile system.From this paper,the readers can get better understanding of the missile’s aerodynamic configuration,guidance and control modes and its warhead,engines and follow-on versions The article also deals with the fire and technical position facilities and equipment of the weapon system.
文摘This article introduces the composition and characteristics of China’s C601 air-to-ship missile weapon system and describes in detail the functions of the missile-borne equipment and launching process of the missile.The technical position and related airfield facilities of the system are also presented here briefly.
文摘研究部署与任务期间导弹武器系统可用性建模方法与仿真实验设计。阐述了可用性概念,明确了量化指标,构建建模与仿真(modeling and simulation,M&S)一体化框架,利用分层组合的思想,提出了基于体系-实体-行为-状态(system-of-system,entity,behavior,state,SEBS)的可用性建模方法,即以体系组织集成建模为框架,以变结构实体建模为主体,以可用性为中心的行为建模为支撑,以基于故障与战损的可用状态建模为核心,并对模型的形式化描述展开研究。探讨了仿真实验设计的关键技术,提出基于测试-使用-维修-保障(test,operation,maintain,support,TOMS)的实验空间串联分割方法,并对随机变量建模、仿真优化设计、仿真系统可信度评估进行阐述。仿真结果表明,该分层组合评估方法快捷有效,仿真实验设计合理可行,极大地提高了可用性评估和分析的效率,为精确保障奠定了基础。
