期刊文献+
共找到2篇文章
< 1 >
每页显示 20 50 100
Bid mediates lysosomal membrane permeabilization and the consequent mitochondrial outer membrane permeabilization in RH-35 hepatoma cells
1
作者 Xingyu Zhao, Kai Zhao, Taotao Wei, Fuyu Yang Institute of Biophysics, Chinese Academy of Sciences, 15 Datun Road, Chaoyang District, Beijing, 100101, China, 《生物物理学报》 CAS CSCD 北大核心 2009年第S1期247-248,共2页
We reported previously that chymotrypsin B is cached in the lysosomes of rat hepatocytes and mediates apoptosis induced by TNF-alpha (1) and H2O2. However, the mechanism
关键词 Bid mediates lysosomal membrane permeabilization and the consequent mitochondrial outer membrane permeabilization in RH-35 hepat RH MOMP
原文传递
MiR-183-5p-PNPT1 Axis Enhances Cisplatin-induced Apoptosis in Bladder Cancer Cells 被引量:3
2
作者 Qing-gang HU Zhi YANG +3 位作者 Jia-wei CHEN Gallina KAZOBINKA Liang TIAN Wen-cheng LI 《Current Medical Science》 SCIE CAS 2022年第4期785-796,共12页
Objective:It has been reported that intrinsic apoptosis is associated with the progression of bladder cancer(BC).Recent evidence suggests that polyribonucleotide nucleotidyltransferase 1(PNPT1)is a pivotal mediator in... Objective:It has been reported that intrinsic apoptosis is associated with the progression of bladder cancer(BC).Recent evidence suggests that polyribonucleotide nucleotidyltransferase 1(PNPT1)is a pivotal mediator involved in RNA decay and cell apoptosis.However,the regulation and roles of PNPT1 in bladder cancer remain largely unclear.Methods:The upstream miRNA regulators were predicted by in silico analysis.The expression levels of PNPT1 were evaluated by real-time PCR,Western blotting,and immunohistochemistry(IHC),while miR-183-5p levels were evaluated by qPCR in BC cell lines and tissues.In vitro and in vivo assays were performed to investigate the function of miR-183-5p and PNPT1 in apoptotic RNA decay and the tumorigenic capability of bladder cancer cells.Results:PNPT1 expression was decreased in BC tissues and cell lines.Overexpression of PNPT1 significantly promoted cisplatin-induced intrinsic apoptosis of BC cells,whereas depletion of PNPT1 potently alleviated these effects.Moreover,oncogenic miR183-5p directly targeted the 3′UTR of PNPT1 and reversed the tumor suppressive role of PNPT1.Intriguingly,miR-183-5p modulated not only PNPT1 but also Bcl2 modifying factor(BMF)to inhibit the mitochondrial outer membrane permeabilization(MOMP)in BC cells.Conclusion:Our results provide new insight into the mechanisms underlying intrinsic apoptosis in BC,suggesting that the miR-183-5p-PNPT1 regulatory axis regulates the apoptosis of BC cells and might represent a potential therapeutic avenue for the treatment of BC. 展开更多
关键词 bladder cancer polyribonucleotide nucleotidyltransferase 1 bcl2 modifying factor mitochondrial outer membrane permeabilization MICRORNA
下载PDF
上一页 1 下一页 到第
使用帮助 返回顶部