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Zn^(2+) loading as a critical contributor to the circ_0008553-mediated oxidative stress and inflammation in response to PM_(2.5) exposures
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作者 Jingzhou Wang Jianbo Jia +5 位作者 Dujia Wang Xiujiao Pan Haiyan Xiong Chengjun Li Yiguo Jiang Bing Yan 《Journal of Environmental Sciences》 SCIE EI CAS CSCD 2023年第2期451-461,共11页
Inflammation is a major adverse outcome induced by inhaled particulate matter with a diameter of≤2.5μm(PM_(2.5)),and a critical trigger ofmost PM_(2.5) exposure-associated diseases.However,the key molecular events r... Inflammation is a major adverse outcome induced by inhaled particulate matter with a diameter of≤2.5μm(PM_(2.5)),and a critical trigger ofmost PM_(2.5) exposure-associated diseases.However,the key molecular events regulating the PM_(2.5)-induced airway inflammation are yet to be elucidated.Considering the critical role of circular RNAs(circRNAs)in regulating inflammation,we predicted 11 circRNAs that may be involved in the PM_(2.5)-induced airway inflammation using three previously reportedmiRNAs through the starBasewebsite.A novel circRNA circ_0008553 was identified to be responsible for the PM_(2.5)-activated inflammatory response in human bronchial epithelial cells(16HBE)via inducing oxidative stress.Using a combinatorial model PM_(2.5) library,we found that the synergistic effect of the insoluble core and loaded Zn^(2+)ions at environmentally relevant concentrations was the major contributor to the upregulation of circ_0008553 and subsequent induction of oxidative stress and inflammation in response to PM2.5 exposures.Our findings provided new insight into the intervention of PM_(2.5)-induced adverse outcomes. 展开更多
关键词 PM(2.5) Toxic composition Combinatorial model PM_(2.5)library Circ_0008553 INFLAMMATION
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