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Dynamic response of mountain tunnel,bridge,and embankment along the Sichuan-Tibet transportation corridor to active fault based on model tests
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作者 HUANG Beixiu QIAO Sijia +2 位作者 CHEN Xulei LI Lihui QI Shengwen 《Journal of Mountain Science》 SCIE CSCD 2024年第1期182-199,共18页
The Sichuan-Tibet transportation corridor is prone to numerous active faults and frequent strong earthquakes.While extensive studies have individually explored the effect of active faults and strong earthquakes on dif... The Sichuan-Tibet transportation corridor is prone to numerous active faults and frequent strong earthquakes.While extensive studies have individually explored the effect of active faults and strong earthquakes on different engineering structures,their combined effect remains unclear.This research employed multiple physical model tests to investigate the dynamic response of various engineering structures,including tunnels,bridges,and embankments,under the simultaneous influence of cumulative earthquakes and stick-slip misalignment of an active fault.The prototype selected for this study was the Kanding No.2 tunnel,which crosses the Yunongxi fault zone within the Sichuan-Tibet transportation corridor.The results demonstrated that the tunnel,bridge,and embankment exhibited amplification in response to the input seismic wave,with the amplification effect gradually decreasing as the input peak ground acceleration(PGA)increased.The PGAs of different engineering structures were weakened by the fault rupture zone.Nevertheless,the misalignment of the active fault may decrease the overall stiffness of the engineering structure,leading to more severe damage,with a small contribution from seismic vibration.Additionally,the seismic vibration effect might be enlarged with the height of the engineering structure,and the tunnel is supposed to have a smaller PGA and lower dynamic earth pressure compared to bridges and embankments in strong earthquake zones crossing active faults.The findings contribute valuable insights for evaluating the dynamic response of various engineering structures crossing an active fault and provide an experimental reference for secure engineering design in the challenging conditions of the Sichuan-Tibet transportation corridor. 展开更多
关键词 Dynamic response Engineering structure Sichuan-Tibet transportation corridor active fault EARTHQUAKE model test
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LOCALIZATION OF OBJECT (SPINE) IN MEDICAL IMAGE USING ACTIVE SHAPE MODELS 被引量:2
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作者 徐涛 蔡宇新 《Transactions of Nanjing University of Aeronautics and Astronautics》 EI 2003年第2期211-217,共7页
Active shape models (ASM), consisting of a shape model and a local gray-level appearance model, can be used to locate the objects in images. In original ASM scheme, the model of object′s gray-level variations is base... Active shape models (ASM), consisting of a shape model and a local gray-level appearance model, can be used to locate the objects in images. In original ASM scheme, the model of object′s gray-level variations is based on the assumption of one-dimensional sampling and searching method. In this work a new way to model the gray-level appearance of the objects is explored, using a two-dimensional sampling and searching technique in a rectangular area around each landmark of object shape. The ASM based on this improvement is compared with the original ASM on an identical medical image set for task of spine localization. Experiments demonstrate that the method produces significantly fast, effective, accurate results for spine localization in medical images. 展开更多
关键词 object localization active shape models (ASM) gray-level appearance model principal component analysis SPINE
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Optimal shape space and searching in the active shape model
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作者 何良华 邹采荣 +1 位作者 赵力 胡蝶 《Journal of Southeast University(English Edition)》 EI CAS 2005年第3期263-267,共5页
A novel idea,called the optimal shape subspace (OSS) is first proposed for optimizing active shape model (ASM) search.It is constructed from the principal shape subspace and the principal shape variance subspace.I... A novel idea,called the optimal shape subspace (OSS) is first proposed for optimizing active shape model (ASM) search.It is constructed from the principal shape subspace and the principal shape variance subspace.It allows the reconstructed shape to vary more than that reconstructed in the standard ASM shape space,hence it is more expressive in representing shapes in real life.Then a cost function is developed,based on a study on the search process.An optimal searching method using the feedback information provided by the evaluation cost is proposed to improve the performance of ASM alignment.Experimental results show that the proposed OSS can offer the maximum shape variation with reserving the principal information and a unique local optimal shape is acquired after optimal searching.The combination of OSS and optimal searching can improve the ASM performance greatly. 展开更多
关键词 active shape model shape subspace search subspace principal component analysis
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Modelling seedling development using thermal effectiveness and photosynthetically active radiation 被引量:5
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作者 ZHOU Tian-mei WU Zhen +4 位作者 WANG Ya-chen SU Xiao-jun QIN Chao-xuan HUO He-qiang JIANG Fang-ling 《Journal of Integrative Agriculture》 SCIE CAS CSCD 2019年第11期2521-2533,共13页
Seedling quality is a prerequisite for successful field performance and therefore influences crop yields. Temperature and illumination are two major factors affecting seedling quality during nursery propagation. Subop... Seedling quality is a prerequisite for successful field performance and therefore influences crop yields. Temperature and illumination are two major factors affecting seedling quality during nursery propagation. Suboptimal temperature or light of nurseries generally result in leggy or weak seedlings and great economic loss. However, production of healthy seedlings is challenging due to the lack of knowledge in systemic management of nursery environments. In this study, we have established simulation models to predict how temperature and illumination coordinately influence the growth of tomato and cabbage seedlings. Specifically, correlation between seedling quality characteristics(root-shoot ratio, G value(growth function: defined as ratio of whole plant dry weight to days of seedling), healthy indexes) and TEP(thermal effectiveness and photosynthetically active radiation) were explored to establish the models, which were validated with independent test data. Our results suggested that the curve of healthy index 1(HI1) and TEP fitted well with high coefficient of determination(R2) in both species, indicating that the model is highly reliable. The HI1 simulation models for tomato and cabbage are HI1=0.0009e0.0308TEP-0.0015 and HI1= 0.0003e0.0671TEP-0.0003, respectively, which can be used for predicting vigors of tomato and cabbage seedlings grown under different temperature and light conditions. 展开更多
关键词 TOMATO CABBAGE simulation model thermal EFFECTIVENESS and photosynthetically active radiation HEALTHY index G VALUE
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Vehicle Active Steering Control Research Based on Two-DOF Robust Internal Model Control 被引量:12
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作者 WU Jian LIU Yahui +3 位作者 WANG Fengbo BAO Chunjiang SUN Qun ZHAO Youqun 《Chinese Journal of Mechanical Engineering》 SCIE EI CAS CSCD 2016年第4期739-746,共8页
Because of vehicle's external disturbances and model uncertainties,robust control algorithms have obtained popularity in vehicle stability control.The robust control usually gives up performance in order to guarantee... Because of vehicle's external disturbances and model uncertainties,robust control algorithms have obtained popularity in vehicle stability control.The robust control usually gives up performance in order to guarantee the robustness of the control algorithm,therefore an improved robust internal model control(IMC) algorithm blending model tracking and internal model control is put forward for active steering system in order to reach high performance of yaw rate tracking with certain robustness.The proposed algorithm inherits the good model tracking ability of the IMC control and guarantees robustness to model uncertainties.In order to separate the design process of model tracking from the robustness design process,the improved 2 degree of freedom(DOF) robust internal model controller structure is given from the standard Youla parameterization.Simulations of double lane change maneuver and those of crosswind disturbances are conducted for evaluating the robust control algorithm,on the basis of a nonlinear vehicle simulation model with a magic tyre model.Results show that the established 2-DOF robust IMC method has better model tracking ability and a guaranteed level of robustness and robust performance,which can enhance the vehicle stability and handling,regardless of variations of the vehicle model parameters and the external crosswind interferences.Contradiction between performance and robustness of active steering control algorithm is solved and higher control performance with certain robustness to model uncertainties is obtained. 展开更多
关键词 active steering internal model control model tracking robust performance crosswind disturbances
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Design of active disturbance rejection internal model control strategy for SISO system with time delay process 被引量:3
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作者 靳其兵 刘立业 《Journal of Central South University》 SCIE EI CAS CSCD 2015年第5期1725-1736,共12页
A novel control scheme of active disturbance rejection internal model control(ADRIMC) is proposed to improve the anti-interference ability and robustness for the dead-time process. The active anti-interference concept... A novel control scheme of active disturbance rejection internal model control(ADRIMC) is proposed to improve the anti-interference ability and robustness for the dead-time process. The active anti-interference concept is introduced into the internal model control(IMC) by analyzing the relationship between IMC and disturbance observer control(DOB). Further, a design process of disturbance filter is presented to realize the active anti-interference ability for ADRIMC scheme. The disturbance filter is used to estimate an equivalent disturbance consisting of both external disturbances and internal disturbances caused by model mismatches.Simulation results demonstrate that the proposed method possesses a good disturbance rejection performance, though losing some partial dynamic performance. In other words, the proposed method shows a tradeoff between the dynamic performance and the system robust. 展开更多
关键词 internal model control (IMC) disturbance observer (DOB) active disturbance rejection internal model controller(ADRIMC) low pass filter (LPF) robusmess
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Active suspension control of a one-wheel car model using single input rule modules fuzzy reasoning and a disturbance observer 被引量:7
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作者 YOSHIMURA Toshio TERAMURA Itaru 《Journal of Zhejiang University-Science A(Applied Physics & Engineering)》 SCIE EI CAS CSCD 2005年第4期251-256,共6页
This paper presents the construction of an active suspension control of a one-wheel car model using fuzzy reasoning and a disturbance observer. The one-wheel car model to be treated here can be approximately described... This paper presents the construction of an active suspension control of a one-wheel car model using fuzzy reasoning and a disturbance observer. The one-wheel car model to be treated here can be approximately described as a nonlinear two degrees of freedom system subject to excitation from a road profile. The active control is designed as the fuzzy control inferred by using single input rule modules fuzzy reasoning, and the active control force is released by actuating a pneumatic actuator. The excitation from the road profile is estimated by using a disturbance observer, and the estimate is denoted as one of the variables in the precondition part of the fuzzy control rules. A compensator is inserted to counter the performance degradation due to the delay of the pneumatic actuator. The experimental result indicates that the proposed active suspension system improves much the vibration suppression of the car model. Key words One-wheel car model - Active suspension system - Single input rule modules fuzzy reasoning - Pneumatic actuator - Disturbance observer Document code A CLC number TH16 展开更多
关键词 One-wheel car model active suspension system Single input rule modules fuzzy reasoning Pneumatic actuator Disturbance observer
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Support Vector Machine active learning for 3D model retrieval 被引量:6
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作者 LENG Biao QIN Zheng LI Li-qun 《Journal of Zhejiang University-Science A(Applied Physics & Engineering)》 SCIE EI CAS CSCD 2007年第12期1953-1961,共9页
In this paper, we present a novel Support Vector Machine active learning algorithm for effective 3D model retrieval using the concept of relevance feedback. The proposed method learns from the most informative objects... In this paper, we present a novel Support Vector Machine active learning algorithm for effective 3D model retrieval using the concept of relevance feedback. The proposed method learns from the most informative objects which are marked by the user, and then creates a boundary separating the relevant models from irrelevant ones. What it needs is only a small number of 3D models labelled by the user. It can grasp the user's semantic knowledge rapidly and accurately. Experimental results showed that the proposed algorithm significantly improves the retrieval effectiveness. Compared with four state-of-the-art query refinement schemes for 3D model retrieval, it provides superior retrieval performance after no more than two rounds of relevance feedback. 展开更多
关键词 3D model retrieval Shape descriptor Relevance feedback Support Vector Machine (SVM) active learning
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Tunnel face reliability analysis using active learning Kriging model——Case of a two-layer soils 被引量:4
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作者 LI Tian-zheng DIAS Daniel 《Journal of Central South University》 SCIE EI CAS CSCD 2019年第7期1735-1746,共12页
This paper is devoted to the probabilistic stability analysis of a tunnel face excavated in a two-layer soil. The interface of the soil layers is assumed to be positioned above the tunnel roof. In the framework of lim... This paper is devoted to the probabilistic stability analysis of a tunnel face excavated in a two-layer soil. The interface of the soil layers is assumed to be positioned above the tunnel roof. In the framework of limit analysis, a rotational failure mechanism is adopted to describe the face failure considering different shear strength parameters in the two layers. The surrogate Kriging model is introduced to replace the actual performance function to perform a Monte Carlo simulation. An active learning function is used to train the Kriging model which can ensure an efficient tunnel face failure probability prediction without loss of accuracy. The deterministic stability analysis is given to validate the proposed tunnel face failure model. Subsequently, the number of initial sampling points, the correlation coefficient, the distribution type and the coefficient of variability of random variables are discussed to show their influences on the failure probability. The proposed approach is an advisable alternative for the tunnel face stability assessment and can provide guidance for tunnel design. 展开更多
关键词 reliability analysis tunnel face Kriging model active learning function failure probability
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Generalized Internal Model Robust Control for Active Front Steering Intervention 被引量:8
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作者 WU Jian ZHAO Youqun +2 位作者 JI Xuewu LIU Yahui ZHANG Lipeng 《Chinese Journal of Mechanical Engineering》 SCIE EI CAS CSCD 2015年第2期285-293,共9页
Because of the tire nonlinearity and vehicle's parameters'uncertainties,robust control methods based on the worst cases,such as H_∞,μsynthesis,have been widely used in active front steering control,however,in orde... Because of the tire nonlinearity and vehicle's parameters'uncertainties,robust control methods based on the worst cases,such as H_∞,μsynthesis,have been widely used in active front steering control,however,in order to guarantee the stability of active front steering system(AFS)controller,the robust control is at the cost of performance so that the robust controller is a little conservative and has low performance for AFS control.In this paper,a generalized internal model robust control(GIMC)that can overcome the contradiction between performance and stability is used in the AFS control.In GIMC,the Youla parameterization is used in an improved way.And GIMC controller includes two sections:a high performance controller designed for the nominal vehicle model and a robust controller compensating the vehicle parameters'uncertainties and some external disturbances.Simulations of double lane change(DLC)maneuver and that of braking on split-μroad are conducted to compare the performance and stability of the GIMC control,the nominal performance PID controller and the H_∞controller.Simulation results show that the high nominal performance PID controller will be unstable under some extreme situations because of large vehicle's parameters variations,H_∞controller is conservative so that the performance is a little low,and only the GIMC controller overcomes the contradiction between performance and robustness,which can both ensure the stability of the AFS controller and guarantee the high performance of the AFS controller.Therefore,the GIMC method proposed for AFS can overcome some disadvantages of control methods used by current AFS system,that is,can solve the instability of PID or LQP control methods and the low performance of the standard H_∞controller. 展开更多
关键词 active front steering system generalized internal model robust control H_∞ optimization PID split-μ road
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Mechanism and active sites of CO oxidation over single-crystal Au surfaces and a Au/TiO_2(110) model surface 被引量:2
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作者 Tadahiro Fujitani Isao Nakamura 《Chinese Journal of Catalysis》 SCIE EI CAS CSCD 北大核心 2016年第10期1676-1683,共8页
We describe the reaction mechanism and active sites for CO oxidation over a Au/TiO2(110) model surface and Au single‐crystal surfaces, along with the role of H2O, on a molecular scale. At low tem‐perature (&lt;3... We describe the reaction mechanism and active sites for CO oxidation over a Au/TiO2(110) model surface and Au single‐crystal surfaces, along with the role of H2O, on a molecular scale. At low tem‐perature (&lt;320 K), H2O played an essential role in promoting CO oxidation, and the active site for CO oxidation was the perimeter of the interface between the gold nanoparticles and the TiO2 sup‐port (Auδ+–Oδ––Ti). We believe that the O–O bond was activated by the formation of OOH, which was produced directly from O2 and H2O at the perimeter of the interface between the gold nanoparticles and the TiO2 support, and consequently OOH reacted with CO to form CO2. This reaction mechanism explains the dependence of the CO2 formation rate on O2 pressure at 300 K. In contrast, at high temperature (&gt;320 K), low‐coordinated gold atoms built up on the surface as a result of surface reconstruction due to exposure to CO. The low‐coordinated gold atoms adsorbed O2, which then dissociated and oxidized CO on the metallic gold surface. 展开更多
关键词 GOLD model catalyst CO oxidation Reaction mechanism active sites
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Pneumatic active suspension system for a one-wheel car model using fuzzy reasoning and a disturbance observer 被引量:3
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作者 YOSHIMURAToshio TAKAGIAtsushi 《Journal of Zhejiang University Science》 CSCD 2004年第9期1060-1068,共9页
This paper presents the construction of a pneumatic active suspension system for a one-wheel car model using fuzzy reasoning and a disturbance observer. The one-wheel car model can be approximately described as a nonl... This paper presents the construction of a pneumatic active suspension system for a one-wheel car model using fuzzy reasoning and a disturbance observer. The one-wheel car model can be approximately described as a nonlinear two degrees of freedom system subject to excitation from a road profile. The active control is composed of fuzzy and disturbance controls, and the active control force is constructed by actuating a pneumatic actuator. A phase lead-lag compensator is inserted to counter the performance degradation due to the delay of the pneumatic actuator. The experimental result indicates that the proposed active suspension improves much the vibration suppression of the car model. 展开更多
关键词 One-wheel car model active suspension system Fuzzy reasoning Pneumatic actuator Disturbance observer
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Research on Dynamic Model's Building of Active Magnetic Suspension Systems 被引量:4
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作者 施建 颜国正 +1 位作者 李黎川 王坤东 《Journal of Donghua University(English Edition)》 EI CAS 2006年第3期131-135,共5页
An experimental method is introduced in this paper to build the dynamics of AMSS (the active magnetic suspension system), which doesn’t depend on system’s physical parameters. The rotor can be reliably suspended und... An experimental method is introduced in this paper to build the dynamics of AMSS (the active magnetic suspension system), which doesn’t depend on system’s physical parameters. The rotor can be reliably suspended under the unit feedback control system designed with the primary dynamic model obtained. Online identification in frequency domain is processed to give the precise model. Comparisons show that the experimental method is much closer to the precise model than the theoretic method based on magnetic circuit law. So this experimental method is a good choice to build the primary dynamic model of AMSS. 展开更多
关键词 active magnetic suspension feedback control dynamic model building experimental method
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Computer simulation of active suspension based on the full-vehicle model 被引量:2
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作者 李军 CHEN Shanguo 《Journal of Chongqing University》 CAS 2002年第2期24-27,共4页
Abstract: The current method to solve the problem of active suspension control for a vehicle is often dealt with a quarter-car or half-car model. But it is not enough to use this kind of model for practical applicatio... Abstract: The current method to solve the problem of active suspension control for a vehicle is often dealt with a quarter-car or half-car model. But it is not enough to use this kind of model for practical applications. In this paper, based on considering the influence of factors such as, seat and passengers, a MDOF(multi-degree-of-freedom) model describing the vehicle motion is set up. The MODF model, which is 8DOF of four independent suspensions and four wheel tracks, is more applicable by comparison of its analysis result with some conventional vehicle models. Therefore, it is more suitable to use the 8DOF full-car model than a conventional 4DOF half-car model in the active control design for car vibration. Based on the derived 8DOF model, a controller is designed by using LQ (linear quadratic ) control theory, and the appropriate control scheme is selected by testing various performance indexes. Computer simulation is carried out for a passenger car running on a road with step disturbance and random road disturbance expressed by Power Spectral Density (PSD). Vibrations corresponding to ride comfort are derived under the foregoing road disturbances. The response results for uncontrolled and controlled system are compared. The response of vehicle vibration is greatly suppressed and quickly damped, which testifies the effect of the active suspension. The results achieved for various controllers are compared to investigate the influence of different control schemes on the control effect. 展开更多
关键词 active suspension LQ control 8DOF model
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DC active power filter based on model predictive control for DC bus overvoltage suppression of accelerator grid power supply 被引量:1
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作者 张鸿淇 朱帮友 +3 位作者 马少翔 李志恒 张明 潘垣 《Plasma Science and Technology》 SCIE EI CAS CSCD 2023年第6期1-13,共13页
The China Fusion Engineering Test Reactor plans to build a 200 k V/25 A acceleration grid power supply(AGPS)for the negative-ion-based neutral beam injector prototype system.The AGPS uses a rectifier-inverter-isolated... The China Fusion Engineering Test Reactor plans to build a 200 k V/25 A acceleration grid power supply(AGPS)for the negative-ion-based neutral beam injector prototype system.The AGPS uses a rectifier-inverter-isolated step-up structure.There is a DC bus between the rectifier and the inverter.In order to limit DC bus voltage ripple and transient fluctuations,a large number of capacitors are used,which degrades the reliability of the power supply and occupies a large amount of space.This work finds that due to the difference in the turn-off time of the rectifier and the inverter,the capacitance mainly depends on the rectifier current when the inverter is turned off.On this basis,an active power filter(APF)scheme is proposed to absorb the current.To enhance the dynamic response ability of the APF,model predictive control is adopted.In this paper,the circuit structure of the APF is introduced,the prediction model is deduced,the corresponding control strategy and signal detection method are proposed,and the simulation and experimental results show that APF can track the transient current of the DC bus and reduce the voltage fluctuation significantly. 展开更多
关键词 CFETR NBI accelerator grid power supply power active filter model predictive control
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A Preliminary Study on a Seismotectonic Model for the Active Faults in the Xining Urban Area 被引量:2
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作者 Tian Qinjian Li Zhimin +1 位作者 Zhang Junlong Ren Zhikun 《Earthquake Research in China》 2008年第1期15-23,共9页
On the basis of the Xining active urban fault survey, we studied the relationship between the active urban fault and fold deformation. The result of this research shows that the Huangshuihe fault and the NW-striking f... On the basis of the Xining active urban fault survey, we studied the relationship between the active urban fault and fold deformation. The result of this research shows that the Huangshuihe fault and the NW-striking fault on the northern bank of the Huangshulbe River are tensional faults on top of an anticline, the Nanchuanhe fault is a transverse tear fault resulting from differential folding on two sides of the fault, the east bank of the Beichuanhe River fault is a compressional fault developed on the core or climb of a syncline. By balance profile analysis of fold deformation and inversion of gravity anomaly data, we obtained the depth of the detachment plane and established the seismotectonic model of the )fining urban area. Based on the seismotectonic model, we analyzed the earthquake potential of the active urban fault. 展开更多
关键词 Urban active fault Weak active fault Seismotectonic model Earthquake risk Xining
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Application of Active Contour Model in Tracking Sequential Nearshore Waves
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作者 Yu-Hung HSIAO Min-Chih HUANG 《China Ocean Engineering》 SCIE EI 2009年第2期251-266,共16页
In the present study, a generalized active contour model of gradient vector flow is combined with the video techniques of Argus system to delineate and track sequential nearshore wave crest profiles in the shoaling pr... In the present study, a generalized active contour model of gradient vector flow is combined with the video techniques of Argus system to delineate and track sequential nearshore wave crest profiles in the shoaling process, up to their breaking on the shoreline. Previous applications of active contour models to water wave problems are limited to controllable wave tank experiments. By contrast, our application in this study is in a nearshore field environment where oblique images obtained under natural and varying condition of ambient light are employed. Existing Argus techniques produce plane image data or time series data from a selected small subset of discrete pixels. By contrast, the active contour model produces line image data along continuous visible curves such as wave crest profiles. The combination of these two existing techniques, the active contour model and Argus methodologies, facilitates the estimates of the direction wave field and phase speeds within the whole area covered by camera. These estimates are useful for the purpose of inverse calculation of the water depth. Applications of the present techniques to Hsi-tzu bay where a beach restoration program is currently undertaken are illustrated. This extension of Argus video techniques provides new application of optical remote sensing to study the hydrodynamics and morphology of a nearshore environment. 展开更多
关键词 active contour model SNAKE video images NEARSHORE
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The Effect of Water Flow Velocity on Heat Collection Performance of Active Heat Storage and Release System for Solar Greenhouses
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作者 Wei Lu Lirui Liang +8 位作者 Dawei Shi Wenjun Peng Yangxia Zheng In-bok Lee Mengyao Li Qichang Yang Jiangtao Hu Xiaopei Tang Chengyao Jiang 《Journal of Electronic Research and Application》 2024年第6期79-88,共10页
In order to explore the influence of water velocity on the heat collection performance of the active heat storage and release system for solar greenhouses,six different flow rates were selected for treatment in this e... In order to explore the influence of water velocity on the heat collection performance of the active heat storage and release system for solar greenhouses,six different flow rates were selected for treatment in this experiment.The comprehensive heat transfer coefficient of the active heat storage and release system at the heat collection stage was calculated by measuring the indoor solar radiation intensity,indoor air temperature and measured water tank temperature.The prediction model of water temperature in the heat collection stage was established,and the initial value of water temperature and the comprehensive heat transfer coefficient were input through MATLAB software.The simulated value of water temperature was compared with the measured value and the results showed that the best heat transfer effect could be achieved when the water flow speed was 1.0 m3h-1.The average relative error between the simulated water tank temperature and the measured value is 2.70-6.91%.The results indicate that the model is established correctly,and the variation trend of water temperature can be predicted according to the model in the heat collection stage. 展开更多
关键词 active heat storage and release Water velocity Coefficient of heat transfer modeling Solar energy
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Model evaluation for the prediction of solubility of active pharmaceutical ingredients(APIs) to guide solid–liquid separator design
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作者 Kuveneshan Moodley Jürgen Rarey Deresh Ramjugernath 《Asian Journal of Pharmaceutical Sciences》 SCIE CAS 2018年第3期265-278,共14页
The assumptions and models for solubility modelling or prediction in systems using nonpolar solvents, or water and complex triterpene and other active pharmaceutical ingredients as solutes aren't well studied. Fur... The assumptions and models for solubility modelling or prediction in systems using nonpolar solvents, or water and complex triterpene and other active pharmaceutical ingredients as solutes aren't well studied. Furthermore, the assumptions concerning heat capacity effects(negligibility, experimental values or approximations) are explored, using non-polar solvents(benzene), or water as reference solvents, for systems with solute melting points in the range of 306–528 K and molecular weights in the range of 90–442 g/mol. New empirical estimation methods for the Δ_(fus)C_(pi) of APIs are presented which correlate the solute molecular masses and van der Waals surface areas with Δ_(fus)C_(pi). Separate empirical parameters were required for oxygenated and non-oxygenated solutes. Subsequently, the predictive capabilities of the various approaches to solubility modelling for complex pharmaceuticals,for which data is limited, are analysed. The solute selection is based on a principal component analysis, considering molecular weights, fusion temperatures, and solubilities in a non-polar solvent, alcohol, and water, where data was available. New NRTL-SAC parameters were determined for selected steroids, by regression. The original UNIFAC, modified UNIFAC(Dortmund), COSMO-RS(OL), and COSMO-SAC activity coefficient predictions are then conducted, based on the availability of group constants and sigma profiles. These are undertaken to assess the predictive capabilities of these models when each assumption concerning heat capacity is employed. The predictive qualities of the models are assessed, based on the mean square deviation and provide guidelines for model selection, and assumptions concerning phase equilibrium, when designing solid–liquid separators for the pharmaceutical industry on process simulation software. The most suitable assumption regarding Δ_(fus)C_(pi) was found to be system specific, with modified UNIFAC(Dortmund) performing well in benzene as a solvent system, while original UNIFAC performs better in aqueous systems.Original UNIFAC outperforms other predictive models tested in the triterpene/steroidal systems,with no significant influence from the assumptions regarding Δ_(fus)C_(pi). 展开更多
关键词 SOLUBILITY Solid–Liquid Equilibrium model PREDICTION active pharmaceutical INGREDIENTS
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Liver Hydatid CT Image Segmentation Using Smoothed Bayesian Classification Method and Modified Parametric Active Contour Model 被引量:2
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作者 HU Yan-ting HAMIT· Murat +3 位作者 CHEN Jian-jun SUN Jing JI Jin-hu KONG De-wei 《Chinese Journal of Biomedical Engineering(English Edition)》 2010年第4期139-147,155,共10页
Liver hydatid disease is a common parasitic disease in farm and pastoral areas, which seriously influences people's health. Based on CT imaging features of this disease, an iterative approach for liver segmentatio... Liver hydatid disease is a common parasitic disease in farm and pastoral areas, which seriously influences people's health. Based on CT imaging features of this disease, an iterative approach for liver segmentation and hydatid lesion extraction simultaneously is proposed. In each iteration, our algorithm consists of two main steps: 1) according to the user-defined pixel seeds in the liver and hydatid lesion, Gaussian probability model fitting and smoothed Bayesian classification are applied to get initial segmentation of liver and lesion; 2) the parametric active contour model using priori shape force field is adopted to refine initial segmentation. We make subjective and objective evaluation on the proposed algorithm validity by the experiments of liver and hydatid lesion segmentation on different patients' CT slices. In comparison with ground-truth manual segmentation results, the experimental results show the effectiveness of our method to segment liver and hydatid lesion. 展开更多
关键词 liver hydatid disease CT image segmentation Bayesian classification active contour model
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