Estimation of Displacement and Extension due to Reverse Drag of Normal Faults: Forward Method

In the case of reverse drag of normal faulting, the displacement and horizontal extension are determined based on the established equations for the three mechanisms: rigid body, vertical shear and inclined shear. There are three sub-cases of basal detachment for the rigid body model: horizontal detachment, antithetic detachment and synthetic detachment. For the rigid body model, the established equations indicate that the total displacement on the synthetic base (Dt2) is the largest, that on the horizontal base (Dt1) is moderate, and that on the antithetic base (Dt3) is the smallest. On the other hand, the value of (Dt1) is larger than the displacement for the vertical shear (Dt4). The value of (Dt1) is larger than or less than the displacement for the inclined shear (Dt5) depending on the original fault dip δ0, bedding angle θ, and the angle of shear direction β. For all original parameters, the value of Dt5 is less than the value of Dt4. Also, by comparing three rotation mechanisms, we find that the inclined shear produces largest extension, the rigid body model with horizontal detachment produces the smallest extension, and the vertical shear model produces moderate extension.

Cenozoic tectono-sedimentary characteristics and extension model of the Northwest Sub-basin,South China Sea

Based on the interpretations of three seismic profiles and one wide-angle seismic profile across the Northwest Sub-basin,South China Sea.stratigraphic sequences,deformation characteristics and an extension model for this sub-basin have been worked out.Three tectonic-stratigraphic units are determined.Detailed analyses of extension show that the event occurred mainly during the Paleogene and resulted in the formation of half-grabens or grabens distributed symmetrically around the spreading center.Sediments are characterized by chaotic and discontinuous reflectors,indicating clastic sediments. Farther to the southwest,the sub-basin features mainly continental rifting instead of sea-floor spreading. The rifting would have been controlled by the shape of the massif and developed just along the northern edge of the Zhongsha-Xisha Block,rather than joined the Xisha Trough.After 25 Ma.a southward ridge jump triggered the opening of the Southwest Sub-basin.The NW-directed stress caused by the sea-floor spreading of the Northwest Sub-basin may have prevented the continuous opening of the sub-basin.After that the Northwest Sub-basin experienced thermal cooling and exhibited broad subsidence.The deep crustal structure shown by the velocity model from a wide-angle seismic profile is also symmetrical around the spreading center,which indicates that the Northwest Sub-basin might have opened in a pure shear model.

The Effects of Infrastructure Projects on House Prices and Rents:Evidence from the HS2 Extension Cancellation in the UK

This paper uses the HS2 extension cancellation in November 2021 as a quasi-experiment to study its impact on house prices and rents in Leeds.Using a DiD approach on repeat sales and monthly rents,I compare property values near the HS2 station and proposed construction site before and after the announcement.Results show a 3.6%decrease in house prices and a 3.9%decline in rents near the station,while properties near the construction site experienced a 2.4%increase in prices and a 2.1%rise in rents.This is the first paper to analyse the HS2 cancellation effect using panel data methods.

Extension Modeling Strategy of Intelligent Detection in D.huoshanense Photosynthesis Process

Aiming at the limitations of the existing knowledge representations in intelligent detection, a new method of Extension-based Knowledge Representation (EKR) was proposed. The definitions, grammar rules, and storage structure of EKR were presented. An Extension Solving Model (ESM) based on EKR was discussed in detail, including creation of the extension constraint graph, extended inference, calculation of relevant functions and generation of extension set. A knowledge base system based on EKR and ESM was developed, which was applied in extension repository system intelligent design of detection in photosynthesis process of D.huoshanense. More reasonable results were obtained than traditional rule-based system. EKR was feasible in intelligent design to solve the problem of intelligent detection knowledge representations.

EXTENSION OF SEQUENCE STRATIGRAPHIC MODELAND SEQUENCE STRATIGRAPHIC ANALYSIS IN LIMNIC DEPOSITIONAL BASIN

The architectural patterns of sedimentary succession are diverse in different depositionalbasins. The sedimentary architecture and geological condition of such basins asepicontinental sea, intraplate limnic basins, etc., differ cIearly from those of continentalmargin basin. Extension, complement and perfection of sequence stratigraphic models are needed in the studies of various depositional basins based on the classical sequence model. This paper, for this reason,expounds the thought, principles of sequence division, methodology and technology of the study of sequence stratigraphy in epicontinental and limnic basins.

Effect Analysis of Gurson Model Parameters on Crack Extension of Pipeline

Leakage-before-break technique is widely used in high energy pipeline of nuclear plant, for which crack stability of pipeline under complex loading condition is a key issue, and crack growth resistance curve of pipeline material is the important foundation for crack stability analysis. In this paper, ferritic steel A533B is studied, Gurson damage model is used to simulate crack process of contact tension specimen under unitension, and effect of Gurson model parameter on simulation result is discussed. The following results are found during simulation: initial porosity factor is the main parameter, when it increases gradually, unstable crack extension will be observed;however, only initial J toughness is affected by critical porosity factor;the minor parameter is load step control, when it increases, stable and convergent result is obtained. All results in this paper can be used to determine parameters in Gurson mode, which will be foundation for crack extension analysis of pipeline.

Two-Dimensional Lithium-Ion Battery Modeling with Electrolyte and Cathode Extensions

A two-dimensional model for transport and the coupled electric field is applied to simulate a charging lithium-ion cell and investigate the effects of lithium concentration gradients within electrodes on cell performance. The lithium concentration gradients within electrodes are affected by the cell geometry. Two different geometries are investigated: extending the length of the electrolyte past the edges of the electrodes and extending the length of the cathode past the edge of the anode. It is found that the electrolyte extension has little impact on the behavior of the electrodes, although it does increase the effective conductivity of the electrolyte in the edge region. However, the extension of the cathode past the edge of the anode, and the possibility for electrochemical reactions on the flooded electrode edges, are both found to impact the concentration gradients of lithium in electrodes and the current distribution within the electrolyte during charging. It is found that concentration gradients of lithium within electrodes may have stronger impacts on electrolytic current distributions, depending on the level of completeness of cell charge. This is because very different gradients of electric potential are expected from similar electrode gradients of lithium concentrations at different levels of cell charge, especially for the LixC6 cathode investigated in this study. This leads to the prediction of significant electric potential gradients along the electrolyte length during early cell charging, and a reduced risk of lithium deposition on the cathode edge during later cell charging, as seen experimentally by others.

NUMERICAL MODELLING OF LITHOSPHERE EVOLUTION IN THE NORTH CHINA CRATON: THERMAL THINNING VERSUS TECTONIC EXTENSION THINNING

The boundary between lithosphere and asthenosphere essentially represents a thermal boundary (the solidus). Temperature variation across this boundary can lead to the change of lithosphere thickness. In the case of elevated temperatures in a lithospheric layer above 1 200℃, partial melting will begin and the result of that is a thinned lithosphere. The other mechanism that can also thin lithosphere is extension. Stretching during an extension event can result in a thinner and longer lithosphere. The two mechanisms above are the reason why we can alserve large variations in lithosphere thickness spatially across various continents and temporally throughout the geological history.

SWAT和WetSpa Extension在罗玉沟流域的应用比较

近年来,运用水文模型来研究流域水文状况越来越普遍,本文以黄土高原丘陵沟壑区第三副区的典型小流域为例,基于SWAT和WetSpa Extension两个模型,从模型的输入数据、模型的参数和模型模拟结果等方面进行比较,以期为该区水沙模拟选择合适水文模型并为将来模型性能的改进提供参考。连续15年的校准验证表明:两个模型都能得到较好的结果,而SWAT模型能应用于水文及泥沙等模拟过程,相对来说功能更全面;WetSpa Extension模型目前仅能提供水文模拟的模块,优点在于模拟时间步长较任意,可进行洪水模拟。

Effects of mesenchymal stem cell on dopaminergic neurons,motor and memory functions in animal models of Parkinson's disease:a systematic review and meta-analysis

Parkinson’s disease is chara cterized by the loss of dopaminergic neurons in the substantia nigra pars com pacta,and although restoring striatal dopamine levels may improve symptoms,no treatment can cure or reve rse the disease itself.Stem cell therapy has a regenerative effect and is being actively studied as a candidate for the treatment of Parkinson’s disease.Mesenchymal stem cells are considered a promising option due to fewer ethical concerns,a lower risk of immune rejection,and a lower risk of teratogenicity.We performed a meta-analysis to evaluate the therapeutic effects of mesenchymal stem cells and their derivatives on motor function,memory,and preservation of dopamine rgic neurons in a Parkinson’s disease animal model.We searched bibliographic databases(PubMed/MEDLINE,Embase,CENTRAL,Scopus,and Web of Science)to identify articles and included only pee r-reviewed in vivo interve ntional animal studies published in any language through J une 28,2023.The study utilized the random-effect model to estimate the 95%confidence intervals(CI)of the standard mean differences(SMD)between the treatment and control groups.We use the systematic review center for laboratory animal expe rimentation’s risk of bias tool and the collaborative approach to meta-analysis and review of animal studies checklist for study quality assessment.A total of 33studies with data from 840 Parkinson’s disease model animals were included in the meta-analysis.Treatment with mesenchymal stem cells significantly improved motor function as assessed by the amphetamine-induced rotational test.Among the stem cell types,the bone marrow MSCs with neurotrophic factor group showed la rgest effect size(SMD[95%CI]=-6.21[-9.50 to-2.93],P=0.0001,I^(2)=0.0%).The stem cell treatment group had significantly more tyrosine hydroxylase positive dopamine rgic neurons in the striatum([95%CI]=1.04[0.59 to 1.49],P=0.0001,I^(2)=65.1%)and substantia nigra(SMD[95%CI]=1.38[0.89 to 1.87],P=0.0001,I^(2)=75.3%),indicating a protective effect on dopaminergic neurons.Subgroup analysis of the amphetamine-induced rotation test showed a significant reduction only in the intracranial-striatum route(SMD[95%CI]=-2.59[-3.25 to-1.94],P=0.0001,I^(2)=74.4%).The memory test showed significant improvement only in the intravenous route(SMD[95%CI]=4.80[1.84 to 7.76],P=0.027,I^(2)=79.6%).Mesenchymal stem cells have been shown to positively impact motor function and memory function and protect dopaminergic neurons in preclinical models of Parkinson’s disease.Further research is required to determine the optimal stem cell types,modifications,transplanted cell numbe rs,and delivery methods for these protocols.

Mesoscale SST perturbation-induced impacts on climatological precipitation in the Kuroshio-Oyashio extension region,as revealed by the WRF simulations

Mesoscale coupling between perturbations of mesoscale sea surface temperature (SST) and lowlevel winds has been extensively studied using available high-resolution satellite observations. However, the climatological impacts of mesoscale SST perturbations (SST meso ) on the free atmosphere have not been fully understood. In this study, the rectified eff ect of SSTmeso on local climatological precipitation in the Kuroshio- Oyashio Extension (KOE) region is investigated using the Weather Research and Forecasting (WRF) Model;two runs are performed, one forced by low-resolution SST fields (almost no mesoscale signals) and another by additional high-resolution SSTmeso fields extracted from satellite observations. Climatological precipitation response to SST meso is characterized mainly by enhanced precipitation on the warmer flank of three oceanic SST fronts in this region. The results show that the positive correlation between the 10-m wind speed perturbations and SSTmeso is well captured by the WRF model with a reasonable spatial pattern but relatively weak strength. The addition of SSTmeso improves the climatological precipitation simulated by WRF with a better representation of fine-scale structures compared with satellite observations. A closer examination on the underlying mechanism suggests that while the pressure adjustment mechanism can explain the climatological precipitation enhancement along the fronts and the relatively high contribution of the convective precipitation, other factors such as synoptic events should also be taken into consideration to account for the seasonality of the precipitation response.

AN APPLICATION OF EXTENSION THEORY TO THE EVALUATION OF SLOPE STABILITY

The slope stability is affected by multiple factors. Thecomprehensive evaluation of the slope stability is a complicateproblem. The principles of extension theory have been used in thispaper to establish the matter-element model for the evaluation ofslope stability. The quantitative evaluated results have been giventhrough the calculation of the matter-element dependent degree.

Optimal Precursors Triggering the Kuroshio Extension State Transition Obtained by the Conditional Nonlinear Optimal Perturbation Approach

In this study, the initial perturbations that are the easiest to trigger the Kuroshio Extension （KE） transition connecting a basic weak jet state and a strong, fairly stable meandering state, are investigated using a reduced-gravity shallow water ocean model and the CNOP （Conditional Nonlinear Optimal Perturbation） approach. This kind of initial perturbation is called an optimal precursor （OPR）. The spatial structures and evolutionary processes of the OPRs are analyzed in detail. The results show that most of the OPRs are in the form of negative sea surface height （SSH） anomalies mainly located in a narrow band region south of the KE jet, in basic agreement with altimetric observations. These negative SSH anomalies reduce the merid- ional SSH gradient within the KE, thus weakening the strength of the jet. The KE jet then becomes more convoluted, with a high-frequency and large-amplitude variability corresponding to a high eddy kinetic energy level; this gradually strengthens the KE jet through an inverse energy cascade. Eventually, the KE reaches a high-energy state characterized by two well defined and fairly stable anticyclonic meanders. Moreover, sensitivity experiments indicate that the spatial structures of the OPRs are not sensitive to the model parameters and to the optimization times used in the analysis.

Application of extension method to fault diagnosis of transformer

A novel extension diagnosis method was proposed for enhancing the diagnosis ability of the conventional dissolved gas analysis. Based on the extension theory a matter-element model was established for qualitatively and quantitatively describing the fault diagnosis problem of power transformers. The degree of relation based on the dependent functions was employed to determine the nature and the grade of the faults in a transformer system. And the proposed method was verified with the experimental data. The results show that accuracy rate of the diagnosis method exceeds 90% and two kinds of faults can be detected at the same time.

Animal models of Alzheimer's disease:Current strategies and new directions

Animal models constructed using pathogenic factors have significantly advanced drug development for Alzheimer's disease(AD).These predominantly transgenic models,mainly in mice,replicate pathological phenotypes through gene mutations associated with familial AD cases,thus serving as vital tools for assessing drug efficacy and for performing mechanistic studies.However,the speciesspecific differences and complex,heterogeneous nature of AD etiology pose considerable challenges for the translatability of these animal models,limiting their utility in drug development.This review offers a comprehensive analysis of widely employed rodent(mice and rats)and non-rodent models(Danio rerio(zebrafish),Drosophila melanogaster,and Caenorhabditis elegans),detailing their phenotypic features and specific research applications.This review also examines the limitations inherent in these models and introduces various strategies for expanding AD modeling across diverse species,emphasizing recent advancement in non-human primates(NHPs)as valuable models.Furthermore,potential insights from the integration of innovative technologies in AD research are discussed,while providing valuable perspectives on the future development of AD animal models.

Risk of shear failure and extensional failure around over-stressed excavations in brittle rock

The authors investigate the failure modes surrounding over-stressed tunnels in rock.Three lines of investigation are employed:failure in over-stressed three-dimensional(3D) models of tunnels bored under 3D stress,failure modes in two-dimensional(2D) numerical simulations of 1000 m and 2000 m deep tunnels using FRACOD,both in intact rock and in rock masses with one or two joint sets,and finally,observations in TBM(tunnel boring machine) tunnels in hard and medium hard massive rocks.The reason for 'stress-induced' failure to initiate,when the assumed maximum tangential stress is approximately(0.4-0.5)σ_c(UCS,uniaxial compressive strength) in massive rock,is now known to be due to exceedance of a critical extensional strain which is generated by a Poisson's ratio effect.However,because similar 'stress/strength' failure limits are found in mining,nuclear waste research excavations,and deep road tunnels in Norway,one is easily misled into thinking of compressive stress induced failure.Because of this,the empirical SRF(stress reduction factor in the Q-system) is set to accelerate as the estimated ratio σ_(θmax)/σ_c >> 0.4.In mining,similar 'stress/strength' ratios are used to suggest depth of break-out.The reality behind the fracture initiation stress/strength ratio of '0.4' is actually because of combinations of familiar tensile and compressive strength ratios(such as 10) with Poisson's ratio(say0.25).We exceed the extensional strain limits and start to see acoustic emission(AE) when tangential stress σθ ≈ 0.4σc,due to simple arithmetic.The combination of 2D theoretical FRACOD models and actual tunnelling suggests frequent initiation of failure by 'stable' extensional strain fracturing,but propagation in 'unstable' and therefore dynamic shearing.In the case of very deep tunnels(and 3D physical simulations),compressive stresses may be too high for extensional strain fracturing,and shearing will dominate,both ahead of the face and following the face.When shallower,the concept of 'extensional strain initiation but propagation' in shear is suggested.The various failure modes are richly illustrated,and the inability of conventional continuum modelling is emphasized,unless cohesion weakening and friction mobilization at different strain levels are used to reach a pseudo state of yield,but still considering a continuum.

A Model of Grand Unified Theory: Suggested Solution for CP-Violation Using Ideas of Phase Paths

This study demonstrates that beyond standard model (BSM) cosmic fundamental interactions—weak, strong, and electromagnetic forces—can be unified through a common basis of representation. This unification allows for the derivation of the fine structure constant with running points of α(t) ≈ 1/(136.9038) at high energy scales, based on electroweak interactions. Through the application of the Ising model, the running point of the elementary charge e at high energy scales is determined, and Coulomb’s law is actually derived from the Yukawa potential. Theoretically, based on S. Weinberg’s electroweak interaction theory, this study unifies the strong and electromagnetic forces by representing them with rYuka, and further advances the reconstruction of the SU(3)C×SU(1)L×U(1)EMframework on the basis of electroweak interaction concepts. In fact, the cosmic fundamental forces can interchange at the mass gap, defined as the Yukawa turning phase at rYuka ≃1.9404 fm, with the SU(3)Diag structural constant fijk on glueballs calculated, estimating a spectrum mass gap of ∆0 > 0.

Evaluating the role of large language models in inflammatory bowel disease patient information

This letter evaluates the article by Gravina et al on ChatGPT’s potential in providing medical information for inflammatory bowel disease patients.While promising,it highlights the need for advanced techniques like reasoning+action and retrieval-augmented generation to improve accuracy and reliability.Emphasizing that simple question and answer testing is insufficient,it calls for more nuanced evaluation methods to truly gauge large language models’capabilities in clinical applications.

Generalized ExcellentExtension and Hom ologicalDim ension

We introduce generalized excellent extension of ring R in [4]. If S is a generalized excellent extension of R, we prove that (1) wgldim S≤ wgldim R and glodim S≤ gldim R; (2) the relations between rings R and rings S.

Calculation of the Standard Model Parameters and Particles Based on a SU(4) Preon Model

This paper describes an extension and a new foundation of the Standard Model of particle physics based on a SU(4)-force called hyper-color, and on preon subparticles. The hyper-color force is a generalization of the SU(2)-based weak interaction and the SU(1)-based right-chiral self-interaction, in which the W-and the Z-bosons are Yukawa residual-field-carriers of the hyper-color force, in the same sense as the pions are the residual-field-carriers of the color SU(3) interaction. Using the method of numerical minimization of the SU(4)-action based on this model, the masses and the inner structure of leptons, quarks and weak bosons are calculated: the mass results are very close to the experimental values. We calculate also precisely the value of the Cabibbo angle, so the mixing matrices of the Standard model, CKM matrix for quarks and PMNS matrix for neutrinos can also be calculated. In total, we reduce the 29 parameters of the Standard Model to a total of 7 parameters.