Background To date murine models of permanent focal cerebral ischemia have not been well characterized. The purposes of this paper were to compare three different permanent middle cerebral artery occlusion (MCAo) mode...Background To date murine models of permanent focal cerebral ischemia have not been well characterized. The purposes of this paper were to compare three different permanent middle cerebral artery occlusion (MCAo) models with or without cra niectomy, and to identify an ideal mouse model of permanent focal cerebral ischemia. Methods Experiments were performed on 45 healthy adult male Kunming mice, weighing 28 to 42 g. The animals were randomly assigned to three groups (n=15 in every group) based on surgical procedure: MCAo via the external carotid artery (ECA), MCAo via the common carotid artery (CCA), and direct ligation of the middle cerebral artery (MCA). Each day post-ischemia, the animals were scored using an eight-grade n eurological function scale, and mortality was also recorded. Seven days post-ischemia, the brains were removed for lesion size determination using triphenyltetrazoli um chloride staining. Correlation analysis of lesion volume and neurological score was carried out. Results Mortality in the group receiving direct MCA ligation was lowest among the three groups, and there was a significant difference between the direct MCA ligation group and the two intraluminal occlusion groups (P<0.05). In all groups, neurological scores gradually increased with prolongation of ischemic duration, peaking after two days, then gradually decreasing. In the direct MCA ligation group, however, neurological scores were relatively stable. There was a significant correlation between infarct volume and neurological score 7 days after MCAo in every group (all r>0.7, P<0.05), suggesting good reproducibility of lesion volume in the three groups, but the infarct volume was more constant in the direct MCA ligation group. Conclusion The direct ligation model of MCAo provides an optimal means of studying permanent focal cerebral ischemia, and is preferable to the models using intraluminal sutures.展开更多
Improved traditional ant colony algorithms,a data routing model used to the data remote exchange on WAN was presented.In the model,random heuristic factors were introduced to realize multi-path search.The updating mod...Improved traditional ant colony algorithms,a data routing model used to the data remote exchange on WAN was presented.In the model,random heuristic factors were introduced to realize multi-path search.The updating model of pheromone could adjust the pheromone concentration on the optimal path according to path load dynamically to make the system keep load balance.The simulation results show that the improved model has a higher performance on convergence and load balance.展开更多
Support vehicles are part of the main body of airport ground operations,and their scheduling efficiency directly impacts flight delays.A mathematical model is constructed and the responsiveness of support vehicles for...Support vehicles are part of the main body of airport ground operations,and their scheduling efficiency directly impacts flight delays.A mathematical model is constructed and the responsiveness of support vehicles for current operational demands is proposed to study optimization algorithms for vehicle scheduling.The model is based on the constraint relationship of the initial operation time,time window,and gate position distribution,which gives an improvement to the ant colony algorithm(ACO).The impacts of the improved ACO as used for support vehicle optimization are compared and analyzed.The results show that the scheduling scheme of refueling trucks based on the improved ACO can reduce flight delays caused by refueling operations by 56.87%,indicating the improved ACO can improve support vehicle scheduling.Besides,the improved ACO can jump out of local optima,which can balance the working time of refueling trucks.This research optimizes the scheduling scheme of support vehicles under the existing conditions of airports,which has practical significance to fully utilize ground service resources,improve the efficiency of airport ground operations,and effectively reduce flight delays caused by ground service support.展开更多
Invasive alien ants(IAAs)are among the most aggressive,competitive,and widespread invasive alien species(IAS)worldwide.Wasmannia auropunctata,the greatest IAAs threat in the Pacific region and listed in“100 of the wo...Invasive alien ants(IAAs)are among the most aggressive,competitive,and widespread invasive alien species(IAS)worldwide.Wasmannia auropunctata,the greatest IAAs threat in the Pacific region and listed in“100 of the world’s worst IAS”,has established itself in many countries and on islands worldwide.Wild populations of W.auropunctata were recently reported in southeastern China,representing a tremendous potential threat to China’s agricultural,economic,environmental,public health,and social well-being.Estimating the potential geographical distribution(PGD)of W.auropunctata in China can illustrate areas that may potentially face invasion risk.Therefore,based on the global distribution records of W.auropunctata and bioclimatic variables,we predicted the geographical distribution pattern of W.auropunctata in China under the effects of climate change using an ensemble model(EM).Our findings showed that artificial neural network(ANN),flexible discriminant analysis(FDA),gradient boosting model(GBM),Random Forest(RF)were more accurate than categorical regression tree analysis(CTA),generalized linear model(GLM),maximum entropy model(MaxEnt)and surface distance envelope(SRE).The mean TSS values of ANN,FDA,GBM,and RF were 0.820,0.810,0.843,and 0.857,respectively,and the mean AUC values were 0.946,0.954,0.968,and 0.979,respectively.The mean TSS and AUC values of EM were 0.882 and 0.972,respectively,indicating that the prediction results with EM were more reliable than those with the single model.The PGD of W.auropunctata in China is mainly located in southern China under current and future climate change.Under climate change,the PGD of W.auropunctata in China will expand to higher-latitude areas.The annual temperature range(bio7)and mean temperature of the warmest quarter(bio10)were the most significant variables affecting the PGD of W.auropunctata in China.The PGD of W.auropunctata in China was mainly attributed to temperature variables,such as the annual temperature range(bio7)and the mean temperature of the warmest quarter(bio10).The populations of W.auropunctata in southern China have broad potential invasion areas.Developing strategies for the early warning,monitoring,prevention,and control of W.auropunctata in southern China requires more attention.展开更多
The common failure mechanism for brittle rocks is known to be axial splitting which happens parallel to the direction of maximum compression. One of the mechanisms proposed for modelling of axial splitting is the slid...The common failure mechanism for brittle rocks is known to be axial splitting which happens parallel to the direction of maximum compression. One of the mechanisms proposed for modelling of axial splitting is the sliding crack or so called, “wing crack” model. Fairhurst-Cook model explains this specific type of failure which starts by a pre-crack and finally breaks the rock by propagating 2-D cracks under uniaxial compression. In this paper, optimization of this model has been considered and the process has been done by a complete sensitivity analysis on the main parameters of the model and excluding the trends of their changes and also their limits and “peak points”. Later on this paper, three artificial intelligence algorithms including Particle Swarm Intelligence (PSO), Ant Colony Optimization (ACO) and genetic algorithm (GA) has been used and compared in order to achieve optimized sets of parameters resulting in near-maximum or near-minimum amounts of wedging forces creating a wing crack.展开更多
In this paper,a cybersecurity threat warning model based on ant colony algorithm is designed to strengthen the accuracy of the cybersecurity threat warning model in the warning process and optimize its algorithm struc...In this paper,a cybersecurity threat warning model based on ant colony algorithm is designed to strengthen the accuracy of the cybersecurity threat warning model in the warning process and optimize its algorithm structure.Through the ant colony algorithm structure,the local global optimal solution is obtained;and the cybersecurity threat warning index system is established.Next,the above two steps are integrated to build the cybersecurity threat warning model based on ant colony algorithm,and comparative experiment is also designed.The experimental results show that,compared with the traditional qualitative differential game-based cybersecurity threat warning model,the cybersecurity threat warning model based on ant colony algorithm has a higher correct rate in the warning process,and the algorithm program is simpler with higher use value.展开更多
文摘Background To date murine models of permanent focal cerebral ischemia have not been well characterized. The purposes of this paper were to compare three different permanent middle cerebral artery occlusion (MCAo) models with or without cra niectomy, and to identify an ideal mouse model of permanent focal cerebral ischemia. Methods Experiments were performed on 45 healthy adult male Kunming mice, weighing 28 to 42 g. The animals were randomly assigned to three groups (n=15 in every group) based on surgical procedure: MCAo via the external carotid artery (ECA), MCAo via the common carotid artery (CCA), and direct ligation of the middle cerebral artery (MCA). Each day post-ischemia, the animals were scored using an eight-grade n eurological function scale, and mortality was also recorded. Seven days post-ischemia, the brains were removed for lesion size determination using triphenyltetrazoli um chloride staining. Correlation analysis of lesion volume and neurological score was carried out. Results Mortality in the group receiving direct MCA ligation was lowest among the three groups, and there was a significant difference between the direct MCA ligation group and the two intraluminal occlusion groups (P<0.05). In all groups, neurological scores gradually increased with prolongation of ischemic duration, peaking after two days, then gradually decreasing. In the direct MCA ligation group, however, neurological scores were relatively stable. There was a significant correlation between infarct volume and neurological score 7 days after MCAo in every group (all r>0.7, P<0.05), suggesting good reproducibility of lesion volume in the three groups, but the infarct volume was more constant in the direct MCA ligation group. Conclusion The direct ligation model of MCAo provides an optimal means of studying permanent focal cerebral ischemia, and is preferable to the models using intraluminal sutures.
基金Sponsored by the National High Technology Research and Development Program of China(2006AA701306)the National Innovation Foundation of Enterprises(05C26212200378)
文摘Improved traditional ant colony algorithms,a data routing model used to the data remote exchange on WAN was presented.In the model,random heuristic factors were introduced to realize multi-path search.The updating model of pheromone could adjust the pheromone concentration on the optimal path according to path load dynamically to make the system keep load balance.The simulation results show that the improved model has a higher performance on convergence and load balance.
基金the Science and Technology Cooperation Research and Development Project of Sichuan Provincial Academy and University(Grant No.2019YFSY0024)the Key Research and Development Program in Sichuan Province of China(Grant No.2019YFG0050)the Natural Science Foundation of Guangxi Province of China(Grant No.AD19245021).
文摘Support vehicles are part of the main body of airport ground operations,and their scheduling efficiency directly impacts flight delays.A mathematical model is constructed and the responsiveness of support vehicles for current operational demands is proposed to study optimization algorithms for vehicle scheduling.The model is based on the constraint relationship of the initial operation time,time window,and gate position distribution,which gives an improvement to the ant colony algorithm(ACO).The impacts of the improved ACO as used for support vehicle optimization are compared and analyzed.The results show that the scheduling scheme of refueling trucks based on the improved ACO can reduce flight delays caused by refueling operations by 56.87%,indicating the improved ACO can improve support vehicle scheduling.Besides,the improved ACO can jump out of local optima,which can balance the working time of refueling trucks.This research optimizes the scheduling scheme of support vehicles under the existing conditions of airports,which has practical significance to fully utilize ground service resources,improve the efficiency of airport ground operations,and effectively reduce flight delays caused by ground service support.
基金supported by the National Key R&D Program of China(2021YFC2600400)the Technology Innovation Program of the Chinese Academy of Agricultural Sciences(caascx-2017-2022-IAS)the Key R&D Program of Yunnan Province,China(202103AF140007)。
文摘Invasive alien ants(IAAs)are among the most aggressive,competitive,and widespread invasive alien species(IAS)worldwide.Wasmannia auropunctata,the greatest IAAs threat in the Pacific region and listed in“100 of the world’s worst IAS”,has established itself in many countries and on islands worldwide.Wild populations of W.auropunctata were recently reported in southeastern China,representing a tremendous potential threat to China’s agricultural,economic,environmental,public health,and social well-being.Estimating the potential geographical distribution(PGD)of W.auropunctata in China can illustrate areas that may potentially face invasion risk.Therefore,based on the global distribution records of W.auropunctata and bioclimatic variables,we predicted the geographical distribution pattern of W.auropunctata in China under the effects of climate change using an ensemble model(EM).Our findings showed that artificial neural network(ANN),flexible discriminant analysis(FDA),gradient boosting model(GBM),Random Forest(RF)were more accurate than categorical regression tree analysis(CTA),generalized linear model(GLM),maximum entropy model(MaxEnt)and surface distance envelope(SRE).The mean TSS values of ANN,FDA,GBM,and RF were 0.820,0.810,0.843,and 0.857,respectively,and the mean AUC values were 0.946,0.954,0.968,and 0.979,respectively.The mean TSS and AUC values of EM were 0.882 and 0.972,respectively,indicating that the prediction results with EM were more reliable than those with the single model.The PGD of W.auropunctata in China is mainly located in southern China under current and future climate change.Under climate change,the PGD of W.auropunctata in China will expand to higher-latitude areas.The annual temperature range(bio7)and mean temperature of the warmest quarter(bio10)were the most significant variables affecting the PGD of W.auropunctata in China.The PGD of W.auropunctata in China was mainly attributed to temperature variables,such as the annual temperature range(bio7)and the mean temperature of the warmest quarter(bio10).The populations of W.auropunctata in southern China have broad potential invasion areas.Developing strategies for the early warning,monitoring,prevention,and control of W.auropunctata in southern China requires more attention.
文摘The common failure mechanism for brittle rocks is known to be axial splitting which happens parallel to the direction of maximum compression. One of the mechanisms proposed for modelling of axial splitting is the sliding crack or so called, “wing crack” model. Fairhurst-Cook model explains this specific type of failure which starts by a pre-crack and finally breaks the rock by propagating 2-D cracks under uniaxial compression. In this paper, optimization of this model has been considered and the process has been done by a complete sensitivity analysis on the main parameters of the model and excluding the trends of their changes and also their limits and “peak points”. Later on this paper, three artificial intelligence algorithms including Particle Swarm Intelligence (PSO), Ant Colony Optimization (ACO) and genetic algorithm (GA) has been used and compared in order to achieve optimized sets of parameters resulting in near-maximum or near-minimum amounts of wedging forces creating a wing crack.
基金This work was supported by the Natural Science Foundation of Fujian Province,ChinaResearch on Network Risk Assessment Method Based on Dynamic Attack Behavior(Grant No.2019J01889)+1 种基金the Education-Scientific research Project for Middle-Aged and Young of Fujian Province,ChinaResearch on Analysis System of Malicious Code Based on API Relevance(Grant No.JT180626).
文摘In this paper,a cybersecurity threat warning model based on ant colony algorithm is designed to strengthen the accuracy of the cybersecurity threat warning model in the warning process and optimize its algorithm structure.Through the ant colony algorithm structure,the local global optimal solution is obtained;and the cybersecurity threat warning index system is established.Next,the above two steps are integrated to build the cybersecurity threat warning model based on ant colony algorithm,and comparative experiment is also designed.The experimental results show that,compared with the traditional qualitative differential game-based cybersecurity threat warning model,the cybersecurity threat warning model based on ant colony algorithm has a higher correct rate in the warning process,and the algorithm program is simpler with higher use value.