Joint inversion of gravity and vertical gradient data based on modified structural similarity index for the structural and petrophysical consistency constraint

Joint inversion is one of the most effective methods for reducing non-uniqueness for geophysical inversion.The current joint inversion methods can be divided into the structural consistency constraint and petrophysical consistency constraint methods,which are mutually independent.Currently,there is a need for joint inversion methods that can comprehensively consider the structural consistency constraints and petrophysical consistency constraints.This paper develops the structural similarity index(SSIM)as a new structural and petrophysical consistency constraint for the joint inversion of gravity and vertical gradient data.The SSIM constraint is in the form of a fraction,which may have analytical singularities.Therefore,converting the fractional form to the subtractive form can solve the problem of analytic singularity and finally form a modified structural consistency index of the joint inversion,which enhances the stability of the SSIM constraint applied to the joint inversion.Compared to the reconstructed results from the cross-gradient inversion,the proposed method presents good performance and stability.The SSIM algorithm is a new joint inversion method for petrophysical and structural constraints.It can promote the consistency of the recovered models from the distribution and the structure of the physical property values.Then,applications to synthetic data illustrate that the algorithm proposed in this paper can well process the synthetic data and acquire good reconstructed results.

Spatiotemporal variations in ecological quality of Otindag Sandy Land based on a new modified remote sensing ecological index

Otindag Sandy Land in China is an important ecological barrier to Beijing;the changes in its ecological quality are major concerns for sustainable development and planning of this area.Based on principal component analysis and path analysis,we first generated a modified remote sensing ecological index(MRSEI)coupled with satellite and ground observational data during 2001–2020 that integrated four local indicators(greenness,wetness,and heatness that reflect vegetation status,water,and heat conditions,respectively,as well as soil erosion).Then,we assessed the ecological quality in Otindag Sandy Land during 2001–2020 based on the MRSEI at different time scales(i.e.,the whole year,growing season,and non-growing season).MRSEI generally increased with an upward rate of 0.006/a during 2001–2020,with clear seasonal and spatial variations.Ecological quality was significantly improved in most regions of Otindag Sandy Land but degraded in the southern part.Regions with ecological degradation expanded to 18.64%of the total area in the non-growing season.The area with the worst grade of MRSEI shrunk by 15.83%of the total area from 2001 to 2020,while the area with the best grade of MRSEI increased by 9.77%of the total area.The temporal heterogeneity of ecological conditions indicated that the improvement process of ecological quality in the growing season may be interrupted or deteriorated in the following non-growing season.The implementation of ecological restoration measures in Otindag Sandy Land should not ignore the seasonal characteristics and spatial heterogeneity of local ecological quality.The results can explore the effectiveness of ecological restoration and provide scientific guides on sustainable development measures for drylands.

Ecological risk assessment of heavy metals in sediments of Xiawan Port based on modified potential ecological risk index

Modified potential ecological risk index （MRI） was proposed based on the potential ecological risk index （RI） and risk assessment code （RAC） by modifying an index. The modified index was relevant to the chemical speciation of heavy metals. Xiawan Port, a typical region contaminated by industrial production, was selected as a case study area. The total concentrations and chemical speciation of heavy metals in sediments of Xiawan Port were analyzed. The experimental data indicate that Xiawan Port is seriously polluted by heavy metals, especially by Cd. The risks of heavy metals are evaluated by RI, RAC and MRI, respectively. The resluts of MRI show that the risks of heavy metals are in the decreasing order of Cd〉Pb〉Cu〉Zn. Comparison of results by different methods reveals that MRI integrates the characters of RI and RAC. MRI is recognized to be useful for risk managemnt of heavy metals in sediments.

Models for amplitude fluctuation of underwater acoustic narrow band signal based on modified modal scintillation index

A self-normalized statistic the modified modal scintillation index MMSI is proposed and defined as the variance of the modulus of modal excitation normalized by the square of its expected value over some observation intervals.It is proved in an analytical form that the MMSI is a depth dependent signature and independent of the source level and the source range under the condition of the ideal waveguide while the classical modal scintillation index MSI depends on both the source level and the source range.The MSI and the MMSI in the Pekeris waveguide at 70 Hz are simulated with different source levels and source ranges by the Kraken normal mode model.The simulation results are consistent with the theoretical deduction.The MMSI probability density functions PDFs of different normal modes for surface and submerged sources are calculated using the mode filtering methods with the same variations of vertical motions.It is indicated that the PDFs can be used to separate the submerged and the surface sources except for the fourth mode.

Modified shock index and mortality rate of emergency patients

BACKGROUND:This study aimed to determine whether modified shock index(MSI)is associated with mortality that is superior to heart rate,blood pressure,or the shock index(SI).in emergency patients.METHODS:A retrospective database review was performed on 22 161 patients who presented to Peking Union Medical College Hospital Emergency Department and received intravenous fluids from January 1 to December 31,2009.We gathered data of the patients on age,gender,vital signs,levels of consciousness,presenting complaints,and SI and MSI were calculated for all patients.RESULTS:Multivariate regression analysis was performed to determine the correlation between risk factors and outcome.There is a significant correlation between emergency patient mortality rate and patient's vital signs obtained at the triage desk(HR>120 beats/min,systolic BP<90 mmHg,diastolic BP<60 mmHg).MSI is a stronger predictor of emergency patient mortality compared to heart rate and blood pressure alone,whereas SI does not have a significant correlation with emergency patient mortality rate.CONCLUSION:MSI is a clinically significant predictor of mortality in emergency patients.It may be better than using heart rate and blood pressure alone.SI is not significantly correlated with the mortality rate of the emergency patient.

A Modified Temperature-Vegetation Dryness Index(MTVDI)for Assessment of Surface Soil Moisture Based on MODIS Data

Spatio-temporal dynamic monitoring of soil moisture is highly important to management of agricultural and vegetation eco-systems.The temperature-vegetation dryness index based on the triangle or trapezoid method has been used widely in previous studies.However,most existing studies simply used linear regression to construct empirical models to fit the edges of the feature space.This requires extensive data from a vast study area,and may lead to subjective results.In this study,a Modified Temperature-Vegetation Dryness Index(MTVDI)was used to monitor surface soil moisture status using MODIS(Moderate-resolution Imaging Spectroradiometer)remote sensing data,in which the dry edge conditions were determined at the pixel scale based on surface energy balance.The MTVDI was validated by field measurements at 30 sites for 10 d and compared with the Temperature-Vegetation Dryness Index(TVDI).The results showed that the R^(2) for MTVDI and soil moisture obviously improved(0.45 for TVDI,0.69 for MTVDI).As for spatial changes,MTVDI can also better reflect the actual soil moisture condition than TVDI.As a result,MTVDI can be considered an effective method to monitor the spatio-temporal changes in surface soil moisture on a regional scale.

A modified TOPMODEL introducing the bedrock surface topographic index in Huangbengliu watershed,China

Subsurface stormflow is a dominant runoff mechanism in steep humid mountainous areas.An insite measurement of subsurface stormflow suggests that the bedrock surface plays an important role in the runoff generation and routing process,which was rarely adopted in hydrological modelling studies.To improve the runoff simulation performance,the bedrock surface topographic index is introduced,and a modified TOPMODEL based on the bedrock surface topographic index is developed to simulate the runoff.The modified TOPMODEL is applied to the Huangbengliu(HBL),a steep watershed in Gongga Mountain,and proved to be more appropriate for the HBL watershed,especially for peak simulation.The Nash-Sutcliffe model efficiency(NSE)is improved from 0.24 to 0.58 in the calibration period and from 0.40 to 0.62 in the verification period.The result of this study can advance the understanding of the mechanism of flash floods and contribute flood control and disaster prevention in the HBL watershed and similar areas.

Differentiation of Algal Blooms and Aquatic Vegetation in Chinese Lakes Using Modified Vegetation Presence Frequency Index Method

Algal blooms in lakes have become a common global environmental problem. Nowadays, remote sensing is widely used to monitor algal blooms in lakes due to the macroscopic, fast, real-time characteristics. However, it is often difficult to distinguish between algal blooms and aquatic vegetation due to their similar spectral characteristics. In this paper, we used modified vegetation presence frequency index(VPF) based on Moderate-resolution Imaging Spectroradiometer(MODIS) imagery to distinguish algal blooms from aquatic vegetation, and analyzed the spatial and temporal variations of algal blooms and aquatic vegetation from a phenological perspective for five large natural lakes with frequent algal bloom outbreaks in China from 2019 to 2020. We simplified the VPF method to make it with a higher spatial transferability so that it could be applied to other lakes in different climatic zones. Through accuracy validation, we found that the modified VPF method can effectively distinguish between algal blooms and aquatic vegetation, and the results vary from lake to lake. The highest accuracy of 97% was achieved in Hulun Lake, where the frequency of algal outbreaks is low and the extent of aquatic vegetation is stable, while the lowest accuracy of 76% was achieved in Dianchi Lake, which is rainy in summer and the lake is small. Analyses suggests that the time period when algal blooms occur most frequently might not coincide with that when they have the largest area. However, in most cases these two are close in terms of time period. The modified VPF method has a broad scope of application, is easy to implement, and has a high practical value. Furthermore, the method could be established using only a small amount of measured data, which is useful for water quality monitoring on large spatial scales.

Analyzing the influences of two types of El Nino on Tropical Cyclone Genesis with a modified genesis potential index

To understand the impacts of large-scale circulation during the evolution of E1 Nifio cycle on tropical cyclones （TC） is important and useful for TC forecast. Based on best-track data from the Joint Typhoon Warning Center and reanalysis data from National Centers for Environmental Prediction for the period 1975- 2014, we investigated the influences of two types of E1 Nifio, the eastern Pacific E1 Nifio （EP-E1 Nifio） and central Pacific E1 Nifio （CP-E1 Nifio）, on global TC genesis. We also examined how various environmental factors contribute to these influences using a modified genesis potential index （MGPI）. The composites reproduced for two types of E1 Nifio, from their developing to decaying phases, were able to qualitatively replicate observed cyclogenesis in several basins except for the Arabian Sea. Certain factors of MGPI with more influence than others in various regions are identified. Over the western North Pacific, five variables were all important in the two E1Nifio types during developing summer （July-August-September） and fall （October- November-December）, and decaying spring （April-May-June） and summer. In the eastern Pacific, vertical shear and relative vorticity are the crucial factors for the two types of El Nifio during developing and decaying summers. In the Atlantic, vertical shear, potential intensity and relative humidity are important for the opposite variation of EP- and CP-EI Nifios during decaying summers. In the Southern Hemisphere, the five variables have varying contributions to TC genesis variation during peak season （January-February-March） for the two types of E1 Nifio. In the Bay of Bengal, relative vorticity, humidity and omega may be responsible for clearly reduced TC genesis during developing fall for the two types and slightly suppressed TC cyclogenesis during EP-E1 Nifio decaying spring. In the Arabian Sea, the EP-E1 Nifio generates a slightly positive anomaly of TC genesis during developing falls and decaying springs, but the MGPI failed to capture this variation.

A novel multimode process monitoring method integrating LCGMM with modified LFDA

Complex processes often work with multiple operation regions, it is critical to develop effective monitoring approaches to ensure the safety of chemical processes. In this work, a discriminant local consistency Gaussian mixture model(DLCGMM) for multimode process monitoring is proposed for multimode process monitoring by integrating LCGMM with modified local Fisher discriminant analysis(MLFDA). Different from Fisher discriminant analysis(FDA) that aims to discover the global optimal discriminant directions, MLFDA is capable of uncovering multimodality and local structure of the data by exploiting the posterior probabilities of observations within clusters calculated from the results of LCGMM. This may enable MLFDA to capture more meaningful discriminant information hidden in the high-dimensional multimode observations comparing to FDA. Contrary to most existing multimode process monitoring approaches, DLCGMM performs LCGMM and MFLDA iteratively, and the optimal subspaces with multi-Gaussianity and the optimal discriminant projection vectors are simultaneously achieved in the framework of supervised and unsupervised learning. Furthermore, monitoring statistics are established on each cluster that represents a specific operation condition and two global Bayesian inference-based fault monitoring indexes are established by combining with all the monitoring results of all clusters. The efficiency and effectiveness of the proposed method are evaluated through UCI datasets, a simulated multimode model and the Tennessee Eastman benchmark process.

上面层改性沥青混合料低温性能综合对比评价

【目的】分析足尺路面试验环道所用7种上面层细粒式改性沥青混合料的低温性能。【方法】通过小梁低温弯曲、中梁线收缩系数和法国M2F梯形梁动态模量3种室内试验开展研究及相关性分析,并应用多指标试验结果的无量纲归一化赋权求和法进行综合对比评价。【结果】最大弯拉应变、应变能密度、线收缩系数、复模量和相位角均可作为改性沥青混合料低温性能的合理评价指标;对比改性沥青类型,采用低温延性强的SBS改性沥青制备的混合料低温性能最优,橡胶沥青混合料的次之,掺抗车辙剂能增强SBS改性AC类混合料的低温性能;对比矿料合成级配,SMA类的低温性能最优,SBS改性AC类中粗集料含量越低,其低温性能越好;多孔排水式高黏SBS改性PAC类具有优良的黏弹性和低温收缩性能。【结论】评价结果可为环道沥青路面低温性能长期监测对比提供参考。

改良俯卧位通气对急性呼吸窘迫综合征患者呼吸功能及预后的影响

目的 探究改良俯卧位通气对急性呼吸窘迫综合征(ARDS)患者血流动力学、呼吸动力学及预后的影响。方法 前瞻性选取河南大学第一附属医院2020年3月至2022年6月收治的98例ARDS患者作为研究对象,通过随机数字表法分为A、B组。通过随机及前瞻性平行对照临床研究,评价不同通气方式在ARDS患者中的作用,其中A组52例接受改良式俯卧位通气,B组46例接受传统俯卧位通气。对比两组患者干预前、干预后(俯卧位通气4 h后)血流动力学[心率(HR)、平均动脉压、中心静脉压]、呼吸动力学指标[气道阻力、静态肺顺应性(Cst)]、氧合指数及腹腔压力的变化。比较两组患者不良事件发生情况,对所有患者进行3个月随访,比较两组患者病死率情况。结果 (1)A组机械通气时间低于B组,撤机成功率高于B组(P<0.05);(2)干预后,两组患者HR均较干预前上升,干预前后差值具有统计学意义(P<0.05);(3)干预后,两组Cst水平均较干预前上升且A组高于B组,干预前后差值具有统计学意义(P<0.05);(4)干预后,两组腹腔压力均较治疗前上升且A组低于B组,干预前后差值具有统计学意义(P<0.05);(5)A组不良事件总发生率[7.69%(4/52)]低于B组[23.91%(11/46)](P<0.05);(6)随访3个月结果显示,A组病死率[23.08%(12/52)]低于B组[43.48%(20/46)](P<0.05)。结论 改良俯卧位通气对ARDS血流动力学、呼吸动力学及相关指标均有显著的改善效果,不良事件的发生率较低且预后状况良好,值得临床参考借鉴。

玉屏风加减煎剂对德化黑鸡柔嫩艾美耳球虫的抗感染效果

【目的】探明玉屏风加减煎剂对柔嫩艾美耳球虫(Eimeria tenella)感染德化黑鸡抗氧化、抗炎、免疫功能的影响及抗球虫效果。【方法】将120只45日龄德化黑鸡随机分为6组,分别是空白对照组(K组)、感染对照组(G组)、常山青蒿低剂量组(CQL组)、玉屏风加减低剂量组(YL组)、常山青蒿高剂量组(CQH组)、玉屏风加减高剂量组(YH组),除空白对照组外,其余各组均感染柔嫩艾美耳球虫,24 h后开始连续7 d饮水给药,第8 d测定比较各组抗球虫指数、免疫功能、抗氧化能力等指标的差异。【结果】与感染对照组(G组)相比,中药处理组CQH、YH、CQL、YL的血便、盲肠病变症状依次减轻。除CQH组外,其他组盲肠病变计分、盲肠黏膜下淋巴细胞密度显著或极显著下降(P<0.05或P<0.01);除CQH组OPG显著下降(P<0.05)外,其他3个中药组OPG下降极显著(P<0.01);YL组和YH组盲肠上皮细胞脱落计分极显著降低(P<0.01)。与CQL、CQH组相比,YL、YH组MDA、盲肠病变计分、盲肠上皮细胞脱落计分和OPG下降极显著(P<0.01)。与G组相比,4个中药组IL-6、 IFN-γ、TNF-α、丙二醛(MDA)含量极显著降低(P<0.01),而IL-2含量、 SIgA水平、谷胱甘肽过氧化物酶(GSH-Px)活性、超氧化物歧化酶(SOD)活性、过氧化氢酶(CAT)活性、总抗氧化能力(T-AOC)极显著升高(P<0.01);YL组IL-2含量、 SIgA水平、GSH-Px活性、SOD活性、CAT活性极显著增高(P<0.01),YH组GSH-Px、 SOD活性极显著升高(P<0.01)。与K组相比,G组、CQL组、YL组、CQH组、YH组的相对增重率分别是79.88%、 103.49%、 107.27%、 95.05%、 96.06%,抗球虫指数(anti-coccidialindex,ACI)分别是96、165.5、177、133.5、162.5。【结论】玉屏风加减煎剂对人工感染柔嫩艾美耳球虫德化黑鸡具有更好抗炎、抗氧化、提高免疫功能的免疫调节作用,并相应具有更好的抗球虫效果,且以玉屏风加减低剂量组(YL)抗球虫效果最好。

加味调肝汤联合西药治疗肝郁肾虚型月经过少疗效及对患者子宫内膜厚度的影响

目的:研究加味调肝汤联合西药治疗肝郁肾虚型月经过少临床疗效及对患者子宫内膜厚度的影响。方法:选取肝郁肾虚型月经过少患者共124例,采用随机数字表法分为观察组和对照组,其中对照组62例采用戊酸雌二醇(E2)、地屈孕酮治疗,观察组62例采用加味调肝汤联合戊酸雌二醇、地屈孕酮治疗。比较两组治疗效果、不良反应发生率,两组治疗前后中医证候积分、子宫内膜厚度、子宫血流阻力指数(RI)和卵泡期性激素水平。结果:观察组治疗总有效率为90.32%,较对照组总有效率75.81%高(P<0.05)。治疗前两组中医证候积分对比差异无统计学意义(P>0.05),治疗3个月后观察组上述积分较对照组更低(P<0.05)。治疗前两组卵泡期子宫内膜厚度、RI值比较,差异无统计学意义(P>0.05),治疗3个月后观察组卵泡期子宫内膜厚度较对照组更厚;RI较之于对照组更低(P<0.05)。治疗前两组卵泡期E2、FSH、LH水平比较无统计学差异(P>0.05);治疗3个月后观察组卵泡期性激素水平比对照组高(P<0.05)。观察组不良反应发生率为11.29%,与对照组的24.19%比较差异无统计学意义(P>0.05)。结论:加味调肝汤联合西药治疗肝郁肾虚型月经过少临床疗效比单用西药治疗效果更佳,能促进子宫内膜生长,降低RI值,调节卵泡期性激素水平。

改良格拉斯哥预后评分和全身免疫炎症指数在宫颈癌患者预后预测中的价值

目的:探讨改良格拉斯哥预后评分(mGPS)和全身免疫炎症指数(SII)在宫颈癌患者预后预测中的价值。方法:回顾2010年-2017年我院的宫颈癌患者143例,收集完整病历并随访至2023年6月30日,采用Kaplan-Meier法绘制生存曲线,Log-rank检验和Cox回归分析影响患者预后的因素。结果:患者3年和5年生存率分别为85.31%和66.43%。受试者工作曲线(ROC)显示:mGPS、SII、白蛋白(ALB)、淋巴细胞(LYM)、中性粒细胞(NEU)和C反应蛋白(CRP)预测患者预后的曲线下面积分别为0.821、0.867、0.875、0.885、0.835和0.696,最佳截断值分别为0.5分、34.65 g/L、1.38×10^(9)/L、5.55×10^(9)/L、7.25 mg/L和475×10^(9)/L。Cox回归分析显示:mGPS、SII和FIGO分期是宫颈癌患者预后的影响因素,其HR分别为2.484(GPS=1)、7.096(mGPS=2)、0.121、9.507(FIGO为Ⅲ期)和23.715(FIGO为Ⅳ期)(P<0.05)。结论:mGPS、SII和FIGO分期是宫颈癌患者预后的重要预测因子。

针刺夹脊穴联合通督调神针刺治疗中风后平衡障碍临床研究

目的:观察针刺夹脊穴联合通督调神针刺治疗中风后平衡障碍的临床效果。方法:将中风后平衡功能障碍患者纳入本次研究,共67例,应用随机数字表法将上述患者分为对照组(34例,常规治疗加通督调神针刺)和试验组(33例,在对照组基础上针刺夹脊穴),两组均治疗4周。治疗后通过使用Berg平衡量表(BBS)、Fugl-Meyer平衡功能评定量表(FMB)、Barthel指数分级法(MBI)、Holden步行功能分级量表(FAC)分别评估患者平衡功能、肢体功能、日常活动能力及步行功能,同时观察生化指标D-二聚体(DD)、同型半胱氨酸(Hcy)、超敏C反应蛋白(hs-CRP)变化,并评价整体疗效。结果:治疗4周后,试验组BBS、FMB、MBI及FAC得分分别为(41.56±7.01)、(13.22±1.62)、(70.13±6.92)、(3.84±1.07)分,均显著高于对照组(P<0.05);试验组Hcy、DD、hs-CRP水平分别为(15.42±3.22)μmol/L、(372.46±39.58)μg/L、(5.61±1.03)mg/L,显著低于对照组(P<0.05);试验组总有效率为96.97%,显著优于对照组(P<0.05)。结论:针刺夹脊穴联合通督调神针刺能有效治疗中风后平衡障碍,提高患者肢体功能、日常活动能力及步行能力,改善凝血功能及炎症反应。

基于分子动力学聚合物改性沥青黏附性能研究

为了增强基质沥青与集料之间界面黏附性,选取PE、SBS、SBR、PU 4种代表性聚合物对其进行改性,采用分子动力学模拟法对沥青-集料和沥青-水-集料模型进行不同工况模拟,并通过室内试验验证模拟结果。通过分析相对浓度分布曲线得到沥青极性组分的变化规律,研究不同温度下各改性沥青混合料黏附性并根据相对浓度参数对其机理进行分析,通过聚合物改性性能对比,得出其适用条件。结果表明:PE与沥青相溶性好,但PE改性沥青混合料水稳定性较差;SBS改性沥青能在温差较大的环境中保持较高的黏附性;SBR改性沥青低温条件下黏附性突出,且水稳定性优越,适用于低温多雨的地区;PU改性沥青综合性能较好,在高温多雨等气候条件复杂的环境中适用性较强。

NLR与MSI对急性NSTEMI短期预后判断价值

目的本研究旨在探讨校正休克指数(MSI)和中性粒细胞/淋巴细胞比值(NLR)在判断急性非ST段抬高型心肌梗死(NSTEMI)患者短期内可能出现不良预后的预测能力。方法研究组选择2020年3月到2021年9月期间,首次就诊急诊科明确诊断为急性非ST段抬高型心肌梗死的276例患者。通过快速急诊绿道监测血压与心率,并于急诊科10 min内抽取血常规、床旁心脏彩超等相关化验检查,依据监测及化验结果,研究小组计算了校正休克指数(MSI)和中性粒细胞/淋巴细胞比值(NLR),然后根据统计结果将患者分为2组:NLR≥5.0组(n=75)与NLR﹤5.0组(n=201);(2)MSI≥1.2组(n=57)与MSI<1.2组(n=219)。比较2组一般资料情况,发生不良心血管事件的比例,采用受试者ROC曲线下面积来评估NLR值和MSI值对NSTEMI院内不良心血管事件的预测能力。结果连续入选的276例NSTEMI患者中,发生不良心血管事件52例,占18.8%,心源性休克患者15例,占5.4%,恶性心律失常患者24例,占8.7%,死亡13例,占4.7%。NLR≥5.0与MSI≥1.2值组的心功能、收缩压(SBP)、舒张压(DBP)及心率(HR)分别与NLR<5.0与MSI<1.2组比较,差异有统计学意义(P<0.05);NLR≥5.0与MSI≥1.2组MACE发生率分别高于NLR<5.0组与MSI<1.2组(P<0.05)。此外,NLR和MSI的ROC曲线下面积分别为0.734和0.703,提示NLR和MSI均具有评价急性非ST段抬高型心肌梗死患者短期不良心血管事件发生能力。结论MSI与NLR是评估NSTEMI短期不良预后的两个简单的重要的易获得指标。

桂枝芍药知母汤加减联合常规治疗类风湿性关节炎的临床研究

目的分析桂枝芍药知母汤加减联合常规治疗类风湿性关节炎的效果。方法2019年1月—2021年12月六安市中医院风湿肾病科收治的类风湿性关节炎患者130例,分为对照组与研究组各65例,方法为随机数字表法。对照组常规西药(塞来昔布、甲氨蝶呤)治疗;研究组在常规西药基础上采用桂枝芍药知母汤加减治疗,均治疗1个月。比较两组治疗,治疗前、治疗1个月后临床症状、血流变学、血小板指标、血清指标。结果治疗1个月后,研究组的总有效率更高(P<0.05)。较治疗前,两组晨僵时间缩短,且研究组更短(P<0.05)。较治疗前,两组关节压痛数、关节肿胀数、疼痛程度,全血黏度高切、平均血小板体积(MPV)、全血黏度低切、红细胞压积(HCT)、血小板分布宽度(PDW),血清类风湿因子(RF),C反应蛋白(CRP),肿瘤坏死因子-α(TNF-α)、白细胞介素6(IL-6)水平降低,且研究组更低(P<0.05)。结论桂枝芍药知母汤加减治疗类风湿性关节炎疗效确切,可减轻其临床症状,分析与其调节血流变学、血小板指标及血清指标有关。

骨质疏松性椎体压缩骨折PVP术后早期脊柱矢状序列与Batherl指数的关系

目的 探讨老年急性椎体压缩骨折接受椎体成形术后矢状面脊柱排列的短期变化及其与Batherl指数变化的关系。方法 选择2020年1月至2021年12月在该院接受PVP治疗的单节段OVCF患者作为研究对象,观察患者术前、术后矢状垂直轴(SVA)、T1骨盆角(TPA)、脊柱骶骨角(SSA)、腰椎前凸角(LL)、胸椎后凸角(TK),术前、术后2周、术后6周、术后12周时的疼痛视觉模拟评分(VAS)、改良Batherl指数(MBI)及其子项目床椅转移(MBI8,15分)、平地行走(MBI9,15分)、上下楼梯(MBI10,10分)的变化;控制混杂变量后,观察ΔSVA、ΔTPA、ΔSSA、ΔLL、ΔTK(Δ表示手术前后的差值)与MBI总分、MBI8、MBI9、MBI10的相关性。结果 术后患者SVA、TPA、TK较术前显著降低(P<0.05),术后患者的SSA、LL与术前相比,差异无统计学意义(P>0.05)。术前、术后2周、术后6周、术后12周时,患者MBI(总分、MBI8、MBI9、MBI10)逐渐升高、VAS均呈逐渐降低趋势(P<0.05)。多元线性回归结果显示,ΔMBI总分与ΔSVA呈负相关,与ΔSSA、ΔTPA、ΔLL和ΔTK均不存在相关性(P>0.05);ΔMBI8、ΔMBI9与ΔSVA、ΔSSA、ΔTPA、ΔLL、ΔTK均不存在相关性(P>0.05);ΔMBI10与ΔSVA存在显著负相关(P<0.05),与ΔSSA、ΔTPA、ΔLL、ΔTK均不存在相关性(P>0.05)。结论 急性OVCF患者PVP术前和术后SVA值与患者术后12周时MBI总分和上下楼梯功能相关。