Nucleoside modified mRNA-lipid nanoparticles as a new delivery platform for the repair of the injured spinal cord

Spinal cord injury and treatment opportunities:The adult mammalian spinal cord has a very limited capacity for spontaneous regeneration due to various intrinsic molecular and cellular factors.Although the spinal cord neurons have the capacity to regenerate their axons,the expression of growth inhibitory factors,lack or suppression of proper guidance cues,and profound inflammatory responses do not permit successful regeneration(Khyeam et al.,2021).

Constitutive equations of 1060 pure aluminum based on modified double multiple nonlinear regression model

In order to study the work-ability and establish the optimum hot formation processing parameters for industrial 1060 pure aluminum, the compressive deformation behavior of pure aluminum was investigated at temperatures of 523?823 K and strain rates of 0.005?10 s?1 on a Gleeble?1500 thermo-simulation machine. The influence rule of processing parameters (strain, strain rate and temperature) on flow stress of pure aluminum was investigated. Nine analysis factors consisting of material parameters and according weights were optimized. Then, the constitutive equations of multilevel series rules, multilevel parallel rules and multilevel series &parallel rules were established. The correlation coefficients (R) are 0.992, 0.988 and 0.990, respectively, and the average absolute relative errors (AAREs) are 6.77%, 8.70% and 7.63%, respectively, which proves that the constitutive equations of multilevel series rules can predict the flow stress of pure aluminum with good correlation and precision.

Modified unscented particle filter for nonlinear Bayesian tracking

A modified unscented particle filtering scheme for nonlinear tracking is proposed, in view of the potential drawbacks （such as, particle impoverishment and numerical sensitivity in calculating the prior） of the conventional unscented particle filter （UPF） confronted in practice. Specifically, a different derivation of the importance weight is presented in detail. The proposed method can avoid the calculation of the prior and reduce the effects of the impoverishment problem caused by sampling from the proposal distribution, Simulations have been performed using two illustrative examples and results have been provided to demonstrate the validity of the modified UPF as well as its improved performance over the conventional one.

An approximate nonlinear modified Mohr-Coulomb shear strength criterion with critical state for intact rocks

In this paper, the Mohr-Coulomb shear strength criterion is modified by mobilising the cohesion and internal friction angle with normal stress, in order to capture the nonlinearity and critical state concept for intact rocks reported in the literature. The mathematical expression for the strength is the same as the classical form, but the terms of cohesion and internal friction angle depend on the normal stress now,leading to a nonlinear relationship between the strength and normal stress. It covers both the tension and compression regions with different expressions for cohesion and internal friction angle. The strengths from the two regions join continuously at the transition of zero normal stress. The part in the compression region approximately satisfies the conditions of critical state, where the maximum shear strength is reached. Due to the nonlinearity, the classical simple relationship between the parameters of cohesion, internal friction angle and uniaxial compressive strength from the linear Mohr-Coulomb criterion does not hold anymore. The equation for determining one of the three parameters in terms of the other two is supplied. This equation is nonlinear and thus a nonlinear equation solver is needed. For simplicity, the classical linear relationship is used as a local approximation. The approximate modified Mohr-Coulomb criterion has been implemented in a fracture mechanics based numerical code FRACOD,and an example case of deep tunnel failure is presented to demonstrate the difference between the original and modified Mohr-Coulomb criteria. It is shown that the nonlinear modified Mohr-Coulomb criterion predicts somewhat deeper and more intensive fracturing regions in the surrounding rock mass than the original linear Mohr-Coulomb criterion. A more comprehensive piecewise nonlinear shear strength criterion is also included in Appendix B for those readers who are interested. It covers the tensile, compressive, brittle-ductile behaviour transition and the critical state, and gives smooth transitions.

A Modified Form of Mild-Slope Equation with Weakly Nonlinear Effect

Nonlinear effect is of importance to waves propagating from deep water to shallow water. The non-linearity of waves is widely discussed due to its high precision in application. But there are still some problems in dealing with the nonlinear waves in practice. In this paper, a modified form of mild-slope equation with weakly nonlinear effect is derived by use of the nonlinear dispersion relation and the steady mild-slope equation containing energy dissipation. The modified form of mild-slope equation is convenient to solve nonlinear effect of waves. The model is tested against the laboratory measurement for the case of a submerged elliptical shoal on a slope beach given by Berkhoff et al. The present numerical results are also compared with those obtained through linear wave theory. Better agreement is obtained as the modified mild-slope equation is employed. And the modified mild-slope equation can reasonably simulate the weakly nonlinear effect of wave propagation from deep water to coast.

BER Modified Decode-and-Forward Protocol for OFDM-Based Linear Multihop Networks

In orthogonal frequency division multiplexing （OFDM） based multihop communications, the conventional decodeand-forward （DF） relay scheme severely suffers from the error propagation problem. This drawback is serious in multihop networks as errors made by any relay node may fail the decoder at the destination in great chance. In this paper, we propose a bit error rate （BER） modified DF protocol （BMDF） which can be applied to systems where error correction channel coding and M-ary modulation are used. By modeling all links except the last one as a binary symmetric channel （BSC）, we derive a log likelihood ratio （LLR） modification function relying only on the accumulated BER of all previous links to be applied to the output of the soft demapper. Furthermore, to reduce the computational complexity and signaling overhead, the modification function is simplified from its original exponential expression and less BERs are delivered between nodes by making successive subcarriers share the same BER. In addition, for situations where the channel state information （CSI） of forward link is available, the proposed BMDF can be further enhanced by combining with subcarrier pairing （SP） and power allocation （PA）, where a sorted-channel gain SP scheme and a greedy PA algorithm are proposed. The simulation results verify thesignificant performance improvement to the conventional DF.

Multi-soliton solutions for the coupled modified nonlinear Schrdinger equations via Riemann–Hilbert approach

The coupled modified nonlinear Schrodinger equations are under investigation in this work. Starting from analyzing the spectral problem of the Lax pair, a Riemann-Hilbert problem for the coupled modified nonlinear Schrodinger equations is formulated. And then, through solving the obtained Riemann-Hilbert problem under the conditions of irregularity and reflectionless case, N-soliton solutions for the equations are presented. Furthermore, the localized structures and dynamic behaviors of the one-soliton solution are shown graphically.

Size-dependent effect on biaxial and shear nonlinear buckling analysis of nonlocal isotropic and orthotropic micro-plate based on surface stress and modified couple stress theories using differential quadrature method

The size-dependent effect on the biaxial and shear nonlinear buckling analysis of an isotropic and orthotropic micro-plate based on the surface stress, the modified couple stress theory （MCST）, and the nonlocal elasticity theories using the differential quadrature method （DQM） is presented. Main advantages of the MCST over the classical theory （CT） are the inclusion of the asymmetric couple stress tensor and the consideration of only one material length scale parameter. Based on the nonlinear von Karman assumption, the governing equations of equilibrium for the micro-classical plate consid- ering midplane displacements are derived based on the minimum principle of potential energy. Using the DQM, the biaxial and shear critical buckling loads of the micro-plate for various boundary conditions are obtained. Accuracy of the obtained results is validated by comparing the solutions with those reported in the literature. A parametric study is conducted to show the effects of the aspect ratio, the side-to-thickness ratio, Eringen＇s nonlocal parameter, the material length scale parameter, Young＇s modulus of the surface layer, the surface residual stress, the polymer matrix coefficients, and various boundary conditions on the dimensionless uniaxial, biaxial, and shear critical buckling loads. The results indicate that the critical buckling loads are strongly sensitive to Eringen＇s nonlocal parameter, the material length scale parameter, and the surface residual stress effects, while the effect of Young＇s modulus of the surface layer on the critical buckling load is negligible. Also, considering the size dependent effect causes the increase in the stiffness of the orthotropic micro-plate. The results show that the critical biaxial buckling load increases with an increase in G12/E2 and vice versa for E1/E2. It is shown that the nonlinear biaxial buckling ratio decreases as the aspect ratio increases and vice versa for the buckling amplitude. Because of the most lightweight micro-composite materials with high strength/weight and stiffness/weight ratios, it is anticipated that the results of the present work are useful in experimental characterization of the mechanical properties of micro-composite plates in the aircraft industry and other engineering applications.

Modified Projective Synchronization of a New Hyperchaotic System via Nonlinear Control

In this paper, a nonlinear control scheme of two identical hyperchaotic Chert systems is developed to realize their modified projective synchronization. We achieve modified projective synchronization between the two identical hyperchaotic systems by directing the scaling factor onto the desired value. With symbolic computation system Maple and Lyapunov stability theory, numerical simulations are given to perform the process of the synchronization.

Soliton excitations and interaction in alpha helical protein with interspine coupling in modified nonlinear Schrodinger equation

The three-coupling modified nonlinear Schr?dinger(MNLS) equation with variable-coefficients is used to describe the dynamics of soliton in alpha helical protein. This MNLS equation with variable-coefficients is firstly transformed to the MNLS equation with constant-coefficients by similarity transformation. And then the one-soliton and two-soliton solutions of the variable-coefficient-MNLS equation are obtained by solving the constant-coefficient-MNLS equation with Hirota method. The effects of different parameter conditions on the soliton solutions are discussed in detail. The interaction between two solitons is also discussed. Our results are helpful to understand the soliton dynamics in alpha helical protein.

A New Approach for the Exact Solutions of Nonlinear Equations of Fractional Order via Modified Simple Equation Method

In this article, the modified simple equation method has been extended to celebrate the exact solutions of nonlinear partial time-space differential equations of fractional order. Firstly, the fractional complex transformation has been implemented to convert nonlinear partial fractional differential equations into nonlinear ordinary differential equations. Afterwards, modified simple equation method has been implemented, to find the exact solutions of these equations, in the sense of modified Riemann-Liouville derivative. For applications, the exact solutions of time-space fractional derivative Burgers’ equation and time-space fractional derivative foam drainage equation have been discussed. Moreover, it can also be concluded that the proposed method is easy, direct and concise as compared to other existing methods.

Changepoint Analysis by Modified Empirical Likelihood Method in Two-phase Linear Regression Models

A changepoint in statistical applications refers to an observational time point at which the structure pattern changes during a somewhat long-term experimentation process. In many cases, the change point time and cause are documented and it is reasonably straightforward to statistically adjust (homogenize) the series for the effects of the changepoint. Sadly many changepoint times are undocumented and the changepoint times themselves are the main purpose of study. In this article, the changepoint analysis in two-phrase linear regression models is developed and discussed. Following Liu and Qian (2010)'s idea in the segmented linear regression models, the modified empirical likelihood ratio statistic is proposed to test if there exists a changepoint during the long-term experiment and observation. The modified empirical likelihood ratio statistic is computation-friendly and its ρ-value can be easily approximated based on the large sample properties. The procedure is applied to the Old Faithful geyser eruption data in October 1980.

Modelling of the elastoplastic behaviour of the bio-cemented soils using an extended Modified Cam Clay model

An elastoplastic constitutive model based on the Modified Cam Clay(MCC)model is developed to describe the mechanical behaviour of soils cemented via microbially induced calcite precipitation(MICP).It considers the increase of the elastic stiffness,the change of the yield surface due to MICP cementation and the degradation of calcium carbonate bonds during shearing.Specifically,to capture the typical contraction-dilation transition in MICP soils,the original volumetric hardening rule in the MCC model is modified to a combined deviatoric and volumetric hardening rule.The model could reproduce a series of drained triaxial tests on MICP-treated soils with different calcium carbonate contents.Further,we carry out a parametric study and observe numerical instability in some cases.In combination with an analytical analysis,our numerical modelling has identified the benefits and limitations of using MCCbased models in the simulation of MICP-cemented soils,leading to suggestions for further model development.

Computer-Based Modelling of Network Functions for Linear Dynamic Circuits Using Modified Nodal Approach

In this paper,a computer-based systematic and efficient formulation method is presented for obtaining the network functions of linear or linearized time-invariant dynamic circuits.The method employs the modified nodal approach to obtain the system equations.The technique is based on developing a matrix formulation for modelling network functions.By using both symbolic manipulation of algebraic expressions and numeric processes,the network functions are expressed with a matrix-based method.Application examples are given to illustrate the features of the method.

Numerical Treatment of Initial Value Problems of Nonlinear Ordinary Differential Equations by Duan-Rach-Wazwaz Modified Adomian Decomposition Method

We employ the Duan-Rach-Wazwaz modified Adomian decomposition method for solving initial value problems for the systems of nonlinear ordinary differential equations numerically. In order to confirm practicality, robustness and reliability of the method, we compare the results from the modified Adomian decomposition method with those from the MATHEMATICA solutions and also from the fourth-order Runge Kutta method solutions in some cases. Furthermore, we apply Padé approximants technique to improve the solutions of the modified decomposition method whenever the exact solutions exist.

Breather and its interaction with rogue wave of the coupled modified nonlinear Schrodinger equation

We investigate the coupled modified nonlinear Schr?dinger equation.Breather solutions are constructed through the traditional Darboux transformation with nonzero plane-wave solutions.To obtain the higher-order localized wave solution,the N-fold generalized Darboux transformation is given.Under the condition that the characteristic equation admits a double-root,we present the expression of the first-order interactional solution.Then we graphically analyze the dynamics of the breather and rogue wave.Due to the simultaneous existence of nonlinear and self-steepening terms in the equation,different profiles in two components for the breathers are presented.

Modified characteristic finite difference fractional step method for moving boundary value problem of nonlinear percolation system

A fractional step scheme with modified characteristic finite differences run- ning in a parallel arithmetic is presented to simulate a nonlinear percolation system of multilayer dynamics of fluids in a porous medium with moving boundary values. With the help of theoretical techniques including the change of regions, piecewise threefold quadratic interpolation, calculus of variations, multiplicative commutation rule of differ- ence operators, multiplicative commutation rule of difference operators, decomposition of high order difference operators, induction hypothesis, and prior estimates, an optimal order in 12 norm is displayed to complete the convergence analysis of the numerical algo- rithm. Some numerical results arising in the actual simulation of migration-accumulation of oil resources by this method are listed in the last section.

ON THE MODIFIED NONLINEAR SCHRDINGER EQUATION IN THE SEMICLASSICAL LIMIT:SUPERSONIC,SUBSONIC,AND TRANSSONIC BEHAVIOR

The purpose of this paper is to present a comparison between the modified nonlinear SchrSdinger （MNLS） equation and the focusing and defocusing variants of the （unmodified） nonlinear SchrSdinger （NLS） equation in the semiclassical limit. We describe aspects of the limiting dynamics and discuss how the nature of the dynamics is evident theoretically through inverse-scattering and noncommutative steepest descent methods. The main message is that, depending on initial data, the MNLS equation can behave either like the defocusing NLS equation, like the focusing NLS equation （in both cases the analogy is asymptotically accurate in the semiclassical limit when the NLS equation is posed with appropriately modified initial data）, or like an interesting mixture of the two. In the latter case, we identify a feature of the dynamics analogous to a sonic line in gas dynamics, a free boundary separating subsonic flow from supersonic flow.

Modified Lindstedt-Poincaré Method for Obtaining Resonance Periodic Solutions of Nonlinear Non-autonomous Oscillators

A modified Lindstedt-Poincar＆#233; （LP） method for obtaining the resonance periodic solutions of nonlinear non-autonomous vibration systems is proposed in this paper. In the modified method, nonlinear non-autonomous equa-tions are converted into a group of linear ordinary differential equations by introducing a set of simple transformations. An approximate resonance solution for the original equation can then be obtained. The periodic solutions of primary, super-harmonic, sub-harmonic, zero-frequency and combination resonances can be solved effectively using the modi-fied method. Some examples, such as damped cubic nonlinear systems under single and double frequency excitation, and damped quadratic nonlinear systems under double frequency excitation, are given to illustrate its convenience and effectiveness. Using the modified LP method, the first-order approximate solutions for each equation are obtained. By comparison, the modified method proposed in this paper produces the same results as the method of multiple scales.