Understanding digital technology requires a shift in mindset that takes into account the broader implications of design,social dynamics,environmental factors,and cultural influences.Acknowledging the fact that technol...Understanding digital technology requires a shift in mindset that takes into account the broader implications of design,social dynamics,environmental factors,and cultural influences.Acknowledging the fact that technology is not confined to the virtual domain but rather has a tangible influence on our daily lives and the surrounding environment,the extensive integration and potential of digital technologies offer a distinctive prospect to fundamentally transform our shared comprehension of architecture.Digital technologies are revolutionizing design practices,manufacturing processes,and our engagement with and understanding of the built environment,by fostering the development of novel models that promote equity and inclusivity.The application of“digital technologies”can function as a methodology for examining and expressing the possible paths of emerging digital technologies.Extrapolate the expected impact of digital technologies on the design,development,and occupancy of the environment to achieve a more sustainable future in the long run.This paper will examine the potential connections and origins of digital technology concerning modularity,as well as the implications of modularity on forthcoming architectural developments in customization.展开更多
Subcortical vascular mild cognitive impairment(svMCI)is a common prodromal stage of vascular dementia.Although mounting evidence has suggested abnormalities in several single brain network metrics,few studies have exp...Subcortical vascular mild cognitive impairment(svMCI)is a common prodromal stage of vascular dementia.Although mounting evidence has suggested abnormalities in several single brain network metrics,few studies have explored the consistency between functional and structural connectivity networks in svMCI.Here,we constructed such networks using resting-state f MRI for functional connectivity and diffusion tensor imaging for structural connectivity in 30 patients with svMCI and 30 normal controls.The functional networks were then parcellated into topological modules,corresponding to several well-defined functional domains.The coupling between the functional and structural networks was finally estimated and compared at the multiscale network level(whole brain and modular level).We found no significant intergroup differences in the functional–structural coupling within the whole brain;however,there was significantly increased functional–structural coupling within the dorsal attention module and decreased functional–structural coupling within the ventral attention module in the svMCI group.In addition,the svMCI patients demonstrated decreased intramodular connectivity strength in the visual,somatomotor,and dorsal attention modules as well as decreased intermodular connectivity strength between several modules in the functional network,mainly linking the visual,somatomotor,dorsal attention,ventral attention,and frontoparietal control modules.There was no significant correlation between the altered module-level functional–structural coupling and cognitive performance in patients with svMCI.These findings demonstrate for the first time that svMCI is reflected in a selective aberrant topological organization in multiscale brain networks and may improve our understanding of the pathophysiological mechanisms underlying svMCI.展开更多
文摘Understanding digital technology requires a shift in mindset that takes into account the broader implications of design,social dynamics,environmental factors,and cultural influences.Acknowledging the fact that technology is not confined to the virtual domain but rather has a tangible influence on our daily lives and the surrounding environment,the extensive integration and potential of digital technologies offer a distinctive prospect to fundamentally transform our shared comprehension of architecture.Digital technologies are revolutionizing design practices,manufacturing processes,and our engagement with and understanding of the built environment,by fostering the development of novel models that promote equity and inclusivity.The application of“digital technologies”can function as a methodology for examining and expressing the possible paths of emerging digital technologies.Extrapolate the expected impact of digital technologies on the design,development,and occupancy of the environment to achieve a more sustainable future in the long run.This paper will examine the potential connections and origins of digital technology concerning modularity,as well as the implications of modularity on forthcoming architectural developments in customization.
基金supported by the Natural Science Foundation of Tianjin Municipal Science and Technology Commission(18JCQNJC10900)Tianjin Natural Science Foundation(17JCZDJC36300)。
文摘Subcortical vascular mild cognitive impairment(svMCI)is a common prodromal stage of vascular dementia.Although mounting evidence has suggested abnormalities in several single brain network metrics,few studies have explored the consistency between functional and structural connectivity networks in svMCI.Here,we constructed such networks using resting-state f MRI for functional connectivity and diffusion tensor imaging for structural connectivity in 30 patients with svMCI and 30 normal controls.The functional networks were then parcellated into topological modules,corresponding to several well-defined functional domains.The coupling between the functional and structural networks was finally estimated and compared at the multiscale network level(whole brain and modular level).We found no significant intergroup differences in the functional–structural coupling within the whole brain;however,there was significantly increased functional–structural coupling within the dorsal attention module and decreased functional–structural coupling within the ventral attention module in the svMCI group.In addition,the svMCI patients demonstrated decreased intramodular connectivity strength in the visual,somatomotor,and dorsal attention modules as well as decreased intermodular connectivity strength between several modules in the functional network,mainly linking the visual,somatomotor,dorsal attention,ventral attention,and frontoparietal control modules.There was no significant correlation between the altered module-level functional–structural coupling and cognitive performance in patients with svMCI.These findings demonstrate for the first time that svMCI is reflected in a selective aberrant topological organization in multiscale brain networks and may improve our understanding of the pathophysiological mechanisms underlying svMCI.