BACKGROUND:Acute liver failure is still a life-threaten- ing disease although it can be treated by liver transplanta- tion. This study was conducted to assess the molecular ad- sorbent recycling system (MARS), which m...BACKGROUND:Acute liver failure is still a life-threaten- ing disease although it can be treated by liver transplanta- tion. This study was conducted to assess the molecular ad- sorbent recycling system (MARS), which may bridge acute liver failure patients to liver transplantation. METHODS: Biochemical indexes and other clinical data were analyzed of 8 patients with acute liver failure, who had been treated by MARS for 34 times and subsequent Piggyback liver transplantation. RESULTS: After treatment with MARS, the levels of tran- saminase and total bilirubin decreased markedly, but coagu- lation function remained unimproved. All patients survived and discharged from the hospital. CONCLUSION: MARS is effective in bridging patients with acute liver failure to liver transplantation.展开更多
AIM:To identify prognostic factors for survival in patients with liver failure treated with a molecular adsorbent recirculating system(MARS). METHODS:MARS is a liver-assisting device that has been used in the treatmen...AIM:To identify prognostic factors for survival in patients with liver failure treated with a molecular adsorbent recirculating system(MARS). METHODS:MARS is a liver-assisting device that has been used in the treatment of liver failure to enable native liver recovery,and as a bridge to liver transplantation(LTX).We analyzed the 1-year outcomes of 188 patients treated with MARS,from 2001 to 2007, in an intensive care unit specializing in liver disease. Demographic,clinical and laboratory parameters were recorded before and after each treatment.One-year survival and the number of LTXs were recorded.Logistic regression analysis was performed to determine factors predicting survival. RESULTS:The study included 113 patients with acute liver failure(ALF),62 with acute-on-chronic liver failure(AOCLF),11 with graft failure(GF),and six with miscellaneous liver failure.LTX was performed for 29% of patients with ALF,18% with AOCLF and 55%with GF.The overall 1-year survival rate was 74% for ALF,27% for AOCLF,and 73% for GF.The poorest survival rate,6%,was noted in non-transplanted patients with alcohol-related AOCLF and cirrhosis,whereas,patients with enlarged and steatotic liver had 55% survival.The etiology of liver failure was the most important predictor of survival(P<0.0001).Other prognostic factors were encephalopathy(P=0.001)in paracetamol-related ALF, coagulation factors(P=0.049)and encephalopathy(P=0.064)in non-paracetamol-related toxic ALF,and alanine aminotransferase(P=0.013)and factor V levels(P =0.022)in ALF of unknown etiology. CONCLUSION:The etiology of liver disease was the most important prognostic factor.MARS treatment appears to be ineffective in AOCLF with end-stage cirrhosis without an LTX option.展开更多
BACKGROUND: Molecular adsorbents recirculating sys- tem (MARS) liver support therapy is the development of albumin dialysis. This study was to assess the successful ap- plication of MARS artificial liver support thera...BACKGROUND: Molecular adsorbents recirculating sys- tem (MARS) liver support therapy is the development of albumin dialysis. This study was to assess the successful ap- plication of MARS artificial liver support therapy as a bridge to re-transplantation in two cases of long anhepatic duration. METHODS: MARS therapy was given after failure plasma- exchange ( PE) treatment, which resulted in circulatory de- rangement and acute renal dysfunction in a 36-year-old male patient. Finally his uncontrolled anhepatic condition led to a successful re-transplantation. In another 48-year- old man who was diagnosed as having primary nonfunction (PNF) during the liver transplantation, 10-hour MARS treatment contributed to smooth bridging of his anhepatic phase. RESULTS: The two anhepatic patients were bridged for 26 and 17 hours respectively to re-transplantation with MARS therapy. CONCLUSION: Our experience proves that MARS artifi- cial liver can be an effective support for long time bridging PNF until re-transplantation is available.展开更多
Flue gas and coal bed methane are two important sources of greenhouse gases.Pressure swing adsorption process has a wide range of application in the field of gas separation,and the selection of adsorbent is crucial.In...Flue gas and coal bed methane are two important sources of greenhouse gases.Pressure swing adsorption process has a wide range of application in the field of gas separation,and the selection of adsorbent is crucial.In this regard,in order to assess the better adsorbent for separating CO_(2) from flue gas and CH_(4) from coal bed methane,adsorption isotherms of CO_(2),CH_(4) and N_(2) on activated carbon and carbon molecular sieve are measured at 303.15,318.15 and 333.15 K,and up to 250 kPa.The experimental data fit better with Langmuir 2 compared to Langmuir 3 and Langmuir-Freundlich models,and Clausius-Clapeyron equation was used to calculate the isosteric heat.Both the order of the adsorbed amount and the adsorption heat on the two adsorbents are CO_(2)>CH_(4)>N_(2).The adsorption kinetics are calculated by the pseudo-first kinetic model,and the order of adsorption rates on activated carbon is N_(2)-CH_(4)>CO_(2),while on carbon molecular sieve,it is CO_(2)-N_(2)>CH_(4).It is shown that relative molecular mass and adsorption heat are the primary effect on kinetics for activated carbon,while kinetic diameter is the main resistance factor for carbon molecular sieve.Moreover,the adsorption selectivity of CH_(4)/N_(2) and CO_(2)/N_(2) were estimated with the ideal adsorption solution theory,and carbon molecular sieve performed best at 318.15 K for both CO_(2) and CH_(4) separation.The study suggested that activated carbon is a better choice for separating flue gas and carbon molecular sieve can be a strong candidate for separating coal bed methane.展开更多
Background: Acute hepatitis C virus infection leading to fulminant hepatitis is very rare whereas Hepatitis C virus (HCV) infection is one of the main causes of chronic liver disease worldwide. The repertoire of subst...Background: Acute hepatitis C virus infection leading to fulminant hepatitis is very rare whereas Hepatitis C virus (HCV) infection is one of the main causes of chronic liver disease worldwide. The repertoire of substances that accumulate in the blood in fulminant hepatic failure cause neurological abnormalities, aggravate injury to the liver and other organs, suppress the ability of residual hepatocytes to perform organ-specific functions (sick cell syndrome), and inhibit the hepatic regenerative response especially in fulminant hepatitis Virus C which has subacute clinical evolution and takes time to manifest. Liver support technology is evolving as different techniques become available that assist the remaining functional cell mass by providing specific liver functions. Case Presentation: We report a case of Fulminant C virus Hepatitis, successfully treated with albumin dialysis Molecular Adsorbent Recirculating System (MARS). At time of admittance the patient presented: Model End-stage Liver Disease (MELD)-36;Child Turcotte Pugh (CTP)-C(13);Sequential Organ Failure Assestment (SOFA)-12, Glasgow Coma Score (GCS)-11. The patient underwent six sessions of MARS in Intensive Care Unit (ICU) in association with standard medical therapy (SMT). The patient survived and was discharged from the hospital in good condition after 40 days without liver transplantation (LT).展开更多
A novel solid support adsorbent for CO2capture was developed by loading pentaethylenehexamine(PEHA)on commercially available mesoporous molecular sieve MCM-41 using wet impregnation method.MCM-41 samples before and af...A novel solid support adsorbent for CO2capture was developed by loading pentaethylenehexamine(PEHA)on commercially available mesoporous molecular sieve MCM-41 using wet impregnation method.MCM-41 samples before and after PEHA loading were characterized by X-ray powder diffraction,N2adsorption/desorption,thermal gravimetric analysis and scanning electron microscope to investigate the textural and thermo-physical properties.CO2adsorption performance was evaluated in a fixed bed adsorption system.Results indicated that the structure of MCM-41 was preserved after loading PEHA.Surface area and total pore volume of PEHA loaded MCM-41 decreased with the increase of loading.The working adsorption capacity of CO2could be significantly improved at 60%of PEHA loading and 75°C.The effect of the height of adsorbent bed was investigated and the best working adsorption capacity for MCM-41-PEHA-60 reached 165 mg·(g adsorbent)-1at 75°C.Adsorption/desorption circle showed that the CO2working adsorption capacity of MCM-41-PEHA kept stable.展开更多
Methane(CH_(4))as a substitute for other mineral fuels plays a crucial role in reducing energy consumption and preventing environmental pollution.The present study employs a solvothermal method to fabricate a porous f...Methane(CH_(4))as a substitute for other mineral fuels plays a crucial role in reducing energy consumption and preventing environmental pollution.The present study employs a solvothermal method to fabricate a porous framework Co-metal-organic framework(Co-MOF)containing two distinct secondary building units(SBUs):an anionic[Co_(2)(μ_(2)-OH)(COO)_(4)(H_(2)O)]and a neutral[CoN_(2)(COO)_(2)].Notably,within the anionic SBUs,the coordinated water molecules induce the generation of divergent unsaturated Co(Ⅱ)centers in the unidirectional porous channels,thereby creating open metal sites.The adsorption performance of Co-MOF towards pure component gases was systematically investigated.The results demonstrated that Co-MOF exhibits superior adsorption capacity for C_(2)-C_(3) hydrocarbons compared to CH_(4),which offers the potential for efficient adsorption and separation of CH_(4) from C_(2)-C_(3) hydrocarbons.The gas selectivity separation ratios of Co-MOF for C_(2)H_(6)/CH_(4) and C_(3)H_8/CH_(4) were calculated using the ideal adsorbed solution theory method at 273/298 K and 0.1 MPa.The results revealed that Co-MOF achieved remarkable equilibrium separation selectivity for CH_(4) and C_(2)-C_(3) hydrocarbon gases among non-modified MOFs,signifying the potential of the synthesized Co-MOF for efficient recovery and purification of CH_(4) from C_(2)-C_(3) hydrocarbons.Breakthrough experiments further demonstrate the ability of Co-MOF to purify methane from C_(2)-C_(3) hydrocarbons in practical gas separation scenarios.Additionally,molecular simulation calculations further substantiate the propensity of anionic SBUs to interact with C_(2)-C_(3) hydrocarbon compounds.This study provides a novel paradigm for the development of porous MOF materials in the application of gas mixture separation.展开更多
Research and development of efficient, economical and resource-based flue gas desulfurization technology has always been a hot spot in the field of air pollution control. Molecular sieve materials have been paid atten...Research and development of efficient, economical and resource-based flue gas desulfurization technology has always been a hot spot in the field of air pollution control. Molecular sieve materials have been paid attention to by SO<sub>2</sub> adsorbent researchers due to their huge specific surface area. In this paper, 13X zeolite was modified with Cu(NO<sub>3</sub>) <sub>2</sub>·3H<sub>2</sub>O to obtain 13x-Xwt %CuO (calculated by the amount of CuO loaded). The adsorption time and capacity of SO<sub>2</sub> penetration sorbent and the isothermal curve of N<sub>2</sub> adsorption-desorption were studied. The results are as follows: 13X-3wt%CuO has the best adsorption effect, the penetration adsorption time is 110 min, the penetration adsorption capacity is 43.41 mg·g<sup>-1</sup>, the saturation adsorption capacity is 49.27 mg·g<sup>-1</sup>;The amount of CuO loading has a great influence on the adsorption effect of modified 13X molecular sieve on SO<sub>2</sub>. SEM and BET characterization showed that CuO modification did not change the external morphology of 13X molecular sieve, changed the pore size, but did not block the original channel of the molecular sieve, before and after modification belong to the type I adsorption isothermal curve. The pore size distribution and type of molecular sieve, as well as the content and type of alkali metal cations jointly control the adsorption process of SO<sub>2</sub> by 13X-xwt %CuO. XPS characterization showed that Cu(NO<sub>3</sub>) <sub>2</sub> decomposed into CuO and Cu<sub>2</sub>O during roasting at 450°C, CuO/Cu<sub>2</sub>O ≈ 1.5. The R<sup>2</sup> values of the quasi-second-order kinetic models obtained from the 13X-Xwt %CuO particle diffusion kinetic models were all above 0.99, indicating that the quasi-second-order kinetic equations were more relevant. Particle diffusion dynamics model in fitting results show that the adsorption process can be divided into two stages, the first phase of surface adsorption and diffusion rate in the granules common control process, more accurate dynamics model of the secondary in the second phase particle diffusion rate control stage, mainly for the micropore adsorption or chemical adsorption, quasi level 2 dynamic model conformity of variation;C is a constant not equal to 0, indicating that the adsorption of SO<sub>2</sub> is not completely through the form of intra-particle diffusion, and a small amount of chemisorption exists. And it is the compound effect of multiple adsorption mechanisms.展开更多
文摘BACKGROUND:Acute liver failure is still a life-threaten- ing disease although it can be treated by liver transplanta- tion. This study was conducted to assess the molecular ad- sorbent recycling system (MARS), which may bridge acute liver failure patients to liver transplantation. METHODS: Biochemical indexes and other clinical data were analyzed of 8 patients with acute liver failure, who had been treated by MARS for 34 times and subsequent Piggyback liver transplantation. RESULTS: After treatment with MARS, the levels of tran- saminase and total bilirubin decreased markedly, but coagu- lation function remained unimproved. All patients survived and discharged from the hospital. CONCLUSION: MARS is effective in bridging patients with acute liver failure to liver transplantation.
基金Supported by A Scientific Grant From the Helsinki University Central Hospital Research Fund(EVO)
文摘AIM:To identify prognostic factors for survival in patients with liver failure treated with a molecular adsorbent recirculating system(MARS). METHODS:MARS is a liver-assisting device that has been used in the treatment of liver failure to enable native liver recovery,and as a bridge to liver transplantation(LTX).We analyzed the 1-year outcomes of 188 patients treated with MARS,from 2001 to 2007, in an intensive care unit specializing in liver disease. Demographic,clinical and laboratory parameters were recorded before and after each treatment.One-year survival and the number of LTXs were recorded.Logistic regression analysis was performed to determine factors predicting survival. RESULTS:The study included 113 patients with acute liver failure(ALF),62 with acute-on-chronic liver failure(AOCLF),11 with graft failure(GF),and six with miscellaneous liver failure.LTX was performed for 29% of patients with ALF,18% with AOCLF and 55%with GF.The overall 1-year survival rate was 74% for ALF,27% for AOCLF,and 73% for GF.The poorest survival rate,6%,was noted in non-transplanted patients with alcohol-related AOCLF and cirrhosis,whereas,patients with enlarged and steatotic liver had 55% survival.The etiology of liver failure was the most important predictor of survival(P<0.0001).Other prognostic factors were encephalopathy(P=0.001)in paracetamol-related ALF, coagulation factors(P=0.049)and encephalopathy(P=0.064)in non-paracetamol-related toxic ALF,and alanine aminotransferase(P=0.013)and factor V levels(P =0.022)in ALF of unknown etiology. CONCLUSION:The etiology of liver disease was the most important prognostic factor.MARS treatment appears to be ineffective in AOCLF with end-stage cirrhosis without an LTX option.
文摘BACKGROUND: Molecular adsorbents recirculating sys- tem (MARS) liver support therapy is the development of albumin dialysis. This study was to assess the successful ap- plication of MARS artificial liver support therapy as a bridge to re-transplantation in two cases of long anhepatic duration. METHODS: MARS therapy was given after failure plasma- exchange ( PE) treatment, which resulted in circulatory de- rangement and acute renal dysfunction in a 36-year-old male patient. Finally his uncontrolled anhepatic condition led to a successful re-transplantation. In another 48-year- old man who was diagnosed as having primary nonfunction (PNF) during the liver transplantation, 10-hour MARS treatment contributed to smooth bridging of his anhepatic phase. RESULTS: The two anhepatic patients were bridged for 26 and 17 hours respectively to re-transplantation with MARS therapy. CONCLUSION: Our experience proves that MARS artifi- cial liver can be an effective support for long time bridging PNF until re-transplantation is available.
基金supported by the renewable energy and hydrogen projects in National Key Research and Development Plan of China(2019YFB1505000).
文摘Flue gas and coal bed methane are two important sources of greenhouse gases.Pressure swing adsorption process has a wide range of application in the field of gas separation,and the selection of adsorbent is crucial.In this regard,in order to assess the better adsorbent for separating CO_(2) from flue gas and CH_(4) from coal bed methane,adsorption isotherms of CO_(2),CH_(4) and N_(2) on activated carbon and carbon molecular sieve are measured at 303.15,318.15 and 333.15 K,and up to 250 kPa.The experimental data fit better with Langmuir 2 compared to Langmuir 3 and Langmuir-Freundlich models,and Clausius-Clapeyron equation was used to calculate the isosteric heat.Both the order of the adsorbed amount and the adsorption heat on the two adsorbents are CO_(2)>CH_(4)>N_(2).The adsorption kinetics are calculated by the pseudo-first kinetic model,and the order of adsorption rates on activated carbon is N_(2)-CH_(4)>CO_(2),while on carbon molecular sieve,it is CO_(2)-N_(2)>CH_(4).It is shown that relative molecular mass and adsorption heat are the primary effect on kinetics for activated carbon,while kinetic diameter is the main resistance factor for carbon molecular sieve.Moreover,the adsorption selectivity of CH_(4)/N_(2) and CO_(2)/N_(2) were estimated with the ideal adsorption solution theory,and carbon molecular sieve performed best at 318.15 K for both CO_(2) and CH_(4) separation.The study suggested that activated carbon is a better choice for separating flue gas and carbon molecular sieve can be a strong candidate for separating coal bed methane.
文摘Background: Acute hepatitis C virus infection leading to fulminant hepatitis is very rare whereas Hepatitis C virus (HCV) infection is one of the main causes of chronic liver disease worldwide. The repertoire of substances that accumulate in the blood in fulminant hepatic failure cause neurological abnormalities, aggravate injury to the liver and other organs, suppress the ability of residual hepatocytes to perform organ-specific functions (sick cell syndrome), and inhibit the hepatic regenerative response especially in fulminant hepatitis Virus C which has subacute clinical evolution and takes time to manifest. Liver support technology is evolving as different techniques become available that assist the remaining functional cell mass by providing specific liver functions. Case Presentation: We report a case of Fulminant C virus Hepatitis, successfully treated with albumin dialysis Molecular Adsorbent Recirculating System (MARS). At time of admittance the patient presented: Model End-stage Liver Disease (MELD)-36;Child Turcotte Pugh (CTP)-C(13);Sequential Organ Failure Assestment (SOFA)-12, Glasgow Coma Score (GCS)-11. The patient underwent six sessions of MARS in Intensive Care Unit (ICU) in association with standard medical therapy (SMT). The patient survived and was discharged from the hospital in good condition after 40 days without liver transplantation (LT).
基金Supported by Research Foundation of Overseas Chinese Affairs Office,the State Council,P.R.China,and FujianProvincial Science and Technology Creation Foundation for Young Researchers(No.2 0 0 1J0 2 3)
文摘Sieve effect, complexation, ionic exchange, electrostatic interaction, hydrogen bonding, hydrophobic interaction, and molecular recognition based on molecular imprinting are comprehensively discussed.
基金Supported by the National Natural Science Foundation of China(20836008,21176132)the Special Research Fund for the Doctoral Program of the Ministry of Education of China(20101012174)
文摘A novel solid support adsorbent for CO2capture was developed by loading pentaethylenehexamine(PEHA)on commercially available mesoporous molecular sieve MCM-41 using wet impregnation method.MCM-41 samples before and after PEHA loading were characterized by X-ray powder diffraction,N2adsorption/desorption,thermal gravimetric analysis and scanning electron microscope to investigate the textural and thermo-physical properties.CO2adsorption performance was evaluated in a fixed bed adsorption system.Results indicated that the structure of MCM-41 was preserved after loading PEHA.Surface area and total pore volume of PEHA loaded MCM-41 decreased with the increase of loading.The working adsorption capacity of CO2could be significantly improved at 60%of PEHA loading and 75°C.The effect of the height of adsorbent bed was investigated and the best working adsorption capacity for MCM-41-PEHA-60 reached 165 mg·(g adsorbent)-1at 75°C.Adsorption/desorption circle showed that the CO2working adsorption capacity of MCM-41-PEHA kept stable.
基金supported by the National Natural Science Foundation of China(21401099)the Natural Science Foundation of Shanxi Province(202203021212331)+3 种基金Science and Technology Innovation Project of Colleges and Universities of Shanxi Province(2022L532)the National Natural Science Foundation of Anhui Province(2008085MB32 and KJ2021ZD0073)Natural Science Foundation of Shandong Province(ZR2021QB159)supported by the Talent Program Foundation of Dezhou University(2021xjrc102)。
文摘Methane(CH_(4))as a substitute for other mineral fuels plays a crucial role in reducing energy consumption and preventing environmental pollution.The present study employs a solvothermal method to fabricate a porous framework Co-metal-organic framework(Co-MOF)containing two distinct secondary building units(SBUs):an anionic[Co_(2)(μ_(2)-OH)(COO)_(4)(H_(2)O)]and a neutral[CoN_(2)(COO)_(2)].Notably,within the anionic SBUs,the coordinated water molecules induce the generation of divergent unsaturated Co(Ⅱ)centers in the unidirectional porous channels,thereby creating open metal sites.The adsorption performance of Co-MOF towards pure component gases was systematically investigated.The results demonstrated that Co-MOF exhibits superior adsorption capacity for C_(2)-C_(3) hydrocarbons compared to CH_(4),which offers the potential for efficient adsorption and separation of CH_(4) from C_(2)-C_(3) hydrocarbons.The gas selectivity separation ratios of Co-MOF for C_(2)H_(6)/CH_(4) and C_(3)H_8/CH_(4) were calculated using the ideal adsorbed solution theory method at 273/298 K and 0.1 MPa.The results revealed that Co-MOF achieved remarkable equilibrium separation selectivity for CH_(4) and C_(2)-C_(3) hydrocarbon gases among non-modified MOFs,signifying the potential of the synthesized Co-MOF for efficient recovery and purification of CH_(4) from C_(2)-C_(3) hydrocarbons.Breakthrough experiments further demonstrate the ability of Co-MOF to purify methane from C_(2)-C_(3) hydrocarbons in practical gas separation scenarios.Additionally,molecular simulation calculations further substantiate the propensity of anionic SBUs to interact with C_(2)-C_(3) hydrocarbon compounds.This study provides a novel paradigm for the development of porous MOF materials in the application of gas mixture separation.
文摘Research and development of efficient, economical and resource-based flue gas desulfurization technology has always been a hot spot in the field of air pollution control. Molecular sieve materials have been paid attention to by SO<sub>2</sub> adsorbent researchers due to their huge specific surface area. In this paper, 13X zeolite was modified with Cu(NO<sub>3</sub>) <sub>2</sub>·3H<sub>2</sub>O to obtain 13x-Xwt %CuO (calculated by the amount of CuO loaded). The adsorption time and capacity of SO<sub>2</sub> penetration sorbent and the isothermal curve of N<sub>2</sub> adsorption-desorption were studied. The results are as follows: 13X-3wt%CuO has the best adsorption effect, the penetration adsorption time is 110 min, the penetration adsorption capacity is 43.41 mg·g<sup>-1</sup>, the saturation adsorption capacity is 49.27 mg·g<sup>-1</sup>;The amount of CuO loading has a great influence on the adsorption effect of modified 13X molecular sieve on SO<sub>2</sub>. SEM and BET characterization showed that CuO modification did not change the external morphology of 13X molecular sieve, changed the pore size, but did not block the original channel of the molecular sieve, before and after modification belong to the type I adsorption isothermal curve. The pore size distribution and type of molecular sieve, as well as the content and type of alkali metal cations jointly control the adsorption process of SO<sub>2</sub> by 13X-xwt %CuO. XPS characterization showed that Cu(NO<sub>3</sub>) <sub>2</sub> decomposed into CuO and Cu<sub>2</sub>O during roasting at 450°C, CuO/Cu<sub>2</sub>O ≈ 1.5. The R<sup>2</sup> values of the quasi-second-order kinetic models obtained from the 13X-Xwt %CuO particle diffusion kinetic models were all above 0.99, indicating that the quasi-second-order kinetic equations were more relevant. Particle diffusion dynamics model in fitting results show that the adsorption process can be divided into two stages, the first phase of surface adsorption and diffusion rate in the granules common control process, more accurate dynamics model of the secondary in the second phase particle diffusion rate control stage, mainly for the micropore adsorption or chemical adsorption, quasi level 2 dynamic model conformity of variation;C is a constant not equal to 0, indicating that the adsorption of SO<sub>2</sub> is not completely through the form of intra-particle diffusion, and a small amount of chemisorption exists. And it is the compound effect of multiple adsorption mechanisms.
